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Entry version 132 (07 Oct 2020)
Sequence version 2 (27 Jul 2011)
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Protein

CUB and sushi domain-containing protein 1

Gene

Csmd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUB and sushi domain-containing protein 1
Alternative name(s):
CUB and sushi multiple domains protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Csmd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2137383, Csmd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 3487ExtracellularSequence analysisAdd BLAST3458
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3488 – 3508HelicalSequence analysisAdd BLAST21
Topological domaini3509 – 3564CytoplasmicSequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002102630 – 3564CUB and sushi domain-containing protein 1Add BLAST3535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 58By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 185By similarity
Disulfide bondi171 ↔ 202By similarity
Disulfide bondi208 ↔ 234By similarity
Disulfide bondi349 ↔ 389By similarity
Disulfide bondi375 ↔ 406By similarity
Disulfide bondi411 ↔ 437By similarity
Disulfide bondi527 ↔ 567By similarity
Disulfide bondi553 ↔ 580By similarity
Disulfide bondi584 ↔ 610By similarity
Glycosylationi587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi697 ↔ 738By similarity
Disulfide bondi723 ↔ 754By similarity
Disulfide bondi758 ↔ 784By similarity
Disulfide bondi873 ↔ 913By similarity
Disulfide bondi899 ↔ 926By similarity
Disulfide bondi930 ↔ 956By similarity
Glycosylationi955N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1015N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1034N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1045 ↔ 1085By similarity
Disulfide bondi1071 ↔ 1100By similarity
Disulfide bondi1104 ↔ 1130By similarity
Glycosylationi1184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1217 ↔ 1258By similarity
Disulfide bondi1244 ↔ 1273By similarity
Disulfide bondi1277 ↔ 1304By similarity
Disulfide bondi1391 ↔ 1431By similarity
Glycosylationi1399N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1417 ↔ 1447By similarity
Disulfide bondi1451 ↔ 1477By similarity
Glycosylationi1454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1564 ↔ 1604By similarity
Glycosylationi1572N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1590 ↔ 1621By similarity
Disulfide bondi1625 ↔ 1651By similarity
Glycosylationi1644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1741 ↔ 1781By similarity
Disulfide bondi1767 ↔ 1798By similarity
Glycosylationi1792N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1802 ↔ 1828By similarity
Glycosylationi1805N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1882N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1915 ↔ 1955By similarity
Disulfide bondi1941 ↔ 1970By similarity
Disulfide bondi1974 ↔ 2000By similarity
Glycosylationi2018N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2087 ↔ 2127By similarity
Disulfide bondi2113 ↔ 2142By similarity
Disulfide bondi2146 ↔ 2172By similarity
Glycosylationi2149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2187N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2258 ↔ 2300By similarity
Disulfide bondi2286 ↔ 2315By similarity
Disulfide bondi2319 ↔ 2347By similarity
Glycosylationi2358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2432 ↔ 2473By similarity
Glycosylationi2445N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2459 ↔ 2490By similarity
Glycosylationi2470N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2495 ↔ 2537By similarity
Glycosylationi2503N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2521 ↔ 2552By similarity
Disulfide bondi2557 ↔ 2602By similarity
Disulfide bondi2588 ↔ 2617By similarity
Glycosylationi2605N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2622 ↔ 2662By similarity
Disulfide bondi2648 ↔ 2675By similarity
Disulfide bondi2680 ↔ 2720By similarity
Disulfide bondi2706 ↔ 2733By similarity
Disulfide bondi2738 ↔ 2778By similarity
Glycosylationi2750N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2761N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2764 ↔ 2791By similarity
Glycosylationi2795N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2796 ↔ 2841By similarity
Disulfide bondi2827 ↔ 2854By similarity
Disulfide bondi2859 ↔ 2899By similarity
Disulfide bondi2885 ↔ 2912By similarity
Glycosylationi2894N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2920 ↔ 2960By similarity
Disulfide bondi2946 ↔ 2973By similarity
Glycosylationi2963N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2978 ↔ 3019By similarity
Disulfide bondi3005 ↔ 3032By similarity
Glycosylationi3022N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3037 ↔ 3079By similarity
Glycosylationi3056N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3063 ↔ 3092By similarity
Glycosylationi3086N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3097 ↔ 3137By similarity
Disulfide bondi3123 ↔ 3150By similarity
Disulfide bondi3155 ↔ 3195By similarity
Disulfide bondi3181 ↔ 3208By similarity
Disulfide bondi3216 ↔ 3257By similarity
Glycosylationi3228N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3243 ↔ 3270By similarity
Glycosylationi3260N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3275 ↔ 3317By similarity
Disulfide bondi3302 ↔ 3330By similarity
Glycosylationi3339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3386N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q923L3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q923L3

