AQP3

Functionⁱ

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).By similarity

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hypoxia
Source: MGI
Inferred from direct assayⁱ
- 24462679
cellular response to oxygen-glucose deprivation Source: Ensembl
excretion
Source: ProtInc
Traceable author statementⁱ
- 7543093
odontogenesis
Source: UniProtKB
Inferred from expression patternⁱ
- 12522663
positive regulation of immune system process
Source: BHF-UCL
Inferred from direct assayⁱ
- 17943189
regulation of keratinocyte differentiation
Source: BHF-UCL
Traceable author statementⁱ
- 17943189
renal water absorption Source: Ensembl
renal water homeostasis Source: Reactome
response to calcium ion
Source: BHF-UCL
Traceable author statementⁱ
- 17943189
response to retinoic acid
Source: BHF-UCL
Inferred from direct assayⁱ
- 17943189
response to vitamin D
Source: BHF-UCL
Traceable author statementⁱ
- 17943189
urea transport Source: Ensembl
water transport
Source: BHF-UCL
Traceable author statementⁱ
- 17943189

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Blood group antigen
Biological process	Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432047 Passive transport by Aquaporins
SIGNORⁱ	Q92482

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aquaporin-3 Short name: AQP-3 Alternative name(s): Aquaglyceroporin-3
Gene namesⁱ	Name:AQP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165272.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:636 AQP3
MIMⁱ	600170 gene
neXtProtⁱ	NX_Q92482

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 28	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	29 – 49	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	50 – 53	ExtracellularSequence analysis	4
Transmembraneⁱ	54 – 74	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	75 – 109	CytoplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	110 – 130	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	131 – 157	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	158 – 178	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	179 – 188	CytoplasmicSequence analysis	10
Transmembraneⁱ	189 – 209	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	210 – 244	ExtracellularSequence analysisAdd BLAST	35
Transmembraneⁱ	245 – 265	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	266 – 292	CytoplasmicSequence analysisAdd BLAST	27

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	360
MIMⁱ	607457 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000165272
PharmGKBⁱ	PA24921

Polymorphism and mutation databases

BioMutaⁱ	AQP3
DMDMⁱ	2497938

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063943	1 – 292	Aquaporin-3Add BLAST		292

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	141	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q92482
PeptideAtlas More...PeptideAtlasⁱ	Q92482
PRIDEⁱ	Q92482
ProteomicsDBⁱ	75263 75264 [Q92482-2]

Expressionⁱ

Tissue specificityⁱ

Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

Inductionⁱ

Up-regulated by magnesium.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000165272 Expressed in 207 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_AQP3
Genevisibleⁱ	Q92482 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014924

HPAⁱ

HPA014924

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	106856, 4 interactors
IntActⁱ	Q92482, 21 interactors
STRINGⁱ	9606.ENSP00000297991

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92482
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	83 – 85	NPA 1		3
Motifⁱ	215 – 217	NPA 2		3

Domainⁱ

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesⁱ

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0224 Eukaryota COG0580 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046311
HOGENOMⁱ	HOG000288287
HOVERGENⁱ	HBG106057
InParanoidⁱ	Q92482
KEGG Orthology (KO) More...KOⁱ	K09876
OMAⁱ	ITSMLMG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FMS
PhylomeDBⁱ	Q92482
TreeFamⁱ	TF313173

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00333 MIP, 1 hit
Gene3Dⁱ	1.20.1080.10, 1 hit
InterProⁱ	View protein in InterPro IPR023271 Aquaporin-like IPR023275 Aquaporin_3 IPR000425 MIP IPR022357 MIP_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00230 MIP, 1 hit
PRINTSⁱ	PR02015 AQUAPORIN3 PR00783 MINTRINSICP
SUPFAMⁱ	SSF81338 SSF81338, 1 hit
TIGRFAMsⁱ	TIGR00861 MIP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00221 MIP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q92482-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR 
        60         70         80         90        100
GTHGGFLTIN LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK 
       110        120        130        140        150
LPIYTLAQTL GAFLGAGIVF GLYYDAIWHF ADNQLFVSGP NGTAGIFATY 
       160        170        180        190        200
PSGHLDMING FFDQFIGTAS LIVCVLAIVD PYNNPVPRGL EAFTVGLVVL 
       210        220        230        240        250
VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ HWWWVPIVSP 
       260        270        280        290 
LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI

Length:292

Mass (Da):31,544

Last modified:November 1, 1997 - v2

Checksum:ⁱA9555E9576EABA9C

GO

Isoform 2 (identifier: Q92482-2) [UniParc]FASTA Add to basket

Also known as: delta5

The sequence of this isoform differs from the canonical sequence as follows:
165-281: FIGTASLIVC...PPPSNEEENV → DRPALVVGAH...FPLDLAQIAP
282-292: Missing.

