Ferd3l

Functionⁱ

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins.1 Publication

GO - Molecular functionⁱ

DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 12217327
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12217327

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell development
Source: MGI
Inferred from mutant phenotypeⁱ
- 20460368
floor plate development
Source: MGI
Inferred from mutant phenotypeⁱ
- 20460368
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12217327
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12217327
regulation of neurogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 20460368

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fer3-like protein Alternative name(s): Basic helix-loop-helix protein N-twist Nephew of atonal 3 Neuronal twist
Gene namesⁱ	Name:Ferd3l Synonyms:Nato, Ntwist
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:2150010 Ferd3l

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000328683	1 – 168	Fer3-like proteinAdd BLAST		168

Proteomic databases

PaxDbⁱ	Q923Z4
PRIDEⁱ	Q923Z4

PTM databases

iPTMnetⁱ	Q923Z4
PhosphoSitePlusⁱ	Q923Z4

Expressionⁱ

Tissue specificityⁱ

Detected in the developing central nervous system, in particular in embryonic ventral neural tube, brain, and spinal cord. Detected in embryonic intestine. Detected in embryonic and adult thalamus, hypothalamus, midbrain, pons and medulla.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000046518 Expressed in 34 organ(s), highest expression level in kidney interstitium
Genevisibleⁱ	Q923Z4 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer with TCF3/E12. Interacts with the bHLH domain of TCF3/E12.1 Publication

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	227826, 1 interactor
STRINGⁱ	10090.ENSMUSP00000058994

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q923Z4
SMRⁱ	Q923Z4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	103 – 155	bHLHPROSITE-ProRule annotationAdd BLAST		53

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	75 – 82	Poly-Glu		8

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110958
HOGENOMⁱ	HOG000046685
HOVERGENⁱ	HBG094853
InParanoidⁱ	Q923Z4
KEGG Orthology (KO) More...KOⁱ	K22400
OMAⁱ	YPQSCVD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YNB
PhylomeDBⁱ	Q923Z4

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q923Z4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAYPESCLD ATVLNFVADL SLASPRHPLL CEFPPGVPFG DRTLGYREGR 
        60         70         80         90        100
PGRLSQFDER YQEVEGDEVE YEDPEEEEEE GEGRGRVASL LGRPKRKRVI 
       110        120        130        140        150
TYAQRQAANI RERKRMFNLN EAFDQLRRKV PTFAYEKRLS RIETLRLAIV 
       160 
YISFMTELLQ SKEEKEAS

Length:168

Mass (Da):19,463

Last modified:December 1, 2001 - v1

Checksum:ⁱ960BA60C19E7237B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF369896 Genomic DNA Translation: AAK72955.1 AF517121 mRNA Translation: AAN04085.1 BC111576 mRNA Translation: AAI11577.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25878.1
NCBI Reference Sequences More...RefSeqⁱ	NP_277057.1, NM_033522.2
UniGeneⁱ	Mm.204643

Genome annotation databases

Ensemblⁱ	ENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518
GeneIDⁱ	114712
KEGGⁱ	mmu:114712
UCSC genome browser More...UCSCⁱ	uc007niv.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q923Z4	Fer3-like (Drosophila) (Predicted)		RAT		166	UniRef90_Q923Z4
UPI000A30DE8A		MUSPA		168
UPI000A31A223		MUSCR		168
UPI000B4E9742		MERUN		167

Protein	Similar proteins		Species	Score	Length	Source
Q923Z4	Fer3-like protein		HUMAN		166	UniRef50_Q923Z4
Fer3-like (Drosophila) (Predicted)		RAT		166
Uncharacterized protein		XENLA		129
fer3-like protein		ODORO		169
fer3-like protein		NEOSC		170
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF369896 Genomic DNA Translation: AAK72955.1 AF517121 mRNA Translation: AAN04085.1 BC111576 mRNA Translation: AAI11577.1
CCDSⁱ	CCDS25878.1
RefSeqⁱ	NP_277057.1, NM_033522.2
UniGeneⁱ	Mm.204643

3D structure databases

ProteinModelPortalⁱ	Q923Z4
SMRⁱ	Q923Z4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	227826, 1 interactor
STRINGⁱ	10090.ENSMUSP00000058994

PTM databases

iPTMnetⁱ	Q923Z4
PhosphoSitePlusⁱ	Q923Z4

Proteomic databases

PaxDbⁱ	Q923Z4
PRIDEⁱ	Q923Z4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518
GeneIDⁱ	114712
KEGGⁱ	mmu:114712
UCSCⁱ	uc007niv.1 mouse

Organism-specific databases

CTDⁱ	222894
MGIⁱ	MGI:2150010 Ferd3l

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00730000110958
HOGENOMⁱ	HOG000046685
HOVERGENⁱ	HBG094853
InParanoidⁱ	Q923Z4
KOⁱ	K22400
OMAⁱ	YPQSCVD
OrthoDBⁱ	EOG091G0YNB
PhylomeDBⁱ	Q923Z4

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q923Z4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000046518 Expressed in 34 organ(s), highest expression level in kidney interstitium
Genevisibleⁱ	Q923Z4 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FER3L_MOUSE
Accessionⁱ	Q923Z4Primary (citable) accession number: Q923Z4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q923Z4 (FER3L_MOUSE)

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Fer3-like protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