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Protein

Protein phosphatase 1 regulatory subunit 16A

Gene

Ppp1r16a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 16A
Alternative name(s):
Myosin phosphatase targeting subunit 3
Gene namesi
Name:Ppp1r16a
Synonyms:Mypt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920312 Ppp1r16a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670411 – 521Protein phosphatase 1 regulatory subunit 16AAdd BLAST521
PropeptideiPRO_0000396708522 – 524Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei432PhosphoserineBy similarity1
Lipidationi520S-palmitoyl cysteineCurated1
Modified residuei521Cysteine methyl esterCurated1
Lipidationi521S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ923M0
PaxDbiQ923M0
PRIDEiQ923M0

PTM databases

iPTMnetiQ923M0
PhosphoSitePlusiQ923M0

Expressioni

Tissue specificityi

Highly expressed in testis, followed by liver, heart, brain and lung.

Gene expression databases

BgeeiENSMUSG00000033819 Expressed in 236 organ(s), highest expression level in intestine
ExpressionAtlasiQ923M0 baseline and differential
GenevisibleiQ923M0 MM

Interactioni

Subunit structurei

Binds PP1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037356

Structurei

3D structure databases

ProteinModelPortaliQ923M0
SMRiQ923M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 99ANK 1Add BLAST30
Repeati103 – 132ANK 2Add BLAST30
Repeati136 – 165ANK 3Add BLAST30
Repeati231 – 260ANK 4Add BLAST30
Repeati264 – 293ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili448 – 469Sequence analysisAdd BLAST22

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000236276
HOVERGENiHBG053644
InParanoidiQ923M0
KOiK17458
OMAiAKDQDGW
OrthoDBiEOG091G06S2
PhylomeDBiQ923M0
TreeFamiTF316803

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017417 Pase-1_reg_su_16AB
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PIRSFiPIRSF038159 PP1_16AB_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q923M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHLELLAE MPMVGRMSTQ ERLKHAQKRR AQQVKMWAQA EKEAHSKKGH
60 70 80 90 100
GERPWKEVAG LRPRKHVLFP PSVALLEAAA RNDLEEVRQF LTSGVSPNLA
110 120 130 140 150
NEDGLTALHQ CCIDDFQEMA QQLLDAGADV NARDSECWTP LHAAATCGHL
160 170 180 190 200
HLVELLISRG ADLLAVNSDG NMPYDLCEDA QTLDCLETAM ANQGITQEGI
210 220 230 240 250
EEARAVPELC MLNDLQNRLQ AGANLSDPLD HGATLLHIAA ANGFSEVATL
260 270 280 290 300
LLEQGASLSA KDHDGWEPLH AAAYWGQVHL VELLVAHGAD LNGKSLVDET
310 320 330 340 350
PLDVCGDEEV RAKLLELKHK QDALLRAQGR QRSLLRRRTS SAGSRGKVVR
360 370 380 390 400
RVSLTHRTNL YRKEHAQEAI VWQQPPPTSP EPLEDEDRQT DAELRLQPPE
410 420 430 440 450
DDGPEVARPH NGQVGAPPGR HLYSKRLDRS VSYHLSPEEN SAPDALVRDK
460 470 480 490 500
AHHTLAELKR QRAAAKLQRP APEGPETFEP GLSVDAGTSQ PDCGFSTIGD
510 520
PPLLKLTAPS EEASVEKRPC CLLM
Length:524
Mass (Da):57,530
Last modified:December 1, 2001 - v1
Checksum:iA0F682A794475429
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CFW6Q8CFW6_MOUSE
Ppp1r16a protein
Ppp1r16a
242Annotation score:
F6TBE5F6TBE5_MOUSE
Protein phosphatase 1 regulatory su...
Ppp1r16a
40Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY010723 mRNA Translation: AAG40949.1
BC057450 mRNA Translation: AAH57450.1
BC096620 mRNA Translation: AAH96620.1
CCDSiCCDS27585.1
RefSeqiNP_203535.1, NM_033371.2
XP_006521530.1, XM_006521467.2
UniGeneiMm.322901
Mm.474349

Genome annotation databases

EnsembliENSMUST00000037551; ENSMUSP00000037356; ENSMUSG00000033819
ENSMUST00000135388; ENSMUSP00000155515; ENSMUSG00000033819
GeneIDi73062
KEGGimmu:73062
UCSCiuc007wlo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY010723 mRNA Translation: AAG40949.1
BC057450 mRNA Translation: AAH57450.1
BC096620 mRNA Translation: AAH96620.1
CCDSiCCDS27585.1
RefSeqiNP_203535.1, NM_033371.2
XP_006521530.1, XM_006521467.2
UniGeneiMm.322901
Mm.474349

3D structure databases

ProteinModelPortaliQ923M0
SMRiQ923M0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037356

PTM databases

iPTMnetiQ923M0
PhosphoSitePlusiQ923M0

Proteomic databases

MaxQBiQ923M0
PaxDbiQ923M0
PRIDEiQ923M0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037551; ENSMUSP00000037356; ENSMUSG00000033819
ENSMUST00000135388; ENSMUSP00000155515; ENSMUSG00000033819
GeneIDi73062
KEGGimmu:73062
UCSCiuc007wlo.1 mouse

Organism-specific databases

CTDi84988
MGIiMGI:1920312 Ppp1r16a

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000236276
HOVERGENiHBG053644
InParanoidiQ923M0
KOiK17458
OMAiAKDQDGW
OrthoDBiEOG091G06S2
PhylomeDBiQ923M0
TreeFamiTF316803

Miscellaneous databases

PROiPR:Q923M0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033819 Expressed in 236 organ(s), highest expression level in intestine
ExpressionAtlasiQ923M0 baseline and differential
GenevisibleiQ923M0 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017417 Pase-1_reg_su_16AB
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PIRSFiPIRSF038159 PP1_16AB_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPP16A_MOUSE
AccessioniPrimary (citable) accession number: Q923M0
Secondary accession number(s): Q4V9Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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