UniProtKB - Q92540 (SMG7_HUMAN)

BLAST

>sp|Q92540|SMG7_HUMAN Protein SMG7 OS=Homo sapiens OX=9606 GN=SMG7 PE=1 SV=2
MSLQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDL
WNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCR
VKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQ
LVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEV
KTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVI
NLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYP
LPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFE
LQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEV
GKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTG
EKPVVTFKENIKTREVNRDQGRSFPPKEVRRDYSKGITVTKNDGKKDNNKRKTETKKCTL
EKLQETGKQNVAVQVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPS
RPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQ
QRPSGPGPMNQGPQQSQPPSQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGK
SPPHHSGFQQYQQADASKQLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVM
QQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGV
FRPEQDPVPRMPFEKSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTS
SSKAELSPSMAPQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHN
HNSVPFSNFGPIGTPDNRDRRTADRWKTDKPAMGGFGIDYLSATSSSESSWHQASTPSGT
WTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH

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History
Entry version 168 (07 Nov 2018)
Sequence version 2 (20 Dec 2005)
Previous versions | rss
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Protein

Protein SMG7

Gene

SMG7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.2 Publications

GO - Molecular functionⁱ

protein phosphatase 2A binding
Source: HGNC
Inferred from direct assayⁱ
- 14636577
ribonuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ribonucleoprotein complex binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
telomerase RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
telomeric DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17916692

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA export from nucleus
Source: HGNC
Traceable author statementⁱ
- 16488880
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of dephosphorylation
Source: HGNC
Traceable author statementⁱ
- 15721257
regulation of RNA stability
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
telomere maintenance via telomerase
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Nonsense-mediated mRNA decay

Biological process

Nonsense-mediated mRNA decay

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SMG7 Alternative name(s): EST1-like protein C SMG-7 homolog Short name: hSMG-7
Gene namesⁱ	Name:SMG7 Synonyms:C1orf16, EST1C, KIAA0250
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116698.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16792 SMG7
MIMⁱ	610964 gene
neXtProtⁱ	NX_Q92540

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	66	K → E: Abolishes interaction with UPF1; when associated with E-163. 1 Publication		1
Mutagenesisⁱ	163	R → E: Abolishes interaction with UPF1; when associated with E-66. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000116698
PharmGKBⁱ	PA25605

Polymorphism and mutation databases

BioMutaⁱ	SMG7
DMDMⁱ	84028262

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000076324	2 – 1137	Protein SMG7Add BLAST		1136

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	520	PhosphoserineCombined sources	1
Modified residueⁱ	624	PhosphothreonineCombined sources	1
Modified residueⁱ	781	PhosphoserineCombined sources	1
Modified residueⁱ	897	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q92540
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92540
PeptideAtlas More...PeptideAtlasⁱ	Q92540
PRIDEⁱ	Q92540
ProteomicsDBⁱ	75298 75299 [Q92540-2] 75300 [Q92540-4]

PTM databases

iPTMnetⁱ	Q92540
PhosphoSitePlusⁱ	Q92540

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116698 Expressed in 233 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_SMG7
ExpressionAtlasⁱ	Q92540 baseline and differential
Genevisibleⁱ	Q92540 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029350

HPAⁱ

HPA029350

Interactionⁱ

Subunit structureⁱ

Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SMG5	Q9UPR3	5	EBI-719830,EBI-3400861
UPF1	Q92900	3	EBI-719830,EBI-373471

GO - Molecular functionⁱ

protein phosphatase 2A binding
Source: HGNC
Inferred from direct assayⁱ
- 14636577

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115218, 36 interactors
IntActⁱ	Q92540, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q92540

