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Protein

Endothelial transcription factor GATA-2

Gene

Gata2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 319GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri349 – 373GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processPhagocytosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial transcription factor GATA-2
Alternative name(s):
GATA-binding protein 2
Gene namesi
Name:Gata2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2664 Gata2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834051 – 480Endothelial transcription factor GATA-2Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei86Asymmetric dimethylarginineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Cross-linki389Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ924Y4

PTM databases

PhosphoSitePlusiQ924Y4

Expressioni

Gene expression databases

BgeeiENSRNOG00000012347
ExpressionAtlasiQ924Y4 baseline and differential
GenevisibleiQ924Y4 RN

Interactioni

Subunit structurei

Interacts with BRD3. Interacts with AR and CCAR1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247224, 1 interactor
STRINGi10116.ENSRNOP00000017240

Structurei

3D structure databases

ProteinModelPortaliQ924Y4
SMRiQ924Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri295 – 319GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri349 – 373GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00760000119221
HOGENOMiHOG000047701
HOVERGENiHBG051705
InParanoidiQ924Y4
KOiK17894
OMAiPRWMAHH
OrthoDBiEOG091G0AUR
PhylomeDBiQ924Y4
TreeFamiTF315391

Family and domain databases

Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR029522 GATA-2
IPR016374 TF_GATA-2/3
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071:SF149 PTHR10071:SF149, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PIRSFiPIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q924Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Length:480
Mass (Da):50,464
Last modified:December 1, 2001 - v1
Checksum:i80FBA84AA4258EAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347T → S in AAL57180 (PubMed:12933836).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032734 mRNA Translation: AAK51128.1
AF345897 mRNA Translation: AAL57180.1
BC061745 mRNA Translation: AAH61745.1
RefSeqiNP_254277.1, NM_033442.1
XP_017447968.1, XM_017592479.1
XP_017447969.1, XM_017592480.1
UniGeneiRn.34322

Genome annotation databases

EnsembliENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347
GeneIDi25159
KEGGirno:25159
UCSCiRGD:2664 rat

Similar proteinsi

Entry informationi

Entry nameiGATA2_RAT
AccessioniPrimary (citable) accession number: Q924Y4
Secondary accession number(s): Q8VHY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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