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Protein

FAS-associated factor 1

Gene

Faf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 1
Gene namesi
Name:Faf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70987 Faf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110401 – 649FAS-associated factor 1Add BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1
Modified residuei579PhosphothreonineBy similarity1
Modified residuei581PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ924K2
PRIDEiQ924K2

PTM databases

iPTMnetiQ924K2
PhosphoSitePlusiQ924K2

Expressioni

Tissue specificityi

Central nervous system.

Interactioni

Subunit structurei

Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250821, 2 interactors
STRINGi10116.ENSRNOP00000011765

Structurei

3D structure databases

ProteinModelPortaliQ924K2
SMRiQ924K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57UBABy similarityAdd BLAST57
Domaini568 – 645UBXPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG1363 Eukaryota
ENOG410XSFS LUCA
HOGENOMiHOG000043073
HOVERGENiHBG002876
InParanoidiQ924K2
KOiK20703
PhylomeDBiQ924K2

Family and domain databases

CDDicd01771 Faf1_UBX, 1 hit
InterProiView protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q924K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG
60 70 80 90 100
ILQSDFGGET MPGPTFDPAS PPAPAPAPSS SAFRPVMPSR QIVERQPRML
110 120 130 140 150
DFRVEYRDRN VDVVLEDSCT VGEIKQILEN ELQIPVPKML LKGWKTGDVE
160 170 180 190 200
DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS HAGALQESLN QNFMLIITHR
210 220 230 240 250
EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP ASATDDSMCL
260 270 280 290 300
AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STVVHMVSDS DGDDFEDASE
310 320 330 340 350
FGVVDGEVFG MASSTMRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV
360 370 380 390 400
FFIGSLEAAF QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV
410 420 430 440 450
SYLSQNFITW AWDLTKDANR ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF
460 470 480 490 500
LIIMGKRSSN EVLNVIQGNT TVDELMMRLM AAMEIFSAQQ QEDIKDEDER
510 520 530 540 550
EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ IRKEQEEERE
560 570 580 590 600
AIRLSLEQAL PPEPEEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD
610 620 630 640
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLLAKE
Length:649
Mass (Da):73,745
Last modified:December 1, 2001 - v1
Checksum:iC4A8086E687F0A3C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LSQ0F1LSQ0_RAT
FAS-associated factor 1
Faf1
613Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293459 mRNA Translation: AAK94676.1
RefSeqiNP_569090.1, NM_130406.1
UniGeneiRn.198288

Genome annotation databases

GeneIDi140657
KEGGirno:140657
UCSCiRGD:70987 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293459 mRNA Translation: AAK94676.1
RefSeqiNP_569090.1, NM_130406.1
UniGeneiRn.198288

3D structure databases

ProteinModelPortaliQ924K2
SMRiQ924K2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250821, 2 interactors
STRINGi10116.ENSRNOP00000011765

PTM databases

iPTMnetiQ924K2
PhosphoSitePlusiQ924K2

Proteomic databases

PaxDbiQ924K2
PRIDEiQ924K2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140657
KEGGirno:140657
UCSCiRGD:70987 rat

Organism-specific databases

CTDi11124
RGDi70987 Faf1

Phylogenomic databases

eggNOGiKOG1363 Eukaryota
ENOG410XSFS LUCA
HOGENOMiHOG000043073
HOVERGENiHBG002876
InParanoidiQ924K2
KOiK20703
PhylomeDBiQ924K2

Miscellaneous databases

PROiPR:Q924K2

Family and domain databases

CDDicd01771 Faf1_UBX, 1 hit
InterProiView protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAF1_RAT
AccessioniPrimary (citable) accession number: Q924K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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