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 16	Combined sources	15
Helixⁱ	17 – 19	Combined sources	3
Beta strandⁱ	22 – 24	Combined sources	3
Beta strandⁱ	26 – 29	Combined sources	4
Helixⁱ	30 – 46	Combined sources	17
Helixⁱ	48 – 54	Combined sources	7
Helixⁱ	56 – 64	Combined sources	9
Helixⁱ	66 – 76	Combined sources	11
Turnⁱ	82 – 85	Combined sources	4
Helixⁱ	86 – 109	Combined sources	24
Helixⁱ	145 – 164	Combined sources	20
Helixⁱ	168 – 181	Combined sources	14
Helixⁱ	187 – 198	Combined sources	12
Helixⁱ	202 – 213	Combined sources	12
Beta strandⁱ	214 – 217	Combined sources	4
Helixⁱ	220 – 233	Combined sources	14
Helixⁱ	246 – 262	Combined sources	17
Helixⁱ	266 – 268	Combined sources	3
Helixⁱ	269 – 285	Combined sources	17
Helixⁱ	291 – 308	Combined sources	18
Helixⁱ	311 – 314	Combined sources	4
Helixⁱ	322 – 347	Combined sources	26
Beta strandⁱ	356 – 360	Combined sources	5
Helixⁱ	361 – 371	Combined sources	11
Helixⁱ	375 – 379	Combined sources	5
Helixⁱ	381 – 384	Combined sources	4
Turnⁱ	385 – 388	Combined sources	4
Helixⁱ	390 – 397	Combined sources	8
Helixⁱ	398 – 400	Combined sources	3
Helixⁱ	416 – 420	Combined sources	5
Turnⁱ	421 – 423	Combined sources	3
Helixⁱ	425 – 427	Combined sources	3
Helixⁱ	428 – 431	Combined sources	4
Helixⁱ	449 – 469	Combined sources	21
Turnⁱ	471 – 473	Combined sources	3
Beta strandⁱ	475 – 479	Combined sources	5
Beta strandⁱ	482 – 486	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q92540
SMRⁱ	Q92540
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q92540

EvolutionaryTraceⁱ

Q92540

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	152 – 185	TPR 11 PublicationAdd BLAST		34
Repeatⁱ	187 – 219	TPR 21 PublicationAdd BLAST		33

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	648 – 843	Gln/Pro-richAdd BLAST		196
Compositional biasⁱ	922 – 1015	Ser-richAdd BLAST		94

Keywords - Domainⁱ

Repeat, TPR repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00560000077120
HOGENOMⁱ	HOG000049052
HOVERGENⁱ	HBG056330
InParanoidⁱ	Q92540
KEGG Orthology (KO) More...KOⁱ	K14409
OMAⁱ	MVTFKEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04DJ
PhylomeDBⁱ	Q92540
TreeFamⁱ	TF327119

Family and domain databases

InterProⁱ	View protein in InterPro IPR018834 DNA/RNA-bd_Est1-type IPR019458 EST1 IPR011990 TPR-like_helical_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10374 EST1, 1 hit PF10373 EST1_DNA_bind, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92540-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY 
        60         70         80         90        100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG 
       110        120        130        140        150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI 
       160        170        180        190        200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG 
       210        220        230        240        250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI 
       260        270        280        290        300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 
       310        320        330        340        350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE 
       360        370        380        390        400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF 
       410        420        430        440        450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ 
       460        470        480        490        500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA 
       510        520        530        540        550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN 
       560        570        580        590        600
IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL 
       610        620        630        640        650
EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH 
       660        670        680        690        700
HPGAFPPLPS RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA 
       710        720        730        740        750
HSPAGNQVQA GKQSHIPYSQ QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ 
       760        770        780        790        800
PTAQSTSQLQ VQALTQQQQS PTKAVPALGK SPPHHSGFQQ YQQADASKQL 
       810        820        830        840        850
WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM QQQPLEKKMK 
       860        870        880        890        900
PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV 
       910        920        930        940        950
FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF 
       960        970        980        990       1000
NEVYGKNLTS SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA 
      1010       1020       1030       1040       1050
SQSPHSSNPS SLPSSPPTHN HNSVPFSNFG PIGTPDNRDR RTADRWKTDK 
      1060       1070       1080       1090       1100
PAMGGFGIDY LSATSSSESS WHQASTPSGT WTGHGPSMED SSAVLMESLK 
      1110       1120       1130 
SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH

Length:1,137

Mass (Da):127,282

Last modified:December 20, 2005 - v2

Checksum:ⁱE152AFAFEF8F3A42

Isoform 2 (identifier: Q92540-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
569-614: Missing.

