UniProtKB - Q92485 (ASM3B_HUMAN)

BLAST

>sp|Q92485|ASM3B_HUMAN Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens OX=9606 GN=SMPDL3B PE=1 SV=2
MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG
DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR
EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL
PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG
FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT
PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQ
LTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQV
DIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL

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History
Entry version 145 (07 Nov 2018)
Sequence version 2 (26 Apr 2005)
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Protein

Acid sphingomyelinase-like phosphodiesterase 3b

Gene

SMPDL3B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	28	Zinc 1By similarity	1
Metal bindingⁱ	30	Zinc 1By similarity	1
Metal bindingⁱ	93	Zinc 1By similarity	1
Metal bindingⁱ	93	Zinc 2By similarity	1
Metal bindingⁱ	134	Zinc 2By similarity	1
Metal bindingⁱ	236	Zinc 2By similarity	1
Metal bindingⁱ	277	Zinc 2By similarity	1
Metal bindingⁱ	279	Zinc 1By similarity	1

GO - Molecular functionⁱ

hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
phosphoric diester hydrolase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26095358
sphingomyelin phosphodiesterase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inflammatory response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
membrane lipid catabolic process Source: UniProtKB
negative regulation of inflammatory response Source: UniProtKB
negative regulation of toll-like receptor signaling pathway Source: UniProtKB
sphingomyelin catabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Biological process	Immunity, Inflammatory response, Innate immunity, Lipid degradation, Lipid metabolism
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acid sphingomyelinase-like phosphodiesterase 3b (EC:3.1.4.-1 Publication) Short name: ASM-like phosphodiesterase 3b
Gene namesⁱ	Name:SMPDL3B Synonyms:ASML3B, ASMLPD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130768.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21416 SMPDL3B
MIMⁱ	617737 gene
neXtProtⁱ	NX_Q92485

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	135	H → A: Reduced phosphodiesterase activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27293
Open Targets More...OpenTargetsⁱ	ENSG00000130768
PharmGKBⁱ	PA134889099

Polymorphism and mutation databases

BioMutaⁱ	SMPDL3B
DMDMⁱ	62906890

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000002331	19 – 455	Acid sphingomyelinase-like phosphodiesterase 3bAdd BLAST		437

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	45 ↔ 64	By similarity
Glycosylationⁱ	72	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	164	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	343	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	415 ↔ 428	By similarity

Post-translational modificationⁱ

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDⁱ	Q92485
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92485
PaxDbⁱ	Q92485
PeptideAtlas More...PeptideAtlasⁱ	Q92485
PRIDEⁱ	Q92485
ProteomicsDBⁱ	75266 75267 [Q92485-2]

PTM databases

iPTMnetⁱ	Q92485
PhosphoSitePlusⁱ	Q92485

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130768 Expressed in 102 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_SMPDL3B
ExpressionAtlasⁱ	Q92485 baseline and differential
Genevisibleⁱ	Q92485 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030561

HPAⁱ

HPA030561

Interactionⁱ

Subunit structureⁱ

Interacts with TLR4, TLR7, TLR8 and TLR9.By similarity

Protein-protein interaction databases

BioGridⁱ	118117, 10 interactors
IntActⁱ	Q92485, 1 interactor
STRINGⁱ	9606.ENSP00000363001

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92485
SMRⁱ	Q92485
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the acid sphingomyelinase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410ISVB Eukaryota ENOG410XRWF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063095
HOGENOMⁱ	HOG000294197
HOVERGENⁱ	HBG050594
InParanoidⁱ	Q92485
KEGG Orthology (KO) More...KOⁱ	K01128
OMAⁱ	HPKSQLP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G080M
PhylomeDBⁱ	Q92485
TreeFamⁱ	TF313674

Family and domain databases

Gene3Dⁱ	3.60.21.10, 1 hit
InterProⁱ	View protein in InterPro IPR017064 ASM-like_Pdiesterase_prd IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149 Metallophos, 1 hit
PIRSFⁱ	PIRSF036767 ASM-like_PDE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92485-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLAWLIFL ANWGGARAEP GKFWHIADLH LDPDYKVSKD PFQVCPSAGS 
        60         70         80         90        100
QPVPDAGPWG DYLCDSPWAL INSSIYAMKE IEPEPDFILW TGDDTPHVPD 
       110        120        130        140        150
EKLGEAAVLE IVERLTKLIR EVFPDTKVYA ALGNHDFHPK NQFPAGSNNI 
       160        170        180        190        200
YNQIAELWKP WLSNESIALF KKGAFYCEKL PGPSGAGRIV VLNTNLYYTS 
       210        220        230        240        250
NALTADMADP GQQFQWLEDV LTDASKAGDM VYIVGHVPPG FFEKTQNKAW 
       260        270        280        290        300
FREGFNEKYL KVVRKHHRVI AGQFFGHHHT DSFRMLYDDA GVPISAMFIT 
       310        320        330        340        350
PGVTPWKTTL PGVVNGANNP AIRVFEYDRA TLSLKDMVTY FMNLSQANAQ 
       360        370        380        390        400
GTPRWELEYQ LTEAYGVPDA SAHSMHTVLD RIAGDQSTLQ RYYVYNSVSY 
       410        420        430        440        450
SAGVCDEACS MQHVCAMRQV DIDAYTTCLY ASGTTPVPQL PLLLMALLGL 

