UniProtKB - Q924Z6 (XPO6_MOUSE)
Protein
Exportin-6
Gene
Xpo6
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.1 Publication
GO - Molecular functioni
- nuclear export signal receptor activity Source: MGI
- Ran GTPase binding Source: InterPro
GO - Biological processi
- protein export from nucleus Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Exportin-6Short name: Exp6 Alternative name(s): Ran-binding protein 20 |
Gene namesi | Name:Xpo6 Synonyms:Ranbp20 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2429950, Xpo6 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000235302 | 2 – 1125 | Exportin-6Add BLAST | 1124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 199 | PhosphoserineCombined sources | 1 | |
Modified residuei | 201 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 204 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Modified residuei | 224 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q924Z6 |
jPOSTi | Q924Z6 |
PaxDbi | Q924Z6 |
PeptideAtlasi | Q924Z6 |
PRIDEi | Q924Z6 |
PTM databases
iPTMneti | Q924Z6 |
PhosphoSitePlusi | Q924Z6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000131, Expressed in forelimb bud and 305 other tissues |
Genevisiblei | Q924Z6, MM |
Interactioni
Subunit structurei
Found in a complex with XPO6, Ran, ACTB and PFN1.
Interacts with ACTB.
Interacts with ACTB in a RanGTP-dependent manner.
By similarityGO - Molecular functioni
- Ran GTPase binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000009344 |
Miscellaneous databases
RNActi | Q924Z6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 97 | Importin N-terminalPROSITE-ProRule annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the exportin family.Curated
Phylogenomic databases
eggNOGi | KOG2020, Eukaryota |
GeneTreei | ENSGT00390000002810 |
HOGENOMi | CLU_004473_0_0_1 |
InParanoidi | Q924Z6 |
OMAi | SKMEGEC |
OrthoDBi | 214523at2759 |
PhylomeDBi | Q924Z6 |
TreeFami | TF323443 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR040016, XPO6 |
PANTHERi | PTHR21452, PTHR21452, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q924Z6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QVGAWRFCLY
60 70 80 90 100
FLSSTRNDYV MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK
110 120 130 140 150
TLPYFIRNKL CKVIVDIGRQ DWPMFYHDFF TNILQLIQSP VTTPLGLIML
160 170 180 190 200
KTTSEELACP REDLSVARKE ELRKLLLDQV QTVLGLLTGI LETVWDKHSV
210 220 230 240 250
TAATPPPSPT SGESGDLLSN LLQSPSSAKL LHQPIPILDV ESEYVCSLAL
260 270 280 290 300
ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDTRARKMA SVNGSSQNCV
310 320 330 340 350
LGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD
360 370 380 390 400
NNAHTVKSRL EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL
410 420 430 440 450
LFKYTFHQPT HEGYFSCLDI WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL
460 470 480 490 500
VLLLTEVLNR IQFRYNQAQL EELDDETLDD DQQTEWQRYL RQSLEVVAKV
510 520 530 540 550
MELLPTHAFS TLFPVLQDNL EVYLGLQQFV VTSGSGHRLN ITAENDCRRL
560 570 580 590 600
HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
610 620 630 640 650
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCG EAHRQNTQQF
660 670 680 690 700
VTLISTTMDA ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ
710 720 730 740 750
KVFNSIIDAS AQRLTDKAQV LVCRALSNTL LLPWPNLPES EQQWPLRSIN
760 770 780 790 800
HASLISALSR DYHSLKPSAT APQRKVPLGD TKVIIHQTLS VLEDIVENIS
810 820 830 840 850
GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS FFLTLFRGLR
860 870 880 890 900
VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
910 920 930 940 950
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW
960 970 980 990 1000
RYFFKSTVLA SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL
1010 1020 1030 1040 1050
FYLETLNTKQ KLYHKKIFRT TMLFQFVNVL LQVLVHKSHD LLQEEIGIAI
1060 1070 1080 1090 1100
YNMASVDFDG FFAAFLPEFL TSCDGVDANQ KNVLGRNFKM DRDLPSFTQN
1110 1120
VHRLVNDLRY YRLCNDSLPP GTVKL
