Endothelial transcription factor GATA-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver."
    Landry J.R., Kinston S., Knezevic K., de Bruijn M.F., Wilson N., Nottingham W.T., Peitz M., Edenhofer F., Pimanda J.E., Ottersbach K., Gottgens B.
    Blood 111:3005-3014(2008) [PubMed] [Europe PMC] [Abstract]
  • "Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis."
    Wozniak R.J., Keles S., Lugus J.J., Young K.H., Boyer M.E., Tran T.M., Choi K., Bresnick E.H.
    Mol. Cell. Biol. 28:6681-6694(2008) [PubMed] [Europe PMC] [Abstract]
  • "A mechanosensitive transcriptional mechanism that controls angiogenesis."
    Mammoto A., Connor K.M., Mammoto T., Yung C.W., Huh D., Aderman C.M., Mostoslavsky G., Smith L.E., Ingber D.E.
    Nature 457:1103-1108(2009) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types."
    Dasen J.S., O'Connell S.M., Flynn S.E., Treier M., Gleiberman A.S., Szeto D.P., Hooshmand F., Aggarwal A.K., Rosenfeld M.G.
    Cell 97:587-598(1999) [PubMed] [Europe PMC] [Abstract]
  • "GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells."
    Yu Y.L., Chiang Y.J., Yen J.J.
    J. Biol. Chem. 277:27144-27153(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2."
    Kitajima K., Tanaka M., Zheng J., Yen H., Sato A., Sugiyama D., Umehara H., Sakai E., Nakano T.
    Blood 107:1857-1863(2006) [PubMed] [Europe PMC] [Abstract]
  • "GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene."
    Ng Y.K., George K.M., Engel J.D., Linzer D.I.
    Development 120:3257-3266(1994) [PubMed] [Europe PMC] [Abstract]
  • "Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter."
    Gordon D.F., Lewis S.R., Haugen B.R., James R.A., McDermott M.T., Wood W.M., Ridgway E.C.
    J. Biol. Chem. 272:24339-24347(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling."
    Minami T., Murakami T., Horiuchi K., Miura M., Noguchi T., Miyazaki J., Hamakubo T., Aird W.C., Kodama T.
    J. Biol. Chem. 279:20626-20635(2004) [PubMed] [Europe PMC] [Abstract]
  • "The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression."
    Mwinyi J., Hofmann Y., Pedersen R.S., Nekvindova J., Cavaco I., Mkrtchian S., Ingelman-Sundberg M.
    Life Sci. 86:699-706(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease."
    Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
    Circulation 134:1973-1990(2016) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation."
    Bottardi S., Zmiri F.A., Bourgoin V., Ross J., Mavoungou L., Milot E.
    Nucleic Acids Res. 39:3505-3519(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells."
    Wagner A.H., Krzesz R., Gao D., Schroeder C., Cattaruzza M., Hecker M.
    Mol. Pharmacol. 58:1333-1340(2000) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling."
    Minami T., Murakami T., Horiuchi K., Miura M., Noguchi T., Miyazaki J., Hamakubo T., Aird W.C., Kodama T.
    J. Biol. Chem. 279:20626-20635(2004) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function."
    Charles M.A., Saunders T.L., Wood W.M., Owens K., Parlow A.F., Camper S.A., Ridgway E.C., Gordon D.F.
    Mol. Endocrinol. 20:1366-1377(2006) [PubMed] [Europe PMC] [Abstract]
• cell differentiation in hindbrain Source: RGDInferred from sequence orthologyⁱ
  • "Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system."
    Nardelli J., Thiesson D., Fujiwara Y., Tsai F.Y., Orkin S.H.
    Dev. Biol. 210:305-321(1999) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell fate determination Source: RGDInferred from sequence orthologyⁱ
  • "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types."
    Dasen J.S., O'Connell S.M., Flynn S.E., Treier M., Gleiberman A.S., Szeto D.P., Hooshmand F., Aggarwal A.K., Rosenfeld M.G.
    Cell 97:587-598(1999) [PubMed] [Europe PMC] [Abstract]
• cell maturation Source: RGDInferred from sequence orthologyⁱ
  • "Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function."
