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Protein

Sodium/glucose cotransporter 2

Gene

Slc5a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 2
Short name:
Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene namesi
Name:Slc5a2
Synonyms:Sglt22 Publications
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2181411 Slc5a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 42HelicalSequence analysisAdd BLAST19
Topological domaini43 – 59ExtracellularSequence analysisAdd BLAST17
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 100CytoplasmicSequence analysisAdd BLAST20
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 166ExtracellularSequence analysisAdd BLAST45
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 203CytoplasmicSequence analysisAdd BLAST16
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 268ExtracellularSequence analysisAdd BLAST44
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 312CytoplasmicSequence analysisAdd BLAST23
Transmembranei313 – 332HelicalSequence analysisAdd BLAST20
Topological domaini333 – 421ExtracellularSequence analysisAdd BLAST89
Transmembranei422 – 441HelicalSequence analysisAdd BLAST20
Topological domaini442 – 453CytoplasmicSequence analysisAdd BLAST12
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 524ExtracellularSequence analysisAdd BLAST50
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 648CytoplasmicSequence analysisAdd BLAST103
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075302
GuidetoPHARMACOLOGYi916

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053731 – 670Sodium/glucose cotransporter 2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ923I7
PaxDbiQ923I7
PRIDEiQ923I7

PTM databases

iPTMnetiQ923I7
PhosphoSitePlusiQ923I7

Expressioni

Gene expression databases

BgeeiENSMUSG00000030781 Expressed in 264 organ(s), highest expression level in proximal tubule
ExpressionAtlasiQ923I7 baseline and differential
GenevisibleiQ923I7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112597

Chemistry databases

BindingDBiQ923I7

Structurei

3D structure databases

ProteinModelPortaliQ923I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiQ923I7
KOiK14382
OMAiCWIPVVQ
OrthoDBiEOG091G077U
PhylomeDBiQ923I7
TreeFamiTF352855

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q923I7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV SKDPSVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK
360 370 380 390 400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS
410 420 430 440 450
TLFTMDIYTR LRPRAGDKEL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL
460 470 480 490 500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLVGG LLMGLARLIP
510 520 530 540 550
EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL GISLCTAPIP
560 570 580 590 600
QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS
610 620 630 640 650
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV
660 670
VNLNALLMMT VAVFLWGFYA
Length:670
Mass (Da):73,008
Last modified:December 1, 2001 - v1
Checksum:i66BD6E48889E15DF
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0A1D3Z0A1_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
276Annotation score:
F6TFB9F6TFB9_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
115Annotation score:
A0A0U1RP15A0A0U1RP15_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
297Annotation score:
A0A0U1RNX5A0A0U1RNX5_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
254Annotation score:
A0A0U1RNI5A0A0U1RNI5_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
382Annotation score:
A0A0U1RNI8A0A0U1RNI8_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
466Annotation score:
A0A0U1RNT9A0A0U1RNT9_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
64Annotation score:
A0A0U1RNL6A0A0U1RNL6_MOUSE
Sodium/glucose cotransporter 2
Slc5a2
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033886 mRNA Translation: AAK61606.1
BC022226 mRNA Translation: AAH22226.1
CCDSiCCDS21894.1
RefSeqiNP_573517.1, NM_133254.3
UniGeneiMm.38870

Genome annotation databases

EnsembliENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781
GeneIDi246787
KEGGimmu:246787
UCSCiuc009jyu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033886 mRNA Translation: AAK61606.1
BC022226 mRNA Translation: AAH22226.1
CCDSiCCDS21894.1
RefSeqiNP_573517.1, NM_133254.3
UniGeneiMm.38870

3D structure databases

ProteinModelPortaliQ923I7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112597

Chemistry databases

BindingDBiQ923I7
ChEMBLiCHEMBL1075302
GuidetoPHARMACOLOGYi916

PTM databases

iPTMnetiQ923I7
PhosphoSitePlusiQ923I7

Proteomic databases

MaxQBiQ923I7
PaxDbiQ923I7
PRIDEiQ923I7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781
GeneIDi246787
KEGGimmu:246787
UCSCiuc009jyu.1 mouse

Organism-specific databases

CTDi6524
MGIiMGI:2181411 Slc5a2

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiQ923I7
KOiK14382
OMAiCWIPVVQ
OrthoDBiEOG091G077U
PhylomeDBiQ923I7
TreeFamiTF352855

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Miscellaneous databases

PROiPR:Q923I7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030781 Expressed in 264 organ(s), highest expression level in proximal tubule
ExpressionAtlasiQ923I7 baseline and differential
GenevisibleiQ923I7 MM

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A2_MOUSE
AccessioniPrimary (citable) accession number: Q923I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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