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Protein

Structural maintenance of chromosomes protein 6

Gene

Smc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 89ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 6
Short name:
SMC protein 6
Short name:
SMC-6
Short name:
mSMC6
Gene namesi
Name:Smc6
Synonyms:Kiaa4103, Smc6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1914491 Smc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709571 – 1097Structural maintenance of chromosomes protein 6Add BLAST1097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei675PhosphoserineBy similarity1
Cross-linki779Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated.By similarity
Sumoylated by NSMCE2/MMS21.By similarity
Ubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ924W5
PaxDbiQ924W5
PeptideAtlasiQ924W5
PRIDEiQ924W5

PTM databases

iPTMnetiQ924W5
PhosphoSitePlusiQ924W5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020608 Expressed in 289 organ(s), highest expression level in presomitic mesoderm
CleanExiMM_SMC6
ExpressionAtlasiQ924W5 baseline and differential
GenevisibleiQ924W5 MM

Interactioni

Subunit structurei

Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. Interacts with NSMCE1. Interacts with NSMCE2. Interacts with SLF1. Interacts with SLF2. Interacts with RAD18.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212040, 10 interactors
IntActiQ924W5, 9 interactors
STRINGi10090.ENSMUSP00000020931

Structurei

3D structure databases

ProteinModelPortaliQ924W5
SMRiQ924W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni458 – 667Flexible hingeAdd BLAST210

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili232 – 348Sequence analysisAdd BLAST117
Coiled coili376 – 457Sequence analysisAdd BLAST82
Coiled coili668 – 920Sequence analysisAdd BLAST253

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi993 – 1028Ala/Asp-rich (DA-box)Add BLAST36

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC6 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0250 Eukaryota
COG1196 LUCA
GeneTreeiENSGT00550000074816
HOVERGENiHBG093964
InParanoidiQ924W5
KOiK22804
OMAiQHISMDG
OrthoDBiEOG091G043K
PhylomeDBiQ924W5
TreeFamiTF314520

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR027132 SMC6
PANTHERiPTHR19306:SF6 PTHR19306:SF6, 1 hit
PfamiView protein in Pfam
PF02463 SMC_N, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q924W5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKRKEENFC SPENAKRPRQ EELEDFDKDG DEDECTISFT NGTSTLTAAE
60 70 80 90 100
VGIIESIQLR NFMCHSMLGP FKFGSNVNFV VGNNGSGKSA VLTALIVGLG
110 120 130 140 150
GKAVATNRGS SLKGFVKAGQ NSADISITLR NRGDDAFRAN VYGDSIVVQQ
160 170 180 190 200
HISVDGSRSY KLKSEKGTVV STRKEELIAI LDHFNIQVDN PVSVLTQEMS
210 220 230 240 250
KQFLQSKNEG DKYKFFMKAT QLEQMKEDYS YIMETKERTK EQINQGEERL
260 270 280 290 300
TELKRQCLEK EERFQNIAGL STMKTNLEYL KHEMAWAVVN EIEKQLNAIR
310 320 330 340 350
DNIKIGEERA AKLDRKMEEQ QVRLNDAEKK YKDIQDKLEK ISEETNARAP
360 370 380 390 400
ECMALKTDVI ARTRAFNDAE VLYNRSLNEY KALKKDGEQL CKRIEELKKS
410 420 430 440 450
TDQSLEPERL ERQKRICWLK EKVKALQDQE HTVNQEAEQF EQAIEKDKQE
460 470 480 490 500
HGRVRKEDIE VRHALNYNQR QLKELKDSKT DRLKRFGPHV PALLEAIDDA
510 520 530 540 550
YRRRQFTHKP IGPLGACIHL RDPELALAIE SCLKGLLQAY CCHNHADERV
560 570 580 590 600
LQSLMKKFYP PGTSRPQIIV SEFRDEVYDV RLRAAYHPEF PTVLTALEID
610 620 630 640 650
NAVVANSLID MRSIETVLLI KNNSVARAVM QSQKPPKNCR EAFTADGDQV
660 670 680 690 700
FAGRYYSSES TRPKFLSRDV DSEISDLETE IENKKGHIIT LQQRLSALEK
710 720 730 740 750
DIKRNEELLK RCQLHYKEIK MKIRKNISEI RELENIEEHQ SVDIATLEDE
760 770 780 790 800
AEENKIKMQM VEKNMEQQKE NMENLKSLKI EAENKYDTIK LKINQLSELA
810 820 830 840 850
DPLKDELNLA DSEVDSQKRG KQHYEDKQKE HLDTLNKKRR ELDMKEKELQ
860 870 880 890 900
EKMSQARQIC PERIEVKKSA SILDKEINRL RQKIQAEHAS HGDREEIMKQ
910 920 930 940 950
YQEARETYLD LDNKVRTLRR FIKLLEEIMT HRYKTYQQFR RCLTLRCKLY
960 970 980 990 1000
FDNLLSQRAY CGKMNFDHKN ETLSITVQPG EGNKASFNDM RALSGGERSF
1010 1020 1030 1040 1050
STVCFILSLW SIAESPFRCL DEFDVYMDMV NRRIAMDMIL KMADSQRFRQ
1060 1070 1080 1090
FILLTPQSMS SLPSSKLIRI LRMSDPERGQ TTLPFRPVTQ EEDDSAS
Length:1,097
Mass (Da):127,198
Last modified:December 1, 2001 - v1
Checksum:i7329C25A85102DE5
GO
Isoform 2 (identifier: Q924W5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-326: RLND → LQAS
     327-1097: Missing.