    Charles M.A., Saunders T.L., Wood W.M., Owens K., Parlow A.F., Camper S.A., Ridgway E.C., Gordon D.F.
    Mol. Endocrinol. 20:1366-1377(2006) [PubMed] [Europe PMC] [Abstract]
• central nervous system neuron development Source: RGDInferred from sequence orthologyⁱ
  • "Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system."
    Nardelli J., Thiesson D., Fujiwara Y., Tsai F.Y., Orkin S.H.
    Dev. Biol. 210:305-321(1999) [PubMed] [Europe PMC] [Abstract]
• cochlea development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture."
    Gross J., Stute K., Moller R., Fuchs J., Amarjargal N., Pohl E.E., Angerstein M., Smorodchenko A., Mazurek B.
    Hear. Res. 261:9-21(2010) [PubMed] [Europe PMC] [Abstract]
• commitment of neuronal cell to specific neuron type in forebrain Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres."
    Virolainen S.M., Achim K., Peltopuro P., Salminen M., Partanen J.
    Development 139:3795-3805(2012) [PubMed] [Europe PMC] [Abstract]
• definitive hemopoiesis Source: RGDInferred from sequence orthologyⁱ
  • "An early haematopoietic defect in mice lacking the transcription factor GATA-2."
    Tsai F.Y., Keller G., Kuo F.C., Weiss M., Chen J., Rosenblatt M., Alt F.W., Orkin S.H.
    Nature 371:221-226(1994) [PubMed] [Europe PMC] [Abstract]
  • "Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development."
    Zhou Y., Lim K.C., Onodera K., Takahashi S., Ohta J., Minegishi N., Tsai F.Y., Orkin S.H., Yamamoto M., Engel J.D.
    EMBO J. 17:6689-6700(1998) [PubMed] [Europe PMC] [Abstract]
• embryonic placenta development Source: RGDInferred from sequence orthologyⁱ
  • "GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo."
    Ma G.T., Roth M.E., Groskopf J.C., Tsai F.Y., Orkin S.H., Grosveld F., Engel J.D., Linzer D.I.
    Development 124:907-914(1997) [PubMed] [Europe PMC] [Abstract]
• eosinophil fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "Essential and instructive roles of GATA factors in eosinophil development."
    Hirasawa R., Shimizu R., Takahashi S., Osawa M., Takayanagi S., Kato Y., Onodera M., Minegishi N., Yamamoto M., Fukao K., Taniguchi H., Nakauchi H., Iwama A.
    J. Exp. Med. 195:1379-1386(2002) [PubMed] [Europe PMC] [Abstract]
• GABAergic neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres."
    Virolainen S.M., Achim K., Peltopuro P., Salminen M., Partanen J.
    Development 139:3795-3805(2012) [PubMed] [Europe PMC] [Abstract]
• homeostasis of number of cells within a tissue Source: RGDInferred from sequence orthologyⁱ
  • "Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development."
    Fujiwara Y., Chang A.N., Williams A.M., Orkin S.H.
    Blood 103:583-585(2004) [PubMed] [Europe PMC] [Abstract]
  • "Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis."
    Rodrigues N.P., Janzen V., Forkert R., Dombkowski D.M., Boyd A.S., Orkin S.H., Enver T., Vyas P., Scadden D.T.
    Blood 106:477-484(2005) [PubMed] [Europe PMC] [Abstract]
• inner ear morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space."
    Haugas M., Lillevali K., Hakanen J., Salminen M.
    Dev. Dyn. 239:2452-2469(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of endothelial cell apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-24 regulates vascularity after myocardial infarction."
    Fiedler J., Jazbutyte V., Kirchmaier B.C., Gupta S.K., Lorenzen J., Hartmann D., Galuppo P., Kneitz S., Pena J.T., Sohn-Lee C., Loyer X., Soutschek J., Brand T., Tuschl T., Heineke J., Martin U., Schulte-Merker S., Ertl G.

    , Engelhardt S., Bauersachs J., Thum T.
    Circulation 124:720-730(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor GATA2 regulates differentiation of brown adipocytes."