PeptideAtlas

More...
PeptideAtlasi
Q923L3

PRoteomics IDEntifications database

More...
PRIDEi
Q923L3

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2241, 6 N-Linked glycans (9 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q923L3, 40 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q923L3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q923L3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000060924, Expressed in cerebral cortex and 112 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q923L3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000080751

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q923L3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q923L3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 140CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini143 – 204Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini208 – 312CUB 2PROSITE-ProRule annotationAdd BLAST105
Domaini347 – 408Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini411 – 522CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini525 – 582Sushi 3PROSITE-ProRule annotationAdd BLAST58
Domaini584 – 692CUB 4PROSITE-ProRule annotationAdd BLAST109
Domaini695 – 756Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini758 – 866CUB 5PROSITE-ProRule annotationAdd BLAST109
Domaini871 – 928Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini930 – 1040CUB 6PROSITE-ProRule annotationAdd BLAST111
Domaini1043 – 1102Sushi 6PROSITE-ProRule annotationAdd BLAST60
Domaini1104 – 1212CUB 7PROSITE-ProRule annotationAdd BLAST109
Domaini1215 – 1275Sushi 7PROSITE-ProRule annotationAdd BLAST61
Domaini1277 – 1386CUB 8PROSITE-ProRule annotationAdd BLAST110
Domaini1389 – 1449Sushi 8PROSITE-ProRule annotationAdd BLAST61
Domaini1451 – 1559CUB 9PROSITE-ProRule annotationAdd BLAST109
Domaini1562 – 1623Sushi 9PROSITE-ProRule annotationAdd BLAST62
Domaini1625 – 1733CUB 10PROSITE-ProRule annotationAdd BLAST109
Domaini1739 – 1800Sushi 10PROSITE-ProRule annotationAdd BLAST62
Domaini1802 – 1910CUB 11PROSITE-ProRule annotationAdd BLAST109
Domaini1913 – 1972Sushi 11PROSITE-ProRule annotationAdd BLAST60
Domaini1974 – 2082CUB 12PROSITE-ProRule annotationAdd BLAST109
Domaini2085 – 2144Sushi 12PROSITE-ProRule annotationAdd BLAST60
Domaini2146 – 2257CUB 13PROSITE-ProRule annotationAdd BLAST112
Domaini2256 – 2317Sushi 13PROSITE-ProRule annotationAdd BLAST62
Domaini2319 – 2430CUB 14PROSITE-ProRule annotationAdd BLAST112
Domaini2430 – 2492Sushi 14PROSITE-ProRule annotationAdd BLAST63
Domaini2493 – 2554Sushi 15PROSITE-ProRule annotationAdd BLAST62
Domaini2555 – 2619Sushi 16PROSITE-ProRule annotationAdd BLAST65
Domaini2620 – 2677Sushi 17PROSITE-ProRule annotationAdd BLAST58
Domaini2678 – 2735Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2736 – 2793Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2794 – 2856Sushi 20PROSITE-ProRule annotationAdd BLAST63
Domaini2857 – 2914Sushi 21PROSITE-ProRule annotationAdd BLAST58
Domaini2918 – 2975Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2976 – 3034Sushi 23PROSITE-ProRule annotationAdd BLAST59
Domaini3035 – 3094Sushi 24PROSITE-ProRule annotationAdd BLAST60
Domaini3095 – 3152Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini3153 – 3210Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3214 – 3272Sushi 27PROSITE-ProRule annotationAdd BLAST59
Domaini3273 – 3332Sushi 28PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSMD family.Curated

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000277_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q923L3

KEGG Orthology (KO)

More...
KOi
K17495

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPGFCGD

Database of Orthologous Groups

More...
OrthoDBi
2377at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316872

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 28 hits
cd00041, CUB, 14 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q923L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAWRKFKSL LLPLVLAVLC AGLLTAAKGQ NCGGLVQGPN GTIESPGFPH
60 70 80 90 100
GYPNYANCTW IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV
110 120 130 140 150
RLSGFQLPSS IVSTGSLLTL WFTTDFAVSA QGFKAMYEVL PSHTCGNPGE
160 170 180 190 200
ILKGVLHGTR FNIGDKIRYS CLSGYILEGH AILTCIVSPG NGASWDFPAP
210 220 230 240 250
FCRAEGACGG TLRGTSGSIS SPHFPSEYDN NADCTWTILA EPGDTIALVF
260 270 280 290 300
TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH
310 320 330 340 350
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDS SHKNSVLTQG GVSLISDMCP
360 370 380 390 400
DPGIPDNGRR AGSDFRVGAN VQFSCEDNYV LQGAKGITCQ RVTETLAAWN
410 420 430 440 450
DHRPICRART CGSNLRGPSG VITSPNYPVQ YEDNAHCVWV ITTTDPDKVI
460 470 480 490 500
KLAFEEFELE RGYDTLTVGD AGKVGDTRSV LYVLTGSSVP DLIVSMSNQM
510 520 530 540 550
WLHLQSDDSI GSPGFKAVYQ EIEKGGCGDP GIPAYGKRTG SSFLHGDTLT
560 570 580 590 600
FECQAAFELV GERVITCQKN NQWSGNKPSC VFSCFFNFTA PSGIILSPNY
610 620 630 640 650
PEEYGNNMNC VWLIISEPGS RIHLIFNDFD VEPQFDFLAV KDDGISDITV
660 670 680 690 700
LGTFSGNEVP AQLASSGHIV RLEFQSDHST TGRGFNITYT TFGQNECHDP
710 720 730 740 750
GIPVNGRRFG DRFLLGSSVS FHCDDGFVKT QGSESITCIL QDGNVVWSST
760 770 780 790 800
VPRCEAPCGG HLTASSGVIL PPGWPGYYKD SLNCEWVIEA KPGHSIKITF
810 820 830 840 850
DRFQTEVNYD TLEVRDGPTS SSPLIGEYHG TQAPQFLIST GNYMYLLFTT
860 870 880 890 900
DSSRASVGFL IHYESVTLES DSCLDPGIPV NGQRHGSNFG IRSTVTFSCD
910 920 930 940 950
PGYTLSDDEP LVCEKNHQWN HALPSCDALC GGYIHGKSGT VLSPGFPDFY
960 970 980 990 1000
PNSLNCTWTI EVSHGKGVQM NFHTFHLESS HDYLLITEDG SFSEPVARLT
1010 1020 1030 1040 1050
GSVLPHTIKA GLFGNFTAQL RFISDFSISY EGFNITFAEY DLEPCDDPGV