« Hide

        10         20         30         40         50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY 
        60         70         80         90        100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG 
       110        120        130        140        150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI 
       160        170        180        190        200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG 
       210        220        230        240        250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI 
       260        270        280        290        300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 
       310        320        330        340        350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE 
       360        370        380        390        400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF 
       410        420        430        440        450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ 
       460        470        480        490        500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA 
       510        520        530        540        550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN 
       560        570        580        590        600
IKTREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPTQASNSQF 
       610        620        630        640        650
IPIHHPGAFP PLPSRPGFPP PTYVIPPPVA FSMGSGYTFP AGVSVPGTFL 
       660        670        680        690        700
QPTAHSPAGN QVQAGKQSHI PYSQQRPSGP GPMNQGPQQS QPPSQQPLTS 
       710        720        730        740        750
LPAQPTAQST SQLQVQALTQ QQQSPTKAVP ALGKSPPHHS GFQQYQQADA 
       760        770        780        790        800
SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD PIKLFEPSLQ PPVMQQQPLE 
       810        820        830        840        850
KKMKPFPMEP YNHNPSEVKV PEFYWDSSYS MADNRSVMAQ QANIDRRGKR 
       860        870        880        890        900
SPGVFRPEQD PVPRMPFEKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN 
       910        920        930        940        950
NSMFNEVYGK NLTSSSKAEL SPSMAPQETS LYSLFEGTPW SPSLPASSDH 
       960        970        980        990       1000
STPASQSPHS SNPSSLPSSP PTHNHNSVPF SNFGPIGTPD NRDRRTADRW 
      1010       1020       1030       1040       1050
KTDKPAMGGF GIDYLSATSS SESSWHQAST PSGTWTGHGP SMEDSSAVLM 
      1060       1070       1080       1090 
ESLKSIWSSS MMHPGPSALE QLLMQQKQKQ QRGQGTMNPP H

Show »

Length:1,091

Mass (Da):122,020

Checksum:ⁱ2E6B7AFB0201D533

Isoform 4 (identifier: Q92540-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-614: Missing.
     914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF
     1101-1137: SIWSSSMMHP...RGQGTMNPPH → KQQHGVQQLG...PFWKRRKKGK