CTLVL

Length:455

Mass (Da):50,814

Last modified:April 26, 2005 - v2

Checksum:ⁱE947E49C3A8449BA

Isoform 2 (identifier: Q92485-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
336-373: DMVTYFMNLS...AYGVPDASAH → VRSPAEARGG...LPLTTEPQEG
374-455: Missing.

« Hide

        10         20         30         40         50
MRLLAWLIFL ANWGGARAEP GKFWHIADLH LDPDYKVSKD PFQVCPSAGS 
        60         70         80         90        100
QPVPDAGPWG DYLCDSPWAL INSSIYAMKE IEPEPDFILW TGDDTPHVPD 
       110        120        130        140        150
EKLGEAAVLE IVERLTKLIR EVFPDTKVYA ALGNHDFHPK NQFPAGSNNI 
       160        170        180        190        200
YNQIAELWKP WLSNESIALF KKGAFYCEKL PGPSGAGRIV VLNTNLYYTS 
       210        220        230        240        250
NALTADMADP GQQFQWLEDV LTDASKAGDM VYIVGHVPPG FFEKTQNKAW 
       260        270        280        290        300
FREGFNEKYL KVVRKHHRVI AGQFFGHHHT DSFRMLYDDA GVPISAMFIT 
       310        320        330        340        350
PGVTPWKTTL PGVVNGANNP AIRVFEYDRA TLSLKVRSPA EARGGGWEGL 
       360        370 
KCITTFPHSQ LIHLPLTTEP QEG

Note: No experimental confirmation available.

Show »

Length:373

Mass (Da):41,689

Checksum:ⁱ464DE3C94BCC1B49

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VWW8	F8VWW8_HUMAN	Acid sphingomyelinase-like phosphod... Acid sphingomyelinase-like phosphodiesterase 3b	SMPDL3B	407	Annotation score:
Q5T0Y8	Q5T0Y8_HUMAN	Acid sphingomyelinase-like phosphod... Acid sphingomyelinase-like phosphodiesterase 3b	SMPDL3B	269	Annotation score:
F8VXS3	F8VXS3_HUMAN	Acid sphingomyelinase-like phosphod... Acid sphingomyelinase-like phosphodiesterase 3b	SMPDL3B	102	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	375 – 376	MH → ID in CAA69328 (Ref. 1) Curated		2
Sequence conflictⁱ	453 – 455	LVL → TRAVTCQAHHSSW in CAA69328 (Ref. 1) Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048340	381	R → H. Corresponds to variant dbSNP:rs34560878Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013478	336 – 373	DMVTY…DASAH → VRSPAEARGGGWEGLKCITT FPHSQLIHLPLTTEPQEG in isoform 2. 1 PublicationAdd BLAST		38
Alternative sequenceⁱVSP_013479	374 – 455	Missing in isoform 2. 1 PublicationAdd BLAST		82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08134 mRNA Translation: CAA69328.1 AK316500 mRNA Translation: BAH14871.1 AL512288 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07721.1 BC014444 mRNA Translation: AAH14444.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30655.1 [Q92485-1] CCDS30656.1 [Q92485-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001009568.1, NM_001009568.2 [Q92485-2] NP_055289.2, NM_014474.3 [Q92485-1]
UniGeneⁱ	Hs.123659

Genome annotation databases

Ensemblⁱ	ENST00000373888; ENSP00000362995; ENSG00000130768 [Q92485-2] ENST00000373894; ENSP00000363001; ENSG00000130768 [Q92485-1]
GeneIDⁱ	27293
KEGGⁱ	hsa:27293
UCSC genome browser More...UCSCⁱ	uc001bpf.4 human [Q92485-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92485	Acid sphingomyelinase-like phosphodiesterase		HUMAN		455	UniRef90_Q92485
Acid sphingomyelinase-like phosphodiesterase		PANPA		455
Acid sphingomyelinase-like phosphodiesterase		NOMLE		455
Acid sphingomyelinase-like phosphodiesterase		GORGO		455
Acid sphingomyelinase-like phosphodiesterase		PANTR		455
+9
Q92485-2	Uncharacterized protein		Cebus capucinus imitator		373	UniRef90_Q92485-2
SMPDL3B isoform 4		PONAB		373
SMPDL3B isoform 3		PANTR		373

