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Entry version 177 (16 Oct 2019)
Sequence version 5 (05 Apr 2011)
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Protein

T-complex protein 1 subunit zeta-2

Gene

CCT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
CCT-zeta-like
TCP-1-zeta-like
Testis-specific Tcp20
Testis-specific protein TSA3031 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCT6B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1621 CCT6B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610730 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92526

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10693

Open Targets

More...
OpenTargetsi
ENSG00000132141

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26184

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92526

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCT6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478610

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001283631 – 530T-complex protein 1 subunit zeta-2Add BLAST530

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92526

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92526

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q92526

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92526

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92526

PeptideAtlas

More...
PeptideAtlasi
Q92526

PRoteomics IDEntifications database

More...
PRIDEi
Q92526

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5399
75285 [Q92526-1]
75286 [Q92526-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00220656

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92526

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92526

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q92526

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132141 Expressed in 152 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92526 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92526 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042996
HPA045576
HPA049949

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115932, 136 interactors

Database of interacting proteins

More...
DIPi
DIP-53269N

Protein interaction database and analysis system

More...
IntActi
Q92526, 68 interactors

Molecular INTeraction database

More...
MINTi
Q92526

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327191

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92526

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0359 Eukaryota
ENOG410XQ3Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156339

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000226733

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92526

KEGG Orthology (KO)

More...
KOi
K09498

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDCINPR

Database of Orthologous Groups

More...
OrthoDBi
482152at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92526

TreeFam database of animal gene trees

More...
TreeFami
TF106333

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03342 TCP1_zeta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.560.10, 2 hits
3.50.7.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00118 Cpn60_TCP1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00304 TCOMPLEXTCP1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02347 chap_CCT_zeta, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIA EGFEAAKIKA LEVLEEVKVT KEMKRKILLD
160 170 180 190 200
VARTSLQTKV HAELADVLTE VVVDSVLAVR RPGYPIDLFM VEIMEMKHKL
210 220 230 240 250
GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE KTEVNSGFFY
260 270 280 290 300
KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF
310 320 330 340 350
SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV
360 370 380 390 400
YEYTLGEEKF TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN
410 420 430 440 450
AIEDGCMVPG AGAIEVAMAE ALVTYKNSIK GRARLGVQAF ADALLIIPKV
460 470 480 490 500
LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD LNTGEPMVAA DAGVWDNYCV
510 520 530
KKQLLHSCTV IATNILLVDE IMRAGMSSLK
Length:530
Mass (Da):57,821
Last modified:April 5, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE28A28E3826C196
GO
Isoform 2 (identifier: Q92526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-112: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):53,100
Checksum:iD8F1B077E65DE6A9
GO
Isoform 3 (identifier: Q92526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-242: Missing.

Show »
Length:493
Mass (Da):53,586
Checksum:iCF7E2D93CFB23B14
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KRI6J3KRI6_HUMAN
T-complex protein 1 subunit zeta-2
CCT6B
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18 – 30AALAV…AARGL → QLWLSIYAPPRV in BAA11347 (PubMed:8812458).CuratedAdd BLAST13
Sequence conflicti86D → G in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti94S → T in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti176 – 178VLA → LFP in BAA11347 (PubMed:8812458).Curated3
Sequence conflicti183G → P in BAA11347 (PubMed:8812458).Curated1
Sequence conflicti529 – 530LK → QMMIEFKINPSRR in BAA11347 (PubMed:8812458).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06029717R → Q1 PublicationCorresponds to variant dbSNP:rs9635769Ensembl.1
Natural variantiVAR_06029848V → A1 PublicationCorresponds to variant dbSNP:rs2230552Ensembl.1
Natural variantiVAR_057269247G → A1 PublicationCorresponds to variant dbSNP:rs2230553Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04304068 – 112Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_047129206 – 242Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78333 mRNA Translation: BAA11347.1
AK301773 mRNA Translation: BAG63232.1
AK302344 mRNA Translation: BAG63672.1
AC022903 Genomic DNA No translation available.
BC026125 mRNA Translation: AAH26125.1
BC027591 mRNA Translation: AAH27591.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32617.1 [Q92526-1]
CCDS54105.1 [Q92526-2]
CCDS54106.1 [Q92526-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001180458.1, NM_001193529.2 [Q92526-3]
NP_001180459.1, NM_001193530.1 [Q92526-2]
NP_006575.2, NM_006584.3 [Q92526-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314144; ENSP00000327191; ENSG00000132141 [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141 [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141 [Q92526-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10693

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10693

UCSC genome browser

More...
UCSCi
uc002hig.4 human [Q92526-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78333 mRNA Translation: BAA11347.1
AK301773 mRNA Translation: BAG63232.1
AK302344 mRNA Translation: BAG63672.1
AC022903 Genomic DNA No translation available.
BC026125 mRNA Translation: AAH26125.1
BC027591 mRNA Translation: AAH27591.1
CCDSiCCDS32617.1 [Q92526-1]
CCDS54105.1 [Q92526-2]
CCDS54106.1 [Q92526-3]
RefSeqiNP_001180458.1, NM_001193529.2 [Q92526-3]
NP_001180459.1, NM_001193530.1 [Q92526-2]
NP_006575.2, NM_006584.3 [Q92526-1]

3D structure databases

SMRiQ92526
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115932, 136 interactors
DIPiDIP-53269N
IntActiQ92526, 68 interactors
MINTiQ92526
STRINGi9606.ENSP00000327191

PTM databases

iPTMnetiQ92526
PhosphoSitePlusiQ92526
SwissPalmiQ92526

Polymorphism and mutation databases

BioMutaiCCT6B
DMDMi327478610

2D gel databases

REPRODUCTION-2DPAGEiIPI00220656

Proteomic databases

EPDiQ92526
jPOSTiQ92526
MassIVEiQ92526
MaxQBiQ92526
PaxDbiQ92526
PeptideAtlasiQ92526
PRIDEiQ92526
ProteomicsDBi5399
75285 [Q92526-1]
75286 [Q92526-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10693

Genome annotation databases

EnsembliENST00000314144; ENSP00000327191; ENSG00000132141 [Q92526-1]
ENST00000421975; ENSP00000398044; ENSG00000132141 [Q92526-3]
ENST00000436961; ENSP00000400917; ENSG00000132141 [Q92526-2]
GeneIDi10693
KEGGihsa:10693
UCSCiuc002hig.4 human [Q92526-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10693
DisGeNETi10693

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCT6B
HGNCiHGNC:1621 CCT6B
HPAiHPA042996
HPA045576
HPA049949
MIMi610730 gene
neXtProtiNX_Q92526
OpenTargetsiENSG00000132141
PharmGKBiPA26184

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00940000156339
HOGENOMiHOG000226733
InParanoidiQ92526
KOiK09498
OMAiEDCINPR
OrthoDBi482152at2759
PhylomeDBiQ92526
TreeFamiTF106333

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCT6B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10693
PharosiQ92526

Protein Ontology

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PROi
PR:Q92526

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132141 Expressed in 152 organ(s), highest expression level in testis
ExpressionAtlasiQ92526 baseline and differential
GenevisibleiQ92526 HS

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPW_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92526
Secondary accession number(s): B4DX20, B4DYB0, Q8TC34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 177 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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