1060 1070 1080 1090 1100
PAFSRRIGFQ FGVGDTLAFT CFQGYRLEGA TKLTCLGGGR RVWSAPLPRC
1110 1120 1130 1140 1150
VAECGASVKG NEGTLLSPNF PSHYDNNHEC IYKIETEAGK GIHLRARTFQ
1160 1170 1180 1190 1200
LFEGDTLKVY DGKDSSSRSL GVFTRSEFMG LVLNSTSNHL RLEFNTNGSD
1210 1220 1230 1240 1250
TAQGFQLTYT SFDLVKCEDP GIPNYGYRIR DDGHFTDTVV LYSCNPGYAM
1260 1270 1280 1290 1300
HGSSTLTCLS GDRRVWDKPM PSCVAECGGL VHAATSGRIL SPGYPAPYDN
1310 1320 1330 1340 1350
NLHCTWTIEA DPGKTISLHF IVFDTETAHD ILKVWDGPVD SNILLKEWSG
1360 1370 1380 1390 1400
SALPEDIHST FNSLTLQFDS DFFISKSGFS IQFSTSIAST CNDPGMPQNG
1410 1420 1430 1440 1450
TRYGDSREPG DTITFQCDPG YQLQGPAKIT CVQLNNRFFW QPDPPSCIAA
1460 1470 1480 1490 1500
CGGNLTGPAG VILSPNYPQP YPPGKECDWR IKVNPDFVIA LIFKSFSMEP
1510 1520 1530 1540 1550
SYDFLHIYEG EDSNSPLIGS FQGSQAPERI ESSGNSLFLA FRSDASVGLS
1560 1570 1580 1590 1600
GFAIEFKEKP REACFDPGNI MNGTRIGTDF KLGSTVTYQC DSGYKIVDPS
1610 1620 1630 1640 1650
SIECVTGADG KPSWDRALPA CQAPCGGQYT GSEGVVLSPN YPHNYTAGQM
1660 1670 1680 1690 1700
CIYSITVPKE FVVFGQFAYF QTALNDLAEL FDGTHPQARL LSSLSGSHSG
1710 1720 1730 1740 1750
ETLPLATSNQ ILLRFSAKSG ASARGFHFVY QAVPRTSDTQ CSSVPEPRYG
1760 1770 1780 1790 1800
RRIGSEFSAG SIVRFECNPG YLLQGSTAIR CQSVPNALAQ WNDTIPSCVV
1810 1820 1830 1840 1850
PCSGNFTQRR GTILSPGYPE PYGNNLNCVW KIIVSEGSGI QIQVISFATE
1860 1870 1880 1890 1900
QNWDSLEIHD GGDMTAPRLG SFSGTTVPAL LNSTSNQLCL HFQSDISVAA
1910 1920 1930 1940 1950
AGFHLEYKTV GLAACQEPAL PSNGIKIGDR YMVNDVLSFQ CEPGYTLQGR
1960 1970 1980 1990 2000
SHISCMPGTV RRWNYPSPLC IATCGGTLTS MSGVILSPGF PGSYPNNLDC
2010 2020 2030 2040 2050
TWKISLPIGY GAHIQFLNFS TEANHDYLEI QNGPYHSSPM MGQFSGPDLP
2060 2070 2080 2090 2100
TSLLSTTHET LIRFYSDHSQ NRQGFKLSYQ AYELQNCPDP PAFQNGFMIN
2110 2120 2130 2140 2150
SDYSVGQSIS FECYPGYILL GHPVLTCQHG TDRNWNYPFP RCDAPCGYNV
2160 2170 2180 2190 2200
TSQNGTIYSP GFPDEYPILK DCLWLVTVPP GHGVYINFTL LQTEAVNDYI
2210 2220 2230 2240 2250
AVWDGPDQNS PQLGVFSGNT ALETAYSSTN QVLLKFHSDF SNGGFFVLNF
2260 2270 2280 2290 2300
HAFQLKRCPP PPAVPQADLL TEDEDFEIGD FVKYQCHPGY TLLGSDTLTC
2310 2320 2330 2340 2350
KLSSQLLFQG SPPTCEAQCP ANEVRTESSG VILSPGYPGN YFNSQTCAWS
2360 2370 2380 2390 2400
