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Protein

Fer3-like protein

Gene

Ferd3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fer3-like protein
Alternative name(s):
Basic helix-loop-helix protein N-twist
Nephew of atonal 3
Neuronal twist
Gene namesi
Name:Ferd3l
Synonyms:Nato, Ntwist
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2150010 Ferd3l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286831 – 168Fer3-like proteinAdd BLAST168

Proteomic databases

PaxDbiQ923Z4
PRIDEiQ923Z4

PTM databases

iPTMnetiQ923Z4
PhosphoSitePlusiQ923Z4

Expressioni

Tissue specificityi

Detected in the developing central nervous system, in particular in embryonic ventral neural tube, brain, and spinal cord. Detected in embryonic intestine. Detected in embryonic and adult thalamus, hypothalamus, midbrain, pons and medulla.2 Publications

Gene expression databases

BgeeiENSMUSG00000046518 Expressed in 34 organ(s), highest expression level in kidney interstitium
GenevisibleiQ923Z4 MM

Interactioni

Subunit structurei

Heterodimer with TCF3/E12. Interacts with the bHLH domain of TCF3/E12.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi227826, 1 interactor
STRINGi10090.ENSMUSP00000058994

Structurei

3D structure databases

ProteinModelPortaliQ923Z4
SMRiQ923Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 155bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 82Poly-Glu8

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00730000110958
HOGENOMiHOG000046685
HOVERGENiHBG094853
InParanoidiQ923Z4
KOiK22400
OMAiYPQSCVD
OrthoDBiEOG091G0YNB
PhylomeDBiQ923Z4

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q923Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAYPESCLD ATVLNFVADL SLASPRHPLL CEFPPGVPFG DRTLGYREGR
60 70 80 90 100
PGRLSQFDER YQEVEGDEVE YEDPEEEEEE GEGRGRVASL LGRPKRKRVI
110 120 130 140 150
TYAQRQAANI RERKRMFNLN EAFDQLRRKV PTFAYEKRLS RIETLRLAIV
160
YISFMTELLQ SKEEKEAS
Length:168
Mass (Da):19,463
Last modified:December 1, 2001 - v1
Checksum:i960BA60C19E7237B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369896 Genomic DNA Translation: AAK72955.1
AF517121 mRNA Translation: AAN04085.1
BC111576 mRNA Translation: AAI11577.1
CCDSiCCDS25878.1
RefSeqiNP_277057.1, NM_033522.2
UniGeneiMm.204643

Genome annotation databases

EnsembliENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518
GeneIDi114712
KEGGimmu:114712
UCSCiuc007niv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369896 Genomic DNA Translation: AAK72955.1
AF517121 mRNA Translation: AAN04085.1
BC111576 mRNA Translation: AAI11577.1
CCDSiCCDS25878.1
RefSeqiNP_277057.1, NM_033522.2
UniGeneiMm.204643

3D structure databases

ProteinModelPortaliQ923Z4
SMRiQ923Z4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227826, 1 interactor
STRINGi10090.ENSMUSP00000058994

PTM databases

iPTMnetiQ923Z4
PhosphoSitePlusiQ923Z4

Proteomic databases

PaxDbiQ923Z4
PRIDEiQ923Z4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061035; ENSMUSP00000058994; ENSMUSG00000046518
GeneIDi114712
KEGGimmu:114712
UCSCiuc007niv.1 mouse

Organism-specific databases

CTDi222894
MGIiMGI:2150010 Ferd3l

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00730000110958
HOGENOMiHOG000046685
HOVERGENiHBG094853
InParanoidiQ923Z4
KOiK22400
OMAiYPQSCVD
OrthoDBiEOG091G0YNB
PhylomeDBiQ923Z4

Miscellaneous databases

PROiPR:Q923Z4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046518 Expressed in 34 organ(s), highest expression level in kidney interstitium
GenevisibleiQ923Z4 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFER3L_MOUSE
AccessioniPrimary (citable) accession number: Q923Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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