« Hide

        10         20         30         40         50
MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR 
        60         70         80         90        100
GTHGGFLTIN LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK 
       110        120        130        140        150
LPIYTLAQTL GAFLGAGIVF GLYYDAIWHF ADNQLFVSGP NGTAGIFATY 
       160        170        180        190        200
PSGHLDMING FFDQDRPALV VGAHRVPTPG LHCGCLRVPA DDRLPPGAAP 
       210        220        230        240        250
TLQRGRECEA GPCEAQGADL SGKGHLPLRC PGLEHPLTVQ GHSQEAPLHD 
       260        270        280 
PPFQAKELPI YPHPTKTAPS GFPLDLAQIA P

Note: Due to a polymorphism at the 5'-splice donor site of intron 5, leading to exon 5 skipping and premature termination of translation. This is the molecular basis of the GIL blood group.

Show »

Length:281

Mass (Da):29,987

Checksum:ⁱC46894A001707CC5

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2R8Y2R4	A0A2R8Y2R4_HUMAN	Aquaporin 3 (Gill blood group), iso... Aquaporin 3 (Gill blood group), isoform CRA_d (Aquaporin-3)	AQP3 hCG_30266	237	Annotation score:
A0A2R8YDV4	A0A2R8YDV4_HUMAN	Aquaporin-3 Aquaporin-3	AQP3	155	Annotation score:
A0A2R8YD22	A0A2R8YD22_HUMAN	Aquaporin-3 Aquaporin-3	AQP3	102	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	23	R → G in BAF84897 (PubMed:14702039).Curated		1
Sequence conflictⁱ	137	V → A in CAG46822 (Ref. 4) Curated		1

Polymorphismⁱ

AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in GIL-negative individuals that lack functional AQP3.

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_025089	43	V → M1 PublicationCorresponds to variant dbSNP:rs34942735Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_003229	165 – 281	FIGTA…EEENV → DRPALVVGAHRVPTPGLHCG CLRVPADDRLPPGAAPTLQR GRECEAGPCEAQGADLSGKG HLPLRCPGLEHPLTVQGHSQ EAPLHDPPFQAKELPIYPHP TKTAPSGFPLDLAQIAP in isoform 2. 1 PublicationAdd BLAST		117
Alternative sequenceⁱVSP_003230	282 – 292	Missing in isoform 2. 1 PublicationAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB001325 mRNA Translation: BAA19237.1 AJ493597 mRNA Translation: CAD38526.1 CR541991 mRNA Translation: CAG46788.1 CR542025 mRNA Translation: CAG46822.1 BT007199 mRNA Translation: AAP35863.1 AK292208 mRNA Translation: BAF84897.1 AK315760 mRNA Translation: BAG38113.1 DQ083949 Genomic DNA Translation: AAY68214.1 AL356218 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58500.1 CH471071 Genomic DNA Translation: EAW58504.1 BC013566 mRNA Translation: AAH13566.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6542.1 [Q92482-1]
PIRⁱ	A57119
NCBI Reference Sequences More...RefSeqⁱ	NP_001305073.1, NM_001318144.1 NP_004916.1, NM_004925.4 [Q92482-1]
UniGeneⁱ	Hs.234642

Genome annotation databases

Ensemblⁱ	ENST00000297991; ENSP00000297991; ENSG00000165272 [Q92482-1]
GeneIDⁱ	360
KEGGⁱ	hsa:360
UCSC genome browser More...UCSCⁱ	uc003zsx.4 human [Q92482-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q92482	Aquaporin-3		BOVIN		292	UniRef90_Q92482
Aquaporin-3		MOUSE		292
Aquaporin-3		RAT		292
Aquaporin-3		PIG		290
Aquaporin-3		CALJA		292
+108

