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Entry version 147 (08 May 2019)
Sequence version 2 (21 Mar 2006)
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Protein

StAR-related lipid transfer protein 8

Gene

STARD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
StAR-related lipid transfer protein 8
Alternative name(s):
Deleted in liver cancer 3 protein
Short name:
DLC-3
START domain-containing protein 8
Short name:
StARD8
START-GAP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STARD8
Synonyms:DLC3, KIAA0189
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19161 STARD8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300689 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92502

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi608R → E: No effect on cell morphology when overexpressed. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9754

Open Targets

More...
OpenTargetsi
ENSG00000130052

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38804

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STARD8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90110072

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206761 – 1023StAR-related lipid transfer protein 8Add BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108PhosphoserineCombined sources1
Modified residuei169Asymmetric dimethylarginineBy similarity1
Modified residuei235PhosphoserineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei506PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92502

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92502

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92502

PeptideAtlas

More...
PeptideAtlasi
Q92502

PRoteomics IDEntifications database

More...
PRIDEi
Q92502

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75270
75271 [Q92502-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92502

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92502

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in kidney, lung and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130052 Expressed in 173 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92502 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92502 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060788

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds both the SH2 and PTB domains of TNS1.

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60949N

Protein interaction database and analysis system

More...
IntActi
Q92502, 2 interactors

Molecular INTeraction database

More...
MINTi
Q92502

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363727

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92502

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini573 – 777Rho-GAPPROSITE-ProRule annotationAdd BLAST205
Domaini809 – 1017STARTPROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 27Poly-Glu4
Compositional biasi338 – 342Poly-Glu5

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2200 Eukaryota
ENOG410XQ10 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039960

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92502

KEGG Orthology (KO)

More...
KOi
K20632

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKVSTEV

Database of Orthologous Groups

More...
OrthoDBi
218349at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92502

TreeFam database of animal gene trees

More...
TreeFami
TF314044

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit
PF01852 START, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92502-1) [UniParc]FASTAAdd to basket
Also known as: DLC3beta

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLNNCASMK LEVHFQSKQN EDSEEEEQCT ISSHWAFQQE SKCWSPMGSS
60 70 80 90 100
DLLAPPSPGL PATSSCESVL TELSATSLPV ITVSLPPEPA DLPLPGRAPS
110 120 130 140 150
SSDRPLLSPT QGQEGPQDKA KKRHRNRSFL KHLESLRRKE KSGSQQAEPK
160 170 180 190 200
HSPATSEKVS KASSFRSCRG FLSAGFYRAK NWAATSAGGS GANTRKAWEA
210 220 230 240 250
WPVASFRHPQ WTHRGDCLVH VPGDHKPGTF PRSLSIESLC PEDGHRLADW
260 270 280 290 300
QPGRRWGCEG RRGSCGSTGS HASTYDNLPE LYPAEPVMVG AEAEDEDDEE
310 320 330 340 350
SGGSYAHLDD ILQHVWGLQQ RVELWSRAMY PDLGPGDEEE EEATSSVEIA
360 370 380 390 400
TVEVKCQAEA LSQMEVPAHG ESPAWAQAEV QPAVLAPAQA PAEAEPVAQE
410 420 430 440 450
EAEAPAPAPA PAPAQDSEQE AHSGGEPTFA SSLSVEEGHS ISDTVASSSE
460 470 480 490 500
LDSSGNSMNE AEAAGPLAGL QASMPRERRD SGVGASLTRP CRKLRWHSFQ
510 520 530 540 550
NSHRPSLNSE SLEINRQFAG QINLLHKGSL LRLTAFMEKY TVPHKQGWVW
560 570 580 590 600
SMPKFMRRNK TPDYRGQHVF GVPPLIHVQR TGQPLPQSIQ QAMRYLRSQC
610 620 630 640 650
LDQVGIFRKS GVKSRIQNLR QMNETSPDNV CYEGQSAYDV ADLLKQYFRD
660 670 680 690 700
LPEPIFTSKL TTTFLQIYQL LPKDQWLAAA QAATLLLPDE NREVLQTLLY
710 720 730 740 750
FLSDIASAEE NQMTAGNLAV CLAPSIFHLN VSKKDSPSPR IKSKRSLIGR
760 770 780 790 800
PGPRDLSDNM AATQGLSHMI SDCKKLFQVP QDMVLQLCSS YSAAELSPPG
810 820 830 840 850
PALAELRQAQ AAGVSLSLYM EENIQDLLRD AAERFKGWMS VPGPQHTELA
860 870 880 890 900
CRKAPDGHPL RLWKASTEVA APPAVVLHRV LRERALWDED LLRAQVLEAL
910 920 930 940 950
MPGVELYHYV TDSMAPHPCR DFVVLRMWRS DLPRGGCLLV SQSLDPEQPV
960 970 980 990 1000
PESGVRALML TSQYLMEPCG LGRSRLTHIC RADLRGRSPD WYNKVFGHLC
1010 1020
AMEVAKIRDS FPTLQAAGPE TKL
Length:1,023
Mass (Da):112,601
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF93804B352450DE2
GO
Isoform 2 (identifier: Q92502-2) [UniParc]FASTAAdd to basket
Also known as: DLC3alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPLLDVFWSC...SLGALCRRLM

Note: No experimental confirmation available.Curated
Show »
Length:1,103
Mass (Da):121,749
Checksum:i2BA1262D4C925551
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFN7E5RFN7_HUMAN
StAR-related lipid transfer protein...
STARD8
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11506 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti466P → S in BAA11506 (PubMed:8724849).Curated1
Isoform 2 (identifier: Q92502-2)
Sequence conflicti71D → G in CAH18253 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036588188G → S in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs139380533Ensembl.1
Natural variantiVAR_036589242E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061816327R → Q. Corresponds to variant dbSNP:rs55962426Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0329841M → MPLLDVFWSCFRKVKCFPLL QVKKNAEAEAKRACEWLQAT GFPQYVQLFEEGSFPLDIGS VKKNHGFLDEDSLGALCRRL M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D80011 mRNA Translation: BAA11506.2 Different initiation.
AK291747 mRNA Translation: BAF84436.1
CR749411 mRNA Translation: CAH18253.1
AL360076 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05374.1
CH471132 Genomic DNA Translation: EAX05375.1
BC035587 mRNA Translation: AAH35587.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14390.1 [Q92502-1]
CCDS48134.1 [Q92502-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
B59430

NCBI Reference Sequences

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RefSeqi
NP_001135975.1, NM_001142503.2 [Q92502-2]
NP_001135976.1, NM_001142504.2 [Q92502-1]
NP_055540.2, NM_014725.4 [Q92502-1]
XP_011529371.1, XM_011531069.2 [Q92502-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252336; ENSP00000252336; ENSG00000130052 [Q92502-1]
ENST00000374597; ENSP00000363725; ENSG00000130052 [Q92502-1]
ENST00000374599; ENSP00000363727; ENSG00000130052 [Q92502-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9754

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9754

UCSC genome browser

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UCSCi
uc004dxa.4 human [Q92502-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D80011 mRNA Translation: BAA11506.2 Different initiation.
AK291747 mRNA Translation: BAF84436.1
CR749411 mRNA Translation: CAH18253.1
AL360076 Genomic DNA No translation available.
CH471132 Genomic DNA Translation: EAX05374.1
CH471132 Genomic DNA Translation: EAX05375.1
BC035587 mRNA Translation: AAH35587.1
CCDSiCCDS14390.1 [Q92502-1]
CCDS48134.1 [Q92502-2]
PIRiB59430
RefSeqiNP_001135975.1, NM_001142503.2 [Q92502-2]
NP_001135976.1, NM_001142504.2 [Q92502-1]
NP_055540.2, NM_014725.4 [Q92502-1]
XP_011529371.1, XM_011531069.2 [Q92502-1]

3D structure databases

SMRiQ92502
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-60949N
IntActiQ92502, 2 interactors
MINTiQ92502
STRINGi9606.ENSP00000363727

PTM databases

iPTMnetiQ92502
PhosphoSitePlusiQ92502

Polymorphism and mutation databases

BioMutaiSTARD8
DMDMi90110072

Proteomic databases

jPOSTiQ92502
MaxQBiQ92502
PaxDbiQ92502
PeptideAtlasiQ92502
PRIDEiQ92502
ProteomicsDBi75270
75271 [Q92502-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9754
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252336; ENSP00000252336; ENSG00000130052 [Q92502-1]
ENST00000374597; ENSP00000363725; ENSG00000130052 [Q92502-1]
ENST00000374599; ENSP00000363727; ENSG00000130052 [Q92502-2]
GeneIDi9754
KEGGihsa:9754
UCSCiuc004dxa.4 human [Q92502-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9754
DisGeNETi9754

GeneCards: human genes, protein and diseases

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GeneCardsi
STARD8
HGNCiHGNC:19161 STARD8
HPAiHPA060788
MIMi300689 gene
neXtProtiNX_Q92502
OpenTargetsiENSG00000130052
PharmGKBiPA38804

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
GeneTreeiENSGT00950000183061
HOGENOMiHOG000039960
InParanoidiQ92502
KOiK20632
OMAiWKVSTEV
OrthoDBi218349at2759
PhylomeDBiQ92502
TreeFamiTF314044

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STARD8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
STARD8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9754

Protein Ontology

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PROi
PR:Q92502

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000130052 Expressed in 173 organ(s), highest expression level in right lung
ExpressionAtlasiQ92502 baseline and differential
GenevisibleiQ92502 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAR8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92502
Secondary accession number(s): A8K6T2
, D3DVT9, Q5JST0, Q68DG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 21, 2006
Last modified: May 8, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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