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Protein

Zinc transporter SLC39A7

Gene

SLC39A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca2+, as well as by exogenous Zn2+.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

TCDBi2.A.5.4.3 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter SLC39A7
Alternative name(s):
Histidine-rich membrane protein Ke4
Really interesting new gene 5 protein
Solute carrier family 39 member 7
Zrt-, Irt-like protein 7
Short name:
ZIP7
Gene namesi
Name:SLC39A7
Synonyms:HKE4, RING5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112473.16
HGNCiHGNC:4927 SLC39A7
MIMi601416 gene
neXtProtiNX_Q92504

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei417 – 436HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi275S → A: Loss of phosphorylation in response to Zn(2+) treatment and of cytosolic Zn(2+) release; when associated with A-276. 1 Publication1
Mutagenesisi276S → A: Loss of phosphorylation in response to Zn(2+) treatment and of cytosolic Zn(2+) release; when associated with A-275. 1 Publication1

Organism-specific databases

DisGeNETi7922
OpenTargetsiENSG00000112473
PharmGKBiPA29305

Polymorphism and mutation databases

BioMutaiSLC39A7
DMDMi12643344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136881 – 469Zinc transporter SLC39A7Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275Phosphoserine; by CK2Combined sources1 Publication1
Modified residuei276Phosphoserine; by CK2Combined sources1 Publication1

Post-translational modificationi

Rapidly phosphorylated by CK2 following Zn2+ treatment. This phosphorylation is required for efficient cytosolic Zn2+ release.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92504
MaxQBiQ92504
PaxDbiQ92504
PeptideAtlasiQ92504
PRIDEiQ92504
ProteomicsDBi75275

PTM databases

iPTMnetiQ92504
PhosphoSitePlusiQ92504

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Inductioni

Down-regulated by Zn(+2).1 Publication

Gene expression databases

BgeeiENSG00000112473 Expressed in 182 organ(s), highest expression level in adenohypophysis
CleanExiHS_SLC39A7
ExpressionAtlasiQ92504 baseline and differential
GenevisibleiQ92504 HS

Organism-specific databases

HPAiHPA053999

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSNK2A1P684004EBI-1051105,EBI-347804

Protein-protein interaction databases

BioGridi113652, 22 interactors
IntActiQ92504, 42 interactors
STRINGi9606.ENSP00000363807

Structurei

3D structure databases

ProteinModelPortaliQ92504
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 114His-richAdd BLAST85
Compositional biasi238 – 263His-richAdd BLAST26

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000185308
HOVERGENiHBG001037
InParanoidiQ92504
KOiK14713
OMAiPWVLPFT
OrthoDBiEOG09370NDT
PhylomeDBiQ92504
TreeFamiTF318470

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q92504-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGLGAPHW VAVGLLTWAT LGLLVAGLGG HDDLHDDLQE DFHGHSHRHS
60 70 80 90 100
HEDFHHGHSH AHGHGHTHES IWHGHTHDHD HGHSHEDLHH GHSHGYSHES
110 120 130 140 150
LYHRGHGHDH EHSHGGYGES GAPGIKQDLD AVTLWAYALG ATVLISAAPF
160 170 180 190 200
FVLFLIPVES NSPRHRSLLQ ILLSFASGGL LGDAFLHLIP HALEPHSHHT
210 220 230 240 250
LEQPGHGHSH SGQGPILSVG LWVLSGIVAF LVVEKFVRHV KGGHGHSHGH
260 270 280 290 300
GHAHSHTRGS HGHGRQERST KEKQSSEEEE KETRGVQKRR GGSTVPKDGP
310 320 330 340 350
VRPQNAEEEK RGLDLRVSGY LNLAADLAHN FTDGLAIGAS FRGGRGLGIL
360 370 380 390 400
TTMTVLLHEV PHEVGDFAIL VQSGCSKKQA MRLQLLTAVG ALAGTACALL
410 420 430 440 450
TEGGAVGSEI AGGAGPGWVL PFTAGGFIYV ATVSVLPELL REASPLQSLL
460
EVLGLLGGVI MMVLIAHLE
Length:469
Mass (Da):50,118
Last modified:January 24, 2001 - v2
Checksum:i6504A1EF5AA6A5B9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AAT0A2AAT0_HUMAN
Zinc transporter SLC39A7
SLC39A7
220Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → G in BAA11528 (PubMed:8812499).Curated1
Sequence conflicti7A → G in AAD12305 (Ref. 2) Curated1
Sequence conflicti376S → T in BAA11528 (PubMed:8812499).Curated1
Sequence conflicti376S → T in AAD12305 (Ref. 2) Curated1
Sequence conflicti397 – 469CALLT…IAHLE → VPFSLKEEQWTVKLQVVQVL AGSCHLLQVALST in BAA11528 (PubMed:8812499).CuratedAdd BLAST73
Sequence conflicti397 – 469CALLT…IAHLE → VPFSLKEEQWTVKLQVVQVL AGSCHLLQVALST in AAD12305 (Ref. 2) CuratedAdd BLAST73

