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Entry version 151 (02 Jun 2021)
Sequence version 2 (12 Jun 2007)
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Protein

Protein capicua homolog

Gene

Cic

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor which plays a role in development of the central nervous system (CNS) (PubMed:17190598).

In concert with ATXN1 and ATXN1L, involved in brain development (PubMed:28288114).

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1107 – 1175HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein capicua homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cic
Synonyms:Kiaa0306
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918972, Cic

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice with conditional knockouts of either ATXN1-ATXN1L or CIC in the developing forebrain exhibit intellectual disability, hyperactivity, social-behavioral deficits and reduced thickness of upper cortical layers.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485991 – 2510Protein capicua homologAdd BLAST2510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei774PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei1053PhosphoserineCombined sources1
Modified residuei1080PhosphoserineBy similarity1
Modified residuei1097Omega-N-methylarginineCombined sources1
Modified residuei1184PhosphoserineBy similarity1
Modified residuei1269PhosphoserineBy similarity1
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1343PhosphoserineCombined sources1
Modified residuei1403PhosphoserineCombined sources1
Modified residuei1604PhosphoserineBy similarity1
Modified residuei1625PhosphoserineCombined sources1
Modified residuei1644PhosphoserineBy similarity1
Modified residuei1768Asymmetric dimethylarginineBy similarity1
Modified residuei1839Omega-N-methylarginineCombined sources1
Modified residuei2169N6-acetyllysineCombined sources1
Modified residuei2192PhosphothreonineCombined sources1
Modified residuei2195PhosphoserineBy similarity1
Modified residuei2253PhosphoserineBy similarity1
Modified residuei2275PhosphoserineCombined sources1
Modified residuei2280PhosphoserineBy similarity1
Modified residuei2284PhosphoserineCombined sources1
Modified residuei2291PhosphoserineBy similarity1
Modified residuei2299PhosphoserineCombined sources1
Modified residuei2300PhosphothreonineBy similarity1
Modified residuei2304PhosphoserineCombined sources1
Modified residuei2311PhosphoserineCombined sources1
Modified residuei2497PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q924A2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q924A2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q924A2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q924A2

PeptideAtlas

More...
PeptideAtlasi
Q924A2

PRoteomics IDEntifications database

More...
PRIDEi
Q924A2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
283918 [Q924A2-4]
283919 [Q924A2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q924A2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q924A2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cortex and hypothalamus (at protein level). Isoform 1: Present in cerebellum (at protein level) (PubMed:17190598). Isoform 2: Present in cerebellum (at protein level) (PubMed:17190598).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed postnatally in the hippocampus, neocortex, olfactory bulb and cerebellum. Expressed in the hippocampus from P0 to P15. Expressed in the posterior region of the neocortex at P4, the anterior region at P9, and is then lost by P15. Expressed in the cerebellum from P0, specifically within the external granule layer (EGL) which contains granule cell precursors. By P7 expression is distributed throughout the EGL and is reduced in the inner granule cell layer (IGL) where granule cells finally differentiate. Expression in the IGL continues to diminish up to P15, when granule cell neurogenesis is complete.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005442, Expressed in adult mammalian kidney and 320 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q924A2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1:

Interacts with ATXN1 (PubMed:17190598). Isoform 2:

Interacts with ATXN1 (PubMed:17190598).

Interacts with ATXN1L (PubMed:17322884).

Found in a complex with ATXN1 and ATXN1L (PubMed:28288114).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
214881, 3 interactors

Database of interacting proteins

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DIPi
DIP-60650N

Protein interaction database and analysis system

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IntActi
Q924A2, 4 interactors

Molecular INTeraction database

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MINTi
Q924A2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000126659

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q924A2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q924A2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q924A2

