UniProtKB - Q92540 (SMG7_HUMAN)
Nonsense-mediated mRNA decay factor SMG7
SMG7
Functioni
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
2 PublicationsGO - Molecular functioni
- protein phosphatase 2A binding Source: HGNC-UCL
- telomerase RNA binding Source: GO_Central
- telomeric DNA binding Source: BHF-UCL
GO - Biological processi
- mRNA export from nucleus Source: HGNC-UCL
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: GO_Central
- regulation of dephosphorylation Source: HGNC-UCL
Keywordsi
Biological process | Nonsense-mediated mRNA decay |
Enzyme and pathway databases
PathwayCommonsi | Q92540 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | Q92540 |
Names & Taxonomyi
Protein namesi | Recommended name: Nonsense-mediated mRNA decay factor SMG7ImportedAlternative name(s): SMG-7 homologImported Short name: hSMG-7 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16792, SMG7 |
MIMi | 610964, gene |
neXtProti | NX_Q92540 |
VEuPathDBi | HostDB:ENSG00000116698 |
Subcellular locationi
Cytoskeleton
- intermediate filament cytoskeleton Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: HGNC-UCL
- telomerase holoenzyme complex Source: GO_Central
Other locations
- cytoplasm Source: HGNC-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 66 | K → E: Abolishes interaction with UPF1; when associated with E-163. 1 Publication | 1 | |
Mutagenesisi | 163 | R → E: Abolishes interaction with UPF1; when associated with E-66. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9887 |
OpenTargetsi | ENSG00000116698 |
PharmGKBi | PA25605 |
Miscellaneous databases
Pharosi | Q92540, Tbio |
Genetic variation databases
BioMutai | SMG7 |
DMDMi | 84028262 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000076324 | 2 – 1137 | Nonsense-mediated mRNA decay factor SMG7Add BLAST | 1136 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 520 | PhosphoserineCombined sources | 1 | |
Modified residuei | 624 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 781 | PhosphoserineCombined sources | 1 | |
Modified residuei | 897 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q92540 |
jPOSTi | Q92540 |
MassIVEi | Q92540 |
MaxQBi | Q92540 |
PeptideAtlasi | Q92540 |
PRIDEi | Q92540 |
ProteomicsDBi | 19450 19888 75298 [Q92540-1] 75299 [Q92540-2] 75300 [Q92540-4] |
PTM databases
GlyGeni | Q92540, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q92540 |
PhosphoSitePlusi | Q92540 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116698, Expressed in oviduct epithelium and 246 other tissues |
ExpressionAtlasi | Q92540, baseline and differential |
Genevisiblei | Q92540, HS |
Organism-specific databases
HPAi | ENSG00000116698, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- protein phosphatase 2A binding Source: HGNC-UCL
Protein-protein interaction databases
BioGRIDi | 115218, 300 interactors |
IntActi | Q92540, 37 interactors |
MINTi | Q92540 |
STRINGi | 9606.ENSP00000425133 |
Miscellaneous databases
RNActi | Q92540, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q92540 |
SMRi | Q92540 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q92540 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 152 – 185 | TPR 11 PublicationAdd BLAST | 34 | |
Repeati | 187 – 219 | TPR 21 PublicationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 620 – 646 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 696 – 794 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 890 – 911 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 988 – 1055 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 1069 – 1089 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1104 – 1137 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 629 – 646 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 696 – 775 | Polar residuesSequence analysisAdd BLAST | 80 | |
Compositional biasi | 988 – 1030 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 1069 – 1087 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG2162, Eukaryota |
GeneTreei | ENSGT00940000158333 |
HOGENOMi | CLU_009299_0_0_1 |
InParanoidi | Q92540 |
OMAi | TWAGHGP |
OrthoDBi | 556396at2759 |
PhylomeDBi | Q92540 |
TreeFami | TF327119 |
Family and domain databases
