UniProtKB - Q92542 (NICA_HUMAN)
Nicastrin
NCSTN
Functioni
GO - Molecular functioni
- ATPase binding Source: ARUK-UCL
- endopeptidase activity Source: Ensembl
- growth factor receptor binding Source: ARUK-UCL
GO - Biological processi
- adult behavior Source: Ensembl
- amyloid-beta formation Source: UniProtKB
- amyloid precursor protein biosynthetic process Source: Ensembl
- amyloid precursor protein catabolic process Source: HGNC-UCL
- amyloid precursor protein metabolic process Source: UniProtKB
- cellular protein metabolic process Source: Reactome
- cellular response to calcium ion Source: Ensembl
- central nervous system myelination Source: Ensembl
- cerebellum development Source: Ensembl
- dopamine receptor signaling pathway Source: Ensembl
- ephrin receptor signaling pathway Source: Reactome
- epithelial cell proliferation Source: Ensembl
- glutamate receptor signaling pathway Source: Ensembl
- learning or memory Source: Ensembl
- membrane protein ectodomain proteolysis Source: HGNC-UCL
- membrane protein intracellular domain proteolysis Source: Reactome
- myeloid cell homeostasis Source: Ensembl
- neuron apoptotic process Source: Ensembl
- neutrophil degranulation Source: Reactome
- Notch receptor processing Source: GO_Central
- Notch receptor processing, ligand-dependent Source: Reactome
- positive regulation of amyloid precursor protein biosynthetic process Source: Ensembl
- positive regulation of apoptotic process Source: Reactome
- positive regulation of catalytic activity Source: HGNC-UCL
- protein processing Source: HGNC-UCL
- proteolysis Source: UniProtKB
- regulation of long-term synaptic potentiation Source: Ensembl
- short-term synaptic potentiation Source: Ensembl
- T cell proliferation Source: Ensembl
Keywordsi
Biological process | Notch signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q92542 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1474228, Degradation of the extracellular matrix R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-205043, NRIF signals cell death from the nucleus R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-6798695, Neutrophil degranulation R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9017802, Noncanonical activation of NOTCH3 R-HSA-977225, Amyloid fiber formation |
SignaLinki | Q92542 |
SIGNORi | Q92542 |
Names & Taxonomyi
Protein namesi | Recommended name: Nicastrin |
Gene namesi | Name:NCSTN Synonyms:KIAA0253 ORF Names:UNQ1874/PRO4317 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17091, NCSTN |
MIMi | 605254, gene |
neXtProti | NX_Q92542 |
VEuPathDBi | HostDB:ENSG00000162736.15 |
Subcellular locationi
Other locations
- Membrane 6 Publications; Single-pass type I membrane protein 6 Publications
- Cytoplasmic vesicle membrane 1 Publication; Single-pass type I membrane protein 6 Publications
- Melanosome 2 Publications
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Endoplasmic reticulum
- endoplasmic reticulum Source: HGNC-UCL
Endosome
- early endosome Source: Ensembl
- endosome membrane Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HGNC-UCL
Lysosome
- azurophil granule membrane Source: Reactome
- lysosomal membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: Ensembl
Plasma Membrane
- gamma-secretase complex Source: UniProtKB
- integral component of plasma membrane Source: HGNC-UCL
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: Reactome
- sarcolemma Source: Ensembl
Other locations
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 669 | Extracellular2 PublicationsAdd BLAST | 636 | |
Transmembranei | 670 – 690 | Helical2 PublicationsAdd BLAST | 21 | |
Topological domaini | 691 – 709 | Cytoplasmic2 PublicationsAdd BLAST | 19 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePathology & Biotechi
Involvement in diseasei
Acne inversa, familial, 1 (ACNINV1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067756 | 211 | P → R in ACNINV1. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 336 – 337 | DY → AA: Increases production of amyloid-beta (beta-APP40 and beta-APP42) in APP processing. 1 Publication | 2 | |
Mutagenesisi | 653 | W → A or F: No effect on gamma-secretase activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 23385 |
MalaCardsi | NCSTN |
MIMi | 142690, phenotype |
OpenTargetsi | ENSG00000162736 |
Orphaneti | 387, NON RARE IN EUROPE: Hidradenitis suppurativa |
PharmGKBi | PA142671271 |
Miscellaneous databases
Pharosi | Q92542, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3418 |
Genetic variation databases
BioMutai | NCSTN |
DMDMi | 12231037 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000019681 | 34 – 709 | NicastrinAdd BLAST | 676 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | |
Disulfide bondi | 50 ↔ 62 | Combined sources2 Publications4 Publications | ||
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Disulfide bondi | 140 ↔ 159 | Combined sources4 Publications | ||
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | |
Disulfide bondi | 195 ↔ 213 | Combined sources1 Publication2 Publications | ||
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 204 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 230 ↔ 248 | Combined sources1 Publication4 Publications | ||
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 387 | N-linked (GlcNAc...) asparagineCombined sources5 Publications | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 435 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 464 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 506 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 530 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 562 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 573 | N-linked (GlcNAc...) asparagineSequence analysisCombined sources3 Publications | 1 | |
Glycosylationi | 580 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 586 ↔ 620 | Combined sources4 Publications | ||
Glycosylationi | 612 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q92542 |
jPOSTi | Q92542 |
MassIVEi | Q92542 |
MaxQBi | Q92542 |
PaxDbi | Q92542 |
PeptideAtlasi | Q92542 |
PRIDEi | Q92542 |
ProteomicsDBi | 75302 [Q92542-1] 75303 [Q92542-2] |
TopDownProteomicsi | Q92542-2 [Q92542-2] |
PTM databases
GlyConnecti | 1567, 6 N-Linked glycans (7 sites) |
GlyGeni | Q92542, 19 sites |
iPTMneti | Q92542 |
PhosphoSitePlusi | Q92542 |
SwissPalmi | Q92542 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000162736, Expressed in placenta and 237 other tissues |
ExpressionAtlasi | Q92542, baseline and differential |
Genevisiblei | Q92542, HS |
Organism-specific databases
HPAi | ENSG00000162736, Low tissue specificity |
Interactioni
Subunit structurei
Component of the gamma-secretase complex (PubMed:10993067, PubMed:30598546, PubMed:30630874). The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2 (PubMed:12740439, PubMed:25043039, PubMed:26623517, PubMed:26280335, PubMed:25918421, PubMed:30598546, PubMed:30630874). Binds to proteolytic processed C-terminal fragments C83 and C99 of the amyloid precursor protein (APP) (PubMed:10993067, PubMed:30630874).
Interacts with PSEN1 and PSEN2 (PubMed:10993067).
8 PublicationsBinary interactionsi
Hide detailsQ92542
GO - Molecular functioni
- ATPase binding Source: ARUK-UCL
- growth factor receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 116961, 151 interactors |
ComplexPortali | CPX-2176, Gamma-secretase complex, APH1A-PSEN1 variant CPX-4231, Gamma-secretase complex, APH1A-PSEN2 variant CPX-4232, Gamma-secretase complex, APH1B-PSEN2 variant CPX-4233, Gamma-secretase complex, APH1B-PSEN1 variant |
CORUMi | Q92542 |
DIPi | DIP-36336N |
IntActi | Q92542, 87 interactors |
MINTi | Q92542 |
STRINGi | 9606.ENSP00000294785 |
Chemistry databases
BindingDBi | Q92542 |
Miscellaneous databases
RNActi | Q92542, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q92542 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2657, Eukaryota |