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 195DisorderedSequence analysisAdd BLAST195
Regioni299 – 322DisorderedSequence analysisAdd BLAST24
Regioni343 – 479DisorderedSequence analysisAdd BLAST137
Regioni529 – 577DisorderedSequence analysisAdd BLAST49
Regioni606 – 638DisorderedSequence analysisAdd BLAST33
Regioni656 – 692DisorderedSequence analysisAdd BLAST37
Regioni710 – 765DisorderedSequence analysisAdd BLAST56
Regioni810 – 861DisorderedSequence analysisAdd BLAST52
Regioni935 – 953Interaction with ATXN11 PublicationAdd BLAST19
Regioni953 – 1108DisorderedSequence analysisAdd BLAST156
Regioni1180 – 1217DisorderedSequence analysisAdd BLAST38
Regioni1233 – 1272DisorderedSequence analysisAdd BLAST40
Regioni1288 – 1348DisorderedSequence analysisAdd BLAST61
Regioni1376 – 1536DisorderedSequence analysisAdd BLAST161
Regioni1691 – 1712DisorderedSequence analysisAdd BLAST22
Regioni1744 – 1773DisorderedSequence analysisAdd BLAST30
Regioni1797 – 1819DisorderedSequence analysisAdd BLAST23
Regioni2032 – 2057DisorderedSequence analysisAdd BLAST26
Regioni2092 – 2248DisorderedSequence analysisAdd BLAST157
Regioni2262 – 2336DisorderedSequence analysisAdd BLAST75
Regioni2423 – 2510DisorderedSequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi40 – 67Acidic residuesSequence analysisAdd BLAST28
Compositional biasi153 – 167Polar residuesSequence analysisAdd BLAST15
Compositional biasi408 – 430Pro residuesSequence analysisAdd BLAST23
Compositional biasi439 – 457Polar residuesSequence analysisAdd BLAST19
Compositional biasi606 – 621Polar residuesSequence analysisAdd BLAST16
Compositional biasi673 – 688Pro residuesSequence analysisAdd BLAST16
Compositional biasi744 – 760Polar residuesSequence analysisAdd BLAST17
Compositional biasi957 – 982Polar residuesSequence analysisAdd BLAST26
Compositional biasi1006 – 1020Pro residuesSequence analysisAdd BLAST15
Compositional biasi1041 – 1059Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1081 – 1108Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1376 – 1396Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1417 – 1432Pro residuesSequence analysisAdd BLAST16
Compositional biasi1435 – 1473Polar residuesSequence analysisAdd BLAST39
Compositional biasi1759 – 1773Polar residuesSequence analysisAdd BLAST15
Compositional biasi2092 – 2112Polar residuesSequence analysisAdd BLAST21
Compositional biasi2125 – 2158Pro residuesSequence analysisAdd BLAST34
Compositional biasi2201 – 2216Polar residuesSequence analysisAdd BLAST16
Compositional biasi2218 – 2232Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2294 – 2321Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi2431 – 2460Pro residuesSequence analysisAdd BLAST30
Compositional biasi2473 – 2503Pro residuesSequence analysisAdd BLAST31

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2746, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159960

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000921_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q924A2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKKACAG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q924A2

