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UniProtKB - Q924Y4 (GATA2_RAT)
Protein
Endothelial transcription factor GATA-2
Gene
Gata2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity).
Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 295 – 319 | GATA-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 349 – 373 | GATA-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: RGD
- chromatin binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription coactivator binding Source: Ensembl
- zinc ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: RGD
- cell differentiation in hindbrain Source: RGD
- cell fate commitment Source: GO_Central
- cell fate determination Source: RGD
- cell maturation Source: RGD
- central nervous system neuron development Source: RGD
- cochlea development Source: RGD
- commitment of neuronal cell to specific neuron type in forebrain Source: RGD
- definitive hemopoiesis Source: RGD
- embryonic placenta development Source: RGD
- eosinophil fate commitment Source: RGD
- GABAergic neuron differentiation Source: RGD
- homeostasis of number of cells within a tissue Source: RGD
- inner ear morphogenesis Source: RGD
- negative regulation of endothelial cell apoptotic process Source: RGD
- negative regulation of fat cell differentiation Source: RGD
- negative regulation of fat cell proliferation Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of macrophage differentiation Source: RGD
- negative regulation of myeloid cell differentiation Source: RGD
- negative regulation of neural precursor cell proliferation Source: RGD
- negative regulation of Notch signaling pathway Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron differentiation Source: RGD
- neuron fate commitment Source: RGD
- neuron migration Source: RGD
- phagocytosis Source: UniProtKB-KW
- pituitary gland development Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of blood vessel endothelial cell migration Source: RGD
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: RGD
- positive regulation of cell migration involved in sprouting angiogenesis Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of erythrocyte differentiation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of mast cell degranulation Source: RGD
- positive regulation of megakaryocyte differentiation Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of phagocytosis, engulfment Source: RGD
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of forebrain neuron differentiation Source: RGD
- regulation of histone acetylation Source: RGD
- regulation of primitive erythrocyte differentiation Source: RGD
- response to lipid Source: RGD
- semicircular canal development Source: RGD
- somatic stem cell population maintenance Source: RGD
- urogenital system development Source: RGD
- vascular wound healing Source: RGD
- ventral spinal cord interneuron differentiation Source: RGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Phagocytosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelial transcription factor GATA-2Alternative name(s): GATA-binding protein 2 |
Gene namesi | Name:Gata2Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2664, Gata2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083405 | 1 – 480 | Endothelial transcription factor GATA-2Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 73 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 192 | PhosphoserineBy similarity | 1 | |
Cross-linki | 389 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q924Y4 |
PTM databases
PhosphoSitePlusi | Q924Y4 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000012347, Expressed in lung and 21 other tissues |
ExpressionAtlasi | Q924Y4, baseline and differential |
Genevisiblei | Q924Y4, RN |
Interactioni
Subunit structurei
Interacts with BRD3.
Interacts with AR and CCAR1.
By similarityGO - Molecular functioni
- C2H2 zinc finger domain binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- transcription coactivator binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 247224, 1 interactor |
STRINGi | 10116.ENSRNOP00000017240 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 208 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 457 – 480 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 457 – 471 | Polar residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 295 – 319 | GATA-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 349 – 373 | GATA-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000156315 |
HOGENOMi | CLU_027524_1_0_1 |
InParanoidi | Q924Y4 |
OMAi | PHHSGRS |
OrthoDBi | 1240204at2759 |
PhylomeDBi | Q924Y4 |
TreeFami | TF315391 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR029522, GATA-2 IPR016374, TF_GATA-2/3 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit PTHR10071:SF149, PTHR10071:SF149, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits |
PIRSFi | PIRSF003027, TF_GATA-1/2/3, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q924Y4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHSPWTVSP FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASPSAGG
210 220 230 240 250
SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SSKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 347 | T → S in AAL57180 (PubMed:12933836).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY032734 mRNA Translation: AAK51128.1 AF345897 mRNA Translation: AAL57180.1 BC061745 mRNA Translation: AAH61745.1 |
RefSeqi | NP_254277.1, NM_033442.1 XP_017447968.1, XM_017592479.1 XP_017447969.1, XM_017592480.1 |
Genome annotation databases
Ensembli | ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347 |
GeneIDi | 25159 |
KEGGi | rno:25159 |
UCSCi | RGD:2664, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY032734 mRNA Translation: AAK51128.1 AF345897 mRNA Translation: AAL57180.1 BC061745 mRNA Translation: AAH61745.1 |
RefSeqi | NP_254277.1, NM_033442.1 XP_017447968.1, XM_017592479.1 XP_017447969.1, XM_017592480.1 |
3D structure databases
SMRi | Q924Y4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247224, 1 interactor |
STRINGi | 10116.ENSRNOP00000017240 |
PTM databases
PhosphoSitePlusi | Q924Y4 |
Proteomic databases
PaxDbi | Q924Y4 |
Genome annotation databases
Ensembli | ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347 |
GeneIDi | 25159 |
KEGGi | rno:25159 |
UCSCi | RGD:2664, rat |
Organism-specific databases
CTDi | 2624 |
RGDi | 2664, Gata2 |
Phylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000156315 |
HOGENOMi | CLU_027524_1_0_1 |
InParanoidi | Q924Y4 |
OMAi | PHHSGRS |
OrthoDBi | 1240204at2759 |
PhylomeDBi | Q924Y4 |
TreeFami | TF315391 |
Enzyme and pathway databases
Reactomei | R-RNO-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-RNO-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
PROi | PR:Q924Y4 |
Gene expression databases
Bgeei | ENSRNOG00000012347, Expressed in lung and 21 other tissues |
ExpressionAtlasi | Q924Y4, baseline and differential |
Genevisiblei | Q924Y4, RN |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR029522, GATA-2 IPR016374, TF_GATA-2/3 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit PTHR10071:SF149, PTHR10071:SF149, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits |
PIRSFi | PIRSF003027, TF_GATA-1/2/3, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GATA2_RAT | |
Accessioni | Q924Y4Primary (citable) accession number: Q924Y4 Secondary accession number(s): Q8VHY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |