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Protein

Urocortin-3

Gene

Ucn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-3
Alternative name(s):
Urocortin III
Short name:
Ucn III
Gene namesi
Name:Ucn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1932970 Ucn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000624724 – 121Add BLAST98
ChainiPRO_0000006248123 – 160Urocortin-3Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160Isoleucine amideSequence analysis1

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiQ924A4
PRIDEiQ924A4

PTM databases

PhosphoSitePlusiQ924A4

Expressioni

Tissue specificityi

Expressed in some areas of the brain including the hypothalamus, amygdala, and brainstem, but is not evident in the cerebellum, pituitary, or cerebral cortex; it is also expressed peripherally in small intestine and skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000044988 Expressed in 10 organ(s), highest expression level in islet of Langerhans
CleanExiMM_UCN3
ExpressionAtlasiQ924A4 baseline and differential
GenevisibleiQ924A4 MM

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219919, 2 interactors
STRINGi10090.ENSMUSP00000049678

Structurei

3D structure databases

ProteinModelPortaliQ924A4
SMRiQ924A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ00 Eukaryota
ENOG410YJR9 LUCA
GeneTreeiENSGT00390000001251
HOGENOMiHOG000230495
HOVERGENiHBG036243
InParanoidiQ924A4
KOiK05257
OMAiKFYKAKP
OrthoDBiEOG091G10Y0
PhylomeDBiQ924A4
TreeFamiTF330723

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q924A4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMPTYFLLP LLLLLGGPRT SLSHKFYNTG PVFSCLNTAL SEVKKNKLED
60 70 80 90 100
VPLLSKKSFG HLPTQDPSGE EDDNQTHLQI KRTFSGAAGG NGAGSTRYRY
110 120 130 140 150
QSQAQHKGKL YPDKPKSDRG TKFTLSLDVP TNIMNILFNI DKAKNLRAKA
160
AANAQLMAQI GKKK
Length:164
Mass (Da):18,063
Last modified:December 1, 2001 - v1
Checksum:i93A77CB93DA56E5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361944 Genomic DNA Translation: AAK67318.1
CCDSiCCDS26217.1
RefSeqiNP_112540.2, NM_031250.5
UniGeneiMm.313662

Genome annotation databases

EnsembliENSMUST00000058610; ENSMUSP00000049678; ENSMUSG00000044988
GeneIDi83428
KEGGimmu:83428
UCSCiuc007pjh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361944 Genomic DNA Translation: AAK67318.1
CCDSiCCDS26217.1
RefSeqiNP_112540.2, NM_031250.5
UniGeneiMm.313662

3D structure databases

ProteinModelPortaliQ924A4
SMRiQ924A4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219919, 2 interactors
STRINGi10090.ENSMUSP00000049678

PTM databases

PhosphoSitePlusiQ924A4

Proteomic databases

PaxDbiQ924A4
PRIDEiQ924A4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058610; ENSMUSP00000049678; ENSMUSG00000044988
GeneIDi83428
KEGGimmu:83428
UCSCiuc007pjh.2 mouse

Organism-specific databases

CTDi114131
MGIiMGI:1932970 Ucn3

Phylogenomic databases

eggNOGiENOG410IZ00 Eukaryota
ENOG410YJR9 LUCA
GeneTreeiENSGT00390000001251
HOGENOMiHOG000230495
HOVERGENiHBG036243
InParanoidiQ924A4
KOiK05257
OMAiKFYKAKP
OrthoDBiEOG091G10Y0
PhylomeDBiQ924A4
TreeFamiTF330723

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

PROiPR:Q924A4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044988 Expressed in 10 organ(s), highest expression level in islet of Langerhans
CleanExiMM_UCN3
ExpressionAtlasiQ924A4 baseline and differential
GenevisibleiQ924A4 MM

Family and domain databases

InterProiView protein in InterPro
IPR000187 CRF
IPR024270 Urocortin_II/III
PANTHERiPTHR17575 PTHR17575, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUCN3_MOUSE
AccessioniPrimary (citable) accession number: Q924A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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