UniProtKB - Q924M5 (BOLL_MOUSE)
Protein
Protein boule-like
Gene
Boll
Organism
Mus musculus (Mouse)
Status
Functioni
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).By similarity
GO - Molecular functioni
- mRNA 3'-UTR binding Source: GO_Central
- translation activator activity Source: MGI
GO - Biological processi
- 3'-UTR-mediated mRNA stabilization Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- meiotic cell cycle Source: MGI
- multicellular organism development Source: UniProtKB-KW
- positive regulation of translational initiation Source: MGI
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Biological process | Differentiation, Spermatogenesis, Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein boule-like |
Gene namesi | Name:Boll Synonyms:Boule |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1922638, Boll |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081496 | 1 – 281 | Protein boule-likeAdd BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q924M5-2) | |||||
Modified residuei | 19 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 21 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 26 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q924M5 |
PRIDEi | Q924M5 |
PTM databases
iPTMneti | Q924M5 |
PhosphoSitePlusi | Q924M5 |
Expressioni
Tissue specificityi
Testis specific. Not expressed in early embryos, primoridal germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.1 Publication
Developmental stagei
First expressed in stage III spermatocytes and peaks in late pachytene or diplotene stage spermatocytes. Expressed in secondary spermatocytes and early spermatids, then decreases until it is undetectable in spermatids.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025977, Expressed in spermatocyte and 71 other tissues |
Genevisiblei | Q924M5, MM |
Interactioni
Subunit structurei
Interacts with DAZ1 and DAZL.
By similarityProtein-protein interaction databases
IntActi | Q924M5, 1 interactor |
STRINGi | 10090.ENSMUSP00000084868 |
Miscellaneous databases
RNActi | Q924M5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 110 | RRMPROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 160 – 184 | DAZPROSITE-ProRule annotationAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the RRM DAZ family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00530000063480 |
InParanoidi | Q924M5 |
OrthoDBi | 1610446at2759 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR037366, BOULE/DAZ IPR043628, DAZ_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR11176, PTHR11176, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51890, DAZ, 1 hit PS50102, RRM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q924M5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQTDSLSPSP NPVSPVPLNN PTSGPRYGTV IPNRIFVGGI DFKTNENDLR
60 70 80 90 100
KFFSQYGSVK EVKIVNDRAG VSKGYGFITF ETQEDAQKIL QEAEKLNYKD
110 120 130 140 150
KKLNIGPAIR KQQVGIPRSS LMPAAGTMYL TTSTGYPYTY HNGVAYFHTP
160 170 180 190 200
EVTSVPPSWP SRSISSSPVM VAQPVYQQPA YHYQAPAQCL PGQWQWGVPQ
210 220 230 240 250
SPASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS VPEPYSDHGV
260 270 280
QAAYHQVYAS SAIAMPAPMM QPEPIKVRSL F
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QPQ9 | E9QPQ9_MOUSE | Protein boule-like | Boll | 293 | Annotation score: | ||
F6TV20 | F6TV20_MOUSE | Protein boule-like | Boll | 87 | Annotation score: | ||
G3UYE8 | G3UYE8_MOUSE | Protein boule-like | Boll | 282 | Annotation score: | ||
E9PWH1 | E9PWH1_MOUSE | Protein boule-like | Boll | 160 | Annotation score: | ||
M0QWZ3 | M0QWZ3_MOUSE | Protein boule-like | Boll | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | M → EFRCCRTESRAQSTNQT (PubMed:11390979).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009447 | 1 | M → METESRAQSTNQT in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_009448 | 119 – 120 | SS → MY in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_009449 | 121 – 281 | Missing in isoform 2. 1 PublicationAdd BLAST | 161 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272859 mRNA Translation: AAK69026.1 AK016125 mRNA Translation: BAB30121.1 BY103870 mRNA No translation available. |
RefSeqi | NP_001106838.1, NM_001113367.1 NP_083543.2, NM_029267.3 |
Genome annotation databases
Ensembli | ENSMUST00000159398; ENSMUSP00000123814; ENSMUSG00000025977 [Q924M5-2] |
GeneIDi | 75388 |
KEGGi | mmu:75388 |
UCSCi | uc007bam.1, mouse [Q924M5-2] uc011wlb.1, mouse [Q924M5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272859 mRNA Translation: AAK69026.1 AK016125 mRNA Translation: BAB30121.1 BY103870 mRNA No translation available. |
RefSeqi | NP_001106838.1, NM_001113367.1 NP_083543.2, NM_029267.3 |
3D structure databases
SMRi | Q924M5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q924M5, 1 interactor |
STRINGi | 10090.ENSMUSP00000084868 |
PTM databases
iPTMneti | Q924M5 |
PhosphoSitePlusi | Q924M5 |
Proteomic databases
PaxDbi | Q924M5 |
PRIDEi | Q924M5 |
Protocols and materials databases
Antibodypediai | 19911, 457 antibodies |
DNASUi | 75388 |
Genome annotation databases
Ensembli | ENSMUST00000159398; ENSMUSP00000123814; ENSMUSG00000025977 [Q924M5-2] |
GeneIDi | 75388 |
KEGGi | mmu:75388 |
UCSCi | uc007bam.1, mouse [Q924M5-2] uc011wlb.1, mouse [Q924M5-1] |
Organism-specific databases
CTDi | 66037 |
MGIi | MGI:1922638, Boll |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00530000063480 |
InParanoidi | Q924M5 |
OrthoDBi | 1610446at2759 |
Miscellaneous databases
BioGRID-ORCSi | 75388, 1 hit in 18 CRISPR screens |
ChiTaRSi | Boll, mouse |
PROi | PR:Q924M5 |
RNActi | Q924M5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025977, Expressed in spermatocyte and 71 other tissues |
Genevisiblei | Q924M5, MM |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR037366, BOULE/DAZ IPR043628, DAZ_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR11176, PTHR11176, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51890, DAZ, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BOLL_MOUSE | |
Accessioni | Q924M5Primary (citable) accession number: Q924M5 Secondary accession number(s): Q9D4V2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | March 1, 2004 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families