UniProtKB - Q92529 (SHC3_HUMAN)

BLAST

>sp|Q92529|SHC3_HUMAN SHC-transforming protein 3 OS=Homo sapiens OX=9606 GN=SHC3 PE=1 SV=1
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ

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History
Entry version 152 (07 Nov 2018)
Sequence version 1 (01 Feb 1997)
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Protein

SHC-transforming protein 3

Gene

SHC3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

GO - Molecular functionⁱ

phosphotyrosine residue binding
Source: CAFA
Inferred from physical interactionⁱ
- 20624904
Ras guanyl-nucleotide exchange factor activity Source: Reactome
receptor tyrosine kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance Source: Reactome
central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 8808684
epidermal growth factor receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8808684
learning or memory Source: Ensembl
MAPK cascade Source: Reactome
Ras protein signal transduction Source: Reactome
synaptic transmission, glutamatergic Source: Ensembl
transmembrane receptor protein tyrosine kinase signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8808684

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167044 Signalling to RAS R-HSA-5673001 RAF/MAP kinase cascade R-HSA-8853659 RET signaling
SignaLinkⁱ	Q92529
SIGNORⁱ	Q92529

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SHC-transforming protein 3 Alternative name(s): Neuronal Shc Short name: N-Shc Protein Rai SHC-transforming protein C Src homology 2 domain-containing-transforming protein C3 Short name: SH2 domain protein C3
Gene namesⁱ	Name:SHC3 Synonyms:NSHC, SHCC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148082.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18181 SHC3
MIMⁱ	605263 gene
neXtProtⁱ	NX_Q92529

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	53358
Open Targets More...OpenTargetsⁱ	ENSG00000148082
PharmGKBⁱ	PA134913435

Polymorphism and mutation databases

BioMutaⁱ	SHC3
DMDMⁱ	48474922

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097734	1 – 594	SHC-transforming protein 3Add BLAST		594

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	402	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Tyrosine phosphorylated.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q92529
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92529
PaxDbⁱ	Q92529
PeptideAtlas More...PeptideAtlasⁱ	Q92529
PRIDEⁱ	Q92529
ProteomicsDBⁱ	75289 75290 [Q92529-2]

PTM databases

iPTMnetⁱ	Q92529
PhosphoSitePlusⁱ	Q92529

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000148082 Expressed in 173 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_SHC3
ExpressionAtlasⁱ	Q92529 baseline and differential
Genevisibleⁱ	Q92529 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031427 HPA046656 HPA072448

HPAⁱ

HPA031427
HPA046656
HPA072448

Interactionⁱ

Subunit structureⁱ

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
APP	P05067	2	EBI-79084,EBI-77613
ERBB2	P04626	2	EBI-79084,EBI-641062
ERBB3	P21860	2	EBI-79084,EBI-720706
GOLGA2	Q08379	3	EBI-79084,EBI-618309
KIT	P10721	3	EBI-79084,EBI-1379503
KRT31	Q15323	5	EBI-79084,EBI-948001
KRT40	Q6A162	5	EBI-79084,EBI-10171697

GO - Molecular functionⁱ

phosphotyrosine residue binding
Source: CAFA
Inferred from physical interactionⁱ
- 20624904
Ras guanyl-nucleotide exchange factor activity Source: Reactome
receptor tyrosine kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119752, 12 interactors
CORUMⁱ	Q92529
IntActⁱ	Q92529, 51 interactors
Molecular INTeraction database More...MINTⁱ	Q92529
STRINGⁱ	9606.ENSP00000364995

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92529
SMRⁱ	Q92529
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	149 – 334	PIDPROSITE-ProRule annotationAdd BLAST		186
Domainⁱ	499 – 590	SH2PROSITE-ProRule annotationAdd BLAST		92

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	335 – 498	CH1Add BLAST		164

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG3697 Eukaryota ENOG410XTJN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018860
HOGENOMⁱ	HOG000231974
HOVERGENⁱ	HBG050121
InParanoidⁱ	Q92529
KEGG Orthology (KO) More...KOⁱ	K17448
OMAⁱ	LKAEPWY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04DC
PhylomeDBⁱ	Q92529
TreeFamⁱ	TF315807