« Hide

        10         20         30         40         50
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY 
        60         70         80         90        100
ALDKKVEQDL WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG 
       110        120        130        140        150
FYTQLLQELC TVFNVDLPCR VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI 
       160        170        180        190        200
CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ LVPSNGQPYN QLAILASSKG 
       210        220        230        240        250
DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV KTKWGVSDFI 
       260        270        280        290        300
KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 
       310        320        330        340        350
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE 
       360        370        380        390        400
SQEESYNAYP LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF 
       410        420        430        440        450
HPHEEDLSSI SATPLPEEFE LQGFLALRPS FRNLDFSKGH QGITGDKEGQ 
       460        470        480        490        500
QRRIRQQRLI SIGKWIADNQ PRLIQCENEV GKLLFITEIP ELILEDPSEA 
       510        520        530        540        550
KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG EKPVVTFKEN 
       560        570        580        590        600
IKTREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPTQASNSQF 
       610        620        630        640        650
IPIHHPGAFP PLPSRPGFPP PTYVIPPPVA FSMGSGYTFP AGVSVPGTFL 
       660        670        680        690        700
QPTAHSPAGN QVQAGKQSHI PYSQQRPSGP GPMNQGPQQS QPPSQQPLTS 
       710        720        730        740        750
LPAQPTAQST SQLQVQALTQ QQQSPTKAVP ALGKSPPHHS GFQQYQQADA 
       760        770        780        790        800
SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD PIKLFEPSLQ PPVMQQQPLE 
       810        820        830        840        850
KKMKPFPMEP YNHNPSEVKV PEFYWDSSYS MADNRSVMAQ QANIDRRGKR 
       860        870        880        890        900
SPGVFRPEQD PVPRMPFEDP KSSPLLPPDL LKSLAALEEE EELIFSNPPD 
       910        920        930        940        950
LYPALLGPLA SLPGRSLFKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN 
       960        970        980        990       1000
NSMFNEVYGK NLTSSSKAEL SPSMAPQETS LYSLFEGTPW SPSLPASSDH 
      1010       1020       1030       1040       1050
STPASQSPHS SNPSSLPSSP PTHNHNSVPF SNFGPIGTPD NRDRRTADRW 
      1060       1070       1080       1090       1100
KTDKPAMGGF GIDYLSATSS SESSWHQAST PSGTWTGHGP SMEDSSAVLM 
      1110       1120       1130       1140       1150
ESLKKQQHGV QQLGPKRQSE EEGSSSICVA HRGPRPLPSC SLPASTFRVK 
      1160       1170 
FKAARTCAHQ AQKKTRRRPF WKRRKKGK

Show »

Length:1,178

Mass (Da):131,650

Checksum:ⁱ2087382714FE3D57

Isoform 5 (identifier: Q92540-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-42: Missing.
914-914: E → EDPKSSPLLPPDLLKSLAALEEEEELIFSNPPDLYPALLGPLASLPGRSLF

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        10         20         30         40         50
MLVTDLEYAL DKKVEQDLWN HAFKNQITTL QGQAKNRANP NRSEVQANLS 
        60         70         80         90        100
LFLEAASGFY TQLLQELCTV FNVDLPCRVK SSQLGIISNK QTHTSAIVKP 
       110        120        130        140        150
QSSSCSYICQ HCLVHLGDIA RYRNQTSQAE SYYRHAAQLV PSNGQPYNQL 
       160        170        180        190        200
AILASSKGDH LTTIFYYCRS IAVKFPFPAA STNLQKALSK ALESRDEVKT 
       210        220        230        240        250
KWGVSDFIKA FIKFHGHVYL SKSLEKLSPL REKLEEQFKR LLFQKAFNSQ 
       260        270        280        290        300
QLVHVTVINL FQLHHLRDFS NETEQHTYSQ DEQLCWTQLL ALFMSFLGIL 
       310        320        330        340        350
CKCPLQNESQ EESYNAYPLP AVKVSMDWLR LRPRVFQEAV VDERQYIWPW 
       360        370        380        390        400
LISLLNSFHP HEEDLSSISA TPLPEEFELQ GFLALRPSFR NLDFSKGHQG 
       410        420        430        440        450
ITGDKEGQQR RIRQQRLISI GKWIADNQPR LIQCENEVGK LLFITEIPEL 
       460        470        480        490        500
ILEDPSEAKE NLILQETSVI ESLAADGSPG LKSVLSTSRN LSNNCDTGEK 
       510        520        530        540        550
PVVTFKENIK TREVNRDQGR SFPPKEVRRD YSKGITVTKN DGKKDNNKRK 
       560        570        580        590        600
TETKKCTLEK LQETGKQNVA VQVKSQTELR KTPVSEARKT PVTQTPTQAS 
       610        620        630        640        650
NSQFIPIHHP GAFPPLPSRP GFPPPTYVIP PPVAFSMGSG YTFPAGVSVP 
       660        670        680        690        700
GTFLQPTAHS PAGNQVQAGK QSHIPYSQQR PSGPGPMNQG PQQSQPPSQQ 
       710        720        730        740        750
PLTSLPAQPT AQSTSQLQVQ ALTQQQQSPT KAVPALGKSP PHHSGFQQYQ 
       760        770        780        790        800
QADASKQLWN PPQVQGPLGK IMPVKQPYYL QTQDPIKLFE PSLQPPVMQQ 
       810        820        830        840        850
QPLEKKMKPF PMEPYNHNPS EVKVPEFYWD SSYSMADNRS VMAQQANIDR 
       860        870        880        890        900
RGKRSPGVFR PEQDPVPRMP FEDPKSSPLL PPDLLKSLAA LEEEEELIFS 
       910        920        930        940        950
NPPDLYPALL GPLASLPGRS LFKSLLEKPS ELMSHSSSFL SLTGFSLNQE 
       960        970        980        990       1000
RYPNNSMFNE VYGKNLTSSS KAELSPSMAP QETSLYSLFE GTPWSPSLPA 
      1010       1020       1030       1040       1050
SSDHSTPASQ SPHSSNPSSL PSSPPTHNHN SVPFSNFGPI GTPDNRDRRT 
      1060       1070       1080       1090       1100
ADRWKTDKPA MGGFGIDYLS ATSSSESSWH QASTPSGTWT GHGPSMEDSS 
      1110       1120       1130       1140 
AVLMESLKSI WSSSMMHPGP SALEQLLMQQ KQKQQRGQGT MNPPH

