UniProtKB - Q923M0 (PP16A_MOUSE)
Protein
Protein phosphatase 1 regulatory subunit 16A
Gene
Ppp1r16a
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.
GO - Molecular functioni
- myosin phosphatase regulator activity Source: GO_Central
- protein phosphatase 1 binding Source: GO_Central
- protein phosphatase regulator activity Source: GO_Central
GO - Biological processi
- regulation of protein dephosphorylation Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 16AAlternative name(s): Myosin phosphatase targeting subunit 3 |
Gene namesi | Name:Ppp1r16a Synonyms:Mypt3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920312, Ppp1r16a |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000067041 | 1 – 521 | Protein phosphatase 1 regulatory subunit 16AAdd BLAST | 521 | |
PropeptideiPRO_0000396708 | 522 – 524 | Removed in mature formCurated | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 432 | PhosphoserineBy similarity | 1 | |
Lipidationi | 520 | S-palmitoyl cysteineCurated | 1 | |
Modified residuei | 521 | Cysteine methyl esterCurated | 1 | |
Lipidationi | 521 | S-farnesyl cysteine1 Publication | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, Phosphoprotein, PrenylationProteomic databases
MaxQBi | Q923M0 |
PaxDbi | Q923M0 |
PRIDEi | Q923M0 |
PTM databases
iPTMneti | Q923M0 |
PhosphoSitePlusi | Q923M0 |
Expressioni
Tissue specificityi
Highly expressed in testis, followed by liver, heart, brain and lung.
Gene expression databases
Bgeei | ENSMUSG00000033819, Expressed in spermatid and 254 other tissues |
ExpressionAtlasi | Q923M0, baseline and differential |
Genevisiblei | Q923M0, MM |
Interactioni
Subunit structurei
Binds PP1.
GO - Molecular functioni
- protein phosphatase 1 binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037356 |
Miscellaneous databases
RNActi | Q923M0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 70 – 99 | ANK 1Add BLAST | 30 | |
Repeati | 103 – 132 | ANK 2Add BLAST | 30 | |
Repeati | 136 – 165 | ANK 3Add BLAST | 30 | |
Repeati | 231 – 260 | ANK 4Add BLAST | 30 | |
Repeati | 264 – 293 | ANK 5Add BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 448 – 469 | Sequence analysisAdd BLAST | 22 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0505, Eukaryota |
GeneTreei | ENSGT00940000154090 |
HOGENOMi | CLU_000134_54_2_1 |
InParanoidi | Q923M0 |
OMAi | PEVARPH |
OrthoDBi | 564568at2759 |
PhylomeDBi | Q923M0 |
TreeFami | TF316803 |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR017417, Pase-1_reg_su_16AB |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PIRSFi | PIRSF038159, PP1_16AB_vert, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q923M0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEHLELLAE MPMVGRMSTQ ERLKHAQKRR AQQVKMWAQA EKEAHSKKGH
60 70 80 90 100
GERPWKEVAG LRPRKHVLFP PSVALLEAAA RNDLEEVRQF LTSGVSPNLA
110 120 130 140 150
NEDGLTALHQ CCIDDFQEMA QQLLDAGADV NARDSECWTP LHAAATCGHL
160 170 180 190 200
HLVELLISRG ADLLAVNSDG NMPYDLCEDA QTLDCLETAM ANQGITQEGI
210 220 230 240 250
EEARAVPELC MLNDLQNRLQ AGANLSDPLD HGATLLHIAA ANGFSEVATL
260 270 280 290 300
LLEQGASLSA KDHDGWEPLH AAAYWGQVHL VELLVAHGAD LNGKSLVDET
310 320 330 340 350
PLDVCGDEEV RAKLLELKHK QDALLRAQGR QRSLLRRRTS SAGSRGKVVR
360 370 380 390 400
RVSLTHRTNL YRKEHAQEAI VWQQPPPTSP EPLEDEDRQT DAELRLQPPE
410 420 430 440 450
DDGPEVARPH NGQVGAPPGR HLYSKRLDRS VSYHLSPEEN SAPDALVRDK
460 470 480 490 500
AHHTLAELKR QRAAAKLQRP APEGPETFEP GLSVDAGTSQ PDCGFSTIGD
510 520
PPLLKLTAPS EEASVEKRPC CLLM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8CFW6 | Q8CFW6_MOUSE | Ppp1r16a protein | Ppp1r16a | 242 | Annotation score: | ||
F6TBE5 | F6TBE5_MOUSE | Protein phosphatase 1 regulatory su... | Ppp1r16a | 40 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY010723 mRNA Translation: AAG40949.1 BC057450 mRNA Translation: AAH57450.1 BC096620 mRNA Translation: AAH96620.1 |
CCDSi | CCDS27585.1 |
RefSeqi | NP_203535.1, NM_033371.2 XP_006521530.1, XM_006521467.2 |
Genome annotation databases
Ensembli | ENSMUST00000037551; ENSMUSP00000037356; ENSMUSG00000033819 ENSMUST00000135388; ENSMUSP00000155515; ENSMUSG00000033819 |
GeneIDi | 73062 |
KEGGi | mmu:73062 |
UCSCi | uc007wlo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY010723 mRNA Translation: AAG40949.1 BC057450 mRNA Translation: AAH57450.1 BC096620 mRNA Translation: AAH96620.1 |
CCDSi | CCDS27585.1 |
RefSeqi | NP_203535.1, NM_033371.2 XP_006521530.1, XM_006521467.2 |
3D structure databases
SMRi | Q923M0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037356 |
PTM databases
iPTMneti | Q923M0 |
PhosphoSitePlusi | Q923M0 |
Proteomic databases
MaxQBi | Q923M0 |
PaxDbi | Q923M0 |
PRIDEi | Q923M0 |
Protocols and materials databases
Antibodypediai | 14950, 88 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000037551; ENSMUSP00000037356; ENSMUSG00000033819 ENSMUST00000135388; ENSMUSP00000155515; ENSMUSG00000033819 |
GeneIDi | 73062 |
KEGGi | mmu:73062 |
UCSCi | uc007wlo.1, mouse |
Organism-specific databases
CTDi | 84988 |
MGIi | MGI:1920312, Ppp1r16a |
Phylogenomic databases
eggNOGi | KOG0505, Eukaryota |
GeneTreei | ENSGT00940000154090 |
HOGENOMi | CLU_000134_54_2_1 |
InParanoidi | Q923M0 |
OMAi | PEVARPH |
OrthoDBi | 564568at2759 |
PhylomeDBi | Q923M0 |
TreeFami | TF316803 |
Miscellaneous databases
BioGRID-ORCSi | 73062, 2 hits in 18 CRISPR screens |
ChiTaRSi | Ppp1r16a, mouse |
PROi | PR:Q923M0 |
RNActi | Q923M0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033819, Expressed in spermatid and 254 other tissues |
ExpressionAtlasi | Q923M0, baseline and differential |
Genevisiblei | Q923M0, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR017417, Pase-1_reg_su_16AB |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PIRSFi | PIRSF038159, PP1_16AB_vert, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 5 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP16A_MOUSE | |
Accessioni | Q923M0Primary (citable) accession number: Q923M0 Secondary accession number(s): Q4V9Z1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 2002 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot