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Protein

SHC-transforming protein 3

Gene

SHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: Reactome
  • central nervous system development Source: ProtInc
  • epidermal growth factor receptor signaling pathway Source: ProtInc
  • learning or memory Source: Ensembl
  • MAPK cascade Source: Reactome
  • Ras protein signal transduction Source: Reactome
  • synaptic transmission, glutamatergic Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-167044 Signalling to RAS
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SignaLinkiQ92529
SIGNORiQ92529

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name:
N-Shc
Protein Rai
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name:
SH2 domain protein C3
Gene namesi
Name:SHC3
Synonyms:NSHC, SHCC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148082.9
HGNCiHGNC:18181 SHC3
MIMi605263 gene
neXtProtiNX_Q92529

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi53358
OpenTargetsiENSG00000148082
PharmGKBiPA134913435

Polymorphism and mutation databases

BioMutaiSHC3
DMDMi48474922

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977341 – 594SHC-transforming protein 3Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei402PhosphoserineBy similarity1

Post-translational modificationi

Tyrosine phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92529
MaxQBiQ92529
PaxDbiQ92529
PeptideAtlasiQ92529
PRIDEiQ92529
ProteomicsDBi75289
75290 [Q92529-2]

PTM databases

iPTMnetiQ92529
PhosphoSitePlusiQ92529

Expressioni

Tissue specificityi

Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.1 Publication

Gene expression databases

BgeeiENSG00000148082
CleanExiHS_SHC3
ExpressionAtlasiQ92529 baseline and differential
GenevisibleiQ92529 HS

Organism-specific databases

HPAiHPA031427
HPA046656
HPA072448

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119752, 12 interactors
CORUMiQ92529
IntActiQ92529, 51 interactors
MINTiQ92529
STRINGi9606.ENSP00000364995

Structurei

3D structure databases

ProteinModelPortaliQ92529
SMRiQ92529
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 334PIDPROSITE-ProRule annotationAdd BLAST186
Domaini499 – 590SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni335 – 498CH1Add BLAST164

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00390000018860
HOGENOMiHOG000231974
HOVERGENiHBG050121
InParanoidiQ92529
KOiK17448
OMAiSDHPYYN
OrthoDBiEOG091G04DC
PhylomeDBiQ92529
TreeFamiTF315807

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029593 Shc3/ShcC/N-Shc
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF4 PTHR10337:SF4, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform p64 (identifier: Q92529-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG
60 70 80 90 100
EALRKAPDDG PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC
110 120 130 140 150
SAPSLAAPDG SAPSAPRAPA MSAARKGRPG DEPLPRPPRG APHASDQVLG
160 170 180 190 200
PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI TREAISRVCE AVPGAKGAFK
210 220 230 240 250
KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIIANHHM
260 270 280 290 300
RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA
310 320 330 340 350
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP
360 370 380 390 400
PPGGFLDTRL KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ
410 420 430 440 450
GSSDIYSTPE GKLHVAPTGE APTYVNTQQI PPQAWPAAVS SAESSPRKDL
460 470 480 490 500
FDMKPFEDAL KNQPLGPVLS KAASVECISP VSPRAPDAKM LEELQAETWY
510 520 530 540 550
QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE
560 570 580 590
GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ
Length:594
Mass (Da):64,056
Last modified:February 1, 1997 - v1
Checksum:i047A9D08002E41BF
GO
Isoform p52 (identifier: Q92529-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: MLPRTKYNRF...DQVLGPGVTY → MHARAAASVMDICRIRLLIRLTIGLERPPGQV

Show »
Length:471
Mass (Da):51,939
Checksum:iBE74C85B97AF30CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58D → V in AAH26314 (PubMed:15489334).Curated1
Sequence conflicti201K → R (PubMed:8760305).Curated1
Sequence conflicti271A → T in AAH26314 (PubMed:15489334).Curated1
Sequence conflicti553I → E (PubMed:8760305).Curated1
Sequence conflicti554R → Q in AAH26314 (PubMed:15489334).Curated1
Sequence conflicti593 – 594KQ → NE (PubMed:8760305).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0098051 – 155MLPRT…PGVTY → MHARAAASVMDICRIRLLIR LTIGLERPPGQV in isoform p52. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84361 mRNA Translation: BAA12322.1
D84361 mRNA Translation: BAA12323.1
AL160054 Genomic DNA No translation available.
AL353150 Genomic DNA No translation available.
BC026314 mRNA Translation: AAH26314.1
CCDSiCCDS6681.1 [Q92529-1]
RefSeqiNP_058544.3, NM_016848.5 [Q92529-1]
UniGeneiHs.292737

Genome annotation databases

EnsembliENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1]
GeneIDi53358
KEGGihsa:53358
UCSCiuc004aqf.2 human [Q92529-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSHC3_HUMAN
AccessioniPrimary (citable) accession number: Q92529
Secondary accession number(s): Q5T7I7, Q8TAP2, Q9UCX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: February 1, 1997
Last modified: July 18, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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