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Protein

Acid sphingomyelinase-like phosphodiesterase 3b

Gene

SMPDL3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28Zinc 1By similarity1
Metal bindingi30Zinc 1By similarity1
Metal bindingi93Zinc 1By similarity1
Metal bindingi93Zinc 2By similarity1
Metal bindingi134Zinc 2By similarity1
Metal bindingi236Zinc 2By similarity1
Metal bindingi277Zinc 2By similarity1
Metal bindingi279Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processImmunity, Inflammatory response, Innate immunity, Lipid degradation, Lipid metabolism
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acid sphingomyelinase-like phosphodiesterase 3b (EC:3.1.4.-1 Publication)
Short name:
ASM-like phosphodiesterase 3b
Gene namesi
Name:SMPDL3B
Synonyms:ASML3B, ASMLPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000130768.14
HGNCiHGNC:21416 SMPDL3B
MIMi617737 gene
neXtProtiNX_Q92485

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135H → A: Reduced phosphodiesterase activity. 1 Publication1

Organism-specific databases

DisGeNETi27293
OpenTargetsiENSG00000130768
PharmGKBiPA134889099

Polymorphism and mutation databases

BioMutaiSMPDL3B
DMDMi62906890

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000233119 – 455Acid sphingomyelinase-like phosphodiesterase 3bAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 64By similarity
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 428By similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ92485
MaxQBiQ92485
PaxDbiQ92485
PeptideAtlasiQ92485
PRIDEiQ92485
ProteomicsDBi75266
75267 [Q92485-2]

PTM databases

iPTMnetiQ92485
PhosphoSitePlusiQ92485

Expressioni

Gene expression databases

BgeeiENSG00000130768
CleanExiHS_SMPDL3B
ExpressionAtlasiQ92485 baseline and differential
GenevisibleiQ92485 HS

Organism-specific databases

HPAiHPA030561

Interactioni

Subunit structurei

Interacts with TLR4, TLR7, TLR8 and TLR9.By similarity

Protein-protein interaction databases

BioGridi118117, 9 interactors
IntActiQ92485, 1 interactor
STRINGi9606.ENSP00000363001

Structurei

3D structure databases

ProteinModelPortaliQ92485
SMRiQ92485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid sphingomyelinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410ISVB Eukaryota
ENOG410XRWF LUCA
GeneTreeiENSGT00530000063095
HOGENOMiHOG000294197
HOVERGENiHBG050594
InParanoidiQ92485
KOiK01128
OMAiDPLQVCP
OrthoDBiEOG091G080M
PhylomeDBiQ92485
TreeFamiTF313674

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR017064 ASM-like_Pdiesterase_prd
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF036767 ASM-like_PDE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92485-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLAWLIFL ANWGGARAEP GKFWHIADLH LDPDYKVSKD PFQVCPSAGS
60 70 80 90 100
QPVPDAGPWG DYLCDSPWAL INSSIYAMKE IEPEPDFILW TGDDTPHVPD
110 120 130 140 150
EKLGEAAVLE IVERLTKLIR EVFPDTKVYA ALGNHDFHPK NQFPAGSNNI
160 170 180 190 200
YNQIAELWKP WLSNESIALF KKGAFYCEKL PGPSGAGRIV VLNTNLYYTS
210 220 230 240 250
NALTADMADP GQQFQWLEDV LTDASKAGDM VYIVGHVPPG FFEKTQNKAW
260 270 280 290 300
FREGFNEKYL KVVRKHHRVI AGQFFGHHHT DSFRMLYDDA GVPISAMFIT
310 320 330 340 350
PGVTPWKTTL PGVVNGANNP AIRVFEYDRA TLSLKDMVTY FMNLSQANAQ
360 370 380 390 400
GTPRWELEYQ LTEAYGVPDA SAHSMHTVLD RIAGDQSTLQ RYYVYNSVSY
410 420 430 440 450
SAGVCDEACS MQHVCAMRQV DIDAYTTCLY ASGTTPVPQL PLLLMALLGL

CTLVL
Length:455
Mass (Da):50,814
Last modified:April 26, 2005 - v2
Checksum:iE947E49C3A8449BA
GO
Isoform 2 (identifier: Q92485-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-373: DMVTYFMNLS...AYGVPDASAH → VRSPAEARGG...LPLTTEPQEG
     374-455: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):41,689
Checksum:i464DE3C94BCC1B49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375 – 376MH → ID in CAA69328 (Ref. 1) Curated2
Sequence conflicti453 – 455LVL → TRAVTCQAHHSSW in CAA69328 (Ref. 1) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048340381R → H. Corresponds to variant dbSNP:rs34560878Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013478336 – 373DMVTY…DASAH → VRSPAEARGGGWEGLKCITT FPHSQLIHLPLTTEPQEG in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_013479374 – 455Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08134 mRNA Translation: CAA69328.1
AK316500 mRNA Translation: BAH14871.1
AL512288 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07721.1
BC014444 mRNA Translation: AAH14444.1
CCDSiCCDS30655.1 [Q92485-1]
CCDS30656.1 [Q92485-2]
RefSeqiNP_001009568.1, NM_001009568.2 [Q92485-2]
NP_055289.2, NM_014474.3 [Q92485-1]
UniGeneiHs.123659

Genome annotation databases

EnsembliENST00000373888; ENSP00000362995; ENSG00000130768 [Q92485-2]
ENST00000373894; ENSP00000363001; ENSG00000130768 [Q92485-1]
GeneIDi27293
KEGGihsa:27293
UCSCiuc001bpf.4 human [Q92485-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiASM3B_HUMAN
AccessioniPrimary (citable) accession number: Q92485
Secondary accession number(s): B7ZB35, Q5T0Z0, Q96CB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: April 26, 2005
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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