TreeFam database of animal gene trees

More...
TreeFami
TF323412

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032147, DUF4819
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16090, DUF4819, 1 hit
PF00505, HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095, SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q924A2-4) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPMKKACPG LAGSASGSKS PPATRAKALR RRGAGEGDKP EEEEEAQPQE
60 70 80 90 100
QAGPEEAEEG EEEEAERDPG AEGTHPELQP NDPTPGLTED PKGDGEAGRW
110 120 130 140 150
EPSLSRKTAT FKSRAPKKKY VEEHGTGNVG VVGAPEERER TPEDASALGV
160 170 180 190 200
PPRPPTSTRS SSTDTASEHS ADLEDEPPEA CGPGPWPSTG TSEGYDLRQL
210 220 230 240 250
RSQRVLARRG DGLFLPAVVR QVRRSQDLGV QFPGDRALTF YEGVPGGGVD
260 270 280 290 300
VVLDVTPPPG ALMVGTAVCT CVEPGVAAYR EGVVVEVATK PAAYKVRLSP
310 320 330 340 350
GPSSHAGPPG TLPQAQQTLH REPEEAVWVT RSSLRLLRPP WEPGALLRKH
360 370 380 390 400
PAGPEEEQAE PGPALPPCPS SVEPKQPEDA EVSNISFGSN LGTRCEEGEE
410 420 430 440 450
KHPPSLGTPV LLPLPPPQLL SPPPKSPAFG GPGRPSEQPS PCQEGSQGGS
460 470 480 490 500
RSSSVASLEK GAAPAARART PLTAAQQKYK KGDVVCTPNG IRKKFNGKQW
510 520 530 540 550
RRLCSRDGCM KESQRRGYCS RHLSMRTKEM EGLADSGPGG TGRPAGVAAR
560 570 580 590 600
EGSTEFDWGD ETSRDSEASS VAARGDSRPR LVAPADLSRF EFDECEAAVM
610 620 630 640 650
LVSLGSSRSG TPSFSPVSTQ SPFSPAPSPS PSPLFGFRPA NFSPINASPV
660 670 680 690 700
IQRTAVRSRH LSASTPKAGV LTPPDLGPHP PPPAPRERHS SGILPTFQTN
710 720 730 740 750
LTFTVPISPG RRKTELLPHP GTLGASGAGG GGAAPDFPKS DSLDSGVDSV
760 770 780 790 800
SHTPTPSTPA GFRAVSPAVP FSRSRQPSPL LLLPPPAGLT SDPGPSVRRV
810 820 830 840 850
PAVQRDSPVI VRNPDVPLPS KFPGEVGTAG EARAGGPGRS CRETPVPPGV
860 870 880 890 900
ASGKPGLPPP LPAPVPITVP PAAPTAVAQP MPTLGLASSP FQPVAFHPSP
910 920 930 940 950
AALLPVLVPS SYPSHPAPKK EVIMGRPGTV WTNVEPRSVA VFPWHSLVPF
960 970 980 990 1000
LAPSQPDPSV QPSEAQQPAS HPVASNQSKE PAESAAVAHE QPPGGTGGAD
1010 1020 1030 1040 1050
PGRPPGAVCP ESPGPGPPLT LGGVDPGKSL PPTTEEEAPG PPGEPRLDSE
1060 1070 1080 1090 1100
TESDHDDAFL SIMSPEIQLP LPPGKRRTQS LSALPKERDS SSEKDGRSPN
1110 1120 1130 1140 1150
KREKDHIRRP MNAFMIFSKR HRALVHQRHP NQDNRTVSKI LGEWWYALGP
1160 1170 1180 1190 1200
KEKQKYHDLA FQVKEAHFKA HPDWKWCNKD RKKSSSEAKP ASLGLAGGHK
1210 1220 1230 1240 1250
ETRERSMSET GTAAAPGVSS ELLSVAAQTL LSSDTKVPGS GPCGAERLHA
1260 1270 1280 1290 1300
VGAPGSARPR AFSHSGVHSL DGGEVDSQAL QELTQMVSGP ASYSGPKPSP
1310 1320 1330 1340 1350
QYGAPGSFAA PGEGGTLATS GRPPLLPSRA SRSQRAASED MTSDEERMVI
1360 1370 1380 1390 1400
CEEEGDDDVI ADDSFGTTDI DLKCKERVTD SESGDSSGED PEGNKGFGRK
1410 1420 1430 1440 1450
VFSPVIRSSF THCRPTLDPE PPGPPDPPAA FSKGYGPTPS SSSSPASTSV
1460 1470 1480 1490 1500
SVSTSFSLGS GTFKTQESGQ GSTAVPLRPP PPGAGGPATP SKATRFPPTD
1510 1520 1530 1540 1550
SATFRRKRPE SVGSLEAPGP SVIAAPPSGG GNLLQTLVLP PSKEDREGTR
1560 1570 1580 1590 1600
VPSAPAPPLA YGAPAAPLCR PAATMVTNVV RPVSSTPVPI ASKPFPTSGR
1610 1620 1630 1640 1650
AEASSNDIAG ARTEMGTGSR VPGGSPMGVS LVYSDKKSAA AATSPAPHLV
1660 1670 1680 1690 1700
AGPLLGTVGK APATVTNLLV GTPGYGAPAS PAVQFIAQGA PGSATPAGSG
1710 1720 1730 1740 1750
ASTGSGPNGP VPLGILQPGA LGKAGGITQV QYILPTLPQQ LQVAPAPAPA
1760 1770 1780 1790 1800
PGTKAAAPSG PAPTTSIRFT LPPGTSTNGK VLAATAPTAG IPILQSVPSA
1810 1820 1830 1840 1850
PPPKAQSVSP VQATPSGGSA QLLPGKVLVP LAAPSMSVRG GGAGQPLPLV
1860 1870 1880 1890 1900
SSPFSVPVQN GAQQPSKIIQ LTPVPVSTPS GLVPPLSPAT MPGPTSQPQK
1910 1920 1930 1940 1950
VLLPSSTRIT YVQSAGGHTL PLGTSSACSQ TGTVTSYGPT SSVALGFTSL
1960 1970 1980 1990 2000
GPSGPAFVQP LLSGQAPLLA PGQVGVSPVP SPQLPPACTA SGGPVITAFY
2010 2020 2030 2040 2050
PGSPAPTSAP LGPPSQAPPS LVYTVATSTT PPAATILPKG PPASATATPA
2060 2070 2080 2090 2100
PTSPFPSATG SMTYSLVAPK AQRPSPKAPQ KVKAAIASIP VGSFESGTTG
2110 2120 2130 2140 2150
RPGSTPRQSS DSGVAREPAA PESELEGQPT PPAPPPPTET WPPTARSSPP
2160 2170 2180 2190 2200
PPLPAEERPG TKGPETASKF PSSSSDWRVP GLGLESRGEP PTPPSPAPAT
2210 2220 2230 2240 2250
GPSGSSSGSS EGSSGRAAGD TPERKEVTSS GKKMKVRPPP LKKTFDSVDK
2260 2270 2280 2290 2300
VLSEVDFEER FAELPEFRPE EVLPSPTLQS LATSPRAILG SYRKKRKNST
2310 2320 2330 2340 2350
DLDSAPEDPT SPKRKMRRRS SCSSEPNTPK SAKCEGDIFT FDRTGTETED
2360 2370 2380 2390 2400
VLGELEYEKV PYSSLRRTLD QRRALVMQLF QDHGFFPSAQ ATAAFQARYA
2410 2420 2430 2440 2450
DIFPSKVCLQ LKIREVRQKI MQAATPTEQP PGAEAPLPGP PPTGMAATPV
2460 2470 2480 2490 2500
PTPSPAGGPD PTSPGSDSGT AQVAPPLPPP PEPGPGQPGW EGAPQPSPPP
2510
SGPSTAATGR
Length:2,510
Mass (Da):258,130
Last modified:June 12, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i092C6CA3CC71B6D9
GO
Isoform 2 (identifier: Q924A2-2) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     1-907: Missing.
     908-929: VPSSYPSHPAPKKEVIMGRPGT → MYSAHRPLIPASGAASRGLGMF
     2250-2250: K → NR

