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UniProtKB - Q92545 (TM131_HUMAN)

Entry version 146 (07 Apr 2021)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
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Protein

Transmembrane protein 131

Gene

TMEM131

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the immune response to viral infection.By similarity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92545

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 131
Alternative name(s):
Protein RW1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM131
Synonyms:KIAA0257, RW1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30366, TMEM131

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615659, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92545

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000075568.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1091 – 1111HelicalSequence analysisAdd BLAST21
Transmembranei1118 – 1138HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23505

Open Targets

More...OpenTargetsi		ENSG00000075568

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485651

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92545, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM131

Domain mapping of disease mutations (DMDM)

More...DMDMi		327478552

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975381 – 1883Transmembrane protein 131Add BLAST1883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi300N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei803PhosphoserineCombined sources1
Modified residuei1322PhosphoserineCombined sources1
Modified residuei1342PhosphoserineCombined sources1
Modified residuei1375PhosphoserineCombined sources1
Modified residuei1863PhosphoserineCombined sources1
Modified residuei1871PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92545

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92545

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92545

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92545

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92545

PeptideAtlas

More...PeptideAtlasi		Q92545

PRoteomics IDEntifications database

More...PRIDEi		Q92545

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75306

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1850, 4 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92545, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92545

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92545

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075568, Expressed in bronchial epithelial cell and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92545, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92545, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075568, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117052, 70 interactors

Protein interaction database and analysis system

More...IntActi		Q92545, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000186436

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92545, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92545

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1297 – 1332Pro-richAdd BLAST36
Compositional biasi1379 – 1474Lys-richAdd BLAST96
Compositional biasi1626 – 1630Poly-Ser5
Compositional biasi1679 – 1815Ser-richAdd BLAST137

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM131 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3620, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002491_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92545

Identification of Orthologs from Complete Genome Data

More...OMAi		VQRQWIT

Database of Orthologous Groups

More...OrthoDBi		45814at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92545

TreeFam database of animal gene trees

More...TreeFami		TF321435

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR039877, TMEM131-like
IPR022113, TMEM131-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR22050, PTHR22050, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12371, TMEM131_like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92545-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM 
        60         70         80         90        100
TLVVAAARAE KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL 
       110        120        130        140        150
YRGNCRPIRF EPPMLDFHEQ PVGMPKMEKV YLHNPSSEET ITLVSISATT 
       160        170        180        190        200
SHFHASFFQN RKILPGGNTS FDVVFLARVV GNVENTLFIN TSNHGVFTYQ 
       210        220        230        240        250
VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL QVVEMYSSGG 
       260        270        280        290        300
DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN 
       310        320        330        340        350
ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS 
       360        370        380        390        400
GTKDVPITSV RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK 
       410        420        430        440        450
PSQFSGKITV KAKEKSYSKL EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD 
       460        470        480        490        500
PVERPIYLTN TFSFAILIHD VLLPEEAKTM FKVHNFSKPV LILPNESGYI 
       510        520        530        540        550
FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY FVLPPKIEER 
       560        570        580        590        600
FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN 
       610        620        630        640        650
RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ 
       660        670        680        690        700
ITTDYEILTI PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS 
       710        720        730        740        750
QKVKIQQIRS LSEDVRFYYK RLRGNKEDLE PGKKSKIANI YFDPGLQCGD 
       760        770        780        790        800
HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD WDLHQSLFKG WTGIKENSGH 
       810        820        830        840        850
RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL TNTNCSSEEE 
       860        870        880        890        900
ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF 
       910        920        930        940        950
QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV 
       960        970        980        990       1000
SSLIIVRNNL TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK 
      1010       1020       1030       1040       1050
DCTDSLKLRE PNFTLKRTFK VENTGQLQIH IETIEISGYS CEGYGFKVVN 
      1060       1070       1080       1090       1100
CQEFTLSANA SRDIIILFTP DFTASRVIRE LKFITTSGSE FVFILNASLP 
      1110       1120       1130       1140       1150
YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY LEAQGIWEPF 
      1160       1170       1180       1190       1200
RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG 
      1210       1220       1230       1240       1250
GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ 
      1260       1270       1280       1290       1300
AASSQSANKT SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ 
      1310       1320       1330       1340       1350
HPQPPLPPPV PQPQEPQPER LSPAPLAHPS HPERASSARH SSEDSDITSL 
      1360       1370       1380       1390       1400
IEAMDKDFDH HDSPALEVFT EQPPSPLPKS KGKGKPLQRK VKPPKKQEEK 
      1410       1420       1430       1440       1450
EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE DTEKQKGKQA 
      1460       1470       1480       1490       1500
MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN 
      1510       1520       1530       1540       1550
LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT 
      1560       1570       1580       1590       1600
SSSEGEKDSP PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP 
      1610       1620       1630       1640       1650
TPASPSPPAA PCPFVARGSY SSIVNSSSSS DPKIKQPNGS KHKLTKAASL 
      1660       1670       1680       1690       1700
PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS NKTGFSSSLG ISHAPVDSDG 
      1710       1720       1730       1740       1750
SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK LGLSRSCNQA 
      1760       1770       1780       1790       1800
SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS 
      1810       1820       1830       1840       1850
TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD 
      1860       1870       1880 
DLGQTYNPWR IWSPTIGRRS SDPWSNSHFP HEN
Length:1,883
Mass (Da):205,138
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBC61F6C939A336E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ05H7BZ05_HUMAN
Transmembrane protein 131
TMEM131
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZV0H7BZV0_HUMAN
Transmembrane protein 131
TMEM131
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6W0C9J6W0_HUMAN
Transmembrane protein 131
TMEM131
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC079337 Genomic DNA No translation available.
AC016699 Genomic DNA No translation available.
D87446 mRNA Translation: BAA13387.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46368.1