Show »
Length:326
Mass (Da):36,744
Checksum:iF4A36072831DA488
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6V7A0A1W2P6V7_MOUSE
Structural maintenance of chromosom...
Smc6
179Annotation score:
A0A1W2P6F2A0A1W2P6F2_MOUSE
Structural maintenance of chromosom...
Smc6
100Annotation score:
A0A1W2P6W0A0A1W2P6W0_MOUSE
Structural maintenance of chromosom...
Smc6
103Annotation score:
A0A1W2P7G6A0A1W2P7G6_MOUSE
Structural maintenance of chromosom...
Smc6
91Annotation score:
A0A1W2P8E7A0A1W2P8E7_MOUSE
Structural maintenance of chromosom...
Smc6
56Annotation score:
A0A1W2P6T0A0A1W2P6T0_MOUSE
Structural maintenance of chromosom...
Smc6
59Annotation score:

Sequence cautioni

The sequence BAB23051 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120Q → W in BAD90287 (Ref. 4) Curated1
Sequence conflicti351E → K in BAE22709 (PubMed:16141072).Curated1
Sequence conflicti460E → A in AAH99955 (PubMed:15489334).Curated1
Sequence conflicti628A → V in AAH99955 (PubMed:15489334).Curated1
Sequence conflicti948K → E in BAB29353 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022254323 – 326RLND → LQAS in isoform 2. 2 Publications4
Alternative sequenceiVSP_022255327 – 1097Missing in isoform 2. 2 PublicationsAdd BLAST771

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310552 mRNA Translation: CAC39250.1
AK003872 mRNA Translation: BAB23051.1 Different initiation.
AK009009 mRNA Translation: BAB26022.3
AK011982 mRNA Translation: BAB27956.1
AK012626 mRNA Translation: BAB28365.1
AK014442 mRNA Translation: BAB29353.2
AK050341 mRNA Translation: BAC34200.2
AK088002 mRNA Translation: BAC40087.2
AK135873 mRNA Translation: BAE22709.1
AK148478 mRNA Translation: BAE28576.1
BC026429 mRNA Translation: AAH26429.1
BC048790 mRNA Translation: AAH48790.1
BC090630 mRNA Translation: AAH90630.1
BC099955 mRNA Translation: AAH99955.1
AK220488 mRNA Translation: BAD90287.1
CCDSiCCDS25815.1 [Q924W5-1]
RefSeqiNP_001311405.1, NM_001324476.1
NP_079971.2, NM_025695.4 [Q924W5-1]
UniGeneiMm.173953

Genome annotation databases

EnsembliENSMUST00000020931; ENSMUSP00000020931; ENSMUSG00000020608 [Q924W5-1]
ENSMUST00000218866; ENSMUSP00000151976; ENSMUSG00000020608 [Q924W5-2]
GeneIDi67241
KEGGimmu:67241
UCSCiuc007nax.1 mouse [Q924W5-2]
uc007nay.1 mouse [Q924W5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310552 mRNA Translation: CAC39250.1
AK003872 mRNA Translation: BAB23051.1 Different initiation.
AK009009 mRNA Translation: BAB26022.3
AK011982 mRNA Translation: BAB27956.1
AK012626 mRNA Translation: BAB28365.1
AK014442 mRNA Translation: BAB29353.2
AK050341 mRNA Translation: BAC34200.2
AK088002 mRNA Translation: BAC40087.2
AK135873 mRNA Translation: BAE22709.1
AK148478 mRNA Translation: BAE28576.1
BC026429 mRNA Translation: AAH26429.1
BC048790 mRNA Translation: AAH48790.1
BC090630 mRNA Translation: AAH90630.1
BC099955 mRNA Translation: AAH99955.1
AK220488 mRNA Translation: BAD90287.1
CCDSiCCDS25815.1 [Q924W5-1]
RefSeqiNP_001311405.1, NM_001324476.1
NP_079971.2, NM_025695.4 [Q924W5-1]
UniGeneiMm.173953

3D structure databases

ProteinModelPortaliQ924W5
SMRiQ924W5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212040, 10 interactors
IntActiQ924W5, 9 interactors
STRINGi10090.ENSMUSP00000020931

PTM databases

iPTMnetiQ924W5
PhosphoSitePlusiQ924W5

Proteomic databases

EPDiQ924W5
PaxDbiQ924W5
PeptideAtlasiQ924W5
PRIDEiQ924W5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020931; ENSMUSP00000020931; ENSMUSG00000020608 [Q924W5-1]
ENSMUST00000218866; ENSMUSP00000151976; ENSMUSG00000020608 [Q924W5-2]
GeneIDi67241
KEGGimmu:67241
UCSCiuc007nax.1 mouse [Q924W5-2]
uc007nay.1 mouse [Q924W5-1]

Organism-specific databases

CTDi79677
MGIiMGI:1914491 Smc6
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0250 Eukaryota
COG1196 LUCA
GeneTreeiENSGT00550000074816
HOVERGENiHBG093964
InParanoidiQ924W5
KOiK22804
OMAiQHISMDG
OrthoDBiEOG091G043K
PhylomeDBiQ924W5
TreeFamiTF314520

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins

Miscellaneous databases

ChiTaRSiSmc6 mouse
PROiPR:Q924W5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020608 Expressed in 289 organ(s), highest expression level in presomitic mesoderm
CleanExiMM_SMC6
ExpressionAtlasiQ924W5 baseline and differential
GenevisibleiQ924W5 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR027132 SMC6
PANTHERiPTHR19306:SF6 PTHR19306:SF6, 1 hit
PfamiView protein in Pfam
PF02463 SMC_N, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSMC6_MOUSE
AccessioniPrimary (citable) accession number: Q924W5
Secondary accession number(s): Q3UFI5
, Q3UX54, Q499E1, Q5DTN2, Q8BFU9, Q8R0T4, Q9CSK7, Q9CV94, Q9CZZ5, Q9D169, Q9D6B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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