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05003487D → N. Corresponds to variant dbSNP:rs34211188Ensembl.1
Natural variantiVAR_050035124G → R. Corresponds to variant dbSNP:rs35690712Ensembl.1
Natural variantiVAR_050036280E → G2 PublicationsCorresponds to variant dbSNP:rs1048778Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82060 mRNA Translation: BAA11528.1
AF117221 Genomic DNA Translation: AAD12305.1
AL031228 Genomic DNA Translation: CAA20238.1
AL645940 Genomic DNA No translation available.
AL662824 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR936877 Genomic DNA No translation available.
CR759733 Genomic DNA No translation available.
CR354565 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03680.1
BC000645 mRNA Translation: AAH00645.1
CCDSiCCDS43453.1
RefSeqiNP_001070984.1, NM_001077516.1
NP_001275706.1, NM_001288777.1
NP_008910.2, NM_006979.2
UniGeneiHs.631995

Genome annotation databases

EnsembliENST00000374675; ENSP00000363807; ENSG00000112473
ENST00000374677; ENSP00000363809; ENSG00000112473
ENST00000383213; ENSP00000372700; ENSG00000206288
ENST00000383214; ENSP00000372701; ENSG00000206288
ENST00000416369; ENSP00000403583; ENSG00000229802
ENST00000418477; ENSP00000416439; ENSG00000226614
ENST00000423043; ENSP00000389623; ENSG00000226614
ENST00000431735; ENSP00000410656; ENSG00000224399
ENST00000441854; ENSP00000391735; ENSG00000229802
ENST00000441953; ENSP00000413027; ENSG00000224399
ENST00000443773; ENSP00000407093; ENSG00000227402
ENST00000456261; ENSP00000414145; ENSG00000227402
GeneIDi7922
KEGGihsa:7922
UCSCiuc003odf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82060 mRNA Translation: BAA11528.1
AF117221 Genomic DNA Translation: AAD12305.1
AL031228 Genomic DNA Translation: CAA20238.1
AL645940 Genomic DNA No translation available.
AL662824 Genomic DNA No translation available.
AL844527 Genomic DNA No translation available.
CR759786 Genomic DNA No translation available.
CR936877 Genomic DNA No translation available.
CR759733 Genomic DNA No translation available.
CR354565 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03680.1
BC000645 mRNA Translation: AAH00645.1
CCDSiCCDS43453.1
RefSeqiNP_001070984.1, NM_001077516.1
NP_001275706.1, NM_001288777.1
NP_008910.2, NM_006979.2
UniGeneiHs.631995

3D structure databases

ProteinModelPortaliQ92504
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113652, 22 interactors
IntActiQ92504, 42 interactors
STRINGi9606.ENSP00000363807

Protein family/group databases

TCDBi2.A.5.4.3 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

iPTMnetiQ92504
PhosphoSitePlusiQ92504

Polymorphism and mutation databases

BioMutaiSLC39A7
DMDMi12643344

Proteomic databases

EPDiQ92504
MaxQBiQ92504
PaxDbiQ92504
PeptideAtlasiQ92504
PRIDEiQ92504
ProteomicsDBi75275

Protocols and materials databases

DNASUi7922
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374675; ENSP00000363807; ENSG00000112473
ENST00000374677; ENSP00000363809; ENSG00000112473
ENST00000383213; ENSP00000372700; ENSG00000206288
ENST00000383214; ENSP00000372701; ENSG00000206288
ENST00000416369; ENSP00000403583; ENSG00000229802
ENST00000418477; ENSP00000416439; ENSG00000226614
ENST00000423043; ENSP00000389623; ENSG00000226614
ENST00000431735; ENSP00000410656; ENSG00000224399
ENST00000441854; ENSP00000391735; ENSG00000229802
ENST00000441953; ENSP00000413027; ENSG00000224399
ENST00000443773; ENSP00000407093; ENSG00000227402
ENST00000456261; ENSP00000414145; ENSG00000227402
GeneIDi7922
KEGGihsa:7922
UCSCiuc003odf.4 human

Organism-specific databases

CTDi7922
DisGeNETi7922
EuPathDBiHostDB:ENSG00000112473.16
GeneCardsiSLC39A7
HGNCiHGNC:4927 SLC39A7
HPAiHPA053999
MIMi601416 gene
neXtProtiNX_Q92504
OpenTargetsiENSG00000112473
PharmGKBiPA29305
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000185308
HOVERGENiHBG001037
InParanoidiQ92504
KOiK14713
OMAiPWVLPFT
OrthoDBiEOG09370NDT
PhylomeDBiQ92504
TreeFamiTF318470

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

ChiTaRSiSLC39A7 human
GeneWikiiSLC39A7
GenomeRNAii7922
PROiPR:Q92504
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112473 Expressed in 182 organ(s), highest expression level in adenohypophysis
CleanExiHS_SLC39A7
ExpressionAtlasiQ92504 baseline and differential
GenevisibleiQ92504 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS39A7_HUMAN
AccessioniPrimary (citable) accession number: Q92504
Secondary accession number(s): B0UXF6, Q5STP8, Q9UIQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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