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UniProtKB - Q923Z4 (FER3L_MOUSE)
Protein
Fer3-like protein
Gene
Ferd3l
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins.
1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell development Source: MGI
- developmental process Source: GO_Central
- floor plate development Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of neurogenesis Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Fer3-like proteinAlternative name(s): Basic helix-loop-helix protein N-twist Nephew of atonal 3 Neuronal twist |
Gene namesi | Name:Ferd3l Synonyms:Nato, Ntwist |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2150010, Ferd3l |
VEuPathDBi | HostDB:ENSMUSG00000046518 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328683 | 1 – 168 | Fer3-like proteinAdd BLAST | 168 |
Proteomic databases
PaxDbi | Q923Z4 |
PRIDEi | Q923Z4 |
PTM databases
iPTMneti | Q923Z4 |
PhosphoSitePlusi | Q923Z4 |
Expressioni
Tissue specificityi
Detected in the developing central nervous system, in particular in embryonic ventral neural tube, brain, and spinal cord. Detected in embryonic intestine. Detected in embryonic and adult thalamus, hypothalamus, midbrain, pons and medulla.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000046518, Expressed in kidney interstitium and 49 other tissues |
Genevisiblei | Q923Z4, MM |
Interactioni
Subunit structurei
Heterodimer with TCF3/E12.
Interacts with the bHLH domain of TCF3/E12.
1 PublicationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 227826, 1 interactor |
STRINGi | 10090.ENSMUSP00000058994 |
Miscellaneous databases
RNActi | Q923Z4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 155 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 65 – 88 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 65 – 80 | Acidic residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161409 |
HOGENOMi | CLU_148882_0_0_1 |
InParanoidi | Q923Z4 |
OMAi | LDGCSRQ |
OrthoDBi | 1513995at2759 |
PhylomeDBi | Q923Z4 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q923Z4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAYPESCLD ATVLNFVADL SLASPRHPLL CEFPPGVPFG DRTLGYREGR
60 70 80 90 100
PGRLSQFDER YQEVEGDEVE YEDPEEEEEE GEGRGRVASL LGRPKRKRVI
110 120 130 140 150
TYAQRQAANI RERKRMFNLN EAFDQLRRKV PTFAYEKRLS RIETLRLAIV
160
YISFMTELLQ SKEEKEAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369896 Genomic DNA Translation: AAK72955.1 AF517121 mRNA Translation: AAN04085.1 BC111576 mRNA Translation: AAI11577.1 |
CCDSi | CCDS25878.1 |
RefSeqi | NP_277057.1, NM_033522.2 |
Genome annotation databases
Ensembli | ENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518 |
GeneIDi | 114712 |
KEGGi | mmu:114712 |
UCSCi | uc007niv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF369896 Genomic DNA Translation: AAK72955.1 AF517121 mRNA Translation: AAN04085.1 BC111576 mRNA Translation: AAI11577.1 |
CCDSi | CCDS25878.1 |
RefSeqi | NP_277057.1, NM_033522.2 |
3D structure databases
SMRi | Q923Z4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 227826, 1 interactor |
STRINGi | 10090.ENSMUSP00000058994 |
PTM databases
iPTMneti | Q923Z4 |
PhosphoSitePlusi | Q923Z4 |
Proteomic databases
PaxDbi | Q923Z4 |
PRIDEi | Q923Z4 |
Protocols and materials databases
Antibodypediai | 11904, 87 antibodies from 20 providers |
DNASUi | 114712 |
Genome annotation databases
Ensembli | ENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518 |
GeneIDi | 114712 |
KEGGi | mmu:114712 |
UCSCi | uc007niv.1, mouse |
Organism-specific databases
CTDi | 222894 |
MGIi | MGI:2150010, Ferd3l |
VEuPathDBi | HostDB:ENSMUSG00000046518 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161409 |
HOGENOMi | CLU_148882_0_0_1 |
InParanoidi | Q923Z4 |
OMAi | LDGCSRQ |
OrthoDBi | 1513995at2759 |
PhylomeDBi | Q923Z4 |
Miscellaneous databases
BioGRID-ORCSi | 114712, 0 hits in 65 CRISPR screens |
PROi | PR:Q923Z4 |
RNActi | Q923Z4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046518, Expressed in kidney interstitium and 49 other tissues |
Genevisiblei | Q923Z4, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FER3L_MOUSE | |
Accessioni | Q923Z4Primary (citable) accession number: Q923Z4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot