Mpi

Functionⁱ

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityⁱ

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactorⁱ

Zn²⁺By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayⁱ: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	110	ZincBy similarity	1
Metal bindingⁱ	112	ZincBy similarity	1
Metal bindingⁱ	137	ZincBy similarity	1
Metal bindingⁱ	276	ZincBy similarity	1
Active siteⁱ	295	By similarity	1

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell wall mannoprotein biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GDP-mannose biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 24218558
glycolytic process from mannose through fructose-6-phosphate
Source: MGI
Inferred by curatorⁱ
- 16339137
mannose to fructose-6-phosphate metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16339137
protein glycosylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-446205 Synthesis of GDP-mannose
UniPathwayⁱ	UPA00126;UER00423

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mannose-6-phosphate isomerase (EC:5.3.1.8) Alternative name(s): Phosphohexomutase Phosphomannose isomerase Short name: PMI
Gene namesⁱ	Name:Mpi Synonyms:Mpi1, Pmi
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:97075 Mpi

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000194237	2 – 423	Mannose-6-phosphate isomeraseAdd BLAST		422

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	102	PhosphoserineBy similarity	1
Modified residueⁱ	108	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q924M7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q924M7
PaxDbⁱ	Q924M7
PRIDEⁱ	Q924M7

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q924M7

REPRODUCTION-2DPAGEⁱ

Q924M7

PTM databases

iPTMnetⁱ	Q924M7
PhosphoSitePlusⁱ	Q924M7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032306 Expressed in 258 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_MPI
ExpressionAtlasⁱ	Q924M7 baseline and differential
Genevisibleⁱ	Q924M7 MM

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q924M7, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q924M7
STRINGⁱ	10090.ENSMUSP00000034856

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q924M7
SMRⁱ	Q924M7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the mannose-6-phosphate isomerase type 1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2757 Eukaryota COG1482 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016075
HOGENOMⁱ	HOG000241277
HOVERGENⁱ	HBG000367
InParanoidⁱ	Q924M7
KEGG Orthology (KO) More...KOⁱ	K01809
OMAⁱ	CADQPLS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G078D
PhylomeDBⁱ	Q924M7
TreeFamⁱ	TF312831

Family and domain databases

Gene3Dⁱ	2.60.120.10, 2 hits
InterProⁱ	View protein in InterPro IPR001250 Man6P_Isoase-1 IPR016305 Mannose-6-P_Isomerase IPR018050 Pmannose_isomerase-type1_CS IPR014710 RmlC-like_jellyroll IPR011051 RmlC_Cupin_sf
PANTHERⁱ	PTHR10309 PTHR10309, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01238 PMI_typeI, 1 hit
PIRSFⁱ	PIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSⁱ	PR00714 MAN6PISMRASE
SUPFAMⁱ	SSF51182 SSF51182, 1 hit
TIGRFAMsⁱ	TIGR00218 manA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00965 PMI_I_1, 1 hit PS00966 PMI_I_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q924M7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW 
        60         70         80         90        100
MGTHPRGDAK ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV 
       110        120        130        140        150
LSVDTALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTSFQGLCG 
       160        170        180        190        200
FRPVEEIVTF MKKVPEFQLL IGDDATAQLK ESVGGDTEAM ASALRNCFSH 
       210        220        230        240        250
LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ LHQQHPGDIG 
       260        270        280        290        300
CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP 
       310        320        330        340        350
KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM 
       360        370        380        390        400
EVPSSVTEYK VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA 
       410        420 
NESVLLKITV PKDLLIFRAC CLL

Length:423

Mass (Da):46,575

Last modified:December 1, 2001 - v1

Checksum:ⁱ3A49506D1249B670

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F6Q3K8	F6Q3K8_MOUSE		Mannose-6-phosphate isomerase Mannose-6-phosphate isomerase	Mpi	122	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF244360 mRNA Translation: AAK69388.1 BC051163 mRNA Translation: AAH51163.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40650.1
NCBI Reference Sequences More...RefSeqⁱ	NP_080113.1, NM_025837.2
UniGeneⁱ	Mm.247218

