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Protein

LETM1 domain-containing protein 1

Gene

Letmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein 1
Alternative name(s):
Cervical cancer receptor
MCC-32
Gene namesi
Name:Letmd1
Synonyms:Mccr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915864 Letmd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 137CytoplasmicSequence analysisAdd BLAST137
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 360Mitochondrial intermembraneSequence analysisAdd BLAST202

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104201 – 360LETM1 domain-containing protein 1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ924L1
PeptideAtlasiQ924L1
PRIDEiQ924L1

PTM databases

iPTMnetiQ924L1
PhosphoSitePlusiQ924L1

Expressioni

Gene expression databases

BgeeiENSMUSG00000037353 Expressed in 268 organ(s), highest expression level in brown adipose tissue
CleanExiMM_LETMD1
GenevisibleiQ924L1 MM

Interactioni

Subunit structurei

Interacts with BRI3BP.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ924L1
SMRiQ924L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 360Letm1 RBDPROSITE-ProRule annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 110Required and sufficient for mitochondrial importBy similarityAdd BLAST110

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4263 Eukaryota
ENOG410ZXCM LUCA
GeneTreeiENSGT00390000018328
HOGENOMiHOG000037443
HOVERGENiHBG108107
InParanoidiQ924L1
OMAiVFRCLQA
OrthoDBiEOG091G0GD0
PhylomeDBiQ924L1
TreeFamiTF314047

Family and domain databases

InterProiView protein in InterPro
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF07766 LETM1, 1 hit
PROSITEiView protein in PROSITE
PS51758 LETM1_RBD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q924L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSRVCWAR AALWGSTVAP GPFVTRRLQL GRSGPAWRAP RSSKLHLSPK
60 70 80 90 100
ADVKNLISYV VTKTRAINGS YHRFLGRHFP RFYALYTTFM KGIQMLWADG
110 120 130 140 150
KKARRIKADM WKQNLKFHQL SYREMEHLRQ FRRDITKCLF VGLISIPPFA
160 170 180 190 200
NYLVFLLMYL FPRQLLVKHF WTPKQQIDFL DVYHGLRRRS HSEVITHLRR
210 220 230 240 250
ASTFVSHEKL RRQLTDLCTK VQSGTHPAAQ DVLALRDCFS TYPLGFSQLQ
260 270 280 290 300
ASQMRALSQA MLLTPYLPPP LLRQRLKSHT TVIHQLDRAL AKLGIGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIADD RCRAWLGEWL HISCSLKEPE LSLLLHNVVL
360
LSTNYLETRR
Length:360
Mass (Da):41,701
Last modified:December 1, 2001 - v1
Checksum:i4689BC4F3D2A0BBD
GO
Isoform 2 (identifier: Q924L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.

Show »
Length:271
Mass (Da):31,627
Checksum:i872AA941E4B7C146
GO
Isoform 3 (identifier: Q924L1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:203
Mass (Da):23,404
Checksum:iDD083332E4B059BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK53A0A2R8VK53_MOUSE
LETM1 domain-containing protein 1
Letmd1
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → T in BAE41093 (PubMed:16141072).Curated1
Sequence conflicti207H → Q in AAM90666 (Ref. 2) Curated1
Sequence conflicti316H → N in BAE32758 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292801 – 157Missing in isoform 3. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0292811 – 89Missing in isoform 2. 2 PublicationsAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287293 mRNA Translation: AAK83032.1
AF401483 mRNA Translation: AAM90666.1
AK045256 mRNA Translation: BAC32283.1
AK080221 mRNA Translation: BAC37851.1
AK154676 mRNA Translation: BAE32758.1
AK169341 mRNA Translation: BAE41093.1
BC021361 mRNA Translation: AAH21361.1
CCDSiCCDS27838.1 [Q924L1-1]
RefSeqiNP_598854.1, NM_134093.2 [Q924L1-1]
XP_006521384.1, XM_006521321.3
XP_006521385.1, XM_006521322.1 [Q924L1-3]
XP_006521386.1, XM_006521323.3
XP_017172228.1, XM_017316739.1 [Q924L1-3]
UniGeneiMm.275272

Genome annotation databases

EnsembliENSMUST00000037001; ENSMUSP00000037546; ENSMUSG00000037353 [Q924L1-1]
ENSMUST00000229648; ENSMUSP00000155084; ENSMUSG00000037353 [Q924L1-2]
ENSMUST00000230294; ENSMUSP00000155807; ENSMUSG00000037353 [Q924L1-3]
GeneIDi68614
KEGGimmu:68614
UCSCiuc007xrg.2 mouse [Q924L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287293 mRNA Translation: AAK83032.1
AF401483 mRNA Translation: AAM90666.1
AK045256 mRNA Translation: BAC32283.1
AK080221 mRNA Translation: BAC37851.1
AK154676 mRNA Translation: BAE32758.1
AK169341 mRNA Translation: BAE41093.1
BC021361 mRNA Translation: AAH21361.1
CCDSiCCDS27838.1 [Q924L1-1]
RefSeqiNP_598854.1, NM_134093.2 [Q924L1-1]
XP_006521384.1, XM_006521321.3
XP_006521385.1, XM_006521322.1 [Q924L1-3]
XP_006521386.1, XM_006521323.3
XP_017172228.1, XM_017316739.1 [Q924L1-3]
UniGeneiMm.275272

3D structure databases

ProteinModelPortaliQ924L1
SMRiQ924L1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ924L1
PhosphoSitePlusiQ924L1

Proteomic databases

PaxDbiQ924L1
PeptideAtlasiQ924L1
PRIDEiQ924L1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037001; ENSMUSP00000037546; ENSMUSG00000037353 [Q924L1-1]
ENSMUST00000229648; ENSMUSP00000155084; ENSMUSG00000037353 [Q924L1-2]
ENSMUST00000230294; ENSMUSP00000155807; ENSMUSG00000037353 [Q924L1-3]
GeneIDi68614
KEGGimmu:68614
UCSCiuc007xrg.2 mouse [Q924L1-1]

Organism-specific databases

CTDi25875
MGIiMGI:1915864 Letmd1

Phylogenomic databases

eggNOGiKOG4263 Eukaryota
ENOG410ZXCM LUCA
GeneTreeiENSGT00390000018328
HOGENOMiHOG000037443
HOVERGENiHBG108107
InParanoidiQ924L1
OMAiVFRCLQA
OrthoDBiEOG091G0GD0
PhylomeDBiQ924L1
TreeFamiTF314047

Miscellaneous databases

PROiPR:Q924L1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037353 Expressed in 268 organ(s), highest expression level in brown adipose tissue
CleanExiMM_LETMD1
GenevisibleiQ924L1 MM

Family and domain databases

InterProiView protein in InterPro
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF07766 LETM1, 1 hit
PROSITEiView protein in PROSITE
PS51758 LETM1_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTMD1_MOUSE
AccessioniPrimary (citable) accession number: Q924L1
Secondary accession number(s): Q3TF05
, Q3U3M7, Q8BLG9, Q8K1F7, Q8VDS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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