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Entry version 157 (22 Apr 2020)
Sequence version 2 (18 May 2010)
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Protein

Sorting nexin-19

Gene

SNX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in intracellular vesicle trafficking and exocytosis (PubMed:24843546). May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion (PubMed:24843546). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei582Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei629Phosphatidylinositol 3-phosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorting nexin-19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNX19
Synonyms:KIAA0254
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21532 SNX19

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
399979

Open Targets

More...
OpenTargetsi
ENSG00000120451

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134904352

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92543 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNX19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138681 – 992Sorting nexin-19Add BLAST992

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92543

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92543

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92543

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92543

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92543

PeptideAtlas

More...
PeptideAtlasi
Q92543

PRoteomics IDEntifications database

More...
PRIDEi
Q92543

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
21412
75304 [Q92543-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000120451 Expressed in corpus callosum and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92543 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92543 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120451 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPRN.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
134476, 9 interactors

Protein interaction database and analysis system

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IntActi
Q92543, 8 interactors

Molecular INTeraction database

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MINTi
Q92543

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265909

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q92543 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92543

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 272PXAPROSITE-ProRule annotationAdd BLAST178
Domaini533 – 663PXPROSITE-ProRule annotationAdd BLAST131

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IH51 Eukaryota
ENOG410XTBC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182856

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012033_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92543

KEGG Orthology (KO)

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KOi
K17930

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDWIHLI

Database of Orthologous Groups

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OrthoDBi
1342782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92543

TreeFam database of animal gene trees

More...
TreeFami
TF324055

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06893 PX_SNX19, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR034908 SNX19
IPR037909 SNX19_PX
IPR013937 Sorting_nexin_C

The PANTHER Classification System

More...
PANTHERi
PTHR22775:SF31 PTHR22775:SF31, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTETVPPFQ ETPAGSSCHL NNLLSSRKLM AVGVLLGWLL VIHLLVNVWL
60 70 80 90 100
LCLLSALLVV LGGWLGSSLA GVASGRLHLE RFIPLATCPP CPEAERQLER
110 120 130 140 150
EINRTIQMII RDFVLSWYRS VSQEPAFEEE MEAAMKGLVQ ELRRRMSVMD
160 170 180 190 200
SHAVAQSVLT LCGCHLQSYI QAKEATAGKN GPVEPSHLWE AYCRATAPHP
210 220 230 240 250
AVHSPSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE LITCNVILPL
260 270 280 290 300
ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL
310 320 330 340 350
PEGRASPVAA PVFLSYSEPE GSAGPSPEVE EGHEAVEGDL GGMCEERKVG
360 370 380 390 400
NNSSHFLQPN VRGPLFLCED SELESPLSEL GKETIMLMTP GSFLSDRIQD
410 420 430 440 450
ALCALESSQA LEPKDGEASE GAEAEEGPGT ETETGLPVST LNSCPEIHID
460 470 480 490 500
TADKEIEQGD VTASVTALLE GPEKTCPSRP SCLEKDLTND VSSLDPTLPP
510 520 530 540 550
VLLSSSPPGP LSSATFSFEP LSSPDGPVII QNLRITGTIT AREHSGTGFH
560 570 580 590 600
PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR
610 620 630 640 650
KFIKNVKGPK KLFPDLPLGN MDSDRVEARK SLLESFLKQL CAIPEIANSE
660 670 680 690 700
EVQEFLALNT DARIAFVKKP FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP
710 720 730 740 750
TEELSEAETE SKPQTEGKKA SKSRLRFSSS KISPALSVTE AQDKILYCLQ
760 770 780 790 800
EGNVESETLS MSAMESFIEK QTKLLEMQPT KAPEKDPEQP PKGRVDSCVS
810 820 830 840 850
DAAVPAQDPS NSDPGTETEL ADTALDLLLL LLTEQWKWLC TENMQKFLRL
860 870 880 890 900
IFGTLVQRWL EVQVANLTSP QRWVQYLLLL QESIWPGGVL PKFPRPVRTQ
910 920 930 940 950
EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CRLSWGLVLE SLQQPLINRH
960 970 980 990
LIYCLGDIIL EFLDLSASVE ESAATTSASD TPGNSKRMGV SS
Length:992
Mass (Da):108,598
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0540670530743C6B
GO
Isoform 2 (identifier: Q92543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     755-771: Missing.
     815-820: GTETEL → AEHAMC
     821-992: Missing.

