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Entry version 125 (13 Nov 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Chloride anion exchanger

Gene

Slc26a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Transport
LigandChloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-427601 Multifunctional anion exchangers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride anion exchanger
Alternative name(s):
Down-regulated in adenoma
Short name:
Protein DRA
Solute carrier family 26 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc26a3
Synonyms:Dra
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Rat genome database

More...
RGDi
620623 Slc26a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 71CytoplasmicCuratedAdd BLAST71
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93ExtracellularCurated1
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 124CytoplasmicCurated10
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 176ExtracellularCuratedAdd BLAST31
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 201CytoplasmicCurated4
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 250ExtracellularCuratedAdd BLAST28
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 278CytoplasmicCurated7
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 335ExtracellularCuratedAdd BLAST36
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Topological domaini357 – 367CytoplasmicCuratedAdd BLAST11
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 404ExtracellularCuratedAdd BLAST16
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 462CytoplasmicCuratedAdd BLAST37
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21
Topological domaini484 – 757ExtracellularCuratedAdd BLAST274

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000801631 – 757Chloride anion exchangerAdd BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q924C9

PRoteomics IDEntifications database

More...
PRIDEi
Q924C9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q924C9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q924C9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000006878 Expressed in 7 organ(s), highest expression level in colon

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q924C9 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDZK1, CFTR, SLC26A6 and SLC9A3R1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009473

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini518 – 713STASPROSITE-ProRule annotationAdd BLAST196

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236 Eukaryota
COG0659 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006546

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q924C9

KEGG Orthology (KO)

More...
KOi
K14078

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLMQFTE

Database of Orthologous Groups

More...
OrthoDBi
690428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q924C9

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030321 SLC26A3
IPR002645 STAS_dom
IPR036513 STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814 PTHR11814, 1 hit
PTHR11814:SF19 PTHR11814:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091 SSF52091, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00815 sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q924C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEAIGNQYV VARPVYSTKA FGEEFKKTYG HHKTFLDHLK GCCSCSSQKA
60 70 80 90 100
KKIALSLFPI ASWLPAYKIK EWLLSDIVSG ISTGLVAVLQ GLAFALLVNI
110 120 130 140 150
PPAYGLYAAF FPVITYFFLG TSRHISVGPF PVLSMMVGVV VTRVASGSDT
160 170 180 190 200
SPALSSSSAE NDSMIEEKVM VAASVTVLSG IIQLLLGVLQ IGFVVIYLSE
210 220 230 240 250
SLISGFTTAA AIHVLVSQLK FMLQLTVPAH SDPFSIFKVL ESVFSQIQKT
260 270 280 290 300
NIADLVTSVI ILVVVFVVKE INQRYRSKLP VPIPIELIMT VIATGISYGC
310 320 330 340 350
NFEQRFGVAV VGNMSLGFQP PITPSVEVFQ DTIGDCFGIA IVGFAVAFSV
360 370 380 390 400
ASVYSLKYDY PIDGNQELIA LGVSNIFTGA FKGFAGSTAL SRSGVQESTG
410 420 430 440 450
GKTQVAGLLS AVIVLIVIVA IGFLLQPLQK SVLAALALGN LKGMLMQFAE
460 470 480 490 500
IGRLWKKDKY DCLIWIMTFI FAIVLGLGLG LAASVAFQLL TIVFRTQFPK
510 520 530 540 550
CSTLANVGRS NIYKNKKNYA DVYEPEGVKI FRCPSPIYFA NIGFFKQKLI
560 570 580 590 600
DAVGFNPLRI LRKRNKALKK IRKLQKQGLI QVTPKGFICT SDGFKDSDEE
610 620 630 640 650
LDNNQIEELD QPINTTDLPF EIDWNADLPL NITIPKISLH SLILDFSAVS
660 670 680 690 700
FLDISSMRGL RTILQEFIRI KVDVYIVGTD DDFIDKLARC EFFDDEVTDS
710 720 730 740 750
IFFLTIHDAI LHIWMKKDYS TSKFNSSQEK ERKFDFTINT NGGLRNRECQ

VPVETKF
Length:757
Mass (Da):83,369
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i195D867306ED8ECF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF337809 mRNA Translation: AAK83221.1

NCBI Reference Sequences

More...
RefSeqi
NP_446207.1, NM_053755.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000009473; ENSRNOP00000009473; ENSRNOG00000006878

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:114629

UCSC genome browser

More...
UCSCi
RGD:620623 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337809 mRNA Translation: AAK83221.1
RefSeqiNP_446207.1, NM_053755.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009473

PTM databases

iPTMnetiQ924C9
PhosphoSitePlusiQ924C9

Proteomic databases

PaxDbiQ924C9
PRIDEiQ924C9

Genome annotation databases

EnsembliENSRNOT00000009473; ENSRNOP00000009473; ENSRNOG00000006878
GeneIDi114629
KEGGirno:114629
UCSCiRGD:620623 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1811
RGDi620623 Slc26a3

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
GeneTreeiENSGT00950000182695
HOGENOMiHOG000006546
InParanoidiQ924C9
KOiK14078
OMAiMLMQFTE
OrthoDBi690428at2759
PhylomeDBiQ924C9
TreeFamiTF313784

Enzyme and pathway databases

ReactomeiR-RNO-427601 Multifunctional anion exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q924C9

Gene expression databases

BgeeiENSRNOG00000006878 Expressed in 7 organ(s), highest expression level in colon
GenevisibleiQ924C9 RN

Family and domain databases

InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030321 SLC26A3
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF19 PTHR11814:SF19, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q924C9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: November 13, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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