Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA damage-binding protein 2

Gene

DDB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.12 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • damaged DNA binding Source: ProtInc
  • DNA binding Source: ProtInc
  • protein-containing complex binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-8951664 Neddylation
SignaLinkiQ92466
SIGNORiQ92466
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DNA damage-binding protein 2
Alternative name(s):
DDB p48 subunit
Short name:
DDBb
Damage-specific DNA-binding protein 2
UV-damaged DNA-binding protein 2
Short name:
UV-DDB 2
Gene namesi
Name:DDB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000134574.11
HGNCiHGNC:2718 DDB2
MIMi600811 gene
neXtProtiNX_Q92466

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Xeroderma pigmentosum complementation group E (XP-E)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-E patients show a mild phenotype with minimal or no neurologic features.
See also OMIM:278740
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010141244K → E in XP-E; impairs DNA-binding of the UV-DDB complex. 4 PublicationsCorresponds to variant dbSNP:rs121434639EnsemblClinVar.1
Natural variantiVAR_010142273R → H in XP-E; impairs interaction with DDB1 and CUL4A. 7 PublicationsCorresponds to variant dbSNP:rs121434640EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi258L → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi262S → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi264D → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi269I → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi270W → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi272L → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi273R → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi350L → P: Impairs interaction with DDB1. 1 Publication1

Keywords - Diseasei

Disease mutation, Xeroderma pigmentosum

Organism-specific databases

DisGeNETi1643
GeneReviewsiDDB2
MalaCardsiDDB2
MIMi278740 phenotype
OpenTargetsiENSG00000134574
Orphaneti276261 Xeroderma pigmentosum complementation group E
PharmGKBiPA27188

Polymorphism and mutation databases

BioMutaiDDB2
DMDMi12230033

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509531 – 427DNA damage-binding protein 2Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation by ABL1 negatively regulate UV-DDB activity.By similarity
Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1.1 Publication
Ubiquitinated, leading to proteasomal degradation, and deubiquitinated by USP24.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92466
MaxQBiQ92466
PaxDbiQ92466
PeptideAtlasiQ92466
PRIDEiQ92466
ProteomicsDBi75255
75256 [Q92466-2]
75257 [Q92466-3]
75258 [Q92466-4]
75259 [Q92466-5]

PTM databases

iPTMnetiQ92466
PhosphoSitePlusiQ92466

Expressioni

Tissue specificityi

Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed.1 Publication

Inductioni

Expression is induced in response to treatment with IR or UV and this requires p53/TP53 activity.1 Publication

Gene expression databases

BgeeiENSG00000134574 Expressed in 184 organ(s), highest expression level in skin of abdomen
CleanExiHS_DDB2
ExpressionAtlasiQ92466 baseline and differential
GenevisibleiQ92466 HS

Organism-specific databases

HPAiCAB025912
HPA058406

Interactioni

Subunit structurei

Component of the UV-DDB complex which includes DDB1 and DDB2. The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit. Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), which includes CUL4A or CUL4B, DDB1, DDB2 and RBX1. DDB2 may function as the substrate recognition module within this complex. The DDB1-CUL4-ROC1 complex may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of the complex. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces DDB2. These targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Isoform D1 and isoform D2 do not interact with DDB1.18 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi108010, 93 interactors
ComplexPortaliCPX-308 UV DNA damage recognition complex DBB1-DBB2
CPX-477 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A variant
CPX-648 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4B variant
CORUMiQ92466
DIPiDIP-36670N
IntActiQ92466, 27 interactors
STRINGi9606.ENSP00000256996

Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ92466
SMRiQ92466
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92466

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 151WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati159 – 194WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati203 – 238WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati244 – 287WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST44
Repeati290 – 329WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati343 – 386WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST44
Repeati396 – 420WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 79Required for interaction with DDB1Add BLAST12
Regioni87 – 98Required for interaction with DDB1Add BLAST12
Regioni334 – 336Photolesion recognition3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi256 – 274DWD boxAdd BLAST19

Domaini

The DWD box is required for interaction with DDB1.1 Publication
Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands.1 Publication

Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IMQS Eukaryota
COG2319 LUCA
GeneTreeiENSGT00510000047881
HOGENOMiHOG000231440
HOVERGENiHBG000713
InParanoidiQ92466
KOiK10140
OMAiVTCLEWH
OrthoDBiEOG091G06BL
PhylomeDBiQ92466
TreeFamiTF331587

