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Protein

Rhombotin-1

Gene

Lmo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of T cell homeostatic proliferation Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyi

Protein namesi
Recommended name:
Rhombotin-1
Alternative name(s):
Cysteine-rich protein TTG-1
LIM domain only protein 1
Short name:
LMO-1
T-cell translocation protein 1
Gene namesi
Name:Lmo1
Synonyms:Rbtn1, Rhom1, Ttg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:102812 Lmo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758951 – 156Rhombotin-1Add BLAST156

Proteomic databases

MaxQBiQ924W9
PaxDbiQ924W9
PRIDEiQ924W9

PTM databases

PhosphoSitePlusiQ924W9

Expressioni

Tissue specificityi

Expressed in the brain and not in the thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000036111 Expressed in 245 organ(s), highest expression level in primary oocyte
CleanExiMM_LMO1
ExpressionAtlasiQ924W9 baseline and differential
GenevisibleiQ924W9 MM

Interactioni

Protein-protein interaction databases

BioGridi224887, 4 interactors
STRINGi10090.ENSMUSP00000037079

Structurei

3D structure databases

ProteinModelPortaliQ924W9
SMRiQ924W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 84LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST63
Domaini86 – 148LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiQ924W9
OrthoDBiEOG091G0LKW
PhylomeDBiQ924W9
TreeFamiTF351071

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q924W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK
60 70 80 90 100
CACCDCRLGE VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM
110 120 130 140 150
VMRARDNVYH LDCFACQLCN QRFCVGDKFF LKNNMILCQV DYEEGHLNGT

FESQVQ
Length:156
Mass (Da):17,805
Last modified:December 1, 2001 - v1
Checksum:i7AAEB122870CCAAC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHX4A0A140LHX4_MOUSE
LIM domain only 1, isoform CRA_b
Lmo1 mCG_2321
145Annotation score:
A0A140LIB4A0A140LIB4_MOUSE
LIM domain only 1, isoform CRA_a
Lmo1 mCG_2321
155Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296304 Genomic DNA Translation: CAC39310.1
BC053074 mRNA Translation: AAH53074.1
CCDSiCCDS40080.1
RefSeqiNP_001289134.1, NM_001302205.1
NP_001289135.1, NM_001302206.1
NP_476514.1, NM_057173.3
XP_006507258.1, XM_006507195.3
UniGeneiMm.360145

Genome annotation databases

EnsembliENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111
GeneIDi109594
KEGGimmu:109594
UCSCiuc009jdk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ296304 Genomic DNA Translation: CAC39310.1
BC053074 mRNA Translation: AAH53074.1
CCDSiCCDS40080.1
RefSeqiNP_001289134.1, NM_001302205.1
NP_001289135.1, NM_001302206.1
NP_476514.1, NM_057173.3
XP_006507258.1, XM_006507195.3
UniGeneiMm.360145

3D structure databases

ProteinModelPortaliQ924W9
SMRiQ924W9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224887, 4 interactors
STRINGi10090.ENSMUSP00000037079

PTM databases

PhosphoSitePlusiQ924W9

Proteomic databases

MaxQBiQ924W9
PaxDbiQ924W9
PRIDEiQ924W9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111
GeneIDi109594
KEGGimmu:109594
UCSCiuc009jdk.2 mouse

Organism-specific databases

CTDi4004
MGIiMGI:102812 Lmo1

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000232175
HOVERGENiHBG054231
InParanoidiQ924W9
OrthoDBiEOG091G0LKW
PhylomeDBiQ924W9
TreeFamiTF351071

Enzyme and pathway databases

ReactomeiR-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Miscellaneous databases

PROiPR:Q924W9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036111 Expressed in 245 organ(s), highest expression level in primary oocyte
CleanExiMM_LMO1
ExpressionAtlasiQ924W9 baseline and differential
GenevisibleiQ924W9 MM

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRBTN1_MOUSE
AccessioniPrimary (citable) accession number: Q924W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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