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01209 PTB_Shc, 1 hit cd09925 SH2_SHC, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006019 PID_Shc-like IPR006020 PTB/PI_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR029593 Shc3/ShcC/N-Shc IPR035676 SHC_SH2
PANTHERⁱ	PTHR10337:SF4 PTHR10337:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit PF00017 SH2, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00629 SHCPIDOMAIN
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit SM00252 SH2, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit PS50001 SH2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform p64 (identifier: Q92529-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG 
        60         70         80         90        100
EALRKAPDDG PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC 
       110        120        130        140        150
SAPSLAAPDG SAPSAPRAPA MSAARKGRPG DEPLPRPPRG APHASDQVLG 
       160        170        180        190        200
PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI TREAISRVCE AVPGAKGAFK 
       210        220        230        240        250
KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIIANHHM 
       260        270        280        290        300
RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 
       310        320        330        340        350
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP 
       360        370        380        390        400
PPGGFLDTRL KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ 
       410        420        430        440        450
GSSDIYSTPE GKLHVAPTGE APTYVNTQQI PPQAWPAAVS SAESSPRKDL 
       460        470        480        490        500
FDMKPFEDAL KNQPLGPVLS KAASVECISP VSPRAPDAKM LEELQAETWY 
       510        520        530        540        550
QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE 
       560        570        580        590 
GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ

Length:594

Mass (Da):64,056

Last modified:February 1, 1997 - v1

Checksum:ⁱ047A9D08002E41BF

Isoform p52 (identifier: Q92529-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-155: MLPRTKYNRF...DQVLGPGVTY → MHARAAASVMDICRIRLLIRLTIGLERPPGQV

« Hide

        10         20         30         40         50
MHARAAASVM DICRIRLLIR LTIGLERPPG QVVVKYLGCI EVLRSMRSLD 
        60         70         80         90        100
FSTRTQITRE AISRVCEAVP GAKGAFKKRK PPSKMLSSIL GKSNLQFAGM 
       110        120        130        140        150
SISLTISTAS LNLRTPDSKQ IIANHHMRSI SFASGGDPDT TDYVAYVAKD 
       160        170        180        190        200
PVNRRACHIL ECCDGLAQDV IGSIGQAFEL RFKQYLQCPT KIPALHDRMQ 
       210        220        230        240        250
SLDEPWTEEE GDGSDHPYYN SIPSKMPPPG GFLDTRLKPR PHAPDTAQFA 
       260        270        280        290        300
GKEQTYYQGR HLGDTFGEDW QQTPLRQGSS DIYSTPEGKL HVAPTGEAPT 
       310        320        330        340        350
YVNTQQIPPQ AWPAAVSSAE SSPRKDLFDM KPFEDALKNQ PLGPVLSKAA 
       360        370        380        390        400
SVECISPVSP RAPDAKMLEE LQAETWYQGE MSRKEAEGLL EKDGDFLVRK 
       410        420        430        440        450
STTNPGSFVL TGMHNGQAKH LLLVDPEGTI RTKDRVFDSI SHLINHHLES 
       460        470 
SLPIVSAGSE LCLQQPVERK Q

Show »

Length:471

Mass (Da):51,939

Checksum:ⁱBE74C85B97AF30CE

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5T7I8	Q5T7I8_HUMAN		SHC-transforming protein 3 SHC-transforming protein 3	SHC3	105	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	58	D → V in AAH26314 (PubMed:15489334).Curated	1
Sequence conflictⁱ	201	K → R (PubMed:8760305).Curated	1
Sequence conflictⁱ	271	A → T in AAH26314 (PubMed:15489334).Curated	1
Sequence conflictⁱ	553	I → E (PubMed:8760305).Curated	1
Sequence conflictⁱ	554	R → Q in AAH26314 (PubMed:15489334).Curated	1
Sequence conflictⁱ	593 – 594	KQ → NE (PubMed:8760305).Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009805	1 – 155	MLPRT…PGVTY → MHARAAASVMDICRIRLLIR LTIGLERPPGQV in isoform p52. 2 PublicationsAdd BLAST		155

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D84361 mRNA Translation: BAA12322.1 D84361 mRNA Translation: BAA12323.1 AL160054 Genomic DNA No translation available. AL353150 Genomic DNA No translation available. BC026314 mRNA Translation: AAH26314.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6681.1 [Q92529-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_058544.3, NM_016848.5 [Q92529-1]
UniGeneⁱ	Hs.292737

Genome annotation databases

Ensemblⁱ	ENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1]
GeneIDⁱ	53358
KEGGⁱ	hsa:53358
UCSC genome browser More...UCSCⁱ	uc004aqf.2 human [Q92529-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q92529	SHC3 isoform 2		PANTR		594	UniRef100_Q92529
Neuronal Shc 3 (Fragment)		PANTR		218

Protein	Similar proteins		Species	Score	Length	Source
Q92529	SHC3 isoform 2		PANTR		594	UniRef90_Q92529
Uncharacterized protein		Cebus capucinus imitator		598
Uncharacterized protein		PAPAN		598
SHC adaptor protein 3		CALJA		598
Uncharacterized protein		CHLSB		598
+32
Q92529-2	SHC-transforming protein 3		MOUSE		474	UniRef90_Q92529-2
SHC-transforming protein 3		HETGA		471
SHC-transforming protein 3		NEOSC		469
Uncharacterized protein		PANTR		466
Uncharacterized protein		PANPA		466
+11