GeneTreei | ENSGT00390000014633 |
HOGENOMi | CLU_024257_0_0_1 |
InParanoidi | Q92542 |
OMAi | SYGSEFA |
OrthoDBi | 777987at2759 |
PhylomeDBi | Q92542 |
TreeFami | TF317086 |
Family and domain databases
InterProi | View protein in InterPro IPR041084, Ncstrn_small IPR008710, Nicastrin |
PANTHERi | PTHR21092, PTHR21092, 1 hit |
Pfami | View protein in Pfam PF18266, Ncstrn_small, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC
60 70 80 90 100
VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES
110 120 130 140 150
KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN
160 170 180 190 200
SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQCYQDHN
210 220 230 240 250
LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF SINPEIVCDP
260 270 280 290 300
LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA
310 320 330 340 350
SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG
360 370 380 390 400
KFPVQLENVD SFVELGQVAL RTSLELWMHT DPVSQKNESV RNQVEDLLAT
410 420 430 440 450
LEKSGAGVPA VILRRPNQSQ PLPPSSLQRF LRARNISGVV LADHSGAFHN
460 470 480 490 500
KYYQSIYDTA ENINVSYPEW LSPEEDLNFV TDTAKALADV ATVLGRALYE
510 520 530 540 550
LAGGTNFSDT VQADPQTVTR LLYGFLIKAN NSWFQSILRQ DLRSYLGDGP
560 570 580 590 600
LQHYIAVSSP TNTTYVVQYA LANLTGTVVN LTREQCQDPS KVPSENKDLY
610 620 630 640 650
EYSWVQGPLH SNETDRLPRC VRSTARLARA LSPAFELSQW SSTEYSTWTE
660 670 680 690 700
SRWKDIRARI FLIASKELEL ITLTVGFGIL IFSLIVTYCI NAKADVLFIA
PREPGAVSY
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T209 | Q5T209_HUMAN | Nicastrin | NCSTN | 255 | Annotation score: | ||
Q5T210 | Q5T210_HUMAN | Nicastrin | NCSTN | 232 | Annotation score: | ||
Q5T211 | Q5T211_HUMAN | Nicastrin | NCSTN | 134 | Annotation score: | ||
H0Y3Z4 | H0Y3Z4_HUMAN | Nicastrin | NCSTN | 316 | Annotation score: | ||
A0A2R8YE20 | A0A2R8YE20_HUMAN | Nicastrin | NCSTN | 71 | Annotation score: | ||
H0Y6T7 | H0Y6T7_HUMAN | Nicastrin | NCSTN | 275 | Annotation score: | ||
Q5T205 | Q5T205_HUMAN | Nicastrin | NCSTN | 219 | Annotation score: | ||
A0A2U3TZL9 | A0A2U3TZL9_HUMAN | Nicastrin | NCSTN | 69 | Annotation score: | ||
A0A2R8YCK1 | A0A2R8YCK1_HUMAN | Nicastrin | NCSTN | 69 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 657 | R → H in AAH47621 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050274 | 75 | V → I. Corresponds to variant dbSNP:rs12045198Ensembl. | 1 | |
Natural variantiVAR_050275 | 77 | E → D. Corresponds to variant dbSNP:rs35603924EnsemblClinVar. | 1 | |
Natural variantiVAR_067756 | 211 | P → R in ACNINV1. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008385 | 1 – 20 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_008386 | 21 – 29 | LSFCVLLAG → MDFNLILES in isoform 2. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF240468 mRNA Translation: AAG11412.1 AY359120 mRNA Translation: AAQ89478.1 AK314764 mRNA Translation: BAG37302.1 AL445230 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52720.1 CH471121 Genomic DNA Translation: EAW52721.1 CH471121 Genomic DNA Translation: EAW52722.1 BC047621 mRNA Translation: AAH47621.1 D87442 mRNA Translation: BAA13383.1 |
CCDSi | CCDS1203.1 [Q92542-1] |
RefSeqi | NP_001277113.1, NM_001290184.1 [Q92542-2] NP_001277115.1, NM_001290186.1 NP_056146.1, NM_015331.2 [Q92542-1] |
Genome annotation databases
Ensembli | ENST00000294785; ENSP00000294785; ENSG00000162736 [Q92542-1] |
GeneIDi | 23385 |
KEGGi | hsa:23385 |
UCSCi | uc001fvx.4, human [Q92542-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF240468 mRNA Translation: AAG11412.1 AY359120 mRNA Translation: AAQ89478.1 AK314764 mRNA Translation: BAG37302.1 AL445230 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52720.1 CH471121 Genomic DNA Translation: EAW52721.1 CH471121 Genomic DNA Translation: EAW52722.1 BC047621 mRNA Translation: AAH47621.1 D87442 mRNA Translation: BAA13383.1 |
CCDSi | CCDS1203.1 [Q92542-1] |
RefSeqi | NP_001277113.1, NM_001290184.1 [Q92542-2] NP_001277115.1, NM_001290186.1 NP_056146.1, NM_015331.2 [Q92542-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N7Q | NMR | - | A | 664-709 | [»] | |