NCBI Reference Sequences

More...RefSeqi		NP_056163.1, NM_015348.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000186436; ENSP00000186436; ENSG00000075568

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23505

UCSC genome browser

More...UCSCi		uc002syh.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079337 Genomic DNA No translation available.
AC016699 Genomic DNA No translation available.
D87446 mRNA Translation: BAA13387.1
CCDSiCCDS46368.1
RefSeqiNP_056163.1, NM_015348.1

3D structure databases

SMRiQ92545
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117052, 70 interactors
IntActiQ92545, 22 interactors
STRINGi9606.ENSP00000186436

PTM databases

GlyConnecti1850, 4 N-Linked glycans (3 sites)
GlyGeniQ92545, 8 sites
iPTMnetiQ92545
PhosphoSitePlusiQ92545

Genetic variation databases

BioMutaiTMEM131
DMDMi327478552

Proteomic databases

EPDiQ92545
jPOSTiQ92545
MassIVEiQ92545
MaxQBiQ92545
PaxDbiQ92545
PeptideAtlasiQ92545
PRIDEiQ92545
ProteomicsDBi75306

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9002, 20 antibodies

Genome annotation databases

EnsembliENST00000186436; ENSP00000186436; ENSG00000075568
GeneIDi23505
KEGGihsa:23505
UCSCiuc002syh.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23505
DisGeNETi23505

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM131
HGNCiHGNC:30366, TMEM131
HPAiENSG00000075568, Low tissue specificity
MIMi615659, gene
neXtProtiNX_Q92545
OpenTargetsiENSG00000075568
PharmGKBiPA143485651
VEuPathDBiHostDB:ENSG00000075568.16

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3620, Eukaryota
GeneTreeiENSGT00530000063614
HOGENOMiCLU_002491_1_1_1
InParanoidiQ92545
OMAiVQRQWIT
OrthoDBi45814at2759
PhylomeDBiQ92545
TreeFamiTF321435

Enzyme and pathway databases

PathwayCommonsiQ92545

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23505, 14 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM131, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TMEM131

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23505
PharosiQ92545, Tbio

Protein Ontology

More...PROi		PR:Q92545
RNActiQ92545, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075568, Expressed in bronchial epithelial cell and 254 other tissues
ExpressionAtlasiQ92545, baseline and differential
GenevisibleiQ92545, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR039877, TMEM131-like
IPR022113, TMEM131-like_dom
PANTHERiPTHR22050, PTHR22050, 1 hit
PfamiView protein in Pfam
PF12371, TMEM131_like, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM131_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92545
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 5, 2011
Last modified: April 7, 2021
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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