Protein	Similar proteins		Species	Score	Length	Source
Q92529	SHC3 isoform 2		PANTR		594	UniRef50_Q92529
Uncharacterized protein		NOMLE		598
Uncharacterized protein		CERAT		598
Uncharacterized protein		CHLSB		598
Uncharacterized protein		Cebus capucinus imitator		598
+48
Q92529-2	SHC-transforming protein 3		MOUSE		474	UniRef50_Q92529-2
SHC-transforming protein 3		HETGA		471
SHC-transforming protein 3		NEOSC		469
Uncharacterized protein		PANPA		466
Uncharacterized protein		PANTR		466
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D84361 mRNA Translation: BAA12322.1 D84361 mRNA Translation: BAA12323.1 AL160054 Genomic DNA No translation available. AL353150 Genomic DNA No translation available. BC026314 mRNA Translation: AAH26314.1
CCDSⁱ	CCDS6681.1 [Q92529-1]
RefSeqⁱ	NP_058544.3, NM_016848.5 [Q92529-1]
UniGeneⁱ	Hs.292737

3D structure databases

ProteinModelPortalⁱ	Q92529
SMRⁱ	Q92529
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119752, 12 interactors
CORUMⁱ	Q92529
IntActⁱ	Q92529, 51 interactors
MINTⁱ	Q92529
STRINGⁱ	9606.ENSP00000364995

PTM databases

iPTMnetⁱ	Q92529
PhosphoSitePlusⁱ	Q92529

Polymorphism and mutation databases

BioMutaⁱ	SHC3
DMDMⁱ	48474922

Proteomic databases

EPDⁱ	Q92529
MaxQBⁱ	Q92529
PaxDbⁱ	Q92529
PeptideAtlasⁱ	Q92529
PRIDEⁱ	Q92529
ProteomicsDBⁱ	75289 75290 [Q92529-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	53358
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375835; ENSP00000364995; ENSG00000148082 [Q92529-1]
GeneIDⁱ	53358
KEGGⁱ	hsa:53358
UCSCⁱ	uc004aqf.2 human [Q92529-1]

Organism-specific databases

CTDⁱ	53358
DisGeNETⁱ	53358
EuPathDBⁱ	HostDB:ENSG00000148082.9
GeneCardsⁱ	SHC3
HGNCⁱ	HGNC:18181 SHC3
HPAⁱ	HPA031427 HPA046656 HPA072448
MIMⁱ	605263 gene
neXtProtⁱ	NX_Q92529
OpenTargetsⁱ	ENSG00000148082
PharmGKBⁱ	PA134913435
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3697 Eukaryota ENOG410XTJN LUCA
GeneTreeⁱ	ENSGT00390000018860
HOGENOMⁱ	HOG000231974
HOVERGENⁱ	HBG050121
InParanoidⁱ	Q92529
KOⁱ	K17448
OMAⁱ	LKAEPWY
OrthoDBⁱ	EOG091G04DC
PhylomeDBⁱ	Q92529
TreeFamⁱ	TF315807

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167044 Signalling to RAS R-HSA-5673001 RAF/MAP kinase cascade R-HSA-8853659 RET signaling
SignaLinkⁱ	Q92529
SIGNORⁱ	Q92529

Miscellaneous databases

ChiTaRSⁱ	SHC3 human
GeneWikiⁱ	SHC3
GenomeRNAiⁱ	53358
Protein Ontology More...PROⁱ	PR:Q92529
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148082 Expressed in 173 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_SHC3
ExpressionAtlasⁱ	Q92529 baseline and differential
Genevisibleⁱ	Q92529 HS

Family and domain databases

CDDⁱ	cd01209 PTB_Shc, 1 hit cd09925 SH2_SHC, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006019 PID_Shc-like IPR006020 PTB/PI_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR029593 Shc3/ShcC/N-Shc IPR035676 SHC_SH2
PANTHERⁱ	PTHR10337:SF4 PTHR10337:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit PF00017 SH2, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00629 SHCPIDOMAIN
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit SM00252 SH2, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit PS50001 SH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHC3_HUMAN
Accessionⁱ	Q92529Primary (citable) accession number: Q92529 Secondary accession number(s): Q5T7I7, Q8TAP2, Q9UCX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	February 1, 1997
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniParc

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Supporting data

UniProtKB - Q92529 (SHC3_HUMAN)

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SHC-transforming protein 3

SHC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