DisProti | DP01844 |
Gene3Di | 1.25.40.10, 1 hit |
IDEALi | IID00090 |
InterProi | View protein in InterPro IPR018834, DNA/RNA-bd_Est1-type IPR045153, Est1/Ebs1-like IPR019458, Est1_N IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR15696, PTHR15696, 1 hit |
Pfami | View protein in Pfam PF10374, EST1, 1 hit PF10373, EST1_DNA_bind, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY
60 70 80 90 100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG
110 120 130 140 150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI
160 170 180 190 200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG
210 220 230 240 250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI
260 270 280 290 300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI
310 320 330 340 350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE
360 370 380 390 400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF
410 420 430 440 450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ
460 470 480 490 500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA
510 520 530 540 550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN
560 570 580 590 600
IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL
610 620 630 640 650
EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH
660 670 680 690 700
HPGAFPPLPS RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA
710 720 730 740 750
HSPAGNQVQA GKQSHIPYSQ QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ
760 770 780 790 800
PTAQSTSQLQ VQALTQQQQS PTKAVPALGK SPPHHSGFQQ YQQADASKQL
810 820 830 840 850
WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM QQQPLEKKMK
860 870 880 890 900
PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV
910 920 930 940 950
FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF
960 970 980 990 1000
NEVYGKNLTS SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA
1010 1020 1030 1040 1050
SQSPHSSNPS SLPSSPPTHN HNSVPFSNFG PIGTPDNRDR RTADRWKTDK
1060 1070 1080 1090 1100
PAMGGFGIDY LSATSSSESS WHQASTPSGT WTGHGPSMED SSAVLMESLK
1110 1120 1130
SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PD50 | E9PD50_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 1,170 | Annotation score: | ||
B1ALB4 | B1ALB4_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 756 | Annotation score: | ||
E9PEK3 | E9PEK3_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 184 | Annotation score: | ||
E9PBK2 | E9PBK2_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 73 | Annotation score: | ||
D6R9J3 | D6R9J3_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 56 | Annotation score: | ||
A0A8I5KSL3 | A0A8I5KSL3_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 1,216 | Annotation score: | ||
A0A8I5KYV3 | A0A8I5KYV3_HUMAN | Nonsense-mediated mRNA decay factor... | SMG7 | 1,187 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 187 | Q → R in BAG61224 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 282 | R → E in BAC53621 (PubMed:14636577).Curated | 1 | ||
Isoform 4 (identifier: Q92540-4) | |||||
Sequence conflicti | 854 | V → I in AAH36381 (PubMed:16710414).Curated | 1 | ||
Sequence conflicti | 898 | P → T in AAH36381 (PubMed:16710414).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051363 | 627 | S → F. Corresponds to variant dbSNP:rs34221194Ensembl. | 1 | |
Natural variantiVAR_051364 | 900 | V → I2 PublicationsCorresponds to variant dbSNP:rs2298083Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047130 | 1 – 42 | Missing in isoform 5. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_016574 | 569 – 614 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_016575 | 914 | E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNPPDLYPALLG PLASLPGRSLF in isoform 4 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_016576 | 1101 – 1137 | SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB085674 mRNA Translation: BAC53621.1 D87437 mRNA Translation: BAA13381.2 Different initiation. AK299178 mRNA Translation: BAG61224.1 AL449223 Genomic DNA No translation available. AL137800 Genomic DNA No translation available. BC036381 mRNA Translation: AAH36381.1 BC052565 mRNA Translation: AAH52565.1 |
CCDSi | CCDS1355.1 [Q92540-1] CCDS41445.2 [Q92540-4] CCDS53444.1 [Q92540-2] CCDS53445.1 [Q92540-5] |
RefSeqi | NP_001167532.1, NM_001174061.1 [Q92540-5] NP_775179.1, NM_173156.2 [Q92540-1] NP_963862.1, NM_201568.2 [Q92540-2] NP_963863.2, NM_201569.2 [Q92540-4] |
Genome annotation databases
Ensembli | ENST00000347615.6; ENSP00000340766.2; ENSG00000116698.22 ENST00000507469.5; ENSP00000425133.1; ENSG00000116698.22 [Q92540-4] ENST00000508461.5; ENSP00000426915.1; ENSG00000116698.22 [Q92540-5] ENST00000515829.6; ENSP00000421358.2; ENSG00000116698.22 [Q92540-2] |
GeneIDi | 9887 |
KEGGi | hsa:9887 |
UCSCi | uc001gqf.4, human [Q92540-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB085674 mRNA Translation: BAC53621.1 D87437 mRNA Translation: BAA13381.2 Different initiation. AK299178 mRNA Translation: BAG61224.1 AL449223 Genomic DNA No translation available. AL137800 Genomic DNA No translation available. BC036381 mRNA Translation: AAH36381.1 BC052565 mRNA Translation: AAH52565.1 |
CCDSi | CCDS1355.1 [Q92540-1] CCDS41445.2 [Q92540-4] CCDS53444.1 [Q92540-2] CCDS53445.1 [Q92540-5] |
RefSeqi | NP_001167532.1, NM_001174061.1 [Q92540-5] NP_775179.1, NM_173156.2 [Q92540-1] NP_963862.1, NM_201568.2 [Q92540-2] NP_963863.2, NM_201569.2 [Q92540-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YA0 | X-ray | 2.55 | A/B | 1-497 | [»] | |
AlphaFoldDBi | Q92540 | |||||
SMRi | Q92540 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115218, 300 interactors |
IntActi | Q92540, 37 interactors |
MINTi | Q92540 |
STRINGi | 9606.ENSP00000425133 |
PTM databases
GlyGeni | Q92540, 3 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q92540 |
PhosphoSitePlusi | Q92540 |
Genetic variation databases
BioMutai | SMG7 |
DMDMi | 84028262 |
Proteomic databases
EPDi | Q92540 |
jPOSTi | Q92540 |
MassIVEi | Q92540 |
MaxQBi | Q92540 |
PeptideAtlasi | Q92540 |
PRIDEi | Q92540 |
ProteomicsDBi | 19450 19888 75298 [Q92540-1] 75299 [Q92540-2] 75300 [Q92540-4] |
Protocols and materials databases
Antibodypediai | 34445, 107 antibodies from 23 providers |
DNASUi | 9887 |
Genome annotation databases
Ensembli | ENST00000347615.6; ENSP00000340766.2; ENSG00000116698.22 ENST00000507469.5; ENSP00000425133.1; ENSG00000116698.22 [Q92540-4] ENST00000508461.5; ENSP00000426915.1; ENSG00000116698.22 [Q92540-5] ENST00000515829.6; ENSP00000421358.2; ENSG00000116698.22 [Q92540-2] |
GeneIDi | 9887 |
KEGGi | hsa:9887 |
UCSCi | uc001gqf.4, human [Q92540-1] |
Organism-specific databases
CTDi | 9887 |
DisGeNETi | 9887 |
GeneCardsi | SMG7 |
HGNCi | HGNC:16792, SMG7 |
HPAi | ENSG00000116698, Low tissue specificity |
MIMi | 610964, gene |
neXtProti | NX_Q92540 |
OpenTargetsi | ENSG00000116698 |
PharmGKBi | PA25605 |
VEuPathDBi | HostDB:ENSG00000116698 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2162, Eukaryota |
GeneTreei | ENSGT00940000158333 |
HOGENOMi | CLU_009299_0_0_1 |
InParanoidi | Q92540 |
OMAi | TWAGHGP |
OrthoDBi | 556396at2759 |
PhylomeDBi | Q92540 |
TreeFami | TF327119 |
Enzyme and pathway databases
PathwayCommonsi | Q92540 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | Q92540 |
Miscellaneous databases
BioGRID-ORCSi | 9887, 374 hits in 1100 CRISPR screens |
ChiTaRSi | SMG7, human |
EvolutionaryTracei | Q92540 |
GeneWikii | SMG7 |
GenomeRNAii | 9887 |
Pharosi | Q92540, Tbio |
PROi | PR:Q92540 |
RNActi | Q92540, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116698, Expressed in oviduct epithelium and 246 other tissues |
ExpressionAtlasi | Q92540, baseline and differential |
Genevisiblei | Q92540, HS |
Family and domain databases
DisProti | DP01844 |
Gene3Di | 1.25.40.10, 1 hit |
IDEALi | IID00090 |
InterProi | View protein in InterPro IPR018834, DNA/RNA-bd_Est1-type IPR045153, Est1/Ebs1-like IPR019458, Est1_N IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR15696, PTHR15696, 1 hit |
Pfami | View protein in Pfam PF10374, EST1, 1 hit PF10373, EST1_DNA_bind, 1 hit |
SUPFAMi | SSF48452, SSF48452, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SMG7_HUMAN | |
Accessioni | Q92540Primary (citable) accession number: Q92540 Secondary accession number(s): B4DRB2 Q8IXC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 20, 2005 | |
Last modified: | May 25, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references