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Protein

Protein FAM3C

Gene

FAM3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Miscellaneous

Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3C
Alternative name(s):
Interleukin-like EMT inducer
Gene namesi
Name:FAM3C
Synonyms:ILEI
ORF Names:GS3786
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000196937.10
HGNCiHGNC:18664 FAM3C
MIMi608618 gene
neXtProtiNX_Q92520

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNETi10447
OpenTargetsiENSG00000196937
PharmGKBiPA38627

Polymorphism and mutation databases

BioMutaiFAM3C
DMDMi3334194

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000875225 – 227Protein FAM3CAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 86By similarity
Disulfide bondi64 ↔ 221By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ92520
MaxQBiQ92520
PaxDbiQ92520
PeptideAtlasiQ92520
PRIDEiQ92520
ProteomicsDBi75279
TopDownProteomicsiQ92520

PTM databases

iPTMnetiQ92520
PhosphoSitePlusiQ92520
SwissPalmiQ92520

Expressioni

Tissue specificityi

Present in most secretory epithelia (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000196937 Expressed in 238 organ(s), highest expression level in jejunal mucosa
CleanExiHS_FAM3C
ExpressionAtlasiQ92520 baseline and differential
GenevisibleiQ92520 HS

Organism-specific databases

HPAiHPA043376
HPA050548

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-2876774,EBI-6942903

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115712, 40 interactors
IntActiQ92520, 44 interactors
MINTiQ92520
STRINGi9606.ENSP00000353025

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92520
SMRiQ92520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEGC Eukaryota
ENOG4111I9K LUCA
GeneTreeiENSGT00530000063020
HOGENOMiHOG000285992
HOVERGENiHBG051544
InParanoidiQ92520
OMAiPKICVED
OrthoDBiEOG091G0IGX
PhylomeDBiQ92520
TreeFamiTF353414

Family and domain databases

CDDicd13940 ILEI_FAM3C, 1 hit
InterProiView protein in InterPro
IPR039220 FAM3
IPR039219 FAM3C
IPR039477 ILEI/PANDER_dom
IPR039475 ILEI_FAM3C
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF10 PTHR14592:SF10, 1 hit
PfamiView protein in Pfam
PF15711 ILEI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q92520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS
60 70 80 90 100
TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV
110 120 130 140 150
GRGINVALAN GKTGEVLDTK YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY
160 170 180 190 200
DDGATKLNDE ARRLIADLGS TSITNLGFRD NWVFCGGKGI KTKSPFEQHI
210 220
KNNKDTNKYE GWPEVVEMEG CIPQKQD
Length:227
Mass (Da):24,680
Last modified:February 1, 1997 - v1
Checksum:i6DC94B259052647F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMN4C9JMN4_HUMAN
Protein FAM3C
FAM3C
151Annotation score:
C9JP35C9JP35_HUMAN
Protein FAM3C
FAM3C
109Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA Translation: BAA13251.1
AK290682 mRNA Translation: BAF83371.1
AK292731 mRNA Translation: BAF85420.1
AC006364 Genomic DNA Translation: AAQ96872.1
CH471070 Genomic DNA Translation: EAW83558.1
BC024200 mRNA Translation: AAH24200.1
BC046932 mRNA Translation: AAH46932.1
BC068526 mRNA Translation: AAH68526.1
CCDSiCCDS5782.1
RefSeqiNP_001035109.1, NM_001040020.1
NP_055703.1, NM_014888.2
XP_011514038.1, XM_011515736.2
XP_011514039.1, XM_011515737.2
UniGeneiHs.272375
Hs.434053

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937
GeneIDi10447
KEGGihsa:10447
UCSCiuc003vjx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87120 mRNA Translation: BAA13251.1
AK290682 mRNA Translation: BAF83371.1
AK292731 mRNA Translation: BAF85420.1
AC006364 Genomic DNA Translation: AAQ96872.1
CH471070 Genomic DNA Translation: EAW83558.1
BC024200 mRNA Translation: AAH24200.1
BC046932 mRNA Translation: AAH46932.1
BC068526 mRNA Translation: AAH68526.1
CCDSiCCDS5782.1
RefSeqiNP_001035109.1, NM_001040020.1
NP_055703.1, NM_014888.2
XP_011514038.1, XM_011515736.2
XP_011514039.1, XM_011515737.2
UniGeneiHs.272375
Hs.434053

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC2X-ray1.80A/B55-227[»]
ProteinModelPortaliQ92520
SMRiQ92520
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115712, 40 interactors
IntActiQ92520, 44 interactors
MINTiQ92520
STRINGi9606.ENSP00000353025

PTM databases

iPTMnetiQ92520
PhosphoSitePlusiQ92520
SwissPalmiQ92520

Polymorphism and mutation databases

BioMutaiFAM3C
DMDMi3334194

Proteomic databases

EPDiQ92520
MaxQBiQ92520
PaxDbiQ92520
PeptideAtlasiQ92520
PRIDEiQ92520
ProteomicsDBi75279
TopDownProteomicsiQ92520

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359943; ENSP00000353025; ENSG00000196937
GeneIDi10447
KEGGihsa:10447
UCSCiuc003vjx.4 human

Organism-specific databases

CTDi10447
DisGeNETi10447
EuPathDBiHostDB:ENSG00000196937.10
GeneCardsiFAM3C
HGNCiHGNC:18664 FAM3C
HPAiHPA043376
HPA050548
MIMi608618 gene
neXtProtiNX_Q92520
OpenTargetsiENSG00000196937
PharmGKBiPA38627
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGC Eukaryota
ENOG4111I9K LUCA
GeneTreeiENSGT00530000063020
HOGENOMiHOG000285992
HOVERGENiHBG051544
InParanoidiQ92520
OMAiPKICVED
OrthoDBiEOG091G0IGX
PhylomeDBiQ92520
TreeFamiTF353414

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiFAM3C human
GeneWikiiFAM3C
GenomeRNAii10447
PROiPR:Q92520
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196937 Expressed in 238 organ(s), highest expression level in jejunal mucosa
CleanExiHS_FAM3C
ExpressionAtlasiQ92520 baseline and differential
GenevisibleiQ92520 HS

Family and domain databases

CDDicd13940 ILEI_FAM3C, 1 hit
InterProiView protein in InterPro
IPR039220 FAM3
IPR039219 FAM3C
IPR039477 ILEI/PANDER_dom
IPR039475 ILEI_FAM3C
PANTHERiPTHR14592 PTHR14592, 1 hit
PTHR14592:SF10 PTHR14592:SF10, 1 hit
PfamiView protein in Pfam
PF15711 ILEI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAM3C_HUMAN
AccessioniPrimary (citable) accession number: Q92520
Secondary accession number(s): A6NDN2, A8K3R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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