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Entry version 131 (29 Sep 2021)
Sequence version 2 (31 Oct 2006)
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Protein

WW domain-containing adapter protein with coiled-coil

Gene

Wac

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WW domain-containing adapter protein with coiled-coil
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Wac
Synonyms:Kiaa1844
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2387357, Wac

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000024283

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002545591 – 646WW domain-containing adapter protein with coiled-coilAdd BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphoserineBy similarity1
Modified residuei131PhosphoserineBy similarity1
Modified residuei142PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei293PhosphothreonineBy similarity1
Modified residuei302N6-acetyllysineBy similarity1
Modified residuei446PhosphoserineBy similarity1
Modified residuei471PhosphothreonineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei525PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q924H7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q924H7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q924H7

PeptideAtlas

More...
PeptideAtlasi
Q924H7

PRoteomics IDEntifications database

More...
PRIDEi
Q924H7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275196 [Q924H7-1]
275197 [Q924H7-2]
275198 [Q924H7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q924H7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q924H7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024283, Expressed in undifferentiated genital tubercle and 307 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q924H7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q924H7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A.

Interacts (via WW domain) with RNA polymerase II.

Interacts with MTOR and other components of the MTOR pathway including RPTOR, RUVBL1, RUVBL2, TTI1 and TTI2.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230359, 2 interactors

Molecular INTeraction database

More...
MINTi
Q924H7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000132117

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q924H7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q924H7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 162WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 138DisorderedSequence analysisAdd BLAST138
Regioni158 – 352DisorderedSequence analysisAdd BLAST195
Regioni428 – 541DisorderedSequence analysisAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili617 – 643Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 51Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi57 – 79Polar residuesSequence analysisAdd BLAST23
Compositional biasi90 – 129Polar residuesSequence analysisAdd BLAST40
Compositional biasi158 – 191Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi194 – 225Polar residuesSequence analysisAdd BLAST32
Compositional biasi258 – 302Polar residuesSequence analysisAdd BLAST45
Compositional biasi313 – 347Polar residuesSequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0152, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037780

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024845_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q924H7

Identification of Orthologs from Complete Genome Data

More...
OMAi
XTSYSPQ

Database of Orthologous Groups

More...
OrthoDBi
1111788at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q924H7

TreeFam database of animal gene trees

More...
TreeFami
TF328635

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201, WW, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038867, WAC
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR15911, PTHR15911, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q924H7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVMYARKQQR LSDGCHDRRG DSQPFQALKY SSKSHPSSGD HRHEKMRDAA
60 70 80 90 100
DPSPPNKMLR RSNSPENKYS DSTGHNKAKN VHTQRVRERD GGTSYSPQEN
110 120 130 140 150
SHNHSALHSS NSHSSNPSNN PSKTSDAPYD SADDWSEHIS SSGKKYYYNC
160 170 180 190 200
RTEVSQWEKP KEWLEREQRQ KEANKLAVNS FPKDRDYRRE VMQATATSGF
210 220 230 240 250
TSGMEDKHSS DASSLLPQNI LSQTSRHNDK DYRLPRAETH SSSTPVQHPI
260 270 280 290 300
KPVVHPTATP STVPSSPFTL QSDHQPKKSF DANGASTLSK LPTPTASLPA
310 320 330 340 350
QKTERKESAP GDKSISHSCT TPSTSSASGL NPTSAPPTSA SAVPVSPVPQ
360 370 380 390 400
STIPPLLQDP NLFRQLLPAL QATLQLNNSN VDISKINEVL TAAVTQASLQ
410 420 430 440 450
SIIHKFLTAG PSAFNITSLI SQAAQLSTQA QPSNQSPMSL TSDASSPRSY
460 470 480 490 500
VSPRISTPQT NTVPMKPLIS TPPVSSQPKV STPVVKQGPV SHSATQQPVT
510 520 530 540 550
ADKQQSHDPV SPRSLQRLSS QRSPSPGPNH TCSSNASTAT VVPQNASARP
560 570 580 590 600
ACSLTPTLAA HFNDNLIKHV QGWPADHAEK QASRLREEAH NMGSVHMSEI
610 620 630 640
CTELKNLRSL VRVCEIQATL REQRILFLRQ QIKELEKLKN QNSFMV
Length:646
Mass (Da):70,680
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62914680DB435756
GO
Isoform 2 (identifier: Q924H7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Show »
Length:601
Mass (Da):65,455
Checksum:iAED0D65F2725EC90
GO
Isoform 3 (identifier: Q924H7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-307: MEDKHSSDAS...LPAQKTERKE → K

