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Protein

tRNA modification GTPase GTPBP3, mitochondrial

Gene

Gtpbp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTPase involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi256 – 263GTPSequence analysis8
Nucleotide bindingi303 – 307GTPSequence analysis5
Nucleotide bindingi374 – 377GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processing
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA modification GTPase GTPBP3, mitochondrial
Alternative name(s):
GTP-binding protein 3
Gene namesi
Name:Gtpbp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1917609 Gtpbp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 81MitochondrionSequence analysisAdd BLAST81
ChainiPRO_000028026682 – 492tRNA modification GTPase GTPBP3, mitochondrialAdd BLAST411

Proteomic databases

EPDiQ923K4
PaxDbiQ923K4
PRIDEiQ923K4

PTM databases

PhosphoSitePlusiQ923K4

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in tissues with high metabolic rates including heart, liver and brain. Weakly expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000007610
CleanExiMM_GTPBP3
ExpressionAtlasiQ923K4 baseline and differential
GenevisibleiQ923K4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007754

Structurei

3D structure databases

ProteinModelPortaliQ923K4
SMRiQ923K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 416TrmE-type GAdd BLAST168

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1191 Eukaryota
COG0486 LUCA
GeneTreeiENSGT00390000016851
HOGENOMiHOG000200714
HOVERGENiHBG081577
InParanoidiQ923K4
KOiK03650
PhylomeDBiQ923K4
TreeFamiTF313153

Family and domain databases

CDDicd04164 trmE, 1 hit
Gene3Di1.20.120.430, 2 hits
3.30.1360.120, 1 hit
HAMAPiMF_00379 GTPase_MnmE, 1 hit
InterProiView protein in InterPro
IPR031168 G_TrmE
IPR018948 GTP-bd_TrmE_N
IPR006073 GTP_binding_domain
IPR004520 GTPase_MnmE
IPR027368 MnmE_dom2
IPR025867 MnmE_helical
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF12631 MnmE_helical, 1 hit
PF10396 TrmE_N, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00450 mnmE_trmE_thdF, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51709 G_TRME, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q923K4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRGLSALVT QAAWAPLRLC ARCSTSAESL VPSSTIFALS SGQGRCAIAV
60 70 80 90 100
IRTSGPASGL ALRSLTALQE PPPARRACLR LLRHPCSGEP LDRSLVLWFP
110 120 130 140 150
GPQSFTGEDC VEFHVHGGPA VVSGVLQALG SVPGLRPAEA GEFTRRAFAH
160 170 180 190 200
GKLSLTEVEG LADLIRAETE AQRRQALRQL DGELSQLCQG WAKTLTKALA
210 220 230 240 250
YVEAYIDFGE DDNLEEGVLE QADREVRALE VALGSHLRDA RRGQRLLSGA
260 270 280 290 300
NVVVTGPPNA GKSSLVNLLS QKPVSIVSPE PGTTRDVLET PVDLAGFPVL
310 320 330 340 350
LSDTAGLREG VGAVEQEGVR RARHRLEQAD IILGVLDASD LASSSSCSFL
360 370 380 390 400
DTVVTPLLAQ SQDSGGQRLL LLLNKSDLLS ANAPACDIAL PPHLLLSCHT
410 420 430 440 450
GAGMDSLLQA LKTELAAVCG DPSTGPPLLT RVRHQYHLQG CLDALGHYQL
460 470 480 490
ATDLALAAEA LRQARRQLNH LTGGGGTEEI LDLIFQDFCV GK
Length:492
Mass (Da):52,175
Last modified:December 1, 2001 - v1
Checksum:i85BB8A5E38F93597
GO
Isoform 2 (identifier: Q923K4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-241: ALAYVEAYID...ALGSHLRDAR → RTEKFEPWRW...DLPMRARAVW
     242-492: Missing.

Note: No experimental confirmation available.
Show »
Length:241
Mass (Da):26,324
Checksum:i05ECB4C9CBBE30B3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023585198 – 241ALAYV…LRDAR → RTEKFEPWRWRWVPTCEMLG VDKGSSRGQMLWSLDLPMRA RAVW in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_023586242 – 492Missing in isoform 2. 1 PublicationAdd BLAST251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361482 mRNA Translation: AAK35216.2
AY029613 Genomic DNA Translation: AAK60410.1
BC092042 mRNA Translation: AAH92042.1
CCDSiCCDS40384.1 [Q923K4-1]
RefSeqiNP_115933.2, NM_032544.3 [Q923K4-1]
UniGeneiMm.142112

Genome annotation databases

EnsembliENSMUST00000007754; ENSMUSP00000007754; ENSMUSG00000007610 [Q923K4-1]
ENSMUST00000095259; ENSMUSP00000092892; ENSMUSG00000007610 [Q923K4-2]
ENSMUST00000150969; ENSMUSP00000114193; ENSMUSG00000007610 [Q923K4-1]
GeneIDi70359
KEGGimmu:70359
UCSCiuc009mdn.1 mouse [Q923K4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGTPB3_MOUSE
AccessioniPrimary (citable) accession number: Q923K4
Secondary accession number(s): Q58E73, Q99M99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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