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Entry version 196 (16 Oct 2019)
Sequence version 1 (01 Feb 1997)
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Protein

DNA damage-binding protein 2

Gene

DDB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.12 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-8951664 Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q92466

SIGNOR Signaling Network Open Resource

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SIGNORi
Q92466

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA damage-binding protein 2
Alternative name(s):
DDB p48 subunit
Short name:
DDBb
Damage-specific DNA-binding protein 2
UV-damaged DNA-binding protein 2
Short name:
UV-DDB 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2718 DDB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600811 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92466

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Xeroderma pigmentosum complementation group E (XP-E)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-E patients show a mild phenotype with minimal or no neurologic features.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010141244K → E in XP-E; impairs DNA-binding of the UV-DDB complex. 4 PublicationsCorresponds to variant dbSNP:rs121434639EnsemblClinVar.1
Natural variantiVAR_010142273R → H in XP-E; impairs interaction with DDB1 and CUL4A. 7 PublicationsCorresponds to variant dbSNP:rs121434640EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi258L → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi262S → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi264D → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi269I → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi270W → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi272L → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi273R → A: Impairs interaction with DDB1. 1 Publication1
Mutagenesisi350L → P: Impairs interaction with DDB1. 1 Publication1

Keywords - Diseasei

Disease mutation, Xeroderma pigmentosum

Organism-specific databases

DisGeNET

More...
DisGeNETi
1643

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DDB2

MalaCards human disease database

More...
MalaCardsi
DDB2
MIMi278740 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134574

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
910 Xeroderma pigmentosum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27188

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q92466

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12230033

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509531 – 427DNA damage-binding protein 2Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by ABL1 negatively regulate UV-DDB activity.By similarity
Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1.1 Publication
Ubiquitinated, leading to proteasomal degradation, and deubiquitinated by USP24.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q92466

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q92466

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q92466

MaxQB - The MaxQuant DataBase

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MaxQBi
Q92466

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q92466

PeptideAtlas

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PeptideAtlasi
Q92466

PRoteomics IDEntifications database

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PRIDEi
Q92466

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
75255 [Q92466-1]
75256 [Q92466-2]
75257 [Q92466-3]
75258 [Q92466-4]
75259 [Q92466-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92466

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q92466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced in response to treatment with IR or UV and this requires p53/TP53 activity.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134574 Expressed in 184 organ(s), highest expression level in skin of abdomen

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q92466 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q92466 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025912
HPA058406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the UV-DDB complex which includes DDB1 and DDB2. The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit.

Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), which includes CUL4A or CUL4B, DDB1, DDB2 and RBX1. DDB2 may function as the substrate recognition module within this complex. The DDB1-CUL4-ROC1 complex may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of the complex. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces DDB2. These targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Isoform D1 and isoform D2 do not interact with DDB1.

18 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108010, 103 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-308 UV DNA damage recognition complex DBB1-DBB2
CPX-477 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A variant
CPX-648 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4B variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q92466

Database of interacting proteins

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DIPi
DIP-36670N

Protein interaction database and analysis system

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IntActi
Q92466, 48 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000256996

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92466

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q92466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati116 – 151WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati159 – 194WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati203 – 238WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati244 – 287WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST44
Repeati290 – 329WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati343 – 386WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST44
Repeati396 – 420WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 79Required for interaction with DDB1Add BLAST12
Regioni87 – 98Required for interaction with DDB1Add BLAST12
Regioni334 – 336Photolesion recognition3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi256 – 274DWD boxAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DWD box is required for interaction with DDB1.1 Publication
Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IMQS Eukaryota
COG2319 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000047881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231440

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92466

KEGG Orthology (KO)

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KOi
K10140

Identification of Orthologs from Complete Genome Data

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OMAi
FIKGKGP

Database of Orthologous Groups

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OrthoDBi
559605at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92466