Show »
Length:803
Mass (Da):87,343
Checksum:iFA52A230597FCBA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLV3E9PLV3_HUMAN
Sorting nexin-19
SNX19
372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJV7E9PJV7_HUMAN
Sorting nexin-19
SNX19
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERC7E7ERC7_HUMAN
Sorting nexin-19
SNX19
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13384 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060288361V → L3 PublicationsCorresponds to variant dbSNP:rs3751037Ensembl.1
Natural variantiVAR_060289396D → E. Corresponds to variant dbSNP:rs1050081Ensembl.1
Natural variantiVAR_057334407S → G. Corresponds to variant dbSNP:rs3190345Ensembl.1
Natural variantiVAR_060290618L → F3 PublicationsCorresponds to variant dbSNP:rs681982Ensembl.1
Natural variantiVAR_060291753N → S3 PublicationsCorresponds to variant dbSNP:rs4414223Ensembl.1
Natural variantiVAR_060292878L → R2 PublicationsCorresponds to variant dbSNP:rs2298566Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057153755 – 771Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_057154815 – 820GTETEL → AEHAMC in isoform 2. 1 Publication6
Alternative sequenceiVSP_057155821 – 992Missing in isoform 2. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF395843 mRNA Translation: AAK73124.1
D87443 mRNA Translation: BAA13384.2 Different initiation.
AP000824 Genomic DNA No translation available.
AP001093 Genomic DNA No translation available.
BC031620 mRNA Translation: AAH31620.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31721.1 [Q92543-1]
CCDS86261.1 [Q92543-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001334847.1, NM_001347918.1
NP_001334848.1, NM_001347919.1
NP_001334849.1, NM_001347920.1
NP_001334850.1, NM_001347921.1
NP_001334851.1, NM_001347922.1
NP_001334852.1, NM_001347923.1
NP_001334853.1, NM_001347924.1
NP_001334854.1, NM_001347925.1
NP_001334855.1, NM_001347926.1
NP_001334856.1, NM_001347927.1
NP_055573.2, NM_014758.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265909; ENSP00000265909; ENSG00000120451 [Q92543-1]
ENST00000533214; ENSP00000435390; ENSG00000120451 [Q92543-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
399979

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:399979

UCSC genome browser

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UCSCi
uc001qgk.5 human [Q92543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395843 mRNA Translation: AAK73124.1
D87443 mRNA Translation: BAA13384.2 Different initiation.
AP000824 Genomic DNA No translation available.
AP001093 Genomic DNA No translation available.
BC031620 mRNA Translation: AAH31620.1
CCDSiCCDS31721.1 [Q92543-1]
CCDS86261.1 [Q92543-2]
RefSeqiNP_001334847.1, NM_001347918.1
NP_001334848.1, NM_001347919.1
NP_001334849.1, NM_001347920.1
NP_001334850.1, NM_001347921.1
NP_001334851.1, NM_001347922.1
NP_001334852.1, NM_001347923.1
NP_001334853.1, NM_001347924.1
NP_001334854.1, NM_001347925.1
NP_001334855.1, NM_001347926.1
NP_001334856.1, NM_001347927.1
NP_055573.2, NM_014758.2

3D structure databases

SMRiQ92543
ModBaseiSearch...

Protein-protein interaction databases

BioGridi134476, 9 interactors
IntActiQ92543, 8 interactors
MINTiQ92543
STRINGi9606.ENSP00000265909

PTM databases

iPTMnetiQ92543
PhosphoSitePlusiQ92543

Polymorphism and mutation databases

BioMutaiSNX19
DMDMi296452910

Proteomic databases

EPDiQ92543
jPOSTiQ92543
MassIVEiQ92543
MaxQBiQ92543
PaxDbiQ92543
PeptideAtlasiQ92543
PRIDEiQ92543
ProteomicsDBi21412
75304 [Q92543-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2996 90 antibodies

Genome annotation databases

EnsembliENST00000265909; ENSP00000265909; ENSG00000120451 [Q92543-1]
ENST00000533214; ENSP00000435390; ENSG00000120451 [Q92543-2]
GeneIDi399979
KEGGihsa:399979
UCSCiuc001qgk.5 human [Q92543-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
399979
DisGeNETi399979

GeneCards: human genes, protein and diseases

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GeneCardsi
SNX19
HGNCiHGNC:21532 SNX19
HPAiENSG00000120451 Low tissue specificity
neXtProtiNX_Q92543
OpenTargetsiENSG00000120451
PharmGKBiPA134904352

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH51 Eukaryota
ENOG410XTBC LUCA
GeneTreeiENSGT00950000182856
HOGENOMiCLU_012033_0_0_1
InParanoidiQ92543
KOiK17930
OMAiPDWIHLI
OrthoDBi1342782at2759
PhylomeDBiQ92543
TreeFamiTF324055

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNX19 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
399979
PharosiQ92543 Tbio

Protein Ontology

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PROi
PR:Q92543
RNActiQ92543 protein

Gene expression databases

BgeeiENSG00000120451 Expressed in corpus callosum and 229 other tissues
ExpressionAtlasiQ92543 baseline and differential
GenevisibleiQ92543 HS

Family and domain databases

CDDicd06893 PX_SNX19, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR003114 Phox_assoc
IPR036871 PX_dom_sf
IPR034908 SNX19
IPR037909 SNX19_PX
IPR013937 Sorting_nexin_C
PANTHERiPTHR22775:SF31 PTHR22775:SF31, 1 hit
PfamiView protein in Pfam
PF08628 Nexin_C, 1 hit
PF00787 PX, 1 hit
PF02194 PXA, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00313 PXA, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS51207 PXA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNX19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92543
Secondary accession number(s): E9PKB9, Q8IV55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: April 22, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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