Show »

Length:1,145

Mass (Da):127,854

Checksum:ⁱ9F9B61B6384AA0FA

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PD50	E9PD50_HUMAN	Protein SMG7 Protein SMG7	SMG7	1,170	Annotation score:
B1ALB4	B1ALB4_HUMAN	Protein SMG7 Protein SMG7	SMG7	756	Annotation score:
E9PEK3	E9PEK3_HUMAN	Protein SMG7 Protein SMG7	SMG7	184	Annotation score:
D6RAD0	D6RAD0_HUMAN	Protein SMG7 Protein SMG7	SMG7	150	Annotation score:
E9PBK2	E9PBK2_HUMAN	Protein SMG7 Protein SMG7	SMG7	73	Annotation score:
D6R9J3	D6R9J3_HUMAN	Protein SMG7 Protein SMG7	SMG7	56	Annotation score:

Sequence cautionⁱ

The sequence BAA13381 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	187	Q → R in BAG61224 (PubMed:14702039).Curated	1
Sequence conflictⁱ	282	R → E in BAC53621 (PubMed:14636577).Curated	1
Isoform 4 (identifier: Q92540-4)
Sequence conflictⁱ	854	V → I in AAH36381 (PubMed:16710414).Curated	1
Sequence conflictⁱ	898	P → T in AAH36381 (PubMed:16710414).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051363	627	S → F. Corresponds to variant dbSNP:rs34221194Ensembl.		1
Natural variantⁱVAR_051364	900	V → I2 PublicationsCorresponds to variant dbSNP:rs2298083Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047130	1 – 42	Missing in isoform 5. 1 PublicationAdd BLAST	42
Alternative sequenceⁱVSP_016574	569 – 614	Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST	46
Alternative sequenceⁱVSP_016575	914	E → EDPKSSPLLPPDLLKSLAAL EEEEELIFSNPPDLYPALLG PLASLPGRSLF in isoform 4 and isoform 5. 2 Publications	1
Alternative sequenceⁱVSP_016576	1101 – 1137	SIWSS…MNPPH → KQQHGVQQLGPKRQSEEEGS SSICVAHRGPRPLPSCSLPA STFRVKFKAARTCAHQAQKK TRRRPFWKRRKKGK in isoform 4. 1 PublicationAdd BLAST	37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085674 mRNA Translation: BAC53621.1 D87437 mRNA Translation: BAA13381.2 Different initiation. AK299178 mRNA Translation: BAG61224.1 AL449223 Genomic DNA No translation available. AL137800 Genomic DNA No translation available. BC036381 mRNA Translation: AAH36381.1 BC052565 mRNA Translation: AAH52565.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1355.1 [Q92540-1] CCDS41445.2 [Q92540-4] CCDS53444.1 [Q92540-2] CCDS53445.1 [Q92540-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_001167532.1, NM_001174061.1 [Q92540-5] NP_775179.1, NM_173156.2 [Q92540-1] NP_963862.1, NM_201568.2 [Q92540-2] NP_963863.2, NM_201569.2 [Q92540-4]
UniGeneⁱ	Hs.591463