TreeFam database of animal gene trees

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TreeFami
TF331587

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033312 DDB2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR15169 PTHR15169, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS
60 70 80 90 100
DCLWVGLAGP QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS
110 120 130 140 150
YRILQKAAPF DRRATSLAWH PTHPSTVAVG SKGGDIMLWN FGIKDKPTFI
160 170 180 190 200
KGIGAGGSIT GLKFNPLNTN QFYASSMEGT TRLQDFKGNI LRVFASSDTI
210 220 230 240 250
NIWFCSLDVS ASSRMVVTGD NVGNVILLNM DGKELWNLRM HKKKVTHVAL
260 270 280 290 300
NPCCDWFLAT ASVDQTVKIW DLRQVRGKAS FLYSLPHRHP VNAACFSPDG
310 320 330 340 350
ARLLTTDQKS EIRVYSASQW DCPLGLIPHP HRHFQHLTPI KAAWHPRYNL
360 370 380 390 400
IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF
410 420
NPMGDTLASA MGYHILIWSQ EEARTRK
Length:427
Mass (Da):47,864
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE881F21242CA44D2
GO
Isoform D1 (identifier: Q92466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-341: Missing.

Show »
Length:238
Mass (Da):26,744
Checksum:iF40BD646C1C26FDA
GO
Isoform D2 (identifier: Q92466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-156: IGAG → HLVL
     157-427: Missing.

Show »
Length:156
Mass (Da):17,434
Checksum:iFBC8A060B4DC7A4D
GO
Isoform D3 (identifier: Q92466-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-152: Missing.

Show »
Length:363
Mass (Da):40,772
Checksum:i2A90D5BD9E322889
GO
Isoform D4 (identifier: Q92466-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-244: WNLRMHKKK → VSVPMEPGS
     245-427: Missing.

Show »
Length:244
Mass (Da):26,758
Checksum:i367D99AA1DD984F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0X5A0A087X0X5_HUMAN
DNA damage-binding protein 2
DDB2
227Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW71A0A087WW71_HUMAN
DNA damage-binding protein 2
DDB2
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYT8A0A087WYT8_HUMAN
DNA damage-binding protein 2
DDB2
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTQ7A0A087WTQ7_HUMAN
DNA damage-binding protein 2
DDB2
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV56A0A087WV56_HUMAN
DNA damage-binding protein 2
DDB2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016337215M → T1 PublicationCorresponds to variant dbSNP:rs4647750Ensembl.1
Natural variantiVAR_010141244K → E in XP-E; impairs DNA-binding of the UV-DDB complex. 4 PublicationsCorresponds to variant dbSNP:rs121434639EnsemblClinVar.1
Natural variantiVAR_010142273R → H in XP-E; impairs interaction with DDB1 and CUL4A. 7 PublicationsCorresponds to variant dbSNP:rs121434640EnsemblClinVar.1
Natural variantiVAR_016338293A → T1 PublicationCorresponds to variant dbSNP:rs4647751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01467489 – 152Missing in isoform D3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_014675153 – 341Missing in isoform D1. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_014676153 – 156IGAG → HLVL in isoform D2. 1 Publication4
Alternative sequenceiVSP_014677157 – 427Missing in isoform D2. 1 PublicationAdd BLAST271
Alternative sequenceiVSP_014678236 – 244WNLRMHKKK → VSVPMEPGS in isoform D4. 1 Publication9
Alternative sequenceiVSP_014679245 – 427Missing in isoform D4. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18300 mRNA Translation: AAB07897.1
AB107037 mRNA Translation: BAD12557.1
AB107038 mRNA Translation: BAD12558.1
AB107039 mRNA Translation: BAD12559.1
AB107040 mRNA Translation: BAD12560.1
BT007139 mRNA Translation: AAP35803.1
AY220533 Genomic DNA Translation: AAO25655.1
AK313262 mRNA Translation: BAG36072.1
CH471064 Genomic DNA Translation: EAW67952.1
BC000093 mRNA Translation: AAH00093.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73284.1 [Q92466-2]
CCDS7927.1 [Q92466-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38909

NCBI Reference Sequences

More...
RefSeqi
NP_000098.1, NM_000107.2 [Q92466-1]
NP_001287663.1, NM_001300734.1 [Q92466-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256996; ENSP00000256996; ENSG00000134574 [Q92466-1]
ENST00000378600; ENSP00000367863; ENSG00000134574 [Q92466-2]
ENST00000378601; ENSP00000367864; ENSG00000134574 [Q92466-5]
ENST00000378603; ENSP00000367866; ENSG00000134574 [Q92466-4]
ENST00000616278; ENSP00000478411; ENSG00000134574 [Q92466-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1643