Show »
Length:1,604
Mass (Da):163,753
Checksum:i348B7AE0567C32EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6T8E9Q6T8_MOUSE
Protein capicua homolog
Cic
1,153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QP01E9QP01_MOUSE
Protein capicua homolog
Cic
1,604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PWB7E9PWB7_MOUSE
Protein capicua homolog
Cic
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QIA9F6QIA9_MOUSE
Protein capicua homolog
Cic
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SAZ4F6SAZ4_MOUSE
Protein capicua homolog
Cic
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC41408 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1089D → E in BAE27978 (PubMed:16141072).Curated1
Sequence conflicti1963S → SA in AAK73516 (PubMed:12393275).Curated1
Sequence conflicti2059T → TA in AAK73516 (PubMed:12393275).Curated1
Sequence conflicti2115A → P in BAB23472 (PubMed:16141072).Curated1
Sequence conflicti2156E → G in BAE27978 (PubMed:16141072).Curated1
Sequence conflicti2212G → V in BAE27813 (PubMed:16141072).Curated1
Sequence conflicti2364S → L in BAB23472 (PubMed:16141072).Curated1
Sequence conflicti2401D → N in BAB23472 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0261401 – 907Missing in isoform 2. 3 PublicationsAdd BLAST907
Alternative sequenceiVSP_026141908 – 929VPSSY…GRPGT → MYSAHRPLIPASGAASRGLG MF in isoform 2. 3 PublicationsAdd BLAST22
Alternative sequenceiVSP_0398042250K → NR in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF363690 mRNA Translation: AAK73516.1
AK004685 mRNA Translation: BAB23472.1
AK147276 mRNA Translation: BAE27813.1
AK147535 mRNA Translation: BAE27978.1
AC156992 Genomic DNA No translation available.
BC040463 mRNA Translation: AAH40463.1
BC058665 mRNA Translation: AAH58665.1
AB093224 mRNA Translation: BAC41408.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52146.1 [Q924A2-2]
CCDS80678.1 [Q924A2-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001289740.1, NM_001302811.1 [Q924A2-4]
NP_082158.2, NM_027882.4 [Q924A2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000163320; ENSMUSP00000126659; ENSMUSG00000005442 [Q924A2-2]
ENSMUST00000169266; ENSMUSP00000132351; ENSMUSG00000005442 [Q924A2-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71722

