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Protein

Sorting nexin-19

Gene

SNX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei582Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei629Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chondrocyte differentiation Source: GO_Central
  • dense core granule maturation Source: GO_Central
  • exocytosis Source: UniProtKB-KW
  • insulin secretion Source: GO_Central

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-19
Gene namesi
Name:SNX19
Synonyms:KIAA0254
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000120451.10
HGNCiHGNC:21532 SNX19
neXtProtiNX_Q92543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi399979
OpenTargetsiENSG00000120451
PharmGKBiPA134904352

Polymorphism and mutation databases

BioMutaiSNX19
DMDMi296452910

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138681 – 992Sorting nexin-19Add BLAST992

Proteomic databases

EPDiQ92543
MaxQBiQ92543
PaxDbiQ92543
PeptideAtlasiQ92543
PRIDEiQ92543
ProteomicsDBi75304

PTM databases

iPTMnetiQ92543
PhosphoSitePlusiQ92543

Expressioni

Gene expression databases

BgeeiENSG00000120451 Expressed in 230 organ(s), highest expression level in corpus callosum
CleanExiHS_SNX19
ExpressionAtlasiQ92543 baseline and differential
GenevisibleiQ92543 HS

Organism-specific databases

HPAiHPA013447

Interactioni

Subunit structurei

Interacts with PTPRN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRNQ168494EBI-728232,EBI-728153

Protein-protein interaction databases

BioGridi134476, 8 interactors
IntActiQ92543, 5 interactors
MINTiQ92543
STRINGi9606.ENSP00000265909

Structurei

3D structure databases

ProteinModelPortaliQ92543
SMRiQ92543
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 272PXAPROSITE-ProRule annotationAdd BLAST178
Domaini533 – 663PXPROSITE-ProRule annotationAdd BLAST131

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IH51 Eukaryota
ENOG410XTBC LUCA
GeneTreeiENSGT00730000111038
HOGENOMiHOG000168459
HOVERGENiHBG062485
InParanoidiQ92543
KOiK17930
OMAiWIHLVLV
OrthoDBiEOG091G08SX
PhylomeDBiQ92543
TreeFamiTF324055

Family and domain databases

CDDicd06893 PX_SNX19, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR034908 SNX19
IPR037909 SNX19_PX
IPR013937 Sorting_nexin_C
PANTHERiPTHR22775:SF31 PTHR22775:SF31, 1 hit
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTETVPPFQ ETPAGSSCHL NNLLSSRKLM AVGVLLGWLL VIHLLVNVWL
60 70 80 90 100
LCLLSALLVV LGGWLGSSLA GVASGRLHLE RFIPLATCPP CPEAERQLER
110 120 130 140 150
EINRTIQMII RDFVLSWYRS VSQEPAFEEE MEAAMKGLVQ ELRRRMSVMD
160 170 180 190 200
SHAVAQSVLT LCGCHLQSYI QAKEATAGKN GPVEPSHLWE AYCRATAPHP
210 220 230 240 250
AVHSPSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE LITCNVILPL
260 270 280 290 300
ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL
310 320 330 340 350
PEGRASPVAA PVFLSYSEPE GSAGPSPEVE EGHEAVEGDL GGMCEERKVG
360 370 380 390 400
NNSSHFLQPN VRGPLFLCED SELESPLSEL GKETIMLMTP GSFLSDRIQD
410 420 430 440 450
ALCALESSQA LEPKDGEASE GAEAEEGPGT ETETGLPVST LNSCPEIHID
460 470 480 490 500
TADKEIEQGD VTASVTALLE GPEKTCPSRP SCLEKDLTND VSSLDPTLPP
510 520 530 540 550
VLLSSSPPGP LSSATFSFEP LSSPDGPVII QNLRITGTIT AREHSGTGFH
560 570 580 590 600
PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR
610 620 630 640 650
KFIKNVKGPK KLFPDLPLGN MDSDRVEARK SLLESFLKQL CAIPEIANSE
660 670 680 690 700
EVQEFLALNT DARIAFVKKP FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP
710 720 730 740 750
TEELSEAETE SKPQTEGKKA SKSRLRFSSS KISPALSVTE AQDKILYCLQ
760 770 780 790 800
EGNVESETLS MSAMESFIEK QTKLLEMQPT KAPEKDPEQP PKGRVDSCVS
810 820 830 840 850
DAAVPAQDPS NSDPGTETEL ADTALDLLLL LLTEQWKWLC TENMQKFLRL
860 870 880 890 900
IFGTLVQRWL EVQVANLTSP QRWVQYLLLL QESIWPGGVL PKFPRPVRTQ
910 920 930 940 950
EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CRLSWGLVLE SLQQPLINRH
960 970 980 990
LIYCLGDIIL EFLDLSASVE ESAATTSASD TPGNSKRMGV SS
Length:992
Mass (Da):108,598
Last modified:May 18, 2010 - v2
Checksum:i0540670530743C6B
GO
Isoform 2 (identifier: Q92543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     755-771: Missing.
     815-820: GTETEL → AEHAMC
     821-992: Missing.