UCSC genome browser

More...
UCSCi
uc001neb.3 human [Q92466-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18300 mRNA Translation: AAB07897.1
AB107037 mRNA Translation: BAD12557.1
AB107038 mRNA Translation: BAD12558.1
AB107039 mRNA Translation: BAD12559.1
AB107040 mRNA Translation: BAD12560.1
BT007139 mRNA Translation: AAP35803.1
AY220533 Genomic DNA Translation: AAO25655.1
AK313262 mRNA Translation: BAG36072.1
CH471064 Genomic DNA Translation: EAW67952.1
BC000093 mRNA Translation: AAH00093.1
CCDSiCCDS73284.1 [Q92466-2]
CCDS7927.1 [Q92466-1]
PIRiI38909
RefSeqiNP_000098.1, NM_000107.2 [Q92466-1]
NP_001287663.1, NM_001300734.1 [Q92466-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EI4X-ray3.30B/D/F10-427[»]
3I7LX-ray2.80B68-81[»]
4E54X-ray2.85B2-427[»]
4E5ZX-ray3.22B2-427[»]
6R8Yelectron microscopy4.30L1-427[»]
6R8Zelectron microscopy3.90L1-427[»]
6R90electron microscopy4.50L1-427[»]
6R91electron microscopy4.10L1-427[»]
6R92electron microscopy4.80L1-427[»]
SMRiQ92466
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108010, 103 interactors
ComplexPortaliCPX-308 UV DNA damage recognition complex DBB1-DBB2
CPX-477 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A variant
CPX-648 CRL4-DDB2 E3 ubiquitin ligase complex, CUL4B variant
CORUMiQ92466
DIPiDIP-36670N
IntActiQ92466, 48 interactors
STRINGi9606.ENSP00000256996

PTM databases

iPTMnetiQ92466
PhosphoSitePlusiQ92466

Polymorphism and mutation databases

BioMutaiDDB2
DMDMi12230033

Proteomic databases

EPDiQ92466
jPOSTiQ92466
MassIVEiQ92466
MaxQBiQ92466
PaxDbiQ92466
PeptideAtlasiQ92466
PRIDEiQ92466
ProteomicsDBi75255 [Q92466-1]
75256 [Q92466-2]
75257 [Q92466-3]
75258 [Q92466-4]
75259 [Q92466-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1643

Genome annotation databases

EnsembliENST00000256996; ENSP00000256996; ENSG00000134574 [Q92466-1]
ENST00000378600; ENSP00000367863; ENSG00000134574 [Q92466-2]
ENST00000378601; ENSP00000367864; ENSG00000134574 [Q92466-5]
ENST00000378603; ENSP00000367866; ENSG00000134574 [Q92466-4]
ENST00000616278; ENSP00000478411; ENSG00000134574 [Q92466-3]
GeneIDi1643
KEGGihsa:1643
UCSCiuc001neb.3 human [Q92466-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1643
DisGeNETi1643

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DDB2
GeneReviewsiDDB2
HGNCiHGNC:2718 DDB2
HPAiCAB025912
HPA058406
MalaCardsiDDB2
MIMi278740 phenotype
600811 gene
neXtProtiNX_Q92466
OpenTargetsiENSG00000134574
Orphaneti910 Xeroderma pigmentosum
PharmGKBiPA27188

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMQS Eukaryota
COG2319 LUCA
GeneTreeiENSGT00510000047881
HOGENOMiHOG000231440
InParanoidiQ92466
KOiK10140
OMAiFIKGKGP
OrthoDBi559605at2759
PhylomeDBiQ92466
TreeFamiTF331587

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-5689880 Ub-specific processing proteases
R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-8951664 Neddylation
SignaLinkiQ92466
SIGNORiQ92466

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DDB2 human
EvolutionaryTraceiQ92466

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DDB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1643
PharosiQ92466

Protein Ontology

More...
PROi
PR:Q92466

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134574 Expressed in 184 organ(s), highest expression level in skin of abdomen
ExpressionAtlasiQ92466 baseline and differential
GenevisibleiQ92466 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR033312 DDB2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR15169 PTHR15169, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92466
Secondary accession number(s): B2R875
, Q76E54, Q76E55, Q76E56, Q76E57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 1, 1997
Last modified: October 16, 2019
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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