UniProtKB - Q924K8 (MTA3_MOUSE)
Metastasis-associated protein MTA3
Mta3
Functioni
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 377 – 404 | GATA-type; atypicalAdd BLAST | 28 |
GO - Molecular functioni
- chromatin binding Source: InterPro
- histone deacetylase binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- protein-containing complex binding Source: MGI
- sequence-specific DNA binding Source: InterPro
- transcription coactivator activity Source: GO_Central
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- chromatin remodeling Source: MGI
- histone deacetylation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of cell population proliferation Source: MGI
- positive regulation of G2/M transition of mitotic cell cycle Source: MGI
- positive regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of cell fate specification Source: ComplexPortal
- regulation of stem cell differentiation Source: ComplexPortal
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3214815, HDACs deacetylate histones R-MMU-73762, RNA Polymerase I Transcription Initiation R-MMU-8943724, Regulation of PTEN gene transcription |
Names & Taxonomyi
Protein namesi | Recommended name: Metastasis-associated protein MTA3 |
Gene namesi | Name:Mta3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2151172, Mta3 |
VEuPathDBi | HostDB:ENSMUSG00000055817 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- NuRD complex Source: MGI
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083499 | 1 – 591 | Metastasis-associated protein MTA3Add BLAST | 591 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 425 | PhosphoserineCombined sources | 1 | |
Modified residuei | 427 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 516 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q924K8 |
jPOSTi | Q924K8 |
MaxQBi | Q924K8 |
PaxDbi | Q924K8 |
PeptideAtlasi | Q924K8 |
PRIDEi | Q924K8 |
ProteomicsDBi | 290067 [Q924K8-1] 290068 [Q924K8-2] |
PTM databases
iPTMneti | Q924K8 |
PhosphoSitePlusi | Q924K8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000055817, Expressed in placenta labyrinth and 301 other tissues |
ExpressionAtlasi | Q924K8, baseline and differential |
Genevisiblei | Q924K8, MM |
Interactioni
Subunit structurei
Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD).
Interacts with BCL6 (By similarity).
Interacts with NACC2 (By similarity).
Interacts with PWWP2B (PubMed:34180153).
By similarity1 PublicationGO - Molecular functioni
- histone deacetylase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 228046, 15 interactors |
ComplexPortali | CPX-953, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-954, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q924K8 |
DIPi | DIP-61664N |
IntActi | Q924K8, 4 interactors |
STRINGi | 10090.ENSMUSP00000068931 |
Miscellaneous databases
RNActi | Q924K8, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q924K8 |
SMRi | Q924K8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q924K8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 147 | BAHPROSITE-ProRule annotationAdd BLAST | 147 | |
Domaini | 148 – 258 | ELM2PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 265 – 317 | SANTPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 417 – 456 | DisorderedSequence analysisAdd BLAST | 40 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 377 – 404 | GATA-type; atypicalAdd BLAST | 28 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
InParanoidi | Q924K8 |
OMAi | GPAHMQC |
OrthoDBi | 802091at2759 |
PhylomeDBi | Q924K8 |
TreeFami | TF106444 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD
60 70 80 90 100
ISNTLIMLAD KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL
110 120 130 140 150
PATHIRGKCS VALLNETESV LSYLDKEDTF FYSLVYDPSV KTLLADKGEI
160 170 180 190 200
RVGPKYQADI PDMLPEDSDE REQSKLEVKV WDPNSPLTDR QIDQFLVVAR
210 220 230 240 250
AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL YRHGYDLSSA
260 270 280 290 300
ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK
310 320 330 340 350
SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS
360 370 380 390 400
SNGKAGTVNG AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL
410 420 430 440 450
CATCWLYWKK YGGLKMPTQS DEEKSPSPTA EDPRARSHMS RQALQGMPVR
460 470 480 490 500
NTGSPKSAVK TRQAFFLRTT YFTKIARQVC KSTLRLRQAA RRPFVAINYA
510 520 530 540 550
AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK KPNVIRSPPS
560 570 580 590
LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q794 | E9Q794_MOUSE | Metastasis-associated protein MTA3 | Mta3 | 514 | Annotation score: | ||
Q3UII8 | Q3UII8_MOUSE | Metastasis-associated protein MTA3 | Mta3 | 586 | Annotation score: | ||
Q3U3A7 | Q3U3A7_MOUSE | Metastasis-associated protein MTA3 | Mta3 | 513 | Annotation score: | ||
H3BIY7 | H3BIY7_MOUSE | Metastasis-associated protein MTA3 | Mta3 | 251 | Annotation score: | ||
H3BLE1 | H3BLE1_MOUSE | Metastasis-associated protein MTA3 | Mta3 | 271 | Annotation score: | ||
H3BJP3 | H3BJP3_MOUSE | Metastasis-associated protein MTA3 | Mta3 | 40 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 166 | E → EG in AAH22124 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001605 | 506 – 512 | YADRHAE → CKTLFNS in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_001606 | 513 – 591 | Missing in isoform 2. 1 PublicationAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF288138 mRNA Translation: AAK83045.1 BC022124 mRNA Translation: AAH22124.1 |
CCDSi | CCDS28997.1 [Q924K8-1] |
RefSeqi | NP_001164525.1, NM_001171054.1 NP_473423.1, NM_054082.2 [Q924K8-1] |
Genome annotation databases
Ensembli | ENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817 [Q924K8-1] |
GeneIDi | 116871 |
KEGGi | mmu:116871 |
UCSCi | uc012axw.1, mouse [Q924K8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF288138 mRNA Translation: AAK83045.1 BC022124 mRNA Translation: AAH22124.1 |
CCDSi | CCDS28997.1 [Q924K8-1] |
RefSeqi | NP_001164525.1, NM_001171054.1 NP_473423.1, NM_054082.2 [Q924K8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CRG | NMR | - | A | 267-323 | [»] | |
AlphaFoldDBi | Q924K8 | |||||
SMRi | Q924K8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 228046, 15 interactors |
ComplexPortali | CPX-953, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-954, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q924K8 |
DIPi | DIP-61664N |
IntActi | Q924K8, 4 interactors |
STRINGi | 10090.ENSMUSP00000068931 |
PTM databases
iPTMneti | Q924K8 |
PhosphoSitePlusi | Q924K8 |
Proteomic databases
EPDi | Q924K8 |
jPOSTi | Q924K8 |
MaxQBi | Q924K8 |
PaxDbi | Q924K8 |
PeptideAtlasi | Q924K8 |
PRIDEi | Q924K8 |
ProteomicsDBi | 290067 [Q924K8-1] 290068 [Q924K8-2] |
Protocols and materials databases
Antibodypediai | 29760, 270 antibodies from 28 providers |
DNASUi | 116871 |
Genome annotation databases
Ensembli | ENSMUST00000067826; ENSMUSP00000068931; ENSMUSG00000055817 [Q924K8-1] |
GeneIDi | 116871 |
KEGGi | mmu:116871 |
UCSCi | uc012axw.1, mouse [Q924K8-1] |
Organism-specific databases
CTDi | 57504 |
MGIi | MGI:2151172, Mta3 |
VEuPathDBi | HostDB:ENSMUSG00000055817 |
Phylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
InParanoidi | Q924K8 |
OMAi | GPAHMQC |
OrthoDBi | 802091at2759 |
PhylomeDBi | Q924K8 |
TreeFami | TF106444 |
Enzyme and pathway databases
Reactomei | R-MMU-3214815, HDACs deacetylate histones R-MMU-73762, RNA Polymerase I Transcription Initiation R-MMU-8943724, Regulation of PTEN gene transcription |
Miscellaneous databases
BioGRID-ORCSi | 116871, 4 hits in 78 CRISPR screens |
ChiTaRSi | Mta3, mouse |
EvolutionaryTracei | Q924K8 |
PROi | PR:Q924K8 |
RNActi | Q924K8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055817, Expressed in placenta labyrinth and 301 other tissues |
ExpressionAtlasi | Q924K8, baseline and differential |
Genevisiblei | Q924K8, MM |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTA3_MOUSE | |
Accessioni | Q924K8Primary (citable) accession number: Q924K8 Secondary accession number(s): Q8VC18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references