Protein	Similar proteins		Species	Score	Length	Source
Q92482	Aquaporin-3		BOVIN		292	UniRef50_Q92482
Aquaporin-3		MOUSE		292
Aquaporin-3		RAT		292
Aquaporin-3		PIG		290
Aquaporin-3		MYODS		292
+322
Q92482-2	Aquaporin 3b-2 (Fragment)		CYPCA		237	UniRef50_Q92482-2
aquaporin-3 isoform X2		Florida manatee		203
aquaporin-3 isoform X2		Enhydra lutris kenyoni		203
Aquaporin 3 (Gill blood group), isoform CRA_d		HUMAN		237
aquaporin-3 isoform X2		ERIEU		237
+23

Cross-referencesⁱ

Web resourcesⁱ

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB001325 mRNA Translation: BAA19237.1 AJ493597 mRNA Translation: CAD38526.1 CR541991 mRNA Translation: CAG46788.1 CR542025 mRNA Translation: CAG46822.1 BT007199 mRNA Translation: AAP35863.1 AK292208 mRNA Translation: BAF84897.1 AK315760 mRNA Translation: BAG38113.1 DQ083949 Genomic DNA Translation: AAY68214.1 AL356218 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58500.1 CH471071 Genomic DNA Translation: EAW58504.1 BC013566 mRNA Translation: AAH13566.1
CCDSⁱ	CCDS6542.1 [Q92482-1]
PIRⁱ	A57119
RefSeqⁱ	NP_001305073.1, NM_001318144.1 NP_004916.1, NM_004925.4 [Q92482-1]
UniGeneⁱ	Hs.234642

3D structure databases

ProteinModelPortalⁱ	Q92482
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106856, 4 interactors
IntActⁱ	Q92482, 21 interactors
STRINGⁱ	9606.ENSP00000297991

Polymorphism and mutation databases

BioMutaⁱ	AQP3
DMDMⁱ	2497938

Proteomic databases

PaxDbⁱ	Q92482
PeptideAtlasⁱ	Q92482
PRIDEⁱ	Q92482
ProteomicsDBⁱ	75263 75264 [Q92482-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	360
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000297991; ENSP00000297991; ENSG00000165272 [Q92482-1]
GeneIDⁱ	360
KEGGⁱ	hsa:360
UCSCⁱ	uc003zsx.4 human [Q92482-1]

Organism-specific databases

CTDⁱ	360
DisGeNETⁱ	360
EuPathDBⁱ	HostDB:ENSG00000165272.14
GeneCardsⁱ	AQP3
HGNCⁱ	HGNC:636 AQP3
HPAⁱ	HPA014924
MIMⁱ	600170 gene 607457 phenotype
neXtProtⁱ	NX_Q92482
OpenTargetsⁱ	ENSG00000165272
PharmGKBⁱ	PA24921
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0224 Eukaryota COG0580 LUCA
GeneTreeⁱ	ENSGT00510000046311
HOGENOMⁱ	HOG000288287
HOVERGENⁱ	HBG106057
InParanoidⁱ	Q92482
KOⁱ	K09876
OMAⁱ	ITSMLMG
OrthoDBⁱ	EOG091G0FMS
PhylomeDBⁱ	Q92482
TreeFamⁱ	TF313173

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432047 Passive transport by Aquaporins
SIGNORⁱ	Q92482

Miscellaneous databases

ChiTaRSⁱ	AQP3 human
GeneWikiⁱ	Aquaporin_3
GenomeRNAiⁱ	360
Protein Ontology More...PROⁱ	PR:Q92482
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165272 Expressed in 207 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_AQP3
Genevisibleⁱ	Q92482 HS

Family and domain databases

CDDⁱ	cd00333 MIP, 1 hit
Gene3Dⁱ	1.20.1080.10, 1 hit
InterProⁱ	View protein in InterPro IPR023271 Aquaporin-like IPR023275 Aquaporin_3 IPR000425 MIP IPR022357 MIP_CS
Pfamⁱ	View protein in Pfam PF00230 MIP, 1 hit
PRINTSⁱ	PR02015 AQUAPORIN3 PR00783 MINTRINSICP
SUPFAMⁱ	SSF81338 SSF81338, 1 hit
TIGRFAMsⁱ	TIGR00861 MIP, 1 hit
PROSITEⁱ	View protein in PROSITE PS00221 MIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AQP3_HUMAN
Accessionⁱ	Q92482Primary (citable) accession number: Q92482 Secondary accession number(s): A8K843 , B2RE16, D3DRL3, O00108, Q6FGT2, Q6FGW6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Blood group antigen proteins
Nomenclature of blood group antigens and list of entries
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Supporting data

UniProtKB - Q92482 (AQP3_HUMAN)

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Aquaporin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