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033312 DDB2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15169 PTHR15169, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS
60 70 80 90 100
DCLWVGLAGP QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS
110 120 130 140 150
YRILQKAAPF DRRATSLAWH PTHPSTVAVG SKGGDIMLWN FGIKDKPTFI
160 170 180 190 200
KGIGAGGSIT GLKFNPLNTN QFYASSMEGT TRLQDFKGNI LRVFASSDTI
210 220 230 240 250
NIWFCSLDVS ASSRMVVTGD NVGNVILLNM DGKELWNLRM HKKKVTHVAL
260 270 280 290 300
NPCCDWFLAT ASVDQTVKIW DLRQVRGKAS FLYSLPHRHP VNAACFSPDG
310 320 330 340 350
ARLLTTDQKS EIRVYSASQW DCPLGLIPHP HRHFQHLTPI KAAWHPRYNL
360 370 380 390 400
IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF
410 420
NPMGDTLASA MGYHILIWSQ EEARTRK
Length:427
Mass (Da):47,864
Last modified:February 1, 1997 - v1
Checksum:iE881F21242CA44D2
GO
Isoform D1 (identifier: Q92466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-341: Missing.

Show »
Length:238
Mass (Da):26,744
Checksum:iF40BD646C1C26FDA
GO
Isoform D2 (identifier: Q92466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-156: IGAG → HLVL
     157-427: Missing.

Show »
Length:156
Mass (Da):17,434
Checksum:iFBC8A060B4DC7A4D
GO
Isoform D3 (identifier: Q92466-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-152: Missing.

Show »
Length:363
Mass (Da):40,772
Checksum:i2A90D5BD9E322889
GO
Isoform D4 (identifier: Q92466-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-244: WNLRMHKKK → VSVPMEPGS
     245-427: Missing.

Show »
Length:244
Mass (Da):26,758
Checksum:i367D99AA1DD984F9
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0X5A0A087X0X5_HUMAN
DNA damage-binding protein 2
DDB2
227Annotation score:
A0A087WW71A0A087WW71_HUMAN
DNA damage-binding protein 2
DDB2
162Annotation score:
A0A087WYT8A0A087WYT8_HUMAN
DNA damage-binding protein 2
DDB2
95Annotation score:
A0A087WTQ7A0A087WTQ7_HUMAN
DNA damage-binding protein 2
DDB2
91Annotation score:
A0A087WV56A0A087WV56_HUMAN
DNA damage-binding protein 2
DDB2
93Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016337215M → T1 PublicationCorresponds to variant dbSNP:rs4647750Ensembl.1
Natural variantiVAR_010141244K → E in XP-E; impairs DNA-binding of the UV-DDB complex. 4 PublicationsCorresponds to variant dbSNP:rs121434639EnsemblClinVar.1
Natural variantiVAR_010142273R → H in XP-E; impairs interaction with DDB1 and CUL4A. 7 PublicationsCorresponds to variant dbSNP:rs121434640EnsemblClinVar.1
Natural variantiVAR_016338293A → T1 PublicationCorresponds to variant dbSNP:rs4647751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01467489 – 152Missing in isoform D3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_014675153 – 341Missing in isoform D1. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_014676153 – 156IGAG → HLVL in isoform D2. 1 Publication4
Alternative sequenceiVSP_014677157 – 427Missing in isoform D2. 1 PublicationAdd BLAST271
Alternative sequenceiVSP_014678236 – 244WNLRMHKKK → VSVPMEPGS in isoform D4. 1 Publication9
Alternative sequenceiVSP_014679245 – 427Missing in isoform D4. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18300 mRNA Translation: AAB07897.1
AB107037 mRNA Translation: BAD12557.1
AB107038 mRNA Translation: BAD12558.1
AB107039 mRNA Translation: BAD12559.1
AB107040 mRNA Translation: BAD12560.1
BT007139 mRNA Translation: AAP35803.1
AY220533 Genomic DNA Translation: AAO25655.1
AK313262 mRNA Translation: BAG36072.1
CH471064 Genomic DNA Translation: EAW67952.1
BC000093 mRNA Translation: AAH00093.1
CCDSiCCDS73284.1 [Q92466-2]
CCDS7927.1 [Q92466-1]
PIRiI38909
RefSeqiNP_000098.1, NM_000107.2 [Q92466-1]
NP_001287663.1, NM_001300734.1 [Q92466-2]
UniGeneiHs.700338

Genome annotation databases

EnsembliENST00000256996; ENSP00000256996; ENSG00000134574 [Q92466-1]
ENST00000378600; ENSP00000367863; ENSG00000134574 [Q92466-2]
ENST00000378601; ENSP00000367864; ENSG00000134574 [Q92466-5]
ENST00000378603; ENSP00000367866; ENSG00000134574 [Q92466-4]
ENST00000616278; ENSP00000478411; ENSG00000134574 [Q92466-3]
GeneIDi1643
KEGGihsa:1643
UCSCiuc001neb.3 human [Q92466-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18300 mRNA Translation: AAB07897.1
AB107037 mRNA Translation: BAD12557.1
AB107038 mRNA Translation: BAD12558.1
AB107039 mRNA Translation: BAD12559.1
AB107040 mRNA Translation: BAD12560.1
BT007139 mRNA Translation: AAP35803.1
AY220533 Genomic DNA Translation: AAO25655.1
AK313262 mRNA Translation: BAG36072.1
CH471064 Genomic DNA Translation: EAW67952.1
BC000093 mRNA Translation: AAH00093.1
CCDSiCCDS73284.1 [Q92466-2]
CCDS7927.1 [Q92466-1]
PIRiI38909
RefSeqiNP_000098.1, NM_000107.2 [Q92466-1]
NP_001287663.1, NM_001300734.1 [Q92466-2]
UniGeneiHs.700338

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EI4X-ray3.30B/D/F10-427[»]
3I7LX-ray2.80B68-81[»]
4E54X-ray2.85B2-427[»]
4E5ZX-ray3.22B2-427[»]
ProteinModelPortaliQ92466
SMRiQ92466
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108010, 93 interactors
ComplexPortaliCPX-308 UV DNA damage recognition complex DBB1-DBB2
CPX-477 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A variant
CPX-648 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4B variant
CORUMiQ92466
DIPiDIP-36670N
IntActiQ92466, 27 interactors
STRINGi9606.ENSP00000256996

PTM databases

iPTMnetiQ92466
PhosphoSitePlusiQ92466

Polymorphism and mutation databases

BioMutaiDDB2
DMDMi12230033

Proteomic databases

EPDiQ92466
MaxQBiQ92466
PaxDbiQ92466
PeptideAtlasiQ92466
PRIDEiQ92466
ProteomicsDBi75255
75256 [Q92466-2]
75257 [Q92466-3]
75258 [Q92466-4]
75259 [Q92466-5]

Protocols and materials databases

DNASUi1643
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256996; ENSP00000256996; ENSG00000134574 [Q92466-1]
ENST00000378600; ENSP00000367863; ENSG00000134574 [Q92466-2]
ENST00000378601; ENSP00000367864; ENSG00000134574 [Q92466-5]
ENST00000378603; ENSP00000367866; ENSG00000134574 [Q92466-4]
ENST00000616278; ENSP00000478411; ENSG00000134574 [Q92466-3]
GeneIDi1643
KEGGihsa:1643
UCSCiuc001neb.3 human [Q92466-1]

Organism-specific databases

CTDi1643
DisGeNETi1643
EuPathDBiHostDB:ENSG00000134574.11
GeneCardsiDDB2
GeneReviewsiDDB2
HGNCiHGNC:2718 DDB2
HPAiCAB025912
HPA058406
MalaCardsiDDB2
MIMi278740 phenotype
600811 gene
neXtProtiNX_Q92466
OpenTargetsiENSG00000134574
Orphaneti276261 Xeroderma pigmentosum complementation group E
PharmGKBiPA27188
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMQS Eukaryota
COG2319 LUCA
GeneTreeiENSGT00510000047881
HOGENOMiHOG000231440
HOVERGENiHBG000713
InParanoidiQ92466
KOiK10140
OMAiVTCLEWH
OrthoDBiEOG091G06BL
PhylomeDBiQ92466
TreeFamiTF331587

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-5689880 Ub-specific processing proteases
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-8951664 Neddylation
SignaLinkiQ92466
SIGNORiQ92466

Miscellaneous databases

ChiTaRSiDDB2 human
EvolutionaryTraceiQ92466
GeneWikiiDDB2
GenomeRNAii1643
PROiPR:Q92466
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134574 Expressed in 184 organ(s), highest expression level in skin of abdomen
CleanExiHS_DDB2
ExpressionAtlasiQ92466 baseline and differential
GenevisibleiQ92466 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033312 DDB2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15169 PTHR15169, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDB2_HUMAN
AccessioniPrimary (citable) accession number: Q92466
Secondary accession number(s): B2R875
, Q76E54, Q76E55, Q76E56, Q76E57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 1, 1997
Last modified: October 10, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again