Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 163 (02 Jun 2021)
Sequence version 3 (10 Jun 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Y+L amino acid transporter 2

Gene

SLC7A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.

8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na+. Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=295 µM for glutamine (in the presence of NaCl)1 Publication
  2. KM=236 µM for leucine (in the presence of NaCl)1 Publication
  3. KM=120 µM for arginine (in the presence of NaCl)1 Publication
  4. KM=138 µM for arginine (in the absence of NaCl)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Antiport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000103064-MONOMER

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q92536

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-210991, Basigin interactions
    R-HSA-352230, Amino acid transport across the plasma membrane

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q92536

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.3.8.23, the amino acid-polyamine-organocation (apc) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Y+L amino acid transporter 2
    Alternative name(s):
    Cationic amino acid transporter, y+ system
    Solute carrier family 7 member 6
    y(+)L-type amino acid transporter 2
    Short name:
    Y+LAT2
    Short name:
    y+LAT-2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC7A6Imported
    Synonyms:KIAA0245Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:11064, SLC7A6

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    605641, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q92536

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000103064.13

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
    Topological domaini66 – 78ExtracellularSequence analysisAdd BLAST13
    Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
    Topological domaini100 – 114CytoplasmicSequence analysisAdd BLAST15
    Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
    Topological domaini136 – 167ExtracellularSequence analysisAdd BLAST32
    Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
    Topological domaini189 – 194CytoplasmicSequence analysis6
    Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
    Topological domaini216 – 235ExtracellularSequence analysisAdd BLAST20
    Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
    Topological domaini257 – 266CytoplasmicSequence analysis10
    Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
    Topological domaini288 – 311ExtracellularSequence analysisAdd BLAST24
    Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
    Topological domaini333 – 363CytoplasmicSequence analysisAdd BLAST31
    Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
    Topological domaini385ExtracellularSequence analysis1
    Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
    Topological domaini407 – 425CytoplasmicSequence analysisAdd BLAST19
    Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
    Topological domaini447 – 451ExtracellularSequence analysis5
    Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
    Topological domaini473 – 515CytoplasmicSequence analysisAdd BLAST43

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    9057

    Open Targets

    More...
    OpenTargetsi
    ENSG00000103064

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35924

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q92536, Tbio

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00130, L-Glutamine

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC7A6

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    190462822

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003414771 – 515Y+L amino acid transporter 2Add BLAST515

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineBy similarity1

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q92536

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q92536

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q92536

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q92536

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q92536

    PeptideAtlas

    More...
    PeptideAtlasi
    Q92536

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q92536

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    75294

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q92536

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q92536

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.6 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000103064, Expressed in gastrocnemius and 218 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q92536, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q92536, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000103064, Tissue enhanced (skeletal)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    114519, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q92536, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000455064

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q92536, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 36Polar residuesSequence analysisAdd BLAST24

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1287, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158295

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_007946_3_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q92536

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LYPAGNY

    Database of Orthologous Groups

    More...
    OrthoDBi
    621852at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q92536

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313355

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002293, AA/rel_permease1

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13520, AA_permease_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

    Q92536-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG
    60 70 80 90 100
    VSLVVGNMIG SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE
    110 120 130 140 150
    LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLVVEPTGQ AIIAITFANY
    160 170 180 190 200
    IIQPSFPSCD PPYLACRLLA AACICLLTFV NCAYVKWGTR VQDTFTYAKV
    210 220 230 240 250
    VALIAIIVMG LVKLCQGHSE HFQDAFEGSS WDMGNLSLAL YSALFSYSGW
    260 270 280 290 300
    DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNISDVLS
    310 320 330 340 350
    SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG
    360 370 380 390 400
    HLPDLLSMIH IERFTPIPAL LFNCTMALIY LIVEDVFQLI NYFSFSYWFF
    410 420 430 440 450
    VGLSVVGQLY LRWKEPKRPR PLKLSVFFPI VFCICSVFLV IVPLFTDTIN
    460 470 480 490 500
    SLIGIGIALS GVPFYFMGVY LPESRRPLFI RNVLAAITRG TQQLCFCVLT
    510
    ELDVAEEKKD ERKTD
    Length:515
    Mass (Da):56,828
    Last modified:June 10, 2008 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E92F6E1972351A9
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H3BUA4H3BUA4_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    123Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7EPZ8E7EPZ8_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    229Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BPV6H3BPV6_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    91Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BSB6H3BSB6_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    74Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BUR2H3BUR2_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    98Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BNF5H3BNF5_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    214Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BRZ8H3BRZ8_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    127Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BPK5H3BPK5_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    28Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QL60J3QL60_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    50Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BSV7H3BSV7_HUMAN
    Y+L amino acid transporter 2
    SLC7A6
    24Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA13376 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8R → G in CAH18146 (PubMed:17974005).Curated1
    Sequence conflicti388Q → R in CAH18146 (PubMed:17974005).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D87432 mRNA Translation: BAA13376.2 Different initiation.
    CR749291 mRNA Translation: CAH18146.1
    CH471092 Genomic DNA Translation: EAW83219.1
    BC028216 mRNA Translation: AAH28216.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS32470.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001070253.1, NM_001076785.2
    NP_003974.3, NM_003983.5
    XP_011521735.1, XM_011523433.1
    XP_011521736.1, XM_011523434.1
    XP_011521740.1, XM_011523438.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000219343; ENSP00000219343; ENSG00000103064
    ENST00000566454; ENSP00000455064; ENSG00000103064