Protein	Similar proteins		Species	Score	Length	Source
Q92485	Acid sphingomyelinase-like phosphodiesterase 3b	)	MOUSE		456	UniRef50_P58242
Acid sphingomyelinase-like phosphodiesterase		AILME		456
acid sphingomyelinase-like phosphodiesterase 3b		URSMA		371
Acid sphingomyelinase-like phosphodiesterase		Bengalese finch		471
Uncharacterized protein		FICAL		388
+299
Q92485-2	Uncharacterized protein		Cebus capucinus imitator		373	UniRef50_Q92485-2
SMPDL3B isoform 3		PANTR		373
SMPDL3B isoform 4		PONAB		373
Acid sphingomyelinase-like phosphodiesterase		PETMA		455
UPI0003EC1219		MYODS		404
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08134 mRNA Translation: CAA69328.1 AK316500 mRNA Translation: BAH14871.1 AL512288 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07721.1 BC014444 mRNA Translation: AAH14444.1
CCDSⁱ	CCDS30655.1 [Q92485-1] CCDS30656.1 [Q92485-2]
RefSeqⁱ	NP_001009568.1, NM_001009568.2 [Q92485-2] NP_055289.2, NM_014474.3 [Q92485-1]
UniGeneⁱ	Hs.123659

3D structure databases

ProteinModelPortalⁱ	Q92485
SMRⁱ	Q92485
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118117, 10 interactors
IntActⁱ	Q92485, 1 interactor
STRINGⁱ	9606.ENSP00000363001

PTM databases

iPTMnetⁱ	Q92485
PhosphoSitePlusⁱ	Q92485

Polymorphism and mutation databases

BioMutaⁱ	SMPDL3B
DMDMⁱ	62906890

Proteomic databases

EPDⁱ	Q92485
MaxQBⁱ	Q92485
PaxDbⁱ	Q92485
PeptideAtlasⁱ	Q92485
PRIDEⁱ	Q92485
ProteomicsDBⁱ	75266 75267 [Q92485-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000373888; ENSP00000362995; ENSG00000130768 [Q92485-2] ENST00000373894; ENSP00000363001; ENSG00000130768 [Q92485-1]
GeneIDⁱ	27293
KEGGⁱ	hsa:27293
UCSCⁱ	uc001bpf.4 human [Q92485-1]

Organism-specific databases

CTDⁱ	27293
DisGeNETⁱ	27293
EuPathDBⁱ	HostDB:ENSG00000130768.14
GeneCardsⁱ	SMPDL3B
HGNCⁱ	HGNC:21416 SMPDL3B
HPAⁱ	HPA030561
MIMⁱ	617737 gene
neXtProtⁱ	NX_Q92485
OpenTargetsⁱ	ENSG00000130768
PharmGKBⁱ	PA134889099
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ISVB Eukaryota ENOG410XRWF LUCA
GeneTreeⁱ	ENSGT00530000063095
HOGENOMⁱ	HOG000294197
HOVERGENⁱ	HBG050594
InParanoidⁱ	Q92485
KOⁱ	K01128
OMAⁱ	HPKSQLP
OrthoDBⁱ	EOG091G080M
PhylomeDBⁱ	Q92485
TreeFamⁱ	TF313674

Miscellaneous databases

ChiTaRSⁱ	SMPDL3B human
GenomeRNAiⁱ	27293
Protein Ontology More...PROⁱ	PR:Q92485
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130768 Expressed in 102 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_SMPDL3B
ExpressionAtlasⁱ	Q92485 baseline and differential
Genevisibleⁱ	Q92485 HS

Family and domain databases

Gene3Dⁱ	3.60.21.10, 1 hit
InterProⁱ	View protein in InterPro IPR017064 ASM-like_Pdiesterase_prd IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like
Pfamⁱ	View protein in Pfam PF00149 Metallophos, 1 hit
PIRSFⁱ	PIRSF036767 ASM-like_PDE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASM3B_HUMAN
Accessionⁱ	Q92485Primary (citable) accession number: Q92485 Secondary accession number(s): B7ZB35, Q5T0Z0, Q96CB7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
	Last sequence update:	April 26, 2005
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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UniProtKB - Q92485 (ASM3B_HUMAN)

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Acid sphingomyelinase-like phosphodiesterase 3b

SMPDL3B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