Endothelial transcription factor GATA-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGD
• chromatin binding Source: RGD
• DNA binding Source: RGD
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells."
    Wagner A.H., Krzesz R., Gao D., Schroeder C., Cattaruzza M., Hecker M.
    Mol Pharmacol 58:1333-1340(2000) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: RGD
• transcription factor binding Source: RGD
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• cell differentiation Source: RGD
• cell differentiation in hindbrain Source: RGD
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell fate determination Source: RGD
• cell maturation Source: RGD
• central nervous system neuron development Source: RGD
• cochlea development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture."
    Gross J., Stute K., Moller R., Fuchs J., Amarjargal N., Pohl E.E., Angerstein M., Smorodchenko A., Mazurek B.
    Hear Res 261:9-21(2010) [PubMed] [Europe PMC] [Abstract]
• commitment of neuronal cell to specific neuron type in forebrain Source: RGD
• definitive hemopoiesis Source: RGD
• embryonic placenta development Source: RGD
• eosinophil fate commitment Source: RGD
• GABAergic neuron differentiation Source: RGD
• homeostasis of number of cells within a tissue Source: RGD
• inner ear morphogenesis Source: RGD
• negative regulation of endothelial cell apoptotic process Source: RGD
• negative regulation of fat cell differentiation Source: RGD
• negative regulation of fat cell proliferation Source: RGD
• negative regulation of gene expression Source: RGD
• negative regulation of macrophage differentiation Source: RGD
• negative regulation of myeloid cell differentiation Source: RGD
• negative regulation of neural precursor cell proliferation Source: RGD
• negative regulation of Notch signaling pathway Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• neuron differentiation Source: RGD
• neuron fate commitment Source: RGD
• neuron migration Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus."
    Willett R.T., Greene L.A.
    J Neurosci 31:4444-4455(2011) [PubMed] [Europe PMC] [Abstract]
• phagocytosis Source: UniProtKB-KW
• pituitary gland development Source: RGD
• positive regulation of angiogenesis Source: RGD
• positive regulation of blood vessel endothelial cell migration Source: RGD
• positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: RGD
• positive regulation of cell migration involved in sprouting angiogenesis Source: RGD
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: RGD
• positive regulation of gene expression Source: RGD
• positive regulation of mast cell degranulation Source: RGDInferred from mutant phenotypeⁱ
  • "GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-gamma1."
    Ishijima Y., Ohmori S., Uenishi A., Ohneda K.
    Genes Cells 17:285-301(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of megakaryocyte differentiation Source: RGD
• positive regulation of neuron differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus."
    Willett R.T., Greene L.A.
    J Neurosci 31:4444-4455(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phagocytosis Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts."
    Lasbury M.E., Tang X., Durant P.J., Lee C.-H.
    Infect. Immun. 71:4943-4952(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN PHAGOCYTOSIS.
• positive regulation of phagocytosis, engulfment Source: RGDInferred from mutant phenotypeⁱ
  • Ref.2

    "Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts."
    Lasbury M.E., Tang X., Durant P.J., Lee C.-H.
    Infect. Immun. 71:4943-4952(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN PHAGOCYTOSIS.
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells."
    Wagner A.H., Krzesz R., Gao D., Schroeder C., Cattaruzza M., Hecker M.
    Mol Pharmacol 58:1333-1340(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of forebrain neuron differentiation Source: RGD
• regulation of histone acetylation Source: RGD
• regulation of primitive erythrocyte differentiation Source: RGD
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to lipid Source: RGDInferred from expression patternⁱ
  • "Retinoid receptor-specific agonists alleviate experimental glomerulonephritis."
    Lehrke I., Schaier M., Schade K., Morath C., Waldherr R., Ritz E., Wagner J.
    Am J Physiol Renal Physiol 282:F741-51(2002) [PubMed] [Europe PMC] [Abstract]
• semicircular canal development Source: RGD
• somatic stem cell population maintenance Source: RGD
• urogenital system development Source: RGD
• vascular wound healing Source: RGD
• ventral spinal cord interneuron differentiation Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• C2H2 zinc finger domain binding Source: RGD
• transcription factor binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN 
        60         70         80         90        100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG 
       110        120        130        140        150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG 
       160        170        180        190        200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG 
       210        220        230        240        250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP 
       260        270        280        290        300
SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
       310        320        330        340        350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA 
       360        370        380        390        400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM 
       410        420        430        440        450
SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG 
       460        470        480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