Genome annotation databases

Ensemblⁱ	ENST00000347615; ENSP00000340766; ENSG00000116698 [Q92540-1] ENST00000507469; ENSP00000425133; ENSG00000116698 [Q92540-4] ENST00000508461; ENSP00000426915; ENSG00000116698 [Q92540-5] ENST00000515829; ENSP00000421358; ENSG00000116698 [Q92540-2]
GeneIDⁱ	9887
KEGGⁱ	hsa:9887
UCSC genome browser More...UCSCⁱ	uc001gqf.4 human [Q92540-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92540	protein SMG7 isoform X5		BALAS		1166	UniRef90_Q92540
SMG7, nonsense mediated mRNA decay factor		BOVIN		1166
protein SMG7 isoform X5		DELLE		1166
protein SMG7 isoform X6		Yangtze finless porpoise		1166
protein SMG7 isoform X4		TARSY		1166
+136
Q92540-2	Uncharacterized protein		FELCA		1115	UniRef90_Q92540-2
protein SMG7 isoform X3		PHYCD		1115
protein SMG7 isoform X6		MESAU		1115
protein SMG7 isoform X3		ERIEU		1100
protein SMG7 isoform X3		DIPOR		1099
+84
Q92540-4	Protein SMG7 (Fragment)		HUMAN		756	UniRef90_Q92540-4
protein SMG7 isoform X2		LIPVE		1180
Uncharacterized protein		MACMU		1178
SMG7 isoform 4		PANTR		1178
Uncharacterized protein		PAPAN		1178
+37
Q92540-5	Protein SMG7		FUKDA		1339	UniRef90_Q92540-5
protein SMG7 isoform X3		Florida manatee		1238
protein SMG7 isoform X1		TURTR		1231
Smg-7-like protein, nonsense mediated mRNA decay factor (Fragment)		MUSPF		398
protein SMG7 isoform X1		BALAS		1216
+140

Protein	Similar proteins		Species	Score	Length	Source
Q92540	protein SMG7 isoform X7		TURTR		1166	UniRef50_Q92540
SMG7, nonsense mediated mRNA decay factor		BOVIN		1166
protein SMG7 isoform X3		LIPVE		1166
protein SMG7 isoform X5		DELLE		1166
protein SMG7 isoform X6		Yangtze finless porpoise		1166
+374
Q92540-2	Protein SMG7		MOUSE		1138	UniRef50_Q92540-2
Uncharacterized protein		FELCA		1115
protein SMG7 isoform X6		MESAU		1115
protein SMG7 isoform X3		PHYCD		1115
protein SMG7 isoform X3		ERIEU		1100
+509
Q92540-4	Isoform 5 of Protein SMG7		HUMAN		1145	UniRef50_Q92540-5
Protein SMG7		FUKDA		1339
protein SMG7 isoform X3		Florida manatee		1238
protein SMG7 isoform X1		TURTR		1231
Smg-7-like protein, nonsense mediated mRNA decay factor (Fragment)		MUSPF		398
+403
Q92540-5	Protein SMG7		FUKDA		1339	UniRef50_Q92540-5
protein SMG7 isoform X3		Florida manatee		1238
protein SMG7 isoform X1		TURTR		1231
Smg-7-like protein, nonsense mediated mRNA decay factor (Fragment)		MUSPF		398
protein SMG7 isoform X1		DELLE		1216
+403

