UniProtKB - Q924M7 (MPI_MOUSE)
Protein
Mannose-6-phosphate isomerase
Gene
Mpi
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity
Catalytic activityi
- EC:5.3.1.8
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
: GDP-alpha-D-mannose biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi)
- Phosphomannomutase 1 (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase 2 (Pmm2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 110 | ZincBy similarity | 1 | |
Metal bindingi | 112 | ZincBy similarity | 1 | |
Metal bindingi | 137 | ZincBy similarity | 1 | |
Metal bindingi | 276 | ZincBy similarity | 1 | |
Active sitei | 295 | By similarity | 1 |
GO - Molecular functioni
- mannose-6-phosphate isomerase activity Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- GDP-mannose biosynthetic process Source: MGI
- glycolytic process from mannose through fructose-6-phosphate Source: MGI
- mannose to fructose-6-phosphate metabolic process Source: MGI
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-446205, Synthesis of GDP-mannose |
UniPathwayi | UPA00126;UER00423 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannose-6-phosphate isomerase (EC:5.3.1.8)Alternative name(s): Phosphohexomutase Phosphomannose isomerase Short name: PMI |
Gene namesi | Name:Mpi Synonyms:Mpi1, Pmi |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97075, Mpi |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000194237 | 2 – 423 | Mannose-6-phosphate isomeraseAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 102 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q924M7 |
jPOSTi | Q924M7 |
MaxQBi | Q924M7 |
PaxDbi | Q924M7 |
PRIDEi | Q924M7 |
2D gel databases
REPRODUCTION-2DPAGEi | Q924M7 |
PTM databases
iPTMneti | Q924M7 |
PhosphoSitePlusi | Q924M7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032306, Expressed in spermatocyte and 274 other tissues |
ExpressionAtlasi | Q924M7, baseline and differential |
Genevisiblei | Q924M7, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 225310, 1 interactor |
IntActi | Q924M7, 2 interactors |
MINTi | Q924M7 |
STRINGi | 10090.ENSMUSP00000034856 |
Miscellaneous databases
RNActi | Q924M7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the mannose-6-phosphate isomerase type 1 family.Curated
Phylogenomic databases
eggNOGi | KOG2757, Eukaryota |
GeneTreei | ENSGT00390000016075 |
HOGENOMi | CLU_026967_2_0_1 |
InParanoidi | Q924M7 |
OMAi | CADQPLS |
OrthoDBi | 1043197at2759 |
PhylomeDBi | Q924M7 |
TreeFami | TF312831 |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00965, PMI_I_1, 1 hit PS00966, PMI_I_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q924M7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPRVFPLS CVVQQYAWGK VGSKSEVACL LASSDPLAQI SEDKPYAELW
60 70 80 90 100
MGTHPRGDAK ILDNRISQKT LGQWIAENPD CLGSKVKNTF NGKLPFLFKV
110 120 130 140 150
LSVDTALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTSFQGLCG
160 170 180 190 200
FRPVEEIVTF MKKVPEFQLL IGDDATAQLK ESVGGDTEAM ASALRNCFSH
210 220 230 240 250
LMKSEKKVVV EQLNLLVKRI SQQVFDGNNM EDIYGKLLLQ LHQQHPGDIG
260 270 280 290 300
CFAIYFLNLL TLKPGEAMFL DANVPHAYLK GDCVECMACS DNTVRAGLTP
310 320 330 340 350
KFIDVPTLCE MLNYTPSPSN NRLFAPAQSQ DDPYLSIYDP PVPDFTVMKM
360 370 380 390 400
EVPSSVTEYK VSTLDSASIL LMVQGTVTAI IPSAHAEIPL YRGGVLFIAA
410 420
NESVLLKITV PKDLLIFRAC CLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6Q3K8 | F6Q3K8_MOUSE | Mannose-6-phosphate isomerase | Mpi | 122 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF244360 mRNA Translation: AAK69388.1 BC051163 mRNA Translation: AAH51163.1 |
CCDSi | CCDS40650.1 |
RefSeqi | NP_080113.1, NM_025837.2 |
Genome annotation databases
Ensembli | ENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306 |
GeneIDi | 110119 |
KEGGi | mmu:110119 |
UCSCi | uc009pvd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF244360 mRNA Translation: AAK69388.1 BC051163 mRNA Translation: AAH51163.1 |
CCDSi | CCDS40650.1 |
RefSeqi | NP_080113.1, NM_025837.2 |
3D structure databases
SMRi | Q924M7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 225310, 1 interactor |
IntActi | Q924M7, 2 interactors |
MINTi | Q924M7 |
STRINGi | 10090.ENSMUSP00000034856 |
PTM databases
iPTMneti | Q924M7 |
PhosphoSitePlusi | Q924M7 |
2D gel databases
REPRODUCTION-2DPAGEi | Q924M7 |
Proteomic databases
EPDi | Q924M7 |
jPOSTi | Q924M7 |
MaxQBi | Q924M7 |
PaxDbi | Q924M7 |
PRIDEi | Q924M7 |
Protocols and materials databases
Antibodypediai | 2008, 377 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034856; ENSMUSP00000034856; ENSMUSG00000032306 |
GeneIDi | 110119 |
KEGGi | mmu:110119 |
UCSCi | uc009pvd.1, mouse |
Organism-specific databases
CTDi | 4351 |
MGIi | MGI:97075, Mpi |
Phylogenomic databases
eggNOGi | KOG2757, Eukaryota |
GeneTreei | ENSGT00390000016075 |
HOGENOMi | CLU_026967_2_0_1 |
InParanoidi | Q924M7 |
OMAi | CADQPLS |
OrthoDBi | 1043197at2759 |
PhylomeDBi | Q924M7 |
TreeFami | TF312831 |
Enzyme and pathway databases
UniPathwayi | UPA00126;UER00423 |
Reactomei | R-MMU-446205, Synthesis of GDP-mannose |
Miscellaneous databases
BioGRID-ORCSi | 110119, 2 hits in 17 CRISPR screens |
ChiTaRSi | Mpi, mouse |
PROi | PR:Q924M7 |
RNActi | Q924M7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032306, Expressed in spermatocyte and 274 other tissues |
ExpressionAtlasi | Q924M7, baseline and differential |
Genevisiblei | Q924M7, MM |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00965, PMI_I_1, 1 hit PS00966, PMI_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MPI_MOUSE | |
Accessioni | Q924M7Primary (citable) accession number: Q924M7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families