IKVEPNFNIT LFVDTFQSEK QFDALEVFDG SSGQSPLLVV LSGNHTEQSN
2410 2420 2430 2440 2450
FTSRSNHLYL RWSTDHATSK KGFKIRYAAP YCSLTSTLRN GGILNKTAGA
2460 2470 2480 2490 2500
VGSKVHYFCK PGYRMIGHSN ATCRRNPVGV YQWDSMAPLC QAVSCGIPEA
2510 2520 2530 2540 2550
PGNGSFTGNE FTLDSKVTYE CNEGFKLDAS QEATTVCQED GLWSNRGKPP
2560 2570 2580 2590 2600
TCKPVPCPSI EGQLSEHVLW RLVSGSLNEY GAQVLLSCSP GYFLQGQRLL
2610 2620 2630 2640 2650
QCQANGTWST EEDRPRCKVI SCGSLSFPPN GNKIGTLTIY GATAIFTCNT
2660 2670 2680 2690 2700
GYTLVGSHVR ECLANGLWSG SETRCLAGHC GSPDPIVNGH ISGDGFSYRD
2710 2720 2730 2740 2750
TVVYQCNPGF RLVGTSVRIC LQDHKWSGQT PVCVPITCGH PGNPAHGLTN
2760 2770 2780 2790 2800
GTEFNLNDLV NFTCHTGYRL QGASRAQCRS NGQWSSPLPI CRVVNCSDPG
2810 2820 2830 2840 2850
SVENAVRHGQ QNFPESFEYG TSVMYHCKTG FYLLGSSALT CMASGLWDRS
2860 2870 2880 2890 2900
LPKCLAISCG HPGVPANAVL TGELFTYGAT VQYSCKGGQI LTGNSTRVCQ
2910 2920 2930 2940 2950
EDSHWSGSLP HCSGNSPGFC GDPGTPAHGS RLGDEFKTKS LLRFSCEMGH
2960 2970 2980 2990 3000
QLRGSAERTC LVNGSWSGVQ PVCEAVSCGN PGTPTNGMIL SSDGILFSSS
3010 3020 3030 3040 3050
VIYACWEGYK TSGLMTRHCT ANGTWTGTAP DCTIISCGDP GTLPNGIQFG
3060 3070 3080 3090 3100
TDFTFNKTVS YQCNPGYLME PPTSPTIRCT KDGTWNQSRP LCKAVLCNQP
3110 3120 3130 3140 3150
PPVPNGKVEG SDFRWGASIS YSCVDGYQLS HSAILSCEGR GVWKGEVPQC
3160 3170 3180 3190 3200
LPVFCGDPGT PAEGRLSGKS FTFKSEVFIQ CKPPFVLVGS SRRTCQADGI
3210 3220 3230 3240 3250
WSGIQPTCID PAHTACPDPG TPHFGIQNSS KGYEVGSTVF FRCRKGYHIQ
3260 3270 3280 3290 3300
GSTTRTCLAN LTWSGIQTEC IPHACRQPET PAHADVRAID LPAFGYTLVY
3310 3320 3330 3340 3350
TCHPGFFLAG GSEHRTCKAD MKWTGKSPVC KSKGVREVNE TVTKTPVPSD
3360 3370 3380 3390 3400
VFFINSVWKG YYEYLGKRQP ATLTVDWFNA TSSKVNATFT AASRVQLELT
3410 3420 3430 3440 3450
GVYKKEEAHL LLKAFHIKGP ADIFVSKFEN DNWGLDGYVS SGLERGGFSF
3460 3470 3480 3490 3500
QGDIHGKDFG KFKLERQDPS NSDADSSNHY QGTSSGSVAA AILVPFFALI
3510 3520 3530 3540 3550
LSGFAFYLYK HRTRPKVQYN GYAGHENSNG QASFENPMYD TNLKPTEAKA
3560
VRFDTTLNTV CTVV
Length:3,564
Mass (Da):387,862
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCBC9BB488908858
GO
Isoform 2 (identifier: Q923L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3332-3347: SKGVREVNETVTKTPV → I

Show »
Length:3,549
Mass (Da):386,249
Checksum:i578A1577BCC5DD6E
GO
Isoform 3 (identifier: Q923L3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-3564: Missing.

Show »
Length:101
Mass (Da):11,092
Checksum:i9A3E87014C04D290
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC30095 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti627N → K in AAG54083 (PubMed:11472063).Curated1
Sequence conflicti1189H → Y in AAG54083 (PubMed:11472063).Curated1
Sequence conflicti1652I → V in AAG54083 (PubMed:11472063).Curated1
Sequence conflicti2222L → P in AAG54083 (PubMed:11472063).Curated1
Sequence conflicti2354E → K in AAG54083 (PubMed:11472063).Curated1
Sequence conflicti2384Q → R in AAG54083 (PubMed:11472063).Curated1
Sequence conflicti2721 – 2731LQDHKWSGQTP → CRTTSGRGRLT in AAG54083 (PubMed:11472063).CuratedAdd BLAST11
Sequence conflicti2955S → F in AAG54083 (PubMed:11472063).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009036102 – 3564Missing in isoform 3. 1 PublicationAdd BLAST3463
Alternative sequenceiVSP_0090373332 – 3347SKGVR…TKTPV → I in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY017475 mRNA Translation: AAG54083.1
AK038679 mRNA Translation: BAC30095.1 Different initiation.
AK082377 mRNA Translation: BAC38482.1
AC101229 Genomic DNA No translation available.
AC122323 Genomic DNA No translation available.
AC122839 Genomic DNA No translation available.
AC122911 Genomic DNA No translation available.
AC123819 Genomic DNA No translation available.
AC123866 Genomic DNA No translation available.
AC123984 Genomic DNA No translation available.
AC124351 Genomic DNA No translation available.
AC125132 Genomic DNA No translation available.
AC125354 Genomic DNA No translation available.
AC132578 Genomic DNA No translation available.
AC144939 Genomic DNA No translation available.
AC154107 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40244.1 [Q923L3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_444401.2, NM_053171.2 [Q923L3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000082104; ENSMUSP00000080751; ENSMUSG00000060924 [Q923L3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:94109

UCSC genome browser

More...
UCSCi
uc009kzp.1, mouse [Q923L3-1]
uc009kzr.1, mouse [Q923L3-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY017475 mRNA Translation: AAG54083.1
AK038679 mRNA Translation: BAC30095.1 Different initiation.
AK082377 mRNA Translation: BAC38482.1
AC101229 Genomic DNA No translation available.
AC122323 Genomic DNA No translation available.
AC122839 Genomic DNA No translation available.
AC122911 Genomic DNA No translation available.
AC123819 Genomic DNA No translation available.
AC123866 Genomic DNA No translation available.
AC123984 Genomic DNA No translation available.
AC124351 Genomic DNA No translation available.
AC125132 Genomic DNA No translation available.
AC125354 Genomic DNA No translation available.
AC132578 Genomic DNA No translation available.
AC144939 Genomic DNA No translation available.
AC154107 Genomic DNA No translation available.
CCDSiCCDS40244.1 [Q923L3-1]
RefSeqiNP_444401.2, NM_053171.2 [Q923L3-1]

3D structure databases

SMRiQ923L3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080751

PTM databases

GlyConnecti2241, 6 N-Linked glycans (9 sites)
GlyGeniQ923L3, 40 sites
iPTMnetiQ923L3
PhosphoSitePlusiQ923L3

Proteomic databases

jPOSTiQ923L3
PaxDbiQ923L3
PeptideAtlasiQ923L3
PRIDEiQ923L3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52810, 77 antibodies

Genome annotation databases

EnsembliENSMUST00000082104; ENSMUSP00000080751; ENSMUSG00000060924 [Q923L3-1]
GeneIDi94109
KEGGimmu:94109
UCSCiuc009kzp.1, mouse [Q923L3-1]
uc009kzr.1, mouse [Q923L3-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64478
MGIiMGI:2137383, Csmd1

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000155701
HOGENOMiCLU_000277_0_0_1
InParanoidiQ923L3
KOiK17495
OMAiSPGFCGD
OrthoDBi2377at2759
TreeFamiTF316872

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
94109, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Csmd1, mouse

Protein Ontology

More...
PROi
PR:Q923L3
RNActiQ923L3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000060924, Expressed in cerebral cortex and 112 other tissues
GenevisibleiQ923L3, MM

Family and domain databases

CDDicd00033, CCP, 28 hits
cd00041, CUB, 14 hits
Gene3Di2.60.120.290, 14 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 14 hits
PF00084, Sushi, 28 hits
SMARTiView protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 14 hits
SUPFAMiSSF49854, SSF49854, 14 hits
SSF57535, SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 14 hits
PS50923, SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSMD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q923L3
Secondary accession number(s): E9QK23, Q8BUV1, Q8BYQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 27, 2011
Last modified: October 7, 2020
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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