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Protein

Cysteinyl leukotriene receptor 2

Gene

Cysltr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neuropeptide signaling pathway Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391906 Leukotriene receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 2
Short name:
CysLTR2
Alternative name(s):
RSBPT32
Gene namesi
Name:Cysltr2
Synonyms:Cyslt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi619797 Cysltr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 56CytoplasmicSequence analysis9
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 137CytoplasmicSequence analysisAdd BLAST18
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 187ExtracellularSequence analysisAdd BLAST29
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 229CytoplasmicSequence analysisAdd BLAST21
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 271ExtracellularSequence analysisAdd BLAST21
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693061 – 309Cysteinyl leukotriene receptor 2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 171PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ924T9
PRIDEiQ924T9

PTM databases

PhosphoSitePlusiQ924T9

Expressioni

Gene expression databases

BgeeiENSRNOG00000015042
GenevisibleiQ924T9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020187

Structurei

3D structure databases

ProteinModelPortaliQ924T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGJM Eukaryota
ENOG410YDV0 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG099611
InParanoidiQ924T9
KOiK04323
OMAiSVNVFML
OrthoDBiEOG091G0EA7
PhylomeDBiQ924T9
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR013311 CLT2_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01903 CYSLT2RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q924T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT
60 70 80 90 100
YKKSTSVNVF MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY
110 120 130 140 150
SLYVNMYTSI YFLTVLSIVR FLATAHPFQM LHITSVRSAW ILCGIIWVFI
160 170 180 190 200
MASSGLLLKH GQEKKNNTTL CFELNLQKFK NLVILNYIAL GVGFLLPFFI
210 220 230 240 250
LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF LLCFLPYHAL
260 270 280 290 300
RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL

RAIFSKDHL
Length:309
Mass (Da):35,507
Last modified:December 1, 2001 - v1
Checksum:iA122AC8177879D56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052661 mRNA Translation: BAB60816.1
RefSeqiNP_596904.1, NM_133413.1
XP_008769065.1, XM_008770843.2
UniGeneiRn.220881
Rn.74252

Genome annotation databases

EnsembliENSRNOT00000020186; ENSRNOP00000020187; ENSRNOG00000015042
GeneIDi170926
KEGGirno:170926
UCSCiRGD:619797 rat

Similar proteinsi

Entry informationi

Entry nameiCLTR2_RAT
AccessioniPrimary (citable) accession number: Q924T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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