Show »
Length:543
Mass (Da):59,491
Checksum:iF89BC56D164A0923
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PVK9E9PVK9_MOUSE
WW domain-containing adapter protei...
Wac
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PXS5E9PXS5_MOUSE
WW domain-containing adapter protei...
Wac
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q020E9Q020_MOUSE
WW domain-containing adapter protei...
Wac
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q4Y9E9Q4Y9_MOUSE
WW domain-containing adapter protei...
Wac
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PZH6E9PZH6_MOUSE
WW domain-containing adapter protei...
Wac
339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5D5E9Q5D5_MOUSE
WW domain-containing adapter protei...
Wac
597Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Z247F6Z247_MOUSE
WW domain-containing adapter protei...
Wac
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7A7S5F7A7S5_MOUSE
WW domain-containing adapter protei...
Wac
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CLA8F7CLA8_MOUSE
WW domain-containing adapter protei...
Wac
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q6U6E9Q6U6_MOUSE
WW domain-containing adapter protei...
Wac
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32552 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti265S → F in BAC40017 (PubMed:16141072).Curated1
Sequence conflicti334S → P in AAK73808 (PubMed:11827461).Curated1
Sequence conflicti509P → S in AAH80851 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0212371 – 45Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_021238204 – 307MEDKH…TERKE → K in isoform 3. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF320996 mRNA Translation: AAK73808.1
AK173274 mRNA Translation: BAD32552.1 Different initiation.
AK044675 mRNA Translation: BAC32029.1
AK087826 mRNA Translation: BAC40017.1
AK156780 mRNA Translation: BAE33852.1
BC080851 mRNA Translation: AAH80851.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29046.1 [Q924H7-1]
CCDS50218.1 [Q924H7-3]
CCDS70869.1 [Q924H7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001139770.1, NM_001146298.2 [Q924H7-3]
NP_001269022.1, NM_001282093.1 [Q924H7-2]
NP_694725.3, NM_153085.4 [Q924H7-1]
XP_006525868.1, XM_006525805.2
XP_011245190.1, XM_011246888.2 [Q924H7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000074919; ENSMUSP00000074454; ENSMUSG00000024283 [Q924H7-2]
ENSMUST00000092112; ENSMUSP00000089746; ENSMUSG00000024283 [Q924H7-3]
ENSMUST00000167020; ENSMUSP00000132117; ENSMUSG00000024283 [Q924H7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
225131

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:225131

UCSC genome browser

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UCSCi
uc008eab.3, mouse [Q924H7-1]
uc008eae.3, mouse [Q924H7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320996 mRNA Translation: AAK73808.1
AK173274 mRNA Translation: BAD32552.1 Different initiation.
AK044675 mRNA Translation: BAC32029.1
AK087826 mRNA Translation: BAC40017.1
AK156780 mRNA Translation: BAE33852.1
BC080851 mRNA Translation: AAH80851.1
CCDSiCCDS29046.1 [Q924H7-1]
CCDS50218.1 [Q924H7-3]
CCDS70869.1 [Q924H7-2]
RefSeqiNP_001139770.1, NM_001146298.2 [Q924H7-3]
NP_001269022.1, NM_001282093.1 [Q924H7-2]
NP_694725.3, NM_153085.4 [Q924H7-1]
XP_006525868.1, XM_006525805.2
XP_011245190.1, XM_011246888.2 [Q924H7-2]

3D structure databases

SMRiQ924H7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230359, 2 interactors
MINTiQ924H7
STRINGi10090.ENSMUSP00000132117

PTM databases

iPTMnetiQ924H7
PhosphoSitePlusiQ924H7

Proteomic databases

EPDiQ924H7
jPOSTiQ924H7
PaxDbiQ924H7
PeptideAtlasiQ924H7
PRIDEiQ924H7
ProteomicsDBi275196 [Q924H7-1]
275197 [Q924H7-2]
275198 [Q924H7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
50013, 129 antibodies

The DNASU plasmid repository

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DNASUi
225131

Genome annotation databases

EnsembliENSMUST00000074919; ENSMUSP00000074454; ENSMUSG00000024283 [Q924H7-2]
ENSMUST00000092112; ENSMUSP00000089746; ENSMUSG00000024283 [Q924H7-3]
ENSMUST00000167020; ENSMUSP00000132117; ENSMUSG00000024283 [Q924H7-1]
GeneIDi225131
KEGGimmu:225131
UCSCiuc008eab.3, mouse [Q924H7-1]
uc008eae.3, mouse [Q924H7-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51322
MGIiMGI:2387357, Wac
VEuPathDBiHostDB:ENSMUSG00000024283

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0152, Eukaryota
GeneTreeiENSGT00440000037780
HOGENOMiCLU_024845_2_1_1
InParanoidiQ924H7
OMAiXTSYSPQ
OrthoDBi1111788at2759
PhylomeDBiQ924H7
TreeFamiTF328635

Enzyme and pathway databases

ReactomeiR-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
225131, 21 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Wac, mouse

Protein Ontology

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PROi
PR:Q924H7
RNActiQ924H7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024283, Expressed in undifferentiated genital tubercle and 307 other tissues
ExpressionAtlasiQ924H7, baseline and differential
GenevisibleiQ924H7, MM

Family and domain databases

CDDicd00201, WW, 1 hit
InterProiView protein in InterPro
IPR038867, WAC
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR15911, PTHR15911, 1 hit
PfamiView protein in Pfam
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00456, WW, 1 hit
SUPFAMiSSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWAC_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q924H7
Secondary accession number(s): Q3U0K1
, Q66JM9, Q69Z92, Q8C2W2, Q8C8Q8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 29, 2021
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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