    Tsai J., Tong Q., Tan G., Chang A.N., Orkin S.H., Hotamisligil G.S.
    EMBO Rep. 6:879-884(2005) [PubMed] [Europe PMC] [Abstract]
  • "GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis."
    Jack B.H., Crossley M.
    J. Biol. Chem. 285:32405-32414(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fat cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis."
    Jack B.H., Crossley M.
    J. Biol. Chem. 285:32405-32414(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease."
    Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
    Circulation 134:1973-1990(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macrophage differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2."
    Kitajima K., Tanaka M., Zheng J., Yen H., Sato A., Sugiyama D., Umehara H., Sakai E., Nakano T.
    Blood 107:1857-1863(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of myeloid cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors."
    de Pooter R.F., Schmitt T.M., de la Pompa J.L., Fujiwara Y., Orkin S.H., Zuniga-Pflucker J.C.
    J. Immunol. 176:5267-5275(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neural precursor cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors."
    El Wakil A., Francius C., Wolff A., Pleau-Varet J., Nardelli J.
    Development 133:2155-2165(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of Notch signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors."
    El Wakil A., Francius C., Wolff A., Pleau-Varet J., Nardelli J.
    Development 133:2155-2165(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor GATA2 regulates differentiation of brown adipocytes."
    Tsai J., Tong Q., Tan G., Chang A.N., Orkin S.H., Hotamisligil G.S.
    EMBO Rep. 6:879-884(2005) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Gata2 specifies serotonergic neurons downstream of sonic hedgehog."
    Craven S.E., Lim K.C., Ye W., Engel J.D., de Sauvage F., Rosenthal A.
    Development 131:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
• neuron fate commitment Source: RGDInferred from sequence orthologyⁱ
  • "Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons."
    Kala K., Haugas M., Lillevali K., Guimera J., Wurst W., Salminen M., Partanen J.
    Development 136:253-262(2009) [PubMed] [Europe PMC] [Abstract]
• neuron migration Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus."
    Willett R.T., Greene L.A.
    J. Neurosci. 31:4444-4455(2011) [PubMed] [Europe PMC] [Abstract]
• phagocytosis Source: UniProtKB-KW
• pituitary gland development Source: RGDInferred from sequence orthologyⁱ
  • "Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function."
    Charles M.A., Saunders T.L., Wood W.M., Owens K., Parlow A.F., Camper S.A., Ridgway E.C., Gordon D.F.
    Mol. Endocrinol. 20:1366-1377(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "A mechanosensitive transcriptional mechanism that controls angiogenesis."
    Mammoto A., Connor K.M., Mammoto T., Yung C.W., Huh D., Aderman C.M., Mostoslavsky G., Smith L.E., Ingber D.E.
    Nature 457:1103-1108(2009) [PubMed] [Europe PMC] [Abstract]
  • "MicroRNA-24 regulates vascularity after myocardial infarction."
    Fiedler J., Jazbutyte V., Kirchmaier B.C., Gupta S.K., Lorenzen J., Hartmann D., Galuppo P., Kneitz S., Pena J.T., Sohn-Lee C., Loyer X., Soutschek J., Brand T., Tuschl T., Heineke J., Martin U., Schulte-Merker S., Ertl G.

    , Engelhardt S., Bauersachs J., Thum T.
    Circulation 124:720-730(2011) [PubMed] [Europe PMC] [Abstract]
  • "GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo."
    Ma G.T., Roth M.E., Groskopf J.C., Tsai F.Y., Orkin S.H., Grosveld F., Engel J.D., Linzer D.I.
    Development 124:907-914(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease."
    Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
    Circulation 134:1973-1990(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration involved in sprouting angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease."
    Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
    Circulation 134:1973-1990(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2."
    Kitajima K., Tanaka M., Zheng J., Yen H., Sato A., Sugiyama D., Umehara H., Sakai E., Nakano T.
    Blood 107:1857-1863(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease."
    Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
    Circulation 134:1973-1990(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mast cell degranulation Source: RGDInferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of megakaryocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2."
    Kitajima K., Tanaka M., Zheng J., Yen H., Sato A., Sugiyama D., Umehara H., Sakai E., Nakano T.
