UniProtKB - Q92545 (TM131_HUMAN)
Protein
Transmembrane protein 131
Gene
TMEM131
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the immune response to viral infection.By similarity
Enzyme and pathway databases
PathwayCommonsi | Q92545 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 131Alternative name(s): Protein RW1 |
Gene namesi | Name:TMEM131 Synonyms:KIAA0257, RW1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30366, TMEM131 |
MIMi | 615659, gene |
neXtProti | NX_Q92545 |
VEuPathDBi | HostDB:ENSG00000075568.16 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1091 – 1111 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1118 – 1138 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23505 |
OpenTargetsi | ENSG00000075568 |
PharmGKBi | PA143485651 |
Miscellaneous databases
Pharosi | Q92545, Tbio |
Genetic variation databases
BioMutai | TMEM131 |
DMDMi | 327478552 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097538 | 1 – 1883 | Transmembrane protein 131Add BLAST | 1883 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 300 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 803 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1322 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1342 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1375 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1863 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1871 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q92545 |
jPOSTi | Q92545 |
MassIVEi | Q92545 |
MaxQBi | Q92545 |
PaxDbi | Q92545 |
PeptideAtlasi | Q92545 |
PRIDEi | Q92545 |
ProteomicsDBi | 75306 |
PTM databases
GlyConnecti | 1850, 4 N-Linked glycans (3 sites) |
GlyGeni | Q92545, 8 sites |
iPTMneti | Q92545 |
PhosphoSitePlusi | Q92545 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075568, Expressed in bronchial epithelial cell and 254 other tissues |
ExpressionAtlasi | Q92545, baseline and differential |
Genevisiblei | Q92545, HS |
Organism-specific databases
HPAi | ENSG00000075568, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 117052, 70 interactors |
IntActi | Q92545, 22 interactors |
STRINGi | 9606.ENSP00000186436 |
Miscellaneous databases
RNActi | Q92545, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1297 – 1332 | Pro-richAdd BLAST | 36 | |
Compositional biasi | 1379 – 1474 | Lys-richAdd BLAST | 96 | |
Compositional biasi | 1626 – 1630 | Poly-Ser | 5 | |
Compositional biasi | 1679 – 1815 | Ser-richAdd BLAST | 137 |
Sequence similaritiesi
Belongs to the TMEM131 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3620, Eukaryota |
GeneTreei | ENSGT00530000063614 |
HOGENOMi | CLU_002491_1_1_1 |
InParanoidi | Q92545 |
OMAi | VQRQWIT |
OrthoDBi | 45814at2759 |
PhylomeDBi | Q92545 |
TreeFami | TF321435 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR039877, TMEM131-like IPR022113, TMEM131-like_dom |
PANTHERi | PTHR22050, PTHR22050, 1 hit |
Pfami | View protein in Pfam PF12371, TMEM131_like, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q92545-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM
60 70 80 90 100
TLVVAAARAE KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL
110 120 130 140 150
YRGNCRPIRF EPPMLDFHEQ PVGMPKMEKV YLHNPSSEET ITLVSISATT
160 170 180 190 200
SHFHASFFQN RKILPGGNTS FDVVFLARVV GNVENTLFIN TSNHGVFTYQ
210 220 230 240 250
VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL QVVEMYSSGG
260 270 280 290 300
DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN
310 320 330 340 350
ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS
360 370 380 390 400
GTKDVPITSV RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK
410 420 430 440 450
PSQFSGKITV KAKEKSYSKL EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD
460 470 480 490 500
PVERPIYLTN TFSFAILIHD VLLPEEAKTM FKVHNFSKPV LILPNESGYI
510 520 530 540 550
FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY FVLPPKIEER
560 570 580 590 600
FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN
610 620 630 640 650
RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ
660 670 680 690 700
ITTDYEILTI PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS
710 720 730 740 750
QKVKIQQIRS LSEDVRFYYK RLRGNKEDLE PGKKSKIANI YFDPGLQCGD
760 770 780 790 800
HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD WDLHQSLFKG WTGIKENSGH
810 820 830 840 850
RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL TNTNCSSEEE
860 870 880 890 900
ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF
910 920 930 940 950
QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV
960 970 980 990 1000
SSLIIVRNNL TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK
