UniProtKB - Q923I7 (SC5A2_MOUSE)
Protein
Sodium/glucose cotransporter 2
Gene
Slc5a2
Organism
Mus musculus (Mouse)
Status
Functioni
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.By similarity
GO - Molecular functioni
- alpha-glucoside transmembrane transporter activity Source: MGI
- D-glucose transmembrane transporter activity Source: MGI
- glucose:sodium symporter activity Source: MGI
GO - Biological processi
- alpha-glucoside transport Source: MGI
- glucose import across plasma membrane Source: MGI
- glucose transmembrane transport Source: MGI
- negative regulation of urine volume Source: MGI
- renal potassium excretion Source: MGI
- sodium ion import across plasma membrane Source: MGI
- sodium ion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Sodium transport, Sugar transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-189200, Cellular hexose transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/glucose cotransporter 2Short name: Na(+)/glucose cotransporter 2 Alternative name(s): Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2 |
Gene namesi | Name:Slc5a2 Synonyms:Sglt22 Publications |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2181411, Slc5a2 |
Subcellular locationi
Other locations
Plasma Membrane
- brush border membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 23 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 24 – 42 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 43 – 59 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 100 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 166 | ExtracellularSequence analysisAdd BLAST | 45 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 203 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 225 – 268 | ExtracellularSequence analysisAdd BLAST | 44 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 312 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 313 – 332 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 333 – 421 | ExtracellularSequence analysisAdd BLAST | 89 | |
Transmembranei | 422 – 441 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 442 – 453 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 454 – 474 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 475 – 524 | ExtracellularSequence analysisAdd BLAST | 50 | |
Transmembranei | 525 – 545 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 546 – 648 | CytoplasmicSequence analysisAdd BLAST | 103 | |
Transmembranei | 649 – 669 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL1075302 |
DrugCentrali | Q923I7 |
GuidetoPHARMACOLOGYi | 916 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105373 | 1 – 670 | Sodium/glucose cotransporter 2Add BLAST | 670 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 248 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q923I7 |
MaxQBi | Q923I7 |
PaxDbi | Q923I7 |
PRIDEi | Q923I7 |
ProteomicsDBi | 255346 |
PTM databases
GlyGeni | Q923I7, 1 site |
iPTMneti | Q923I7 |
PhosphoSitePlusi | Q923I7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030781, Expressed in proximal tubule and 276 other tissues |
Genevisiblei | Q923I7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000112597 |
Chemistry databases
BindingDBi | Q923I7 |
Miscellaneous databases
RNActi | Q923I7, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000160533 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | Q923I7 |
OMAi | VVGRVWV |
OrthoDBi | 243316at2759 |
PhylomeDBi | Q923I7 |
TreeFami | TF352855 |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q923I7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV SKDPSVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK
360 370 380 390 400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS
410 420 430 440 450
TLFTMDIYTR LRPRAGDKEL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL
460 470 480 490 500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLVGG LLMGLARLIP
510 520 530 540 550
EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL GISLCTAPIP
560 570 580 590 600
QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS
610 620 630 640 650
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV
660 670
VNLNALLMMT VAVFLWGFYA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RNI8 | A0A0U1RNI8_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 466 | Annotation score: | ||
A0A0U1RNL6 | A0A0U1RNL6_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 154 | Annotation score: | ||
D3Z0A1 | D3Z0A1_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 276 | Annotation score: | ||
A0A0U1RP15 | A0A0U1RP15_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 297 | Annotation score: | ||
F6TFB9 | F6TFB9_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 115 | Annotation score: | ||
A0A0U1RNI5 | A0A0U1RNI5_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 382 | Annotation score: | ||
A0A0U1RNT9 | A0A0U1RNT9_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 64 | Annotation score: | ||
A0A0U1RNX5 | A0A0U1RNX5_MOUSE | Sodium/glucose cotransporter 2 | Slc5a2 | 254 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY033886 mRNA Translation: AAK61606.1 BC022226 mRNA Translation: AAH22226.1 |
CCDSi | CCDS21894.1 |
RefSeqi | NP_573517.1, NM_133254.3 |
Genome annotation databases
Ensembli | ENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781 |
GeneIDi | 246787 |
KEGGi | mmu:246787 |
UCSCi | uc009jyu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY033886 mRNA Translation: AAK61606.1 BC022226 mRNA Translation: AAH22226.1 |
CCDSi | CCDS21894.1 |
RefSeqi | NP_573517.1, NM_133254.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000112597 |
Chemistry databases
BindingDBi | Q923I7 |
ChEMBLi | CHEMBL1075302 |
DrugCentrali | Q923I7 |
GuidetoPHARMACOLOGYi | 916 |
PTM databases
GlyGeni | Q923I7, 1 site |
iPTMneti | Q923I7 |
PhosphoSitePlusi | Q923I7 |
Proteomic databases
jPOSTi | Q923I7 |
MaxQBi | Q923I7 |
PaxDbi | Q923I7 |
PRIDEi | Q923I7 |
ProteomicsDBi | 255346 |
Protocols and materials databases
Antibodypediai | 27902, 202 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781 |
GeneIDi | 246787 |
KEGGi | mmu:246787 |
UCSCi | uc009jyu.1, mouse |
Organism-specific databases
CTDi | 6524 |
MGIi | MGI:2181411, Slc5a2 |
Phylogenomic databases
eggNOGi | KOG2349, Eukaryota |
GeneTreei | ENSGT00940000160533 |
HOGENOMi | CLU_018808_9_2_1 |
InParanoidi | Q923I7 |
OMAi | VVGRVWV |
OrthoDBi | 243316at2759 |
PhylomeDBi | Q923I7 |
TreeFami | TF352855 |
Enzyme and pathway databases
Reactomei | R-MMU-189200, Cellular hexose transport |
Miscellaneous databases
BioGRID-ORCSi | 246787, 1 hit in 52 CRISPR screens |
PROi | PR:Q923I7 |
RNActi | Q923I7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030781, Expressed in proximal tubule and 276 other tissues |
Genevisiblei | Q923I7, MM |
Family and domain databases
Gene3Di | 1.20.1730.10, 1 hit |
InterProi | View protein in InterPro IPR038377, Na/Glc_symporter_sf IPR001734, Na/solute_symporter IPR018212, Na/solute_symporter_CS |
Pfami | View protein in Pfam PF00474, SSF, 1 hit |
TIGRFAMsi | TIGR00813, sss, 1 hit |
PROSITEi | View protein in PROSITE PS00456, NA_SOLUT_SYMP_1, 1 hit PS00457, NA_SOLUT_SYMP_2, 1 hit PS50283, NA_SOLUT_SYMP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SC5A2_MOUSE | |
Accessioni | Q923I7Primary (citable) accession number: Q923I7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families