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UniProtKB - Q92540 (SMG7_HUMAN)

Entry version 190 (25 May 2022)
Sequence version 2 (20 Dec 2005)
Previous versions | rss
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Protein

Nonsense-mediated mRNA decay factor SMG7

Gene

SMG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92540

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92540

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonsense-mediated mRNA decay factor SMG7Imported
Alternative name(s):
SMG-7 homologImported
Short name:
hSMG-7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMG7Imported
Synonyms:C1orf16Imported, EST1CImported, KIAA0250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16792, SMG7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610964, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92540

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116698

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi66K → E: Abolishes interaction with UPF1; when associated with E-163. 1 Publication1
Mutagenesisi163R → E: Abolishes interaction with UPF1; when associated with E-66. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9887

Open Targets

More...OpenTargetsi		ENSG00000116698

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25605

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92540, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SMG7

Domain mapping of disease mutations (DMDM)

More...DMDMi		84028262

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763242 – 1137Nonsense-mediated mRNA decay factor SMG7Add BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei624PhosphothreonineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q92540

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92540

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92540

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92540

PeptideAtlas

More...PeptideAtlasi		Q92540

PRoteomics IDEntifications database

More...PRIDEi		Q92540

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19450
19888
75298 [Q92540-1]
75299 [Q92540-2]
75300 [Q92540-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q92540, 3 sites, 2 O-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92540

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92540

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116698, Expressed in oviduct epithelium and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92540, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92540, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116698, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1 (PubMed:14636577).

Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115218, 300 interactors

Protein interaction database and analysis system

More...IntActi		Q92540, 37 interactors

Molecular INTeraction database

More...MINTi		Q92540

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000425133

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92540, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q92540

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92540

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q92540

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati152 – 185TPR 11 PublicationAdd BLAST34
Repeati187 – 219TPR 21 PublicationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni620 – 646DisorderedSequence analysisAdd BLAST27
Regioni696 – 794DisorderedSequence analysisAdd BLAST99
Regioni890 – 911DisorderedSequence analysisAdd BLAST22
Regioni988 – 1055DisorderedSequence analysisAdd BLAST68
Regioni1069 – 1089DisorderedSequence analysisAdd BLAST21
Regioni1104 – 1137DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi629 – 646Polar residuesSequence analysisAdd BLAST18
Compositional biasi696 – 775Polar residuesSequence analysisAdd BLAST80
Compositional biasi988 – 1030Polar residuesSequence analysisAdd BLAST43
Compositional biasi1069 – 1087Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2162, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158333

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009299_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92540

Identification of Orthologs from Complete Genome Data

More...OMAi		TWAGHGP

Database of Orthologous Groups

More...OrthoDBi		556396at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92540

TreeFam database of animal gene trees

More...TreeFami		TF327119

Family and domain databases

Database of protein disorder

More...DisProti		DP01844

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00090

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018834, DNA/RNA-bd_Est1-type
IPR045153, Est1/Ebs1-like
IPR019458, Est1_N
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR15696, PTHR15696, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10374, EST1, 1 hit
PF10373, EST1_DNA_bind, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92540-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY 
        60         70         80         90        100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG 
       110        120        130        140        150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI 
       160        170        180        190        200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG 
       210        220        230        240        250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI 
       260        270        280        290        300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 
       310        320        330        340        350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE 
       360        370        380        390        400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF 
       410        420        430        440        450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ 
       460        470        480        490        500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA 
       510        520        530        540        550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN 
       560        570        580        590        600
IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL 
       610        620        630        640        650
EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH 
       660        670        680        690        700
HPGAFPPLPS RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA 
       710        720        730        740        750
HSPAGNQVQA GKQSHIPYSQ QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ 
       760        770        780        790        800
PTAQSTSQLQ VQALTQQQQS PTKAVPALGK SPPHHSGFQQ YQQADASKQL 
       810        820        830        840        850
WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM QQQPLEKKMK 
       860        870        880        890        900
PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV 
       910        920        930        940        950
FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF 
       960        970        980        990       1000
NEVYGKNLTS SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA 
      1010       1020       1030       1040       1050
SQSPHSSNPS SLPSSPPTHN HNSVPFSNFG PIGTPDNRDR RTADRWKTDK 
      1060       1070       1080       1090       1100
PAMGGFGIDY LSATSSSESS WHQASTPSGT WTGHGPSMED SSAVLMESLK 
      1110       1120       1130 
SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH
Length:1,137
Mass (Da):127,282
Last modified:December 20, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE152AFAFEF8F3A42
GO
Isoform 2 (identifier: Q92540-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.

Show »
Length:1,091
Mass (Da):122,020
Checksum:i2E6B7AFB0201D533
GO
Isoform 4 (identifier: Q92540-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF
     1101-1137: SIWSSSMMHP...RGQGTMNPPH → KQQHGVQQLG...PFWKRRKKGK

Show »
Length:1,178
Mass (Da):131,650
Checksum:i2087382714FE3D57
GO
Isoform 5 (identifier: Q92540-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF

Show »
Length:1,145
Mass (Da):127,854
Checksum:i9F9B61B6384AA0FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PD50E9PD50_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
1,170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ALB4B1ALB4_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
756Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEK3E9PEK3_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBK2E9PBK2_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9J3D6R9J3_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KSL3A0A8I5KSL3_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
1,216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I5KYV3A0A8I5KYV3_HUMAN
Nonsense-mediated mRNA decay factor...
SMG7
1,187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13381 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187Q → R in BAG61224 (PubMed:14702039).Curated1
Sequence conflicti282R → E in BAC53621 (PubMed:14636577).Curated1
Isoform 4 (identifier: Q92540-4)
Sequence conflicti854V → I in AAH36381 (PubMed:16710414).Curated1
Sequence conflicti898P → T in AAH36381 (PubMed:16710414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051363627S → F. Corresponds to variant dbSNP:rs34221194Ensembl.1
Natural variantiVAR_051364900V → I2 PublicationsCorresponds to variant dbSNP:rs2298083Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471301 – 42Missing in isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_016574569 – 614Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_016575914E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNPPDLYPALLG PLASLPGRSLF in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0165761101 – 1137SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB085674 mRNA Translation: BAC53621.1
D87437 mRNA Translation: BAA13381.2 Different initiation.
AK299178 mRNA Translation: BAG61224.1
AL449223 Genomic DNA No translation available.
AL137800 Genomic DNA No translation available.
BC036381 mRNA Translation: AAH36381.1
BC052565 mRNA Translation: AAH52565.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1355.1 [Q92540-1]
CCDS41445.2 [Q92540-4]
CCDS53444.1 [Q92540-2]
CCDS53445.1 [Q92540-5]

NCBI Reference Sequences

More...RefSeqi		NP_001167532.1, NM_001174061.1 [Q92540-5]
NP_775179.1, NM_173156.2 [Q92540-1]
NP_963862.1, NM_201568.2 [Q92540-2]
NP_963863.2, NM_201569.2 [Q92540-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000347615.6; ENSP00000340766.2; ENSG00000116698.22
ENST00000507469.5; ENSP00000425133.1; ENSG00000116698.22 [Q92540-4]
ENST00000508461.5; ENSP00000426915.1; ENSG00000116698.22 [Q92540-5]
ENST00000515829.6; ENSP00000421358.2; ENSG00000116698.22 [Q92540-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9887

UCSC genome browser

More...UCSCi		uc001gqf.4, human [Q92540-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085674 mRNA Translation: BAC53621.1
D87437 mRNA Translation: BAA13381.2 Different initiation.
AK299178 mRNA Translation: BAG61224.1
AL449223 Genomic DNA No translation available.
AL137800 Genomic DNA No translation available.
BC036381 mRNA Translation: AAH36381.1
BC052565 mRNA Translation: AAH52565.1
CCDSiCCDS1355.1 [Q92540-1]
CCDS41445.2 [Q92540-4]
CCDS53444.1 [Q92540-2]
CCDS53445.1 [Q92540-5]
RefSeqiNP_001167532.1, NM_001174061.1 [Q92540-5]
NP_775179.1, NM_173156.2 [Q92540-1]
NP_963862.1, NM_201568.2 [Q92540-2]
NP_963863.2, NM_201569.2 [Q92540-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YA0X-ray2.55A/B1-497[»]
AlphaFoldDBiQ92540
SMRiQ92540
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115218, 300 interactors
IntActiQ92540, 37 interactors
MINTiQ92540
STRINGi9606.ENSP00000425133

PTM databases

GlyGeniQ92540, 3 sites, 2 O-linked glycans (3 sites)
iPTMnetiQ92540
PhosphoSitePlusiQ92540

Genetic variation databases

BioMutaiSMG7
DMDMi84028262

Proteomic databases

EPDiQ92540
jPOSTiQ92540
MassIVEiQ92540
MaxQBiQ92540
PeptideAtlasiQ92540
PRIDEiQ92540
ProteomicsDBi19450
19888
75298 [Q92540-1]
75299 [Q92540-2]
75300 [Q92540-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34445, 107 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		9887

Genome annotation databases

EnsembliENST00000347615.6; ENSP00000340766.2; ENSG00000116698.22
ENST00000507469.5; ENSP00000425133.1; ENSG00000116698.22 [Q92540-4]
ENST00000508461.5; ENSP00000426915.1; ENSG00000116698.22 [Q92540-5]
ENST00000515829.6; ENSP00000421358.2; ENSG00000116698.22 [Q92540-2]
GeneIDi9887
KEGGihsa:9887
UCSCiuc001gqf.4, human [Q92540-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9887
DisGeNETi9887

GeneCards: human genes, protein and diseases

More...GeneCardsi		SMG7
HGNCiHGNC:16792, SMG7
HPAiENSG00000116698, Low tissue specificity
MIMi610964, gene
neXtProtiNX_Q92540
OpenTargetsiENSG00000116698
PharmGKBiPA25605
VEuPathDBiHostDB:ENSG00000116698

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2162, Eukaryota
GeneTreeiENSGT00940000158333
HOGENOMiCLU_009299_0_0_1
InParanoidiQ92540
OMAiTWAGHGP
OrthoDBi556396at2759
PhylomeDBiQ92540
TreeFamiTF327119

Enzyme and pathway databases

PathwayCommonsiQ92540
ReactomeiR-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiQ92540

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9887, 374 hits in 1100 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SMG7, human
EvolutionaryTraceiQ92540

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SMG7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9887
PharosiQ92540, Tbio

Protein Ontology

More...PROi		PR:Q92540
RNActiQ92540, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116698, Expressed in oviduct epithelium and 246 other tissues
ExpressionAtlasiQ92540, baseline and differential
GenevisibleiQ92540, HS

Family and domain databases

DisProtiDP01844
Gene3Di1.25.40.10, 1 hit
IDEALiIID00090
InterProiView protein in InterPro
IPR018834, DNA/RNA-bd_Est1-type
IPR045153, Est1/Ebs1-like
IPR019458, Est1_N
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR15696, PTHR15696, 1 hit
PfamiView protein in Pfam
PF10374, EST1, 1 hit
PF10373, EST1_DNA_bind, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMG7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92540
Secondary accession number(s): B4DRB2
, E9PCI0, E9PEH2, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 20, 2005
Last modified: May 25, 2022
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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