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UniProtKB - Q92529 (SHC3_HUMAN)

Entry version 172 (02 Jun 2021)
Sequence version 1 (01 Feb 1997)
Previous versions | rss
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Protein

SHC-transforming protein 3

Gene

SHC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q92529

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167044, Signalling to RAS
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-8853659, RET signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q92529

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q92529

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name:
N-Shc
Protein Rai
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name:
SH2 domain protein C3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHC3
Synonyms:NSHC, SHCC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18181, SHC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605263, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q92529

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000148082.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		53358

Open Targets

More...OpenTargetsi		ENSG00000148082

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134913435

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q92529, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SHC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		48474922

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977341 – 594SHC-transforming protein 3Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei402PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q92529

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q92529

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92529

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92529

PeptideAtlas

More...PeptideAtlasi		Q92529

PRoteomics IDEntifications database

More...PRIDEi		Q92529

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		75289 [Q92529-1]
75290 [Q92529-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92529

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q92529

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148082, Expressed in Brodmann (1909) area 23 and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q92529, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q92529, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148082, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2.

Interacts with activated EGF receptors.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q92529
With#Exp.IntAct
ANKRD10 - isoform 2 [Q9NXR5-2]3EBI-79084,EBI-12102070
APP [P05067]5EBI-79084,EBI-77613
ASPG [Q86U10]3EBI-79084,EBI-19946665
BMF [Q96LC9]3EBI-79084,EBI-3919268
CCNC [P24863]3EBI-79084,EBI-395261
CDCA4 [Q9BXL8]3EBI-79084,EBI-1773949
CEACAM6 [P40199]3EBI-79084,EBI-4314501
COPS6 [Q7L5N1]3EBI-79084,EBI-486838
CT55 [Q8WUE5]3EBI-79084,EBI-6873363
DOK3 - isoform 3 [Q7L591-3]3EBI-79084,EBI-10694655
ERBB2 [P04626]2EBI-79084,EBI-641062
ERBB3 [P21860]2EBI-79084,EBI-720706
FTO - isoform 2 [Q9C0B1-2]3EBI-79084,EBI-18138793
GOLGA2 [Q08379]3EBI-79084,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-79084,EBI-5916454
KIT [P10721]3EBI-79084,EBI-1379503
KRT31 [Q15323]6EBI-79084,EBI-948001
KRT33B [Q14525]3EBI-79084,EBI-1049638
KRT34 [O76011]3EBI-79084,EBI-1047093
KRT35 [Q92764]3EBI-79084,EBI-1058674
KRT39 [Q6A163]3EBI-79084,EBI-11958242
KRT40 [Q6A162]6EBI-79084,EBI-10171697
KRT86 [O43790]3EBI-79084,EBI-9996498
PMF1 [Q6P1K2]3EBI-79084,EBI-713832
PNMA1 [Q8ND90]3EBI-79084,EBI-302345
PPP1R16B [Q96T49]3EBI-79084,EBI-10293968
PRKAR1B [P31321]3EBI-79084,EBI-2805516
PSMD8 [P48556]3EBI-79084,EBI-359304
REL - isoform 2 [Q04864-2]3EBI-79084,EBI-10829018
SMYD3 [Q9H7B4]3EBI-79084,EBI-347919
STX11 [O75558]3EBI-79084,EBI-714135
TRAF1 [Q13077]3EBI-79084,EBI-359224
TRAF2 [Q12933]3EBI-79084,EBI-355744
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-79084,EBI-17716262
TRIM54 [Q9BYV2]3EBI-79084,EBI-2130429
TSC1 [Q86WV8]5EBI-79084,EBI-12806590
UBAP2 [Q5T6F2]3EBI-79084,EBI-2514383
USHBP1 [Q8N6Y0]3EBI-79084,EBI-739895
USP54 - isoform 6 [Q70EL1-9]3EBI-79084,EBI-11975223
VPS28 - isoform 2 [Q9UK41-2]3EBI-79084,EBI-12146727
WWOX - isoform 5 [Q9NZC7-5]5EBI-79084,EBI-12040603
YPEL5 [P62699]3EBI-79084,EBI-11721624
ZMYND12 [Q9H0C1]3EBI-79084,EBI-12030590

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119752, 59 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q92529

Protein interaction database and analysis system

More...IntActi		Q92529, 49 interactors

Molecular INTeraction database

More...MINTi		Q92529

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364995

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q92529, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92529

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 334PIDPROSITE-ProRule annotationAdd BLAST186
Domaini499 – 590SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni98 – 147DisorderedSequence analysisAdd BLAST50
Regioni335 – 498CH1Add BLAST164
Regioni351 – 373DisorderedSequence analysisAdd BLAST23
Regioni386 – 405DisorderedSequence analysisAdd BLAST20

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3697, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029532_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92529

Identification of Orthologs from Complete Genome Data

More...OMAi		EAPTYIN

Database of Orthologous Groups

More...OrthoDBi		1351843at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92529

TreeFam database of animal gene trees

More...TreeFami		TF315807

Family and domain databases

Conserved Domains Database

More...CDDi		cd01209, PTB_Shc, 1 hit
cd09925, SH2_SHC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR006019, PID_Shc-like
IPR006020, PTB/PI_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR029593, Shc3/ShcC/N-Shc
IPR035676, SHC_SH2

The PANTHER Classification System

More...PANTHERi		PTHR10337:SF4, PTHR10337:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00640, PID, 1 hit
PF00017, SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00401, SH2DOMAIN
PR00629, SHCPIDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00462, PTB, 1 hit
SM00252, SH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01179, PID, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform p64 (identifier: Q92529-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG 
        60         70         80         90        100
EALRKAPDDG PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC 
       110        120        130        140        150
SAPSLAAPDG SAPSAPRAPA MSAARKGRPG DEPLPRPPRG APHASDQVLG 
       160        170        180        190        200
PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI TREAISRVCE AVPGAKGAFK 
       210        220        230        240        250
KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIIANHHM 
       260        270        280        290        300
RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 
       310        320        330        340        350
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP 
       360        370        380        390        400
PPGGFLDTRL KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ 
       410        420        430        440        450
GSSDIYSTPE GKLHVAPTGE APTYVNTQQI PPQAWPAAVS SAESSPRKDL 
       460        470        480        490        500
FDMKPFEDAL KNQPLGPVLS KAASVECISP VSPRAPDAKM LEELQAETWY 
       510        520        530        540        550
QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE 
       560        570        580        590 
GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ
Length:594
Mass (Da):64,056
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i047A9D08002E41BF
GO
Isoform p52 (identifier: Q92529-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: MLPRTKYNRF...DQVLGPGVTY → MHARAAASVMDICRIRLLIRLTIGLERPPGQV

Show »
Length:471
Mass (Da):51,939
Checksum:iBE74C85B97AF30CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T7I8Q5T7I8_HUMAN
SHC-transforming protein 3
SHC3
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58D → V in AAH26314 (PubMed:15489334).Curated1
Sequence conflicti201K → R (PubMed:8760305).Curated1
Sequence conflicti271A → T in AAH26314 (PubMed:15489334).Curated1
Sequence conflicti553I → E (PubMed:8760305).Curated1
Sequence conflicti554R → Q in AAH26314 (PubMed:15489334).Curated1
Sequence conflicti593 – 594KQ → NE (PubMed:8760305).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0098051 – 155MLPRT…PGVTY → MHARAAASVMDICRIRLLIR LTIGLERPPGQV in isoform p52. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D84361 mRNA Translation: BAA12322.1
D84361 mRNA Translation: BAA12323.1
AL160054 Genomic DNA No translation available.
AL353150 Genomic DNA No translation available.
BC026314 mRNA Translation: AAH26314.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6681.1 [Q92529-1]

NCBI Reference Sequences

More...RefSeqi		NP_058544.3, NM_016848.5 [Q92529-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53358

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53358

UCSC genome browser

More...UCSCi		uc004aqf.2, human [Q92529-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84361 mRNA Translation: BAA12322.1
D84361 mRNA Translation: BAA12323.1
AL160054 Genomic DNA No translation available.
AL353150 Genomic DNA No translation available.
BC026314 mRNA Translation: AAH26314.1
CCDSiCCDS6681.1 [Q92529-1]
RefSeqiNP_058544.3, NM_016848.5 [Q92529-1]

3D structure databases

SMRiQ92529
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119752, 59 interactors
CORUMiQ92529
IntActiQ92529, 49 interactors
MINTiQ92529
STRINGi9606.ENSP00000364995

PTM databases

iPTMnetiQ92529
PhosphoSitePlusiQ92529

Genetic variation databases

BioMutaiSHC3
DMDMi48474922

Proteomic databases

jPOSTiQ92529
MassIVEiQ92529
MaxQBiQ92529
PaxDbiQ92529
PeptideAtlasiQ92529
PRIDEiQ92529
ProteomicsDBi75289 [Q92529-1]
75290 [Q92529-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27964, 215 antibodies

The DNASU plasmid repository

More...DNASUi		53358

Genome annotation databases

EnsembliENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1]
GeneIDi53358
KEGGihsa:53358
UCSCiuc004aqf.2, human [Q92529-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53358
DisGeNETi53358

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHC3
HGNCiHGNC:18181, SHC3
HPAiENSG00000148082, Tissue enhanced (brain)
MIMi605263, gene
neXtProtiNX_Q92529
OpenTargetsiENSG00000148082
PharmGKBiPA134913435
VEuPathDBiHostDB:ENSG00000148082.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3697, Eukaryota
GeneTreeiENSGT00950000182870
HOGENOMiCLU_029532_2_1_1
InParanoidiQ92529
OMAiEAPTYIN
OrthoDBi1351843at2759
PhylomeDBiQ92529
TreeFamiTF315807

Enzyme and pathway databases

PathwayCommonsiQ92529
ReactomeiR-HSA-167044, Signalling to RAS
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-8853659, RET signaling
SignaLinkiQ92529
SIGNORiQ92529

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53358, 12 hits in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SHC3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SHC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53358
PharosiQ92529, Tbio

Protein Ontology

More...PROi		PR:Q92529
RNActiQ92529, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148082, Expressed in Brodmann (1909) area 23 and 189 other tissues
ExpressionAtlasiQ92529, baseline and differential
GenevisibleiQ92529, HS

Family and domain databases

CDDicd01209, PTB_Shc, 1 hit
cd09925, SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR006019, PID_Shc-like
IPR006020, PTB/PI_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR029593, Shc3/ShcC/N-Shc
IPR035676, SHC_SH2
PANTHERiPTHR10337:SF4, PTHR10337:SF4, 1 hit
PfamiView protein in Pfam
PF00640, PID, 1 hit
PF00017, SH2, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00629, SHCPIDOMAIN
SMARTiView protein in SMART
SM00462, PTB, 1 hit
SM00252, SH2, 1 hit
SUPFAMiSSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179, PID, 1 hit
PS50001, SH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92529
Secondary accession number(s): Q5T7I7, Q8TAP2, Q9UCX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: February 1, 1997
Last modified: June 2, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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