1010 1020 1030 1040 1050
DCTDSLKLRE PNFTLKRTFK VENTGQLQIH IETIEISGYS CEGYGFKVVN
1060 1070 1080 1090 1100
CQEFTLSANA SRDIIILFTP DFTASRVIRE LKFITTSGSE FVFILNASLP
1110 1120 1130 1140 1150
YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY LEAQGIWEPF
1160 1170 1180 1190 1200
RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG
1210 1220 1230 1240 1250
GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ
1260 1270 1280 1290 1300
AASSQSANKT SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ
1310 1320 1330 1340 1350
HPQPPLPPPV PQPQEPQPER LSPAPLAHPS HPERASSARH SSEDSDITSL
1360 1370 1380 1390 1400
IEAMDKDFDH HDSPALEVFT EQPPSPLPKS KGKGKPLQRK VKPPKKQEEK
1410 1420 1430 1440 1450
EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE DTEKQKGKQA
1460 1470 1480 1490 1500
MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN
1510 1520 1530 1540 1550
LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT
1560 1570 1580 1590 1600
SSSEGEKDSP PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP
1610 1620 1630 1640 1650
TPASPSPPAA PCPFVARGSY SSIVNSSSSS DPKIKQPNGS KHKLTKAASL
1660 1670 1680 1690 1700
PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS NKTGFSSSLG ISHAPVDSDG
1710 1720 1730 1740 1750
SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK LGLSRSCNQA
1760 1770 1780 1790 1800
SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS
1810 1820 1830 1840 1850
TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD
1860 1870 1880
DLGQTYNPWR IWSPTIGRRS SDPWSNSHFP HEN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZ05 | H7BZ05_HUMAN | Transmembrane protein 131 | TMEM131 | 142 | Annotation score: | ||
H7BZV0 | H7BZV0_HUMAN | Transmembrane protein 131 | TMEM131 | 332 | Annotation score: | ||
C9J6W0 | C9J6W0_HUMAN | Transmembrane protein 131 | TMEM131 | 128 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079337 Genomic DNA No translation available. AC016699 Genomic DNA No translation available. D87446 mRNA Translation: BAA13387.1 |
CCDSi | CCDS46368.1 |
RefSeqi | NP_056163.1, NM_015348.1 |
Genome annotation databases
Ensembli | ENST00000186436; ENSP00000186436; ENSG00000075568 |
GeneIDi | 23505 |
KEGGi | hsa:23505 |
UCSCi | uc002syh.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079337 Genomic DNA No translation available. AC016699 Genomic DNA No translation available. D87446 mRNA Translation: BAA13387.1 |
CCDSi | CCDS46368.1 |
RefSeqi | NP_056163.1, NM_015348.1 |
3D structure databases
SMRi | Q92545 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117052, 70 interactors |
IntActi | Q92545, 22 interactors |
STRINGi | 9606.ENSP00000186436 |
PTM databases
GlyConnecti | 1850, 4 N-Linked glycans (3 sites) |
GlyGeni | Q92545, 8 sites |
iPTMneti | Q92545 |
PhosphoSitePlusi | Q92545 |
Genetic variation databases
BioMutai | TMEM131 |
DMDMi | 327478552 |
Proteomic databases
EPDi | Q92545 |
jPOSTi | Q92545 |
MassIVEi | Q92545 |
MaxQBi | Q92545 |
PaxDbi | Q92545 |
PeptideAtlasi | Q92545 |
PRIDEi | Q92545 |
ProteomicsDBi | 75306 |
Protocols and materials databases
Antibodypediai | 9002, 20 antibodies |
Genome annotation databases
Ensembli | ENST00000186436; ENSP00000186436; ENSG00000075568 |
GeneIDi | 23505 |
KEGGi | hsa:23505 |
UCSCi | uc002syh.5, human |
Organism-specific databases
CTDi | 23505 |
DisGeNETi | 23505 |
GeneCardsi | TMEM131 |
HGNCi | HGNC:30366, TMEM131 |
HPAi | ENSG00000075568, Low tissue specificity |
MIMi | 615659, gene |
neXtProti | NX_Q92545 |
OpenTargetsi | ENSG00000075568 |
PharmGKBi | PA143485651 |
VEuPathDBi | HostDB:ENSG00000075568.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3620, Eukaryota |
GeneTreei | ENSGT00530000063614 |
HOGENOMi | CLU_002491_1_1_1 |
InParanoidi | Q92545 |
OMAi | VQRQWIT |
OrthoDBi | 45814at2759 |
PhylomeDBi | Q92545 |
TreeFami | TF321435 |
Enzyme and pathway databases
PathwayCommonsi | Q92545 |
Miscellaneous databases
BioGRID-ORCSi | 23505, 14 hits in 996 CRISPR screens |
ChiTaRSi | TMEM131, human |
GeneWikii | TMEM131 |
GenomeRNAii | 23505 |
Pharosi | Q92545, Tbio |
PROi | PR:Q92545 |
RNActi | Q92545, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075568, Expressed in bronchial epithelial cell and 254 other tissues |
ExpressionAtlasi | Q92545, baseline and differential |
Genevisiblei | Q92545, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR039877, TMEM131-like IPR022113, TMEM131-like_dom |
PANTHERi | PTHR22050, PTHR22050, 1 hit |
Pfami | View protein in Pfam PF12371, TMEM131_like, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM131_HUMAN | |
Accessioni | Q92545Primary (citable) accession number: Q92545 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families