Genome annotation databases

Ensemblⁱ	ENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306
GeneIDⁱ	110119
KEGGⁱ	mmu:110119
UCSC genome browser More...UCSCⁱ	uc009pvd.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q924M7	Mannose-6-phosphate isomerase		MOUSE		423	UniRef100_Q924M7
UPI0003D7629C		MOUSE		234

Protein	Similar proteins		Species	Score	Length	Source
Q924M7	Mannose-6-phosphate isomerase		MOUSE		423	UniRef90_Q924M7
UPI000A307350		MUSPA		423
UPI000A3172D2		MUSCR		423
Mannose-6-phosphate isomerase		MOUSE		423
UPI0003D7629C		MOUSE		234

Protein	Similar proteins		Species	Score	Length	Source
Q924M7	Mannose-6-phosphate isomerase		RAT		423	UniRef50_Q924M7
Mannose-6-phosphate isomerase		MOUSE		423
Mannose-6-phosphate isomerase		CALSU		423
Mannose-6-phosphate isomerase		COLVI		373
Mannose-6-phosphate isomerase		CHICK		373
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF244360 mRNA Translation: AAK69388.1 BC051163 mRNA Translation: AAH51163.1
CCDSⁱ	CCDS40650.1
RefSeqⁱ	NP_080113.1, NM_025837.2
UniGeneⁱ	Mm.247218

3D structure databases

ProteinModelPortalⁱ	Q924M7
SMRⁱ	Q924M7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q924M7, 2 interactors
MINTⁱ	Q924M7
STRINGⁱ	10090.ENSMUSP00000034856

PTM databases

iPTMnetⁱ	Q924M7
PhosphoSitePlusⁱ	Q924M7

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q924M7

REPRODUCTION-2DPAGEⁱ

Q924M7

Proteomic databases

EPDⁱ	Q924M7
MaxQBⁱ	Q924M7
PaxDbⁱ	Q924M7
PRIDEⁱ	Q924M7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306
GeneIDⁱ	110119
KEGGⁱ	mmu:110119
UCSCⁱ	uc009pvd.1 mouse

Organism-specific databases

CTDⁱ	4351
MGIⁱ	MGI:97075 Mpi

Phylogenomic databases

eggNOGⁱ	KOG2757 Eukaryota COG1482 LUCA
GeneTreeⁱ	ENSGT00390000016075
HOGENOMⁱ	HOG000241277
HOVERGENⁱ	HBG000367
InParanoidⁱ	Q924M7
KOⁱ	K01809
OMAⁱ	CADQPLS
OrthoDBⁱ	EOG091G078D
PhylomeDBⁱ	Q924M7
TreeFamⁱ	TF312831

Enzyme and pathway databases

UniPathwayⁱ	UPA00126;UER00423
Reactomeⁱ	R-MMU-446205 Synthesis of GDP-mannose

Miscellaneous databases

ChiTaRSⁱ	Mpi mouse
Protein Ontology More...PROⁱ	PR:Q924M7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032306 Expressed in 258 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_MPI
ExpressionAtlasⁱ	Q924M7 baseline and differential
Genevisibleⁱ	Q924M7 MM

Family and domain databases

Gene3Dⁱ	2.60.120.10, 2 hits
InterProⁱ	View protein in InterPro IPR001250 Man6P_Isoase-1 IPR016305 Mannose-6-P_Isomerase IPR018050 Pmannose_isomerase-type1_CS IPR014710 RmlC-like_jellyroll IPR011051 RmlC_Cupin_sf
PANTHERⁱ	PTHR10309 PTHR10309, 1 hit
Pfamⁱ	View protein in Pfam PF01238 PMI_typeI, 1 hit
PIRSFⁱ	PIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSⁱ	PR00714 MAN6PISMRASE
SUPFAMⁱ	SSF51182 SSF51182, 1 hit
TIGRFAMsⁱ	TIGR00218 manA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00965 PMI_I_1, 1 hit PS00966 PMI_I_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MPI_MOUSE
Accessionⁱ	Q924M7Primary (citable) accession number: Q924M7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

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UniProtKB - Q924M7 (MPI_MOUSE)

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Mannose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: GDP-alpha-D-mannose biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: GDP-alpha-D-mannose biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