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71722

UCSC genome browser

More...
UCSCi
uc009fsa.3, mouse [Q924A2-4]
uc009fsc.3, mouse [Q924A2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363690 mRNA Translation: AAK73516.1
AK004685 mRNA Translation: BAB23472.1
AK147276 mRNA Translation: BAE27813.1
AK147535 mRNA Translation: BAE27978.1
AC156992 Genomic DNA No translation available.
BC040463 mRNA Translation: AAH40463.1
BC058665 mRNA Translation: AAH58665.1
AB093224 mRNA Translation: BAC41408.1 Sequence problems.
CCDSiCCDS52146.1 [Q924A2-2]
CCDS80678.1 [Q924A2-4]
RefSeqiNP_001289740.1, NM_001302811.1 [Q924A2-4]
NP_082158.2, NM_027882.4 [Q924A2-2]

3D structure databases

BMRBiQ924A2
SMRiQ924A2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi214881, 3 interactors
DIPiDIP-60650N
IntActiQ924A2, 4 interactors
MINTiQ924A2
STRINGi10090.ENSMUSP00000126659

PTM databases

iPTMnetiQ924A2
PhosphoSitePlusiQ924A2

Proteomic databases

EPDiQ924A2
jPOSTiQ924A2
MaxQBiQ924A2
PaxDbiQ924A2
PeptideAtlasiQ924A2
PRIDEiQ924A2
ProteomicsDBi283918 [Q924A2-4]
283919 [Q924A2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17427, 257 antibodies

The DNASU plasmid repository

More...
DNASUi
71722

Genome annotation databases

EnsembliENSMUST00000163320; ENSMUSP00000126659; ENSMUSG00000005442 [Q924A2-2]
ENSMUST00000169266; ENSMUSP00000132351; ENSMUSG00000005442 [Q924A2-4]
GeneIDi71722
KEGGimmu:71722
UCSCiuc009fsa.3, mouse [Q924A2-4]
uc009fsc.3, mouse [Q924A2-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23152
MGIiMGI:1918972, Cic

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2746, Eukaryota
GeneTreeiENSGT00940000159960
HOGENOMiCLU_000921_0_0_1
InParanoidiQ924A2
OMAiMKKACAG
PhylomeDBiQ924A2
TreeFamiTF323412

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
71722, 9 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cic, mouse

Protein Ontology

More...
PROi
PR:Q924A2
RNActiQ924A2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005442, Expressed in adult mammalian kidney and 320 other tissues
GenevisibleiQ924A2, MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR032147, DUF4819
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
PfamiView protein in Pfam
PF16090, DUF4819, 1 hit
PF00505, HMG_box, 1 hit
SMARTiView protein in SMART
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118, HMG_BOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIC_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q924A2
Secondary accession number(s): Q3UH79
, Q3UHP4, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 12, 2007
Last modified: June 2, 2021
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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