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Protein

Ras-related protein Rab-30

Gene

Rab30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi64 – 68GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-30
Gene namesi
Name:Rab30
Synonyms:Rsb30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1923235 Rab30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212311 – 200Ras-related protein Rab-30Add BLAST200
PropeptideiPRO_0000370827201 – 203Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi199S-geranylgeranyl cysteineBy similarity1
Modified residuei200Cysteine methyl esterSequence analysis1
Lipidationi200S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ923S9
PaxDbiQ923S9
PRIDEiQ923S9

PTM databases

iPTMnetiQ923S9
PhosphoSitePlusiQ923S9

Expressioni

Gene expression databases

BgeeiENSMUSG00000030643 Expressed in 225 organ(s), highest expression level in small intestine
CleanExiMM_RAB30
ExpressionAtlasiQ923S9 baseline and differential
GenevisibleiQ923S9 MM

Interactioni

Protein-protein interaction databases

IntActiQ923S9, 5 interactors
MINTiQ923S9
STRINGi10090.ENSMUSP00000032879

Structurei

3D structure databases

ProteinModelPortaliQ923S9
SMRiQ923S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0095 Eukaryota
ENOG410XRPC LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ923S9
KOiK07917
OMAiQPSFDCL
OrthoDBiEOG091G0HS5
PhylomeDBiQ923S9
TreeFamiTF300097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q923S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA TIGVDFMIKT
60 70 80 90 100
VEINGEKVKL QIWDTAGQER FRSITQSYYR SANALILTYD ITCEESFRCL
110 120 130 140 150
PEWLREIEQY ASNKVITVLV GNKIDLAERR EVSQQRAEEF SEAQDMYYLE
160 170 180 190 200
TSAKESDNVE KLFLDLACRL ISEARQNTLV NNVSSPLPGE GKSISYLTCC

NFN
Length:203
Mass (Da):23,058
Last modified:December 1, 2001 - v1
Checksum:i935E56DBD48DD7C2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YV16D3YV16_MOUSE
Ras-related protein Rab-30
Rab30
175Annotation score:
A0A140LHW9A0A140LHW9_MOUSE
Ras-related protein Rab-30
Rab30
107Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67G → V in BAB30625 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399756 mRNA Translation: AAK94019.1
AK017185 mRNA Translation: BAB30625.1
AK142206 mRNA Translation: BAE24976.1
BC017550 mRNA Translation: AAH17550.1
CCDSiCCDS21450.1
RefSeqiNP_083770.2, NM_029494.2
XP_006508356.1, XM_006508293.3
XP_006508357.1, XM_006508294.2
UniGeneiMm.323004
Mm.389966

Genome annotation databases

EnsembliENSMUST00000032879; ENSMUSP00000032879; ENSMUSG00000030643
ENSMUST00000107180; ENSMUSP00000102798; ENSMUSG00000030643
GeneIDi75985
KEGGimmu:75985
UCSCiuc009iif.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399756 mRNA Translation: AAK94019.1
AK017185 mRNA Translation: BAB30625.1
AK142206 mRNA Translation: BAE24976.1
BC017550 mRNA Translation: AAH17550.1
CCDSiCCDS21450.1
RefSeqiNP_083770.2, NM_029494.2
XP_006508356.1, XM_006508293.3
XP_006508357.1, XM_006508294.2
UniGeneiMm.323004
Mm.389966

3D structure databases

ProteinModelPortaliQ923S9
SMRiQ923S9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ923S9, 5 interactors
MINTiQ923S9
STRINGi10090.ENSMUSP00000032879

PTM databases

iPTMnetiQ923S9
PhosphoSitePlusiQ923S9

Proteomic databases

MaxQBiQ923S9
PaxDbiQ923S9
PRIDEiQ923S9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032879; ENSMUSP00000032879; ENSMUSG00000030643
ENSMUST00000107180; ENSMUSP00000102798; ENSMUSG00000030643
GeneIDi75985
KEGGimmu:75985
UCSCiuc009iif.1 mouse

Organism-specific databases

CTDi27314
MGIiMGI:1923235 Rab30

Phylogenomic databases

eggNOGiKOG0095 Eukaryota
ENOG410XRPC LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ923S9
KOiK07917
OMAiQPSFDCL
OrthoDBiEOG091G0HS5
PhylomeDBiQ923S9
TreeFamiTF300097

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:Q923S9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030643 Expressed in 225 organ(s), highest expression level in small intestine
CleanExiMM_RAB30
ExpressionAtlasiQ923S9 baseline and differential
GenevisibleiQ923S9 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB30_MOUSE
AccessioniPrimary (citable) accession number: Q923S9
Secondary accession number(s): Q3UQR3, Q9D3Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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