UniProtKB - Q92529 (SHC3_HUMAN)
SHC-transforming protein 3
SHC3
Functioni
GO - Molecular functioni
- phosphotyrosine residue binding Source: CAFA
- protein kinase binding Source: GO_Central
- receptor tyrosine kinase binding Source: GO_Central
GO - Biological processi
- axon guidance Source: Reactome
- central nervous system development Source: ProtInc
- epidermal growth factor receptor signaling pathway Source: ProtInc
- learning or memory Source: Ensembl
- MAPK cascade Source: Reactome
- Ras protein signal transduction Source: Reactome
- synaptic transmission, glutamatergic Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q92529 |
Reactomei | R-HSA-167044, Signalling to RAS R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8853659, RET signaling |
SignaLinki | Q92529 |
SIGNORi | Q92529 |
Names & Taxonomyi
Protein namesi | Recommended name: SHC-transforming protein 3Alternative name(s): Neuronal Shc Short name: N-Shc Protein Rai SHC-transforming protein C Src homology 2 domain-containing-transforming protein C3 Short name: SH2 domain protein C3 |
Gene namesi | Name:SHC3 Synonyms:NSHC, SHCC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148082.9 |
HGNCi | HGNC:18181, SHC3 |
MIMi | 605263, gene |
neXtProti | NX_Q92529 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- synapse Source: GOC
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 53358 |
OpenTargetsi | ENSG00000148082 |
PharmGKBi | PA134913435 |
Miscellaneous databases
Pharosi | Q92529, Tbio |
Polymorphism and mutation databases
BioMutai | SHC3 |
DMDMi | 48474922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097734 | 1 – 594 | SHC-transforming protein 3Add BLAST | 594 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 402 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q92529 |
MassIVEi | Q92529 |
MaxQBi | Q92529 |
PaxDbi | Q92529 |
PeptideAtlasi | Q92529 |
PRIDEi | Q92529 |
ProteomicsDBi | 75289 [Q92529-1] 75290 [Q92529-2] |
PTM databases
iPTMneti | Q92529 |
PhosphoSitePlusi | Q92529 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000148082, Expressed in Brodmann (1909) area 23 and 189 other tissues |
ExpressionAtlasi | Q92529, baseline and differential |
Genevisiblei | Q92529, HS |
Organism-specific databases
HPAi | ENSG00000148082, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2.
Interacts with activated EGF receptors.
1 PublicationBinary interactionsi
Hide detailsQ92529
GO - Molecular functioni
- phosphotyrosine residue binding Source: CAFA
- protein kinase binding Source: GO_Central
- receptor tyrosine kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119752, 54 interactors |
CORUMi | Q92529 |
IntActi | Q92529, 49 interactors |
MINTi | Q92529 |
STRINGi | 9606.ENSP00000364995 |
Miscellaneous databases
RNActi | Q92529, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 334 | PIDPROSITE-ProRule annotationAdd BLAST | 186 | |
Domaini | 499 – 590 | SH2PROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 498 | CH1Add BLAST | 164 |
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG3697, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_029532_2_1_1 |
InParanoidi | Q92529 |
OMAi | EAPTYIN |
OrthoDBi | 1351843at2759 |
PhylomeDBi | Q92529 |
TreeFami | TF315807 |
Family and domain databases
CDDi | cd01209, PTB_Shc, 1 hit cd09925, SH2_SHC, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006019, PID_Shc-like IPR006020, PTB/PI_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR029593, Shc3/ShcC/N-Shc IPR035676, SHC_SH2 |
PANTHERi | PTHR10337:SF4, PTHR10337:SF4, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00629, SHCPIDOMAIN |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50001, SH2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG
60 70 80 90 100
EALRKAPDDG PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC
110 120 130 140 150
SAPSLAAPDG SAPSAPRAPA MSAARKGRPG DEPLPRPPRG APHASDQVLG
160 170 180 190 200
PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI TREAISRVCE AVPGAKGAFK
210 220 230 240 250
KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIIANHHM
260 270 280 290 300
RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA
310 320 330 340 350
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP
360 370 380 390 400
PPGGFLDTRL KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ
410 420 430 440 450
GSSDIYSTPE GKLHVAPTGE APTYVNTQQI PPQAWPAAVS SAESSPRKDL
460 470 480 490 500
FDMKPFEDAL KNQPLGPVLS KAASVECISP VSPRAPDAKM LEELQAETWY
510 520 530 540 550
QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE
560 570 580 590
GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ
The sequence of this isoform differs from the canonical sequence as follows:
1-155: MLPRTKYNRF...DQVLGPGVTY → MHARAAASVMDICRIRLLIRLTIGLERPPGQV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T7I8 | Q5T7I8_HUMAN | SHC-transforming protein 3 | SHC3 | 105 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 58 | D → V in AAH26314 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 201 | K → R (PubMed:8760305).Curated | 1 | |
Sequence conflicti | 271 | A → T in AAH26314 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 553 | I → E (PubMed:8760305).Curated | 1 | |
Sequence conflicti | 554 | R → Q in AAH26314 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 593 – 594 | KQ → NE (PubMed:8760305).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009805 | 1 – 155 | MLPRT…PGVTY → MHARAAASVMDICRIRLLIR LTIGLERPPGQV in isoform p52. 2 PublicationsAdd BLAST | 155 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84361 mRNA Translation: BAA12322.1 D84361 mRNA Translation: BAA12323.1 AL160054 Genomic DNA No translation available. AL353150 Genomic DNA No translation available. BC026314 mRNA Translation: AAH26314.1 |
CCDSi | CCDS6681.1 [Q92529-1] |
RefSeqi | NP_058544.3, NM_016848.5 [Q92529-1] |
Genome annotation databases
Ensembli | ENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1] |
GeneIDi | 53358 |
KEGGi | hsa:53358 |
UCSCi | uc004aqf.2, human [Q92529-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84361 mRNA Translation: BAA12322.1 D84361 mRNA Translation: BAA12323.1 AL160054 Genomic DNA No translation available. AL353150 Genomic DNA No translation available. BC026314 mRNA Translation: AAH26314.1 |
CCDSi | CCDS6681.1 [Q92529-1] |
RefSeqi | NP_058544.3, NM_016848.5 [Q92529-1] |
3D structure databases
SMRi | Q92529 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119752, 54 interactors |
CORUMi | Q92529 |
IntActi | Q92529, 49 interactors |
MINTi | Q92529 |
STRINGi | 9606.ENSP00000364995 |
PTM databases
iPTMneti | Q92529 |
PhosphoSitePlusi | Q92529 |
Polymorphism and mutation databases
BioMutai | SHC3 |
DMDMi | 48474922 |
Proteomic databases
jPOSTi | Q92529 |
MassIVEi | Q92529 |
MaxQBi | Q92529 |
PaxDbi | Q92529 |
PeptideAtlasi | Q92529 |
PRIDEi | Q92529 |
ProteomicsDBi | 75289 [Q92529-1] 75290 [Q92529-2] |
Protocols and materials databases
Antibodypediai | 27964, 204 antibodies |
DNASUi | 53358 |
Genome annotation databases
Ensembli | ENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1] |
GeneIDi | 53358 |
KEGGi | hsa:53358 |
UCSCi | uc004aqf.2, human [Q92529-1] |
Organism-specific databases
CTDi | 53358 |
DisGeNETi | 53358 |
EuPathDBi | HostDB:ENSG00000148082.9 |
GeneCardsi | SHC3 |
HGNCi | HGNC:18181, SHC3 |
HPAi | ENSG00000148082, Tissue enhanced (brain) |
MIMi | 605263, gene |
neXtProti | NX_Q92529 |
OpenTargetsi | ENSG00000148082 |
PharmGKBi | PA134913435 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3697, Eukaryota |
GeneTreei | ENSGT00950000182870 |
HOGENOMi | CLU_029532_2_1_1 |
InParanoidi | Q92529 |
OMAi | EAPTYIN |
OrthoDBi | 1351843at2759 |
PhylomeDBi | Q92529 |
TreeFami | TF315807 |
Enzyme and pathway databases
PathwayCommonsi | Q92529 |
Reactomei | R-HSA-167044, Signalling to RAS R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8853659, RET signaling |
SignaLinki | Q92529 |
SIGNORi | Q92529 |
Miscellaneous databases
BioGRID-ORCSi | 53358, 10 hits in 848 CRISPR screens |
ChiTaRSi | SHC3, human |
GeneWikii | SHC3 |
GenomeRNAii | 53358 |
Pharosi | Q92529, Tbio |
PROi | PR:Q92529 |
RNActi | Q92529, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148082, Expressed in Brodmann (1909) area 23 and 189 other tissues |
ExpressionAtlasi | Q92529, baseline and differential |
Genevisiblei | Q92529, HS |
Family and domain databases
CDDi | cd01209, PTB_Shc, 1 hit cd09925, SH2_SHC, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR006019, PID_Shc-like IPR006020, PTB/PI_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR029593, Shc3/ShcC/N-Shc IPR035676, SHC_SH2 |
PANTHERi | PTHR10337:SF4, PTHR10337:SF4, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00629, SHCPIDOMAIN |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHC3_HUMAN | |
Accessioni | Q92529Primary (citable) accession number: Q92529 Secondary accession number(s): Q5T7I7, Q8TAP2, Q9UCX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
Last sequence update: | February 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot