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Protein

Translocating chain-associated membrane protein 2

Gene

Tram2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for collagen type I synthesis. May couple the activity of the ER Ca2+ pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca2+ concentration at the site of collagen synthesis, and a high Ca2+ concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Translocating chain-associated membrane protein 2
Gene namesi
Name:Tram2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924817 Tram2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicCuratedAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 75ExtracellularCuratedAdd BLAST32
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 119CytoplasmicCuratedAdd BLAST23
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 159ExtracellularCuratedAdd BLAST19
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 191CytoplasmicCuratedAdd BLAST11
Transmembranei192 – 209HelicalSequence analysisAdd BLAST18
Topological domaini210 – 214ExtracellularCurated5
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 250CytoplasmicCuratedAdd BLAST15
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 287ExtracellularCuratedAdd BLAST16
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 370CytoplasmicCuratedAdd BLAST62

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855331 – 370Translocating chain-associated membrane protein 2Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ924Z5
PaxDbiQ924Z5
PeptideAtlasiQ924Z5
PRIDEiQ924Z5

PTM databases

iPTMnetiQ924Z5
PhosphoSitePlusiQ924Z5

Expressioni

Gene expression databases

BgeeiENSMUSG00000041779 Expressed in 203 organ(s), highest expression level in petrous part of temporal bone
GenevisibleiQ924Z5 MM

Interactioni

Subunit structurei

Interacts with COL1A1 (By similarity). Interacts with SERCA2B.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047992

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 321TLCPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TRAM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1608 Eukaryota
ENOG410XSB3 LUCA
GeneTreeiENSGT00510000046470
HOGENOMiHOG000007494
HOVERGENiHBG054402
InParanoidiQ924Z5
OMAiCLYVVVT
OrthoDBiEOG091G077N
PhylomeDBiQ924Z5
TreeFamiTF314319

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
IPR013599 TRAM1
IPR016447 Translocation_assoc_membrane
PANTHERiPTHR12371 PTHR12371, 1 hit
PfamiView protein in Pfam
PF08390 TRAM1, 1 hit
PF03798 TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005449 Translocation_assoc_membrane, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit

Sequencei

Sequence statusi: Complete.

Q924Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFRRRTKSY PLFSQEFIIH NHADIGFCLV LCVLIGLMFE VTAKTAFLFI
60 70 80 90 100
LPQYNISVPT ADSETVHYHY GPKDLVTILF YVVITIIFHA VVQEYILDKI
110 120 130 140 150
SKRLHLSKVK HSKFNESGQL LVFHLSAVAW CFYVIVTEGY LTNPRSLWED
160 170 180 190 200
YPHVYLSFQV KFFYLGQLAY WLHSLPELYF QKVRKEEVPR QLQYICLYLL
210 220 230 240 250
HITGAYLLNL SRLGLILLLL QYSTEALFHM ARLFHFADEN NERLFNAWAA
260 270 280 290 300
VFGVTRLFIL TLAVLTIGFG LARVENQVFD PEKGNFNTLP CRLGMLLLVC
310 320 330 340 350
VAQAWLMWRF IHSQLRHWRE YWKEQSAKRR VSAVPRPPAK LLKREPGYHE
360 370
NGVVKAENGT SSRTKKLKSP
Length:370
Mass (Da):43,183
Last modified:December 1, 2001 - v1
Checksum:iF8E768AFB0582548
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029530 mRNA Translation: AAK40298.1
AK082751 mRNA Translation: BAC38601.1
BC018212 mRNA Translation: AAH18212.1
CCDSiCCDS14846.1
RefSeqiNP_803128.1, NM_177409.3
UniGeneiMm.185680
Mm.273241

Genome annotation databases

EnsembliENSMUST00000037998; ENSMUSP00000047992; ENSMUSG00000041779
GeneIDi170829
KEGGimmu:170829
UCSCiuc007alg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029530 mRNA Translation: AAK40298.1
AK082751 mRNA Translation: BAC38601.1
BC018212 mRNA Translation: AAH18212.1
CCDSiCCDS14846.1
RefSeqiNP_803128.1, NM_177409.3
UniGeneiMm.185680
Mm.273241

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047992

PTM databases

iPTMnetiQ924Z5
PhosphoSitePlusiQ924Z5

Proteomic databases

MaxQBiQ924Z5
PaxDbiQ924Z5
PeptideAtlasiQ924Z5
PRIDEiQ924Z5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037998; ENSMUSP00000047992; ENSMUSG00000041779
GeneIDi170829
KEGGimmu:170829
UCSCiuc007alg.2 mouse

Organism-specific databases

CTDi9697
MGIiMGI:1924817 Tram2

Phylogenomic databases

eggNOGiKOG1608 Eukaryota
ENOG410XSB3 LUCA
GeneTreeiENSGT00510000046470
HOGENOMiHOG000007494
HOVERGENiHBG054402
InParanoidiQ924Z5
OMAiCLYVVVT
OrthoDBiEOG091G077N
PhylomeDBiQ924Z5
TreeFamiTF314319

Miscellaneous databases

PROiPR:Q924Z5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041779 Expressed in 203 organ(s), highest expression level in petrous part of temporal bone
GenevisibleiQ924Z5 MM

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
IPR013599 TRAM1
IPR016447 Translocation_assoc_membrane
PANTHERiPTHR12371 PTHR12371, 1 hit
PfamiView protein in Pfam
PF08390 TRAM1, 1 hit
PF03798 TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005449 Translocation_assoc_membrane, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRAM2_MOUSE
AccessioniPrimary (citable) accession number: Q924Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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