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9057

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:9057

    UCSC genome browser

    More...
    UCSCi
    uc002evt.3, human

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D87432 mRNA Translation: BAA13376.2 Different initiation.
    CR749291 mRNA Translation: CAH18146.1
    CH471092 Genomic DNA Translation: EAW83219.1
    BC028216 mRNA Translation: AAH28216.1
    CCDSiCCDS32470.1
    RefSeqiNP_001070253.1, NM_001076785.2
    NP_003974.3, NM_003983.5
    XP_011521735.1, XM_011523433.1
    XP_011521736.1, XM_011523434.1
    XP_011521740.1, XM_011523438.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi114519, 12 interactors
    IntActiQ92536, 4 interactors
    STRINGi9606.ENSP00000455064

    Chemistry databases

    DrugBankiDB00130, L-Glutamine

    Protein family/group databases

    TCDBi2.A.3.8.23, the amino acid-polyamine-organocation (apc) family

    PTM databases

    iPTMnetiQ92536
    PhosphoSitePlusiQ92536

    Genetic variation databases

    BioMutaiSLC7A6
    DMDMi190462822

    Proteomic databases

    EPDiQ92536
    jPOSTiQ92536
    MassIVEiQ92536
    MaxQBiQ92536
    PaxDbiQ92536
    PeptideAtlasiQ92536
    PRIDEiQ92536
    ProteomicsDBi75294

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    55124, 105 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    9057

    Genome annotation databases

    EnsembliENST00000219343; ENSP00000219343; ENSG00000103064
    ENST00000566454; ENSP00000455064; ENSG00000103064
    GeneIDi9057
    KEGGihsa:9057
    UCSCiuc002evt.3, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9057
    DisGeNETi9057

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC7A6
    HGNCiHGNC:11064, SLC7A6
    HPAiENSG00000103064, Tissue enhanced (skeletal)
    MIMi605641, gene
    neXtProtiNX_Q92536
    OpenTargetsiENSG00000103064
    PharmGKBiPA35924
    VEuPathDBiHostDB:ENSG00000103064.13

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1287, Eukaryota
    GeneTreeiENSGT00940000158295
    HOGENOMiCLU_007946_3_0_1
    InParanoidiQ92536
    OMAiLYPAGNY
    OrthoDBi621852at2759
    PhylomeDBiQ92536
    TreeFamiTF313355

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000103064-MONOMER
    PathwayCommonsiQ92536
    ReactomeiR-HSA-210991, Basigin interactions
    R-HSA-352230, Amino acid transport across the plasma membrane
    SABIO-RKiQ92536

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    9057, 21 hits in 995 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC7A6, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC7A6

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9057
    PharosiQ92536, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q92536
    RNActiQ92536, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000103064, Expressed in gastrocnemius and 218 other tissues
    ExpressionAtlasiQ92536, baseline and differential
    GenevisibleiQ92536, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR002293, AA/rel_permease1
    PfamiView protein in Pfam
    PF13520, AA_permease_2, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYLAT2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92536
    Secondary accession number(s): Q68DS4, Q7L1N3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: June 2, 2021
    This is version 163 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again