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085674 mRNA Translation: BAC53621.1 D87437 mRNA Translation: BAA13381.2 Different initiation. AK299178 mRNA Translation: BAG61224.1 AL449223 Genomic DNA No translation available. AL137800 Genomic DNA No translation available. BC036381 mRNA Translation: AAH36381.1 BC052565 mRNA Translation: AAH52565.1
CCDSⁱ	CCDS1355.1 [Q92540-1] CCDS41445.2 [Q92540-4] CCDS53444.1 [Q92540-2] CCDS53445.1 [Q92540-5]
RefSeqⁱ	NP_001167532.1, NM_001174061.1 [Q92540-5] NP_775179.1, NM_173156.2 [Q92540-1] NP_963862.1, NM_201568.2 [Q92540-2] NP_963863.2, NM_201569.2 [Q92540-4]
UniGeneⁱ	Hs.591463

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YA0	X-ray	2.55	A/B	1-497	[»]
ProteinModelPortalⁱ	Q92540
SMRⁱ	Q92540
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115218, 36 interactors
IntActⁱ	Q92540, 22 interactors
MINTⁱ	Q92540

PTM databases

iPTMnetⁱ	Q92540
PhosphoSitePlusⁱ	Q92540

Polymorphism and mutation databases

BioMutaⁱ	SMG7
DMDMⁱ	84028262

Proteomic databases

EPDⁱ	Q92540
MaxQBⁱ	Q92540
PeptideAtlasⁱ	Q92540
PRIDEⁱ	Q92540
ProteomicsDBⁱ	75298 75299 [Q92540-2] 75300 [Q92540-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000347615; ENSP00000340766; ENSG00000116698 [Q92540-1] ENST00000507469; ENSP00000425133; ENSG00000116698 [Q92540-4] ENST00000508461; ENSP00000426915; ENSG00000116698 [Q92540-5] ENST00000515829; ENSP00000421358; ENSG00000116698 [Q92540-2]
GeneIDⁱ	9887
KEGGⁱ	hsa:9887
UCSCⁱ	uc001gqf.4 human [Q92540-1]

Organism-specific databases

CTDⁱ	9887
EuPathDBⁱ	HostDB:ENSG00000116698.20
GeneCardsⁱ	SMG7
H-InvDBⁱ	HIX0001408
HGNCⁱ	HGNC:16792 SMG7
HPAⁱ	HPA029350
MIMⁱ	610964 gene
neXtProtⁱ	NX_Q92540
OpenTargetsⁱ	ENSG00000116698
PharmGKBⁱ	PA25605
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00560000077120
HOGENOMⁱ	HOG000049052
HOVERGENⁱ	HBG056330
InParanoidⁱ	Q92540
KOⁱ	K14409
OMAⁱ	MVTFKEN
OrthoDBⁱ	EOG091G04DJ
PhylomeDBⁱ	Q92540
TreeFamⁱ	TF327119

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	SMG7 human
EvolutionaryTraceⁱ	Q92540
GeneWikiⁱ	SMG7
GenomeRNAiⁱ	9887
Protein Ontology More...PROⁱ	PR:Q92540
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116698 Expressed in 233 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_SMG7
ExpressionAtlasⁱ	Q92540 baseline and differential
Genevisibleⁱ	Q92540 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018834 DNA/RNA-bd_Est1-type IPR019458 EST1 IPR011990 TPR-like_helical_dom_sf
Pfamⁱ	View protein in Pfam PF10374 EST1, 1 hit PF10373 EST1_DNA_bind, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMG7_HUMAN
Accessionⁱ	Q92540Primary (citable) accession number: Q92540 Secondary accession number(s): B4DRB2 Q8IXC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	December 20, 2005
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q92540 (SMG7_HUMAN)

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Protein SMG7

SMG7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