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6WSY2 | F6WSY2_MOUSE | Exportin-6 | Xpo6 | 255 | Annotation score: | ||
F6Z1I1 | F6Z1I1_MOUSE | Exportin-6 | Xpo6 | 142 | Annotation score: | ||
F6XQN1 | F6XQN1_MOUSE | Exportin-6 | Xpo6 | 135 | Annotation score: | ||
F6Y2I6 | F6Y2I6_MOUSE | Exportin-6 | Xpo6 | 132 | Annotation score: | ||
F6YJ47 | F6YJ47_MOUSE | Exportin-6 | Xpo6 | 71 | Annotation score: | ||
F7B8F0 | F7B8F0_MOUSE | Exportin-6 | Xpo6 | 87 | Annotation score: | ||
E9Q6V5 | E9Q6V5_MOUSE | Exportin-6 | Xpo6 | 28 | Annotation score: | ||
E9Q081 | E9Q081_MOUSE | Exportin-6 | Xpo6 | 35 | Annotation score: | ||
F6U927 | F6U927_MOUSE | Exportin-6 | Xpo6 | 65 | Annotation score: | ||
F6ZUE3 | F6ZUE3_MOUSE | Exportin-6 | Xpo6 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 483 | Missing in AAH58090 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 626 | A → S in BAE32778 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1072 | S → R in BAE32778 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018466 | 1 – 879 | Missing in isoform 3. 1 PublicationAdd BLAST | 879 | |
Alternative sequenceiVSP_018467 | 482 | Missing in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_018468 | 880 – 928 | HEGST…PIIAE → MAQGLLHGKWQKCGWDMSTG YCLAPLRLLWWPPPSCMEGR CSVVWISLQ in isoform 3. 1 PublicationAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029528 mRNA Translation: AAK40296.1 AK011324 mRNA Translation: BAB27545.1 AK154709 mRNA Translation: BAE32778.1 BC058090 mRNA Translation: AAH58090.1 |
CCDSi | CCDS52396.1 [Q924Z6-2] CCDS80800.1 [Q924Z6-1] |
RefSeqi | NP_001298072.1, NM_001311143.1 [Q924Z6-1] NP_083092.2, NM_028816.2 [Q924Z6-2] |
Genome annotation databases
Ensembli | ENSMUST00000009344; ENSMUSP00000009344; ENSMUSG00000000131 [Q924Z6-2] ENSMUST00000168189; ENSMUSP00000130527; ENSMUSG00000000131 [Q924Z6-1] |
GeneIDi | 74204 |
KEGGi | mmu:74204 |
UCSCi | uc009jqq.1, mouse [Q924Z6-1] uc009jqr.1, mouse [Q924Z6-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029528 mRNA Translation: AAK40296.1 AK011324 mRNA Translation: BAB27545.1 AK154709 mRNA Translation: BAE32778.1 BC058090 mRNA Translation: AAH58090.1 |
CCDSi | CCDS52396.1 [Q924Z6-2] CCDS80800.1 [Q924Z6-1] |
RefSeqi | NP_001298072.1, NM_001311143.1 [Q924Z6-1] NP_083092.2, NM_028816.2 [Q924Z6-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000009344 |
PTM databases
iPTMneti | Q924Z6 |
PhosphoSitePlusi | Q924Z6 |
Proteomic databases
EPDi | Q924Z6 |
jPOSTi | Q924Z6 |
PaxDbi | Q924Z6 |
PeptideAtlasi | Q924Z6 |
PRIDEi | Q924Z6 |
Protocols and materials databases
Antibodypediai | 26312, 54 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000009344; ENSMUSP00000009344; ENSMUSG00000000131 [Q924Z6-2] ENSMUST00000168189; ENSMUSP00000130527; ENSMUSG00000000131 [Q924Z6-1] |
GeneIDi | 74204 |
KEGGi | mmu:74204 |
UCSCi | uc009jqq.1, mouse [Q924Z6-1] uc009jqr.1, mouse [Q924Z6-2] |
Organism-specific databases
CTDi | 23214 |
MGIi | MGI:2429950, Xpo6 |
Phylogenomic databases
eggNOGi | KOG2020, Eukaryota |
GeneTreei | ENSGT00390000002810 |
HOGENOMi | CLU_004473_0_0_1 |
InParanoidi | Q924Z6 |
OMAi | SKMEGEC |
OrthoDBi | 214523at2759 |
PhylomeDBi | Q924Z6 |
TreeFami | TF323443 |
Miscellaneous databases
BioGRID-ORCSi | 74204, 1 hit in 19 CRISPR screens |
ChiTaRSi | Xpo6, mouse |
PROi | PR:Q924Z6 |
RNActi | Q924Z6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000131, Expressed in forelimb bud and 305 other tissues |
Genevisiblei | Q924Z6, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR040016, XPO6 |
PANTHERi | PTHR21452, PTHR21452, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XPO6_MOUSE | |
Accessioni | Q924Z6Primary (citable) accession number: Q924Z6 Secondary accession number(s): Q3U3K7, Q6PEF3, Q9D0K9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | May 16, 2006 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families