Note: No experimental confirmation available.
Show »
Length:803
Mass (Da):87,343
Checksum:iFA52A230597FCBA0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLV3E9PLV3_HUMAN
Sorting nexin-19
SNX19
372Annotation score:
E9PJV7E9PJV7_HUMAN
Sorting nexin-19
SNX19
232Annotation score:
E7ERC7E7ERC7_HUMAN
Sorting nexin-19
SNX19
160Annotation score:

Sequence cautioni

The sequence BAA13384 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060288361V → L3 PublicationsCorresponds to variant dbSNP:rs3751037Ensembl.1
Natural variantiVAR_060289396D → E. Corresponds to variant dbSNP:rs1050081Ensembl.1
Natural variantiVAR_057334407S → G. Corresponds to variant dbSNP:rs3190345Ensembl.1
Natural variantiVAR_060290618L → F3 PublicationsCorresponds to variant dbSNP:rs681982Ensembl.1
Natural variantiVAR_060291753N → S3 PublicationsCorresponds to variant dbSNP:rs4414223Ensembl.1
Natural variantiVAR_060292878L → R2 PublicationsCorresponds to variant dbSNP:rs2298566Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057153755 – 771Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_057154815 – 820GTETEL → AEHAMC in isoform 2. 1 Publication6
Alternative sequenceiVSP_057155821 – 992Missing in isoform 2. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395843 mRNA Translation: AAK73124.1
D87443 mRNA Translation: BAA13384.2 Different initiation.
AP000824 Genomic DNA No translation available.
AP001093 Genomic DNA No translation available.
BC031620 mRNA Translation: AAH31620.1
CCDSiCCDS31721.1 [Q92543-1]
CCDS86261.1 [Q92543-2]
RefSeqiNP_001334847.1, NM_001347918.1
NP_001334848.1, NM_001347919.1
NP_001334849.1, NM_001347920.1
NP_001334850.1, NM_001347921.1
NP_001334851.1, NM_001347922.1
NP_001334852.1, NM_001347923.1
NP_001334853.1, NM_001347924.1
NP_001334854.1, NM_001347925.1
NP_001334855.1, NM_001347926.1
NP_001334856.1, NM_001347927.1
NP_055573.2, NM_014758.2
UniGeneiHs.444024

Genome annotation databases

EnsembliENST00000265909; ENSP00000265909; ENSG00000120451 [Q92543-1]
ENST00000533214; ENSP00000435390; ENSG00000120451 [Q92543-2]
GeneIDi399979
KEGGihsa:399979
UCSCiuc001qgk.5 human [Q92543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395843 mRNA Translation: AAK73124.1
D87443 mRNA Translation: BAA13384.2 Different initiation.
AP000824 Genomic DNA No translation available.
AP001093 Genomic DNA No translation available.
BC031620 mRNA Translation: AAH31620.1
CCDSiCCDS31721.1 [Q92543-1]
CCDS86261.1 [Q92543-2]
RefSeqiNP_001334847.1, NM_001347918.1
NP_001334848.1, NM_001347919.1
NP_001334849.1, NM_001347920.1
NP_001334850.1, NM_001347921.1
NP_001334851.1, NM_001347922.1
NP_001334852.1, NM_001347923.1
NP_001334853.1, NM_001347924.1
NP_001334854.1, NM_001347925.1
NP_001334855.1, NM_001347926.1
NP_001334856.1, NM_001347927.1
NP_055573.2, NM_014758.2
UniGeneiHs.444024

3D structure databases

ProteinModelPortaliQ92543
SMRiQ92543
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134476, 8 interactors
IntActiQ92543, 5 interactors
MINTiQ92543
STRINGi9606.ENSP00000265909

PTM databases

iPTMnetiQ92543
PhosphoSitePlusiQ92543

Polymorphism and mutation databases

BioMutaiSNX19
DMDMi296452910

Proteomic databases

EPDiQ92543
MaxQBiQ92543
PaxDbiQ92543
PeptideAtlasiQ92543
PRIDEiQ92543
ProteomicsDBi75304

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265909; ENSP00000265909; ENSG00000120451 [Q92543-1]
ENST00000533214; ENSP00000435390; ENSG00000120451 [Q92543-2]
GeneIDi399979
KEGGihsa:399979
UCSCiuc001qgk.5 human [Q92543-1]

Organism-specific databases

CTDi399979
DisGeNETi399979
EuPathDBiHostDB:ENSG00000120451.10
GeneCardsiSNX19
HGNCiHGNC:21532 SNX19
HPAiHPA013447
neXtProtiNX_Q92543
OpenTargetsiENSG00000120451
PharmGKBiPA134904352
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH51 Eukaryota
ENOG410XTBC LUCA
GeneTreeiENSGT00730000111038
HOGENOMiHOG000168459
HOVERGENiHBG062485
InParanoidiQ92543
KOiK17930
OMAiWIHLVLV
OrthoDBiEOG091G08SX
PhylomeDBiQ92543
TreeFamiTF324055

Miscellaneous databases

ChiTaRSiSNX19 human
GenomeRNAii399979
PROiPR:Q92543

Gene expression databases

BgeeiENSG00000120451 Expressed in 230 organ(s), highest expression level in corpus callosum
CleanExiHS_SNX19
ExpressionAtlasiQ92543 baseline and differential
GenevisibleiQ92543 HS

Family and domain databases

CDDicd06893 PX_SNX19, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR034908 SNX19
IPR037909 SNX19_PX
IPR013937 Sorting_nexin_C
PANTHERiPTHR22775:SF31 PTHR22775:SF31, 1 hit
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX19_HUMAN
AccessioniPrimary (citable) accession number: Q92543
Secondary accession number(s): E9PKB9, Q8IV55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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