Gata2

Functionⁱ

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	295 – 319	GATA-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	349 – 373	GATA-type 2PROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

C2H2 zinc finger domain binding Source: Ensembl
chromatin binding Source: Ensembl
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 11093771
transcription factor binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure formation involved in morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
animal organ morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation in hindbrain Source: Ensembl
cell fate determination Source: Ensembl
cell maturation Source: Ensembl
central nervous system neuron development Source: Ensembl
cochlea development
Source: RGD
Inferred from expression patternⁱ
- 20006695
commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
definitive hemopoiesis Source: Ensembl
embryonic placenta development Source: Ensembl
eosinophil fate commitment Source: Ensembl
GABAergic neuron differentiation Source: Ensembl
heart development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
homeostasis of number of cells within a tissue Source: Ensembl
inner ear morphogenesis Source: Ensembl
negative regulation of endothelial cell apoptotic process Source: Ensembl
negative regulation of fat cell differentiation Source: Ensembl
negative regulation of fat cell proliferation Source: Ensembl
negative regulation of macrophage differentiation Source: Ensembl
negative regulation of neural precursor cell proliferation Source: Ensembl
negative regulation of Notch signaling pathway Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuron migration
Source: RGD
Inferred from mutant phenotypeⁱ
- 21430145
phagocytosis Source: UniProtKB-KW
pituitary gland development Source: Ensembl
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: Ensembl
positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
positive regulation of cytosolic calcium ion concentration
Source: RGD
Inferred from mutant phenotypeⁱ
- 22390417
positive regulation of erythrocyte differentiation Source: Ensembl
positive regulation of mast cell degranulation
Source: RGD
Inferred from mutant phenotypeⁱ
- 22390417
positive regulation of megakaryocyte differentiation Source: Ensembl
positive regulation of neuron differentiation
Source: RGD
Inferred from mutant phenotypeⁱ
- 21430145
positive regulation of phagocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 12933836
positive regulation of phagocytosis, engulfment
Source: RGD
Inferred from mutant phenotypeⁱ
- 12933836
positive regulation of transcription by RNA polymerase II
Source: RGD
Inferred from mutant phenotypeⁱ
- 11093771
pri-miRNA transcription by RNA polymerase II Source: Ensembl
regulation of forebrain neuron differentiation Source: Ensembl
regulation of histone acetylation Source: Ensembl
regulation of primitive erythrocyte differentiation Source: Ensembl
response to lipid
Source: RGD
Inferred from expression patternⁱ
- 11880336
semicircular canal development Source: Ensembl
somatic stem cell population maintenance Source: Ensembl
tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
urogenital system development Source: Ensembl
ventral spinal cord interneuron differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Phagocytosis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endothelial transcription factor GATA-2 Alternative name(s): GATA-binding protein 2
Gene namesⁱ	Name:Gata2Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 4

Organism-specific databases

Rat genome database More...RGDⁱ	2664 Gata2

RGDⁱ

2664 Gata2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083405	1 – 480	Endothelial transcription factor GATA-2Add BLAST		480

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	73	PhosphoserineBy similarity	1
Modified residueⁱ	86	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	192	PhosphoserineBy similarity	1
Cross-linkⁱ	389	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q924Y4
PRIDEⁱ	Q924Y4

PTM databases

PhosphoSitePlusⁱ	Q924Y4

PhosphoSitePlusⁱ

Q924Y4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000012347 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasⁱ	Q924Y4 baseline and differential
Genevisibleⁱ	Q924Y4 RN

Interactionⁱ

Subunit structureⁱ

Interacts with BRD3. Interacts with AR and CCAR1.By similarity

GO - Molecular functionⁱ

C2H2 zinc finger domain binding Source: Ensembl
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247224, 1 interactor
STRINGⁱ	10116.ENSRNOP00000017240

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q924Y4
SMRⁱ	Q924Y4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	295 – 319	GATA-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	349 – 373	GATA-type 2PROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000047701
HOVERGENⁱ	HBG051705
InParanoidⁱ	Q924Y4
KEGG Orthology (KO) More...KOⁱ	K17894
OMAⁱ	PRWMAHH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AUR
PhylomeDBⁱ	Q924Y4
TreeFamⁱ	TF315391

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 2 hits
Gene3Dⁱ	3.30.50.10, 2 hits
InterProⁱ	View protein in InterPro IPR029522 GATA-2 IPR016374 TF_GATA-2/3 IPR039355 Transcription_factor_GATA IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit PTHR10071:SF149 PTHR10071:SF149, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00320 GATA, 2 hits
PIRSFⁱ	PIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00401 ZnF_GATA, 2 hits
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 2 hits PS50114 GATA_ZN_FINGER_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q924Y4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN 
        60         70         80         90        100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG 
       110        120        130        140        150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG 
       160        170        180        190        200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG 
       210        220        230        240        250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP 
       260        270        280        290        300
SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
       310        320        330        340        350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA 
       360        370        380        390        400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM 
       410        420        430        440        450
SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG 
       460        470        480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG

Length:480

Mass (Da):50,464

Last modified:December 1, 2001 - v1

Checksum:ⁱ80FBA84AA4258EAD

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	347	T → S in AAL57180 (PubMed:12933836).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY032734 mRNA Translation: AAK51128.1 AF345897 mRNA Translation: AAL57180.1 BC061745 mRNA Translation: AAH61745.1
NCBI Reference Sequences More...RefSeqⁱ	NP_254277.1, NM_033442.1 XP_017447968.1, XM_017592479.1 XP_017447969.1, XM_017592480.1
UniGeneⁱ	Rn.34322

Genome annotation databases

Ensemblⁱ	ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347
GeneIDⁱ	25159
KEGGⁱ	rno:25159
UCSC genome browser More...UCSCⁱ	RGD:2664 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q924Y4	GATA binding protein 2, isoform CRA_a		RAT		480	UniRef100_Q924Y4

Protein	Similar proteins		Species	Score	Length	Source
Q924Y4	Endothelial transcription factor GATA-2		HUMAN		480	UniRef90_P23769
Endothelial transcription factor GATA-2		MOUSE		480
GATA binding protein 2		PANTR		480
GATA2 isoform 1		PONAB		480
Uncharacterized protein		PANPA		480
+112

Protein	Similar proteins		Species	Score	Length	Source
Q924Y4	Endothelial transcription factor GATA-2		HUMAN		480	UniRef50_P23769
Endothelial transcription factor GATA-2		MOUSE		480
GATA binding protein 2		PANTR		480
GATA2 isoform 1		PONAB		480
Uncharacterized protein		PANPA		480
+188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY032734 mRNA Translation: AAK51128.1 AF345897 mRNA Translation: AAL57180.1 BC061745 mRNA Translation: AAH61745.1
RefSeqⁱ	NP_254277.1, NM_033442.1 XP_017447968.1, XM_017592479.1 XP_017447969.1, XM_017592480.1
UniGeneⁱ	Rn.34322

3D structure databases

ProteinModelPortalⁱ	Q924Y4
SMRⁱ	Q924Y4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247224, 1 interactor
STRINGⁱ	10116.ENSRNOP00000017240

PTM databases

PhosphoSitePlusⁱ	Q924Y4

PhosphoSitePlusⁱ

Q924Y4

Proteomic databases

PaxDbⁱ	Q924Y4
PRIDEⁱ	Q924Y4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347
GeneIDⁱ	25159
KEGGⁱ	rno:25159
UCSCⁱ	RGD:2664 rat

Organism-specific databases

CTDⁱ	2624
RGDⁱ	2664 Gata2

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000047701
HOVERGENⁱ	HBG051705
InParanoidⁱ	Q924Y4
KOⁱ	K17894
OMAⁱ	PRWMAHH
OrthoDBⁱ	EOG091G0AUR
PhylomeDBⁱ	Q924Y4
TreeFamⁱ	TF315391

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q924Y4

PROⁱ

PR:Q924Y4

Gene expression databases

Bgeeⁱ	ENSRNOG00000012347 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasⁱ	Q924Y4 baseline and differential
Genevisibleⁱ	Q924Y4 RN

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 2 hits
Gene3Dⁱ	3.30.50.10, 2 hits
InterProⁱ	View protein in InterPro IPR029522 GATA-2 IPR016374 TF_GATA-2/3 IPR039355 Transcription_factor_GATA IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit PTHR10071:SF149 PTHR10071:SF149, 1 hit
Pfamⁱ	View protein in Pfam PF00320 GATA, 2 hits
PIRSFⁱ	PIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00401 ZnF_GATA, 2 hits
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 2 hits PS50114 GATA_ZN_FINGER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GATA2_RAT
Accessionⁱ	Q924Y4Primary (citable) accession number: Q924Y4 Secondary accession number(s): Q8VHY4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q924Y4 (GATA2_RAT)

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Endothelial transcription factor GATA-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