UniProtKB - Q923X8 (TAA7B_RAT)
Protein
Trace amine-associated receptor 7b
Gene
Taar7b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
GO - Molecular functioni
- trace-amine receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Trace amine-associated receptor 7bShort name: TaR-7b Short name: Trace amine receptor 7b Alternative name(s): Trace amine receptor 12 Short name: TaR-12 |
Gene namesi | Name:Taar7b Synonyms:Ta12, Tar12, Trar12 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 631392, Taar7b |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 47 | ExtracellularSequence analysisAdd BLAST | 47 | |
Transmembranei | 48 – 68 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 69 – 83 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 84 – 104 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 125 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 147 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 148 – 166 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 167 – 187 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 211 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 212 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 274 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 275 – 295 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 296 – 309 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 310 – 332 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 333 – 358 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070165 | 1 – 358 | Trace amine-associated receptor 7bAdd BLAST | 358 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 120 ↔ 205 | PROSITE-ProRule annotation | ||
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q923X8 |
PRIDEi | Q923X8 |
PTM databases
GlyGeni | Q923X8, 2 sites |
Interactioni
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000021559 |
Chemistry databases
BindingDBi | Q923X8 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160273 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | Q923X8 |
OMAi | FGNSFCK |
OrthoDBi | 973471at2759 |
PhylomeDBi | Q923X8 |
TreeFami | TF343107 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR009132, TAAR_fam |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01830, TRACEAMINER |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q923X8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATDDDRFPW DQDSILSRDL LSASSMQLCY EKLNRSCVRS PYSPGPRLIL
60 70 80 90 100
YAVFGFGAVL AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV
110 120 130 140 150
MPFSMVRSVE GCWYFGDIYC KFHSSFDGSF CYSSIFHLCF ISADRYIAVS
160 170 180 190 200
DPLIYPTRFT ASVSGKCITF SWLLSIIYSF SLFYTGVNEA GLEDLVSALT
210 220 230 240 250
CVGGCQIAVN QSWVFINFLL FLVPALVMMT VYSKIFLIAK QQAQNIEKMG
260 270 280 290 300
KQTARASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
310 320 330 340 350
FVTPTYVYEI LVWIGYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS
SATNLFPE
Sequence cautioni
The sequence AAK71251 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF380200 Genomic DNA Translation: AAK71251.1 Different initiation. AY702319 Genomic DNA Translation: AAV70131.1 |
RefSeqi | NP_783176.2, NM_175586.2 |
Genome annotation databases
Ensembli | ENSRNOT00000021559; ENSRNOP00000021559; ENSRNOG00000046302 |
GeneIDi | 294126 |
KEGGi | rno:294126 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF380200 Genomic DNA Translation: AAK71251.1 Different initiation. AY702319 Genomic DNA Translation: AAV70131.1 |
RefSeqi | NP_783176.2, NM_175586.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000021559 |
Chemistry databases
BindingDBi | Q923X8 |
ChEMBLi | CHEMBL2176813 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q923X8, 2 sites |
Proteomic databases
PaxDbi | Q923X8 |
PRIDEi | Q923X8 |
Genome annotation databases
Ensembli | ENSRNOT00000021559; ENSRNOP00000021559; ENSRNOG00000046302 |
GeneIDi | 294126 |
KEGGi | rno:294126 |
Organism-specific databases
CTDi | 209517 |
RGDi | 631392, Taar7b |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160273 |
HOGENOMi | CLU_009579_11_0_1 |
InParanoidi | Q923X8 |
OMAi | FGNSFCK |
OrthoDBi | 973471at2759 |
PhylomeDBi | Q923X8 |
TreeFami | TF343107 |
Miscellaneous databases
PROi | PR:Q923X8 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR009132, TAAR_fam |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01830, TRACEAMINER |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAA7B_RAT | |
Accessioni | Q923X8Primary (citable) accession number: Q923X8 Secondary accession number(s): Q5QD22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | November 22, 2005 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families