2N7R | NMR | - | A | 664-709 | [»] | |
4UIS | electron microscopy | 4.40 | A | 42-665 | [»] | |
5A63 | electron microscopy | 3.40 | A | 1-709 | [»] | |
5FN2 | electron microscopy | 4.20 | A | 1-709 | [»] | |
5FN3 | electron microscopy | 4.10 | A | 1-709 | [»] | |
5FN4 | electron microscopy | 4.00 | A | 1-709 | [»] | |
5FN5 | electron microscopy | 4.30 | A | 1-709 | [»] | |
6IDF | electron microscopy | 2.70 | A | 1-709 | [»] | |
6IYC | electron microscopy | 2.60 | A | 1-709 | [»] | |
SMRi | Q92542 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116961, 151 interactors |
ComplexPortali | CPX-2176, Gamma-secretase complex, APH1A-PSEN1 variant CPX-4231, Gamma-secretase complex, APH1A-PSEN2 variant CPX-4232, Gamma-secretase complex, APH1B-PSEN2 variant CPX-4233, Gamma-secretase complex, APH1B-PSEN1 variant |
CORUMi | Q92542 |
DIPi | DIP-36336N |
IntActi | Q92542, 87 interactors |
MINTi | Q92542 |
STRINGi | 9606.ENSP00000294785 |
Chemistry databases
BindingDBi | Q92542 |
ChEMBLi | CHEMBL3418 |
PTM databases
GlyConnecti | 1567, 6 N-Linked glycans (7 sites) |
GlyGeni | Q92542, 19 sites |
iPTMneti | Q92542 |
PhosphoSitePlusi | Q92542 |
SwissPalmi | Q92542 |
Genetic variation databases
BioMutai | NCSTN |
DMDMi | 12231037 |
Proteomic databases
EPDi | Q92542 |
jPOSTi | Q92542 |
MassIVEi | Q92542 |
MaxQBi | Q92542 |
PaxDbi | Q92542 |
PeptideAtlasi | Q92542 |
PRIDEi | Q92542 |
ProteomicsDBi | 75302 [Q92542-1] 75303 [Q92542-2] |
TopDownProteomicsi | Q92542-2 [Q92542-2] |
Protocols and materials databases
Antibodypediai | 20490, 533 antibodies |
DNASUi | 23385 |
Genome annotation databases
Ensembli | ENST00000294785; ENSP00000294785; ENSG00000162736 [Q92542-1] |
GeneIDi | 23385 |
KEGGi | hsa:23385 |
UCSCi | uc001fvx.4, human [Q92542-1] |
Organism-specific databases
CTDi | 23385 |
DisGeNETi | 23385 |
GeneCardsi | NCSTN |
HGNCi | HGNC:17091, NCSTN |
HPAi | ENSG00000162736, Low tissue specificity |
MalaCardsi | NCSTN |
MIMi | 142690, phenotype 605254, gene |
neXtProti | NX_Q92542 |
OpenTargetsi | ENSG00000162736 |
Orphaneti | 387, NON RARE IN EUROPE: Hidradenitis suppurativa |
PharmGKBi | PA142671271 |
VEuPathDBi | HostDB:ENSG00000162736.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2657, Eukaryota |
GeneTreei | ENSGT00390000014633 |
HOGENOMi | CLU_024257_0_0_1 |
InParanoidi | Q92542 |
OMAi | SYGSEFA |
OrthoDBi | 777987at2759 |
PhylomeDBi | Q92542 |
TreeFami | TF317086 |
Enzyme and pathway databases
PathwayCommonsi | Q92542 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-1474228, Degradation of the extracellular matrix R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-205043, NRIF signals cell death from the nucleus R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-6798695, Neutrophil degranulation R-HSA-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9017802, Noncanonical activation of NOTCH3 R-HSA-977225, Amyloid fiber formation |
SignaLinki | Q92542 |
SIGNORi | Q92542 |
Miscellaneous databases
BioGRID-ORCSi | 23385, 25 hits in 876 CRISPR screens |
ChiTaRSi | NCSTN, human |
GeneWikii | Nicastrin |
GenomeRNAii | 23385 |
Pharosi | Q92542, Tbio |
PROi | PR:Q92542 |
RNActi | Q92542, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162736, Expressed in placenta and 237 other tissues |
ExpressionAtlasi | Q92542, baseline and differential |
Genevisiblei | Q92542, HS |
Family and domain databases
InterProi | View protein in InterPro IPR041084, Ncstrn_small IPR008710, Nicastrin |
PANTHERi | PTHR21092, PTHR21092, 1 hit |
Pfami | View protein in Pfam PF18266, Ncstrn_small, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NICA_HUMAN | |
Accessioni | Q92542Primary (citable) accession number: Q92542 Secondary accession number(s): Q5T207, Q5T208, Q86VV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 11, 2001 | |
Last modified: | February 10, 2021 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants