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Entry version 147 (13 Feb 2019)
Sequence version 2 (26 Feb 2008)
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Protein

Transmembrane 9 superfamily member 4

Gene

TM9SF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell adhesion Source: UniProtKB
  • phagocytosis Source: UniProtKB
  • positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB
  • positive regulation of protein localization to cell surface Source: UniProtKB
  • protein localization to membrane Source: GO_Central
  • regulation of intracellular pH Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • vacuolar proton-transporting V-type ATPase complex assembly Source: UniProtKB

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.68.1.3 the endomembrane protein-70 (emp70) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 4
Alternative name(s):
Tumor cannibalism associated protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TM9SF4
Synonyms:KIAA0255, TUCAP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101337.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30797 TM9SF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617727 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92544

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 281ExtracellularSequence analysisAdd BLAST258
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 346CytoplasmicSequence analysisAdd BLAST44
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 376ExtracellularSequence analysis9
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 416CytoplasmicSequence analysisAdd BLAST19
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 449ExtracellularSequence analysisAdd BLAST12
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 501CytoplasmicSequence analysisAdd BLAST31
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 535ExtracellularSequence analysisAdd BLAST13
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 570CytoplasmicSequence analysisAdd BLAST14
Transmembranei571 – 591HelicalSequence analysisAdd BLAST21
Topological domaini592 – 598ExtracellularSequence analysis7
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 642CytoplasmicSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9777

Open Targets

More...
OpenTargetsi
ENSG00000101337

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937613

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TM9SF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172045829

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000021017824 – 642Transmembrane 9 superfamily member 4Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei312PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92544

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92544

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92544

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92544

PeptideAtlas

More...
PeptideAtlasi
Q92544

PRoteomics IDEntifications database

More...
PRIDEi
Q92544

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75305

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92544

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92544

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92544

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34+ hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcriptionally repressed following hypoxia by HIF1A in leukemic cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101337 Expressed in 229 organ(s), highest expression level in epithelium of bronchus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92544 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92544 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064099

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATP6V1H in colon cancer cells (PubMed:25659576).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115121, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q92544, 32 interactors

Molecular INTeraction database

More...
MINTi
Q92544

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381104

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q92544

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1278 Eukaryota
ENOG410XPIW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000216679

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054197

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92544

KEGG Orthology (KO)

More...
KOi
K17086

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMVLTFW

Database of Orthologous Groups

More...
OrthoDBi
641127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92544

TreeFam database of animal gene trees

More...
TreeFami
TF354239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004240 EMP70

The PANTHER Classification System

More...
PANTHERi
PTHR10766 PTHR10766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02990 EMP70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q92544-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAMDWLPW SLLLFSLMCE TSAFYVPGVA PINFHQNDPV EIKAVKLTSS
60 70 80 90 100
RTQLPYEYYS LPFCQPSKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC
110 120 130 140 150
EVLCSQSNKP VTLTVEQSRL VAERITEDYY VHLIADNLPV ATRLELYSNR
160 170 180 190 200
DSDDKKKEKD VQFEHGYRLG FTDVNKIYLH NHLSFILYYH REDMEEDQEH
210 220 230 240 250
TYRVVRFEVI PQSIRLEDLK ADEKSSCTLP EGTNSSPQEI DPTKENQLYF
260 270 280 290 300
TYSVHWEESD IKWASRWDTY LTMSDVQIHW FSIINSVVVV FFLSGILSMI
310 320 330 340 350
IIRTLRKDIA NYNKEDDIED TMEESGWKLV HGDVFRPPQY PMILSSLLGS
360 370 380 390 400
GIQLFCMILI VIFVAMLGML SPSSRGALMT TACFLFMFMG VFGGFSAGRL
410 420 430 440 450
YRTLKGHRWK KGAFCTATLY PGVVFGICFV LNCFIWGKHS SGAVPFPTMV
460 470 480 490 500
ALLCMWFGIS LPLVYLGYYF GFRKQPYDNP VRTNQIPRQI PEQRWYMNRF
510 520 530 540 550
VGILMAGILP FGAMFIELFF IFSAIWENQF YYLFGFLFLV FIILVVSCSQ
560 570 580 590 600
ISIVMVYFQL CAEDYRWWWR NFLVSGGSAF YVLVYAIFYF VNKLDIVEFI
610 620 630 640
PSLLYFGYTA LMVLSFWLLT GTIGFYAAYM FVRKIYAAVK ID
Length:642
Mass (Da):74,519
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91E8F925D64A5AE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2L1F2Z2L1_HUMAN
Transmembrane 9 superfamily member
TM9SF4
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFM1A0A0C4DFM1_HUMAN
Transmembrane 9 superfamily member
TM9SF4 hCG_38809
625Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCN2F8WCN2_HUMAN
Transmembrane 9 superfamily member
TM9SF4
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21107 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA13385 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D87444 mRNA Translation: BAA13385.2 Different initiation.
AL049539 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76391.1
BC021107 mRNA Translation: AAH21107.1 Different initiation.
BC022850 mRNA Translation: AAH22850.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13196.2

NCBI Reference Sequences

More...
RefSeqi
NP_055557.2, NM_014742.3
XP_005260679.1, XM_005260622.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654665

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398022; ENSP00000381104; ENSG00000101337

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9777

UCSC genome browser

More...
UCSCi
uc002wxj.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87444 mRNA Translation: BAA13385.2 Different initiation.
AL049539 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76391.1
BC021107 mRNA Translation: AAH21107.1 Different initiation.
BC022850 mRNA Translation: AAH22850.2
CCDSiCCDS13196.2
RefSeqiNP_055557.2, NM_014742.3
XP_005260679.1, XM_005260622.4
UniGeneiHs.654665

3D structure databases

ProteinModelPortaliQ92544
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115121, 54 interactors
IntActiQ92544, 32 interactors
MINTiQ92544
STRINGi9606.ENSP00000381104

Protein family/group databases

TCDBi8.A.68.1.3 the endomembrane protein-70 (emp70) family

PTM databases

iPTMnetiQ92544
PhosphoSitePlusiQ92544
SwissPalmiQ92544

Polymorphism and mutation databases

BioMutaiTM9SF4
DMDMi172045829

Proteomic databases

EPDiQ92544
jPOSTiQ92544
MaxQBiQ92544
PaxDbiQ92544
PeptideAtlasiQ92544
PRIDEiQ92544
ProteomicsDBi75305

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398022; ENSP00000381104; ENSG00000101337
GeneIDi9777
KEGGihsa:9777
UCSCiuc002wxj.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9777
DisGeNETi9777
EuPathDBiHostDB:ENSG00000101337.15

GeneCards: human genes, protein and diseases

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GeneCardsi
TM9SF4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0015722
HGNCiHGNC:30797 TM9SF4
HPAiHPA064099
MIMi617727 gene
neXtProtiNX_Q92544
OpenTargetsiENSG00000101337
PharmGKBiPA134937613

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1278 Eukaryota
ENOG410XPIW LUCA
GeneTreeiENSGT00940000157198
HOGENOMiHOG000216679
HOVERGENiHBG054197
InParanoidiQ92544
KOiK17086
OMAiLMVLTFW
OrthoDBi641127at2759
PhylomeDBiQ92544
TreeFamiTF354239

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TM9SF4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9777

Protein Ontology

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PROi
PR:Q92544

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101337 Expressed in 229 organ(s), highest expression level in epithelium of bronchus
ExpressionAtlasiQ92544 baseline and differential
GenevisibleiQ92544 HS

Family and domain databases

InterProiView protein in InterPro
IPR004240 EMP70
PANTHERiPTHR10766 PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990 EMP70, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM9S4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92544
Secondary accession number(s): B0QYT7, Q9NUA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 26, 2008
Last modified: February 13, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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