    Blood 107:1857-1863(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus."
    Willett R.T., Greene L.A.
    J. Neurosci. 31:4444-4455(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phagocytosis Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts."
    Lasbury M.E., Tang X., Durant P.J., Lee C.-H.
    Infect. Immun. 71:4943-4952(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN PHAGOCYTOSIS.
• positive regulation of phagocytosis, engulfment Source: RGDInferred from mutant phenotypeⁱ
  • Ref.2

    "Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts."
    Lasbury M.E., Tang X., Durant P.J., Lee C.-H.
    Infect. Immun. 71:4943-4952(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN PHAGOCYTOSIS.
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease."
    Hartmann D., Fiedler J., Sonnenschein K., Just A., Pfanne A., Zimmer K., Remke J., Foinquinos A., Butzlaff M., Schimmel K., Maegdefessel L., Hilfiker-Kleiner D., Lachmann N., Schober A., Froese N., Heineke J., Bauersachs J., Batkai S., Thum T.
    Circulation 134:1973-1990(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells."
    Wagner A.H., Krzesz R., Gao D., Schroeder C., Cattaruzza M., Hecker M.
    Mol. Pharmacol. 58:1333-1340(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of forebrain neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres."
    Virolainen S.M., Achim K., Peltopuro P., Salminen M., Partanen J.
    Development 139:3795-3805(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of histone acetylation Source: RGDInferred from sequence orthologyⁱ
  • "Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2."
    Kitajima K., Tanaka M., Zheng J., Yen H., Sato A., Sugiyama D., Umehara H., Sakai E., Nakano T.
    Blood 107:1857-1863(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of primitive erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development."
    Fujiwara Y., Chang A.N., Williams A.M., Orkin S.H.
    Blood 103:583-585(2004) [PubMed] [Europe PMC] [Abstract]
• response to lipid Source: RGDInferred from expression patternⁱ
  • "Retinoid receptor-specific agonists alleviate experimental glomerulonephritis."
    Lehrke I., Schaier M., Schade K., Morath C., Waldherr R., Ritz E., Wagner J.
    Am. J. Physiol. Renal Physiol. 282:F741-51(2002) [PubMed] [Europe PMC] [Abstract]
• semicircular canal development Source: RGDInferred from sequence orthologyⁱ
  • "Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space."
    Haugas M., Lillevali K., Hakanen J., Salminen M.
    Dev. Dyn. 239:2452-2469(2010) [PubMed] [Europe PMC] [Abstract]
• somatic stem cell population maintenance Source: RGDInferred from sequence orthologyⁱ
  • "The transcription factor GATA2 regulates differentiation of brown adipocytes."
    Tsai J., Tong Q., Tan G., Chang A.N., Orkin S.H., Hotamisligil G.S.
    EMBO Rep. 6:879-884(2005) [PubMed] [Europe PMC] [Abstract]
• transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene."
    Dannenberg L.O., Chen H.J., Edenberg H.J.
    DNA Cell Biol. 24:543-552(2005) [PubMed] [Europe PMC] [Abstract]
• urogenital system development Source: RGDInferred from sequence orthologyⁱ
  • "Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development."
    Zhou Y., Lim K.C., Onodera K., Takahashi S., Ohta J., Minegishi N., Tsai F.Y., Orkin S.H., Yamamoto M., Engel J.D.
    EMBO J. 17:6689-6700(1998) [PubMed] [Europe PMC] [Abstract]
• ventral spinal cord interneuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "GATA2 is required for the generation of V2 interneurons."
    Zhou Y., Yamamoto M., Engel J.D.
    Development 127:3829-3838(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling."
    Minami T., Murakami T., Horiuchi K., Miura M., Noguchi T., Miyazaki J., Hamakubo T., Aird W.C., Kodama T.
    J. Biol. Chem. 279:20626-20635(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN 
        60         70         80         90        100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG 
       110        120        130        140        150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG 
       160        170        180        190        200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG 
       210        220        230        240        250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP 
       260        270        280        290        300
SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
       310        320        330        340        350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA 
       360        370        380        390        400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM 
       410        420        430        440        450
SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG 
       460        470        480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