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Protein

C-type lectin domain family 2 member B

Gene

CLEC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 2 member B
Alternative name(s):
Activation-induced C-type lectin
C-type lectin superfamily member 2
IFN-alpha-2b-inducing-related protein 1
Gene namesi
Name:CLEC2B
Synonyms:AICL, CLECSF2, IFNRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110852.4
HGNCiHGNC:2053 CLEC2B
MIMi603242 gene
neXtProtiNX_Q92478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini26 – 149ExtracellularSequence analysisAdd BLAST124

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9976
OpenTargetsiENSG00000110852
PharmGKBiPA26582

Polymorphism and mutation databases

BioMutaiCLEC2B
DMDMi33860149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466111 – 149C-type lectin domain family 2 member BAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi63 ↔ 144PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi123 ↔ 136PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ92478
MaxQBiQ92478
PaxDbiQ92478
PeptideAtlasiQ92478
PRIDEiQ92478
ProteomicsDBi75260

PTM databases

iPTMnetiQ92478
PhosphoSitePlusiQ92478

Expressioni

Tissue specificityi

Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.

Gene expression databases

BgeeiENSG00000110852 Expressed in 216 organ(s), highest expression level in blood
CleanExiHS_CLEC2B
ExpressionAtlasiQ92478 baseline and differential
GenevisibleiQ92478 HS

Organism-specific databases

HPAiHPA008194

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-13350535,EBI-13350535

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115300, 40 interactors
DIPiDIP-58612N
IntActiQ92478, 1 interactor
STRINGi9606.ENSP00000228438

Structurei

3D structure databases

ProteinModelPortaliQ92478
SMRiQ92478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 145C-type lectinPROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000059595
InParanoidiQ92478
KOiK10071
OMAiDNTEEMN
OrthoDBiEOG091G0N3M
PhylomeDBiQ92478
TreeFamiTF351467

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q92478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTKHKKCFI IVGVLITTNI ITLIVKLTRD SQSLCPYDWI GFQNKCYYFS
60 70 80 90 100
KEEGDWNSSK YNCSTQHADL TIIDNIEEMN FLRRYKCSSD HWIGLKMAKN
110 120 130 140
RTGQWVDGAT FTKSFGMRGS EGCAYLSDDG AATARCYTER KWICRKRIH
Length:149
Mass (Da):17,307
Last modified:August 15, 2003 - v2
Checksum:i0B4FED23424F6C55
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H631F5H631_HUMAN
C-type lectin domain family 2 membe...
CLEC2B
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79M → T in AAH05254 (PubMed:15489334).Curated1
Sequence conflicti107D → H in CAA65480 (PubMed:9038101).Curated1
Sequence conflicti132 – 137ATARCY → TTAQIQ (Ref. 6) Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96719 mRNA Translation: CAA65480.1
AB015628 mRNA Translation: BAA76495.1
AK313916 mRNA Translation: BAG36638.1
CH471094 Genomic DNA Translation: EAW96127.1
BC005254 mRNA Translation: AAH05254.1
AY142147 mRNA Translation: AAN46677.1
CCDSiCCDS8605.1
RefSeqiNP_005118.2, NM_005127.2
UniGeneiHs.85201

Genome annotation databases

EnsembliENST00000228438; ENSP00000228438; ENSG00000110852
GeneIDi9976
KEGGihsa:9976
UCSCiuc001qwn.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD69 homolog

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96719 mRNA Translation: CAA65480.1
AB015628 mRNA Translation: BAA76495.1
AK313916 mRNA Translation: BAG36638.1
CH471094 Genomic DNA Translation: EAW96127.1
BC005254 mRNA Translation: AAH05254.1
AY142147 mRNA Translation: AAN46677.1
CCDSiCCDS8605.1
RefSeqiNP_005118.2, NM_005127.2
UniGeneiHs.85201

3D structure databases

ProteinModelPortaliQ92478
SMRiQ92478
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115300, 40 interactors
DIPiDIP-58612N
IntActiQ92478, 1 interactor
STRINGi9606.ENSP00000228438

PTM databases

iPTMnetiQ92478
PhosphoSitePlusiQ92478

Polymorphism and mutation databases

BioMutaiCLEC2B
DMDMi33860149

Proteomic databases

EPDiQ92478
MaxQBiQ92478
PaxDbiQ92478
PeptideAtlasiQ92478
PRIDEiQ92478
ProteomicsDBi75260

Protocols and materials databases

DNASUi9976
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228438; ENSP00000228438; ENSG00000110852
GeneIDi9976
KEGGihsa:9976
UCSCiuc001qwn.4 human

Organism-specific databases

CTDi9976
DisGeNETi9976
EuPathDBiHostDB:ENSG00000110852.4
GeneCardsiCLEC2B
HGNCiHGNC:2053 CLEC2B
HPAiHPA008194
MIMi603242 gene
neXtProtiNX_Q92478
OpenTargetsiENSG00000110852
PharmGKBiPA26582
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000059595
InParanoidiQ92478
KOiK10071
OMAiDNTEEMN
OrthoDBiEOG091G0N3M
PhylomeDBiQ92478
TreeFamiTF351467

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiCLEC2B human
GeneWikiiCLEC2B
GenomeRNAii9976
PROiPR:Q92478
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110852 Expressed in 216 organ(s), highest expression level in blood
CleanExiHS_CLEC2B
ExpressionAtlasiQ92478 baseline and differential
GenevisibleiQ92478 HS

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC2B_HUMAN
AccessioniPrimary (citable) accession number: Q92478
Secondary accession number(s): B2R9U1
, Q8IZE9, Q9BS74, Q9UQB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: August 15, 2003
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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