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UniProtKB - Q924M0 (Q924M0_RAT)

Entry version 142 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein
Submitted name:

GABA type B receptor 1f

Gene

Gabbr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorARBA annotation, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GABA type B receptor 1fImported
Submitted name:
Gamma-aminobutyric acid (GABA) B receptor 1, isoform CRA_aImported
Submitted name:
Gamma-aminobutyric acid type B receptor subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gabbr1Imported
ORF Names:rCG_58602Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Rat genome database

More...RGDi		621537, Gabbr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei583 – 608HelicalSequence analysisAdd BLAST26
Transmembranei620 – 639HelicalSequence analysisAdd BLAST20
Transmembranei659 – 679HelicalSequence analysisAdd BLAST21
Transmembranei700 – 723HelicalSequence analysisAdd BLAST24
Transmembranei794 – 812HelicalSequence analysisAdd BLAST19
Transmembranei832 – 849HelicalSequence analysisAdd BLAST18
Transmembranei855 – 877HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501410776120 – 984Sequence analysisAdd BLAST965

Keywords - PTMi

Disulfide bondARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000000774, Expressed in brain and 22 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 158SushiInterPro annotationAdd BLAST62
Domaini590 – 899G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST310

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni890 – 915DisorderedSequence analysisAdd BLAST26
Regioni932 – 984DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi890 – 907Polar residuesSequence analysisAdd BLAST18
Compositional biasi950 – 964Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.ARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157642

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005240_2_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		WAGGEAC

Family and domain databases

Conserved Domains Database

More...CDDi		cd15291, 7tmC_GABA-B-R1, 1 hit
cd00033, CCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR002455, GPCR3_GABA-B
IPR017978, GPCR_3_C
IPR002456, GPCR_3_GABA_rcpt_B1
IPR028082, Peripla_BP_I
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

The PANTHER Classification System

More...PANTHERi		PTHR10519, PTHR10519, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF00084, Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit
SSF57535, SSF57535, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q924M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLLLVPLF LRPLGAGGAQ TPNATSEGCQ IIHPPWEGGI RYRGLTRDQV 
        60         70         80         90        100
KAINFLPVDY EIEYVCRGER EVVGPKVRKC LANGSWTDMD TPSRCVRICS 
       110        120        130        140        150
KSYLTLENGK VFLTGGDLPA LDGARVEFRC DPDFHLVGSS RSVCSQGQWS 
       160        170        180        190        200
TPKPHCQERR AVYIGALFPM SGGWPGGQAC QPAVEMALED VNSRRDILPD 
       210        220        230        240        250
YELKLIHHDS KCDPGQATKY LYELLYNDPI KIILMPGCSS VSTLVAEAAR 
       260        270        280        290        300
MWNLIVLSYG SSSPALSNRQ RFPTFFRTHP SATLHNPTRV KLFEKWGWKK 
       310        320        330        340        350
IATIQQTTEV FTSTLDDLEE RVKEAGIEIT FRQSFFSDPA VPVKNLKRQD 
       360        370        380        390        400
ARIIVGLFYE TEARKVFCEV YKERLFGKKY VWFLIGWYAD NWFKTYDPSI 
       410        420        430        440        450
NCTVEEMTEA VEGHITTEIV MLNPANTRSI SNMTSQEFVE KLTKRLKRHP 
       460        470        480        490        500
EETGGFQEAP LAYDAIWALA LALNKTSGGG GRSGVRLEDF NYNNQTITDQ 
       510        520        530        540        550
IYRAMNSSSF EGVSGHVVFD ASGSRMAWTL IEQLQGGSYK KIGYYDSTKD 
       560        570        580        590        600
DLSWSKTDKW IGGSPPADQT LVIKTFRFLS QKLFISVSVL SSLGIVLAVV 
       610        620        630        640        650
CLSFNIYNSH VRYIQNSQPN LNNLTAVGCS LALAAVFPLG LDGYHIGRSQ 
       660        670        680        690        700
FPFVCQARLW LLGLGFSLGY GSMFTKIWWV HTVFTKKEEK KEWRKTLEPW 
       710        720        730        740        750
KLYATVGLLV GMDVLTLAIW QIVDPLHRTI ETFAKEEPKE DIDVSILPQL 
       760        770        780        790        800
EHCSSKKMNT WLGELWSFAV SSDVQRRATV GGDSPICVWP APESIFYGYK 
       810        820        830        840        850
GLLLLLGIFL AYETKSVSTE KINDHRAVGM AIYNVAVLCL ITAPVTMILS 
       860        870        880        890        900
SQQDAAFAFA SLAIVFSSYI TLVVLFVPKM RRLITRGEWQ SETQDTMKTG 
       910        920        930        940        950
SSTNNNEEEK SRLLEKENRE LEKIIAEKEE RVSELRHQLQ SRQQLRSRRH 
       960        970        980 
PPTPPDPSGG LPRGPSEPPD RLSCDGSRVH LLYK
Length:984
Mass (Da):110,742
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA93012CFA296FBDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Z0U4GABR1_RAT
Gamma-aminobutyric acid type B rece...
Gabbr1
991Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5CC44Q5CC44_RAT
GABA-BR1h receptor
Gabbr1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF283276 mRNA Translation: AAK69540.1
CH474093 Genomic DNA Translation: EDL84628.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000040232.7; ENSRNOP00000047788.5; ENSRNOG00000000774.9

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283276 mRNA Translation: AAK69540.1
CH474093 Genomic DNA Translation: EDL84628.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

Genome annotation databases

EnsembliENSRNOT00000040232.7; ENSRNOP00000047788.5; ENSRNOG00000000774.9

Organism-specific databases

RGDi621537, Gabbr1

Phylogenomic databases

GeneTreeiENSGT00940000157642
HOGENOMiCLU_005240_2_0_1
OMAiWAGGEAC

Gene expression databases

BgeeiENSRNOG00000000774, Expressed in brain and 22 other tissues

Family and domain databases

CDDicd15291, 7tmC_GABA-B-R1, 1 hit
cd00033, CCP, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR002455, GPCR3_GABA-B
IPR017978, GPCR_3_C
IPR002456, GPCR_3_GABA_rcpt_B1
IPR028082, Peripla_BP_I
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PANTHERiPTHR10519, PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF00084, Sushi, 1 hit
SMARTiView protein in SMART
SM00032, CCP, 2 hits
SUPFAMiSSF53822, SSF53822, 1 hit
SSF57535, SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit
PS50923, SUSHI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ924M0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q924M0
Secondary accession number(s): F7FE05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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