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UniProtKB - Q92519 (TRIB2_HUMAN)
Protein
Tribbles homolog 2
Gene
TRIB2
Organism
Homo sapiens (Human)
Status
Functioni
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
By similarityMiscellaneous
Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.
GO - Molecular functioni
- mitogen-activated protein kinase kinase binding Source: GO_Central
- protein kinase inhibitor activity Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: BHF-UCL
- ubiquitin-protein transferase regulator activity Source: BHF-UCL
GO - Biological processi
- negative regulation of fat cell differentiation Source: BHF-UCL
- negative regulation of interleukin-10 production Source: BHF-UCL
- negative regulation of protein kinase activity Source: BHF-UCL
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
- regulation of MAP kinase activity Source: UniProtKB
Keywordsi
Molecular function | Protein kinase inhibitor |
Enzyme and pathway databases
PathwayCommonsi | Q92519 |
SignaLinki | Q92519 |
SIGNORi | Q92519 |
Names & Taxonomyi
Protein namesi | Recommended name: Tribbles homolog 2Short name: TRB-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30809, TRIB2 |
MIMi | 609462, gene |
neXtProti | NX_Q92519 |
VEuPathDBi | HostDB:ENSG00000071575 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: May associate with the cytoskeleton.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 28951 |
OpenTargetsi | ENSG00000071575 |
PharmGKBi | PA128394647 |
Miscellaneous databases
Pharosi | Q92519, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523417 |
Genetic variation databases
BioMutai | TRIB2 |
DMDMi | 74762638 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000131863 | 1 – 343 | Tribbles homolog 2Add BLAST | 343 |
Proteomic databases
MassIVEi | Q92519 |
PaxDbi | Q92519 |
PeptideAtlasi | Q92519 |
PRIDEi | Q92519 |
ProteomicsDBi | 75278 |
PTM databases
GlyGeni | Q92519, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92519 |
PhosphoSitePlusi | Q92519 |
Expressioni
Tissue specificityi
Highly expressed in peripheral blood leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000071575, Expressed in metanephric glomerulus and 233 other tissues |
ExpressionAtlasi | Q92519, baseline and differential |
Genevisiblei | Q92519, HS |
Organism-specific databases
HPAi | ENSG00000071575, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with COP1 (PubMed:27041596).
1 PublicationBinary interactionsi
GO - Molecular functioni
- mitogen-activated protein kinase kinase binding Source: GO_Central
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 118779, 26 interactors |
IntActi | Q92519, 26 interactors |
MINTi | Q92519 |
STRINGi | 9606.ENSP00000155926 |
Chemistry databases
BindingDBi | Q92519 |
Miscellaneous databases
RNActi | Q92519, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 308 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 248 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 50 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 50 | Polar residuesSequence analysisAdd BLAST | 23 |
Domaini
The protein kinase domain is predicted to be catalytically inactive.
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00950000182986 |
InParanoidi | Q92519 |
OMAi | CKVFDIR |
OrthoDBi | 1362510at2759 |
PhylomeDBi | Q92519 |
TreeFami | TF329785 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR024104, Tribbles/Ser_Thr_kinase_40 |
PANTHERi | PTHR22961, PTHR22961, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q92519-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE
60 70 80 90 100
TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES
110 120 130 140 150
LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE
160 170 180 190 200
EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY
210 220 230 240 250
ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG
260 270 280 290 300
RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ
310 320 330 340
EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MCX4 | B5MCX4_HUMAN | Tribbles homolog 2 | TRIB2 | 252 | Annotation score: | ||
F8WA18 | F8WA18_HUMAN | Tribbles homolog 2 | TRIB2 | 207 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042371 | 4 | H → R1 PublicationCorresponds to variant dbSNP:rs55813198Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87119 mRNA Translation: BAA13250.1 AY245544 mRNA Translation: AAO89231.1 AK313237 mRNA Translation: BAG36048.1 AC009486 Genomic DNA Translation: AAY15015.1 CH471053 Genomic DNA Translation: EAX00907.1 CH471053 Genomic DNA Translation: EAX00908.1 CH471053 Genomic DNA Translation: EAX00909.1 BC002637 mRNA Translation: AAH02637.1 |
CCDSi | CCDS1683.1 |
RefSeqi | NP_067675.1, NM_021643.3 |
Genome annotation databases
Ensembli | ENST00000155926; ENSP00000155926; ENSG00000071575 |
GeneIDi | 28951 |
KEGGi | hsa:28951 |
MANE-Selecti | ENST00000155926.9; ENSP00000155926.4; NM_021643.4; NP_067675.1 |
UCSCi | uc002rbv.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87119 mRNA Translation: BAA13250.1 AY245544 mRNA Translation: AAO89231.1 AK313237 mRNA Translation: BAG36048.1 AC009486 Genomic DNA Translation: AAY15015.1 CH471053 Genomic DNA Translation: EAX00907.1 CH471053 Genomic DNA Translation: EAX00908.1 CH471053 Genomic DNA Translation: EAX00909.1 BC002637 mRNA Translation: AAH02637.1 |
CCDSi | CCDS1683.1 |
RefSeqi | NP_067675.1, NM_021643.3 |
3D structure databases
SMRi | Q92519 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118779, 26 interactors |
IntActi | Q92519, 26 interactors |
MINTi | Q92519 |
STRINGi | 9606.ENSP00000155926 |
Chemistry databases
BindingDBi | Q92519 |
ChEMBLi | CHEMBL4523417 |
PTM databases
GlyGeni | Q92519, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q92519 |
PhosphoSitePlusi | Q92519 |
Genetic variation databases
BioMutai | TRIB2 |
DMDMi | 74762638 |
Proteomic databases
MassIVEi | Q92519 |
PaxDbi | Q92519 |
PeptideAtlasi | Q92519 |
PRIDEi | Q92519 |
ProteomicsDBi | 75278 |
Protocols and materials databases
Antibodypediai | 674, 276 antibodies from 33 providers |
DNASUi | 28951 |
Genome annotation databases
Ensembli | ENST00000155926; ENSP00000155926; ENSG00000071575 |
GeneIDi | 28951 |
KEGGi | hsa:28951 |
MANE-Selecti | ENST00000155926.9; ENSP00000155926.4; NM_021643.4; NP_067675.1 |
UCSCi | uc002rbv.5, human |
Organism-specific databases
CTDi | 28951 |
DisGeNETi | 28951 |
GeneCardsi | TRIB2 |
HGNCi | HGNC:30809, TRIB2 |
HPAi | ENSG00000071575, Low tissue specificity |
MIMi | 609462, gene |
neXtProti | NX_Q92519 |
OpenTargetsi | ENSG00000071575 |
PharmGKBi | PA128394647 |
VEuPathDBi | HostDB:ENSG00000071575 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00950000182986 |
InParanoidi | Q92519 |
OMAi | CKVFDIR |
OrthoDBi | 1362510at2759 |
PhylomeDBi | Q92519 |
TreeFami | TF329785 |
Enzyme and pathway databases
PathwayCommonsi | Q92519 |
SignaLinki | Q92519 |
SIGNORi | Q92519 |
Miscellaneous databases
BioGRID-ORCSi | 28951, 15 hits in 1079 CRISPR screens |
ChiTaRSi | TRIB2, human |
GeneWikii | TRIB2 |
GenomeRNAii | 28951 |
Pharosi | Q92519, Tbio |
PROi | PR:Q92519 |
RNActi | Q92519, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000071575, Expressed in metanephric glomerulus and 233 other tissues |
ExpressionAtlasi | Q92519, baseline and differential |
Genevisiblei | Q92519, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR024104, Tribbles/Ser_Thr_kinase_40 |
PANTHERi | PTHR22961, PTHR22961, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRIB2_HUMAN | |
Accessioni | Q92519Primary (citable) accession number: Q92519 Secondary accession number(s): B2R851, D6W510 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | February 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families