UniProtKB - Q923I7 (SC5A2_MOUSE)

BLAST

>sp|Q923I7|SC5A2_MOUSE Sodium/glucose cotransporter 2 OS=Mus musculus OX=10090 GN=Slc5a2 PE=1 SV=1
MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSM
VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGV
ITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALL
GITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTV
SKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCL
AGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCS
NIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKEL
LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNE
KGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTL
GISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQS
PAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMT
VAVFLWGFYA

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History
Entry version 127 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Sodium/glucose cotransporter 2

Gene

Slc5a2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na⁺/glucose cotransporter arranged in series along kidney proximal tubules.By similarity

GO - Molecular functionⁱ

glucose:sodium symporter activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glucose transmembrane transport Source: MGI
negative regulation of urine volume Source: MGI
renal potassium excretion Source: MGI
sodium ion transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Sodium transport, Sugar transport, Symport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-189200 Cellular hexose transport

Reactomeⁱ

R-MMU-189200 Cellular hexose transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium/glucose cotransporter 2 Short name: Na(+)/glucose cotransporter 2 Alternative name(s): Low affinity sodium-glucose cotransporter Solute carrier family 5 member 2
Gene namesⁱ	Name:Slc5a2 Synonyms:Sglt22 Publications
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2181411 Slc5a2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 23	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	24 – 42	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	43 – 59	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	81 – 100	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	101 – 121	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	122 – 166	ExtracellularSequence analysisAdd BLAST	45
Transmembraneⁱ	167 – 187	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	188 – 203	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	204 – 224	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	225 – 268	ExtracellularSequence analysisAdd BLAST	44
Transmembraneⁱ	269 – 289	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	290 – 312	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	313 – 332	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	333 – 421	ExtracellularSequence analysisAdd BLAST	89
Transmembraneⁱ	422 – 441	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	442 – 453	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	454 – 474	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	475 – 524	ExtracellularSequence analysisAdd BLAST	50
Transmembraneⁱ	525 – 545	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	546 – 648	CytoplasmicSequence analysisAdd BLAST	103
Transmembraneⁱ	649 – 669	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL1075302
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	916

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000105373	1 – 670	Sodium/glucose cotransporter 2Add BLAST		670

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	248	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q923I7
PaxDbⁱ	Q923I7
PRIDEⁱ	Q923I7

PTM databases

iPTMnetⁱ	Q923I7
PhosphoSitePlusⁱ	Q923I7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030781 Expressed in 264 organ(s), highest expression level in proximal tubule
ExpressionAtlasⁱ	Q923I7 baseline and differential
Genevisibleⁱ	Q923I7 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000112597

STRINGⁱ

10090.ENSMUSP00000112597

Chemistry databases

BindingDBⁱ

Q923I7

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q923I7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IP49 Eukaryota COG4146 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118955
HOGENOMⁱ	HOG000025422
HOVERGENⁱ	HBG052859
InParanoidⁱ	Q923I7
KEGG Orthology (KO) More...KOⁱ	K14382
OMAⁱ	CWIPVVQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G077U
PhylomeDBⁱ	Q923I7
TreeFamⁱ	TF352855

Family and domain databases

Gene3Dⁱ	1.20.1730.10, 1 hit
InterProⁱ	View protein in InterPro IPR038377 Na/Glc_symporter_sf IPR001734 Na/solute_symporter IPR018212 Na/solute_symporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00474 SSF, 1 hit
TIGRFAMsⁱ	TIGR00813 sss, 1 hit
PROSITEⁱ	View protein in PROSITE PS00456 NA_SOLUT_SYMP_1, 1 hit PS00457 NA_SOLUT_SYMP_2, 1 hit PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

Q923I7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEQHVEAGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV 
        60         70         80         90        100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA 
       110        120        130        140        150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGHRIRLYL SVLSLFLYIF 
       160        170        180        190        200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT 
       210        220        230        240        250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAMTSLTV SKDPSVGNIS 
       260        270        280        290        300
STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL 
       310        320        330        340        350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK 
       360        370        380        390        400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS 
       410        420        430        440        450
TLFTMDIYTR LRPRAGDKEL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL 
       460        470        480        490        500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLVGG LLMGLARLIP 
       510        520        530        540        550
EFFFGSGSCV RPSACPALFC RVHYLYFAII LFICSGILTL GISLCTAPIP 
       560        570        580        590        600
QKHLHRLVFS LRHSKEERED LDADELEGPA PAPVQNGGQE CAMEMEEVQS 
       610        620        630        640        650
PAPGLLRRCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPRWARV 
       660        670
VNLNALLMMT VAVFLWGFYA

Length:670

Mass (Da):73,008

Last modified:December 1, 2001 - v1

Checksum:ⁱ66BD6E48889E15DF

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z0A1	D3Z0A1_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	276	Annotation score:
F6TFB9	F6TFB9_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	115	Annotation score:
A0A0U1RP15	A0A0U1RP15_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	297	Annotation score:
A0A0U1RNX5	A0A0U1RNX5_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	254	Annotation score:
A0A0U1RNI5	A0A0U1RNI5_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	382	Annotation score:
A0A0U1RNI8	A0A0U1RNI8_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	466	Annotation score:
A0A0U1RNT9	A0A0U1RNT9_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	64	Annotation score:
A0A0U1RNL6	A0A0U1RNL6_MOUSE	Sodium/glucose cotransporter 2 Sodium/glucose cotransporter 2	Slc5a2	154	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY033886 mRNA Translation: AAK61606.1 BC022226 mRNA Translation: AAH22226.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21894.1
NCBI Reference Sequences More...RefSeqⁱ	NP_573517.1, NM_133254.3
UniGeneⁱ	Mm.38870

Genome annotation databases

Ensemblⁱ	ENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781
GeneIDⁱ	246787
KEGGⁱ	mmu:246787
UCSC genome browser More...UCSCⁱ	uc009jyu.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q923I7	Sodium/glucose cotransporter 2 (Fragment)		MOUSE		297	UniRef100_Q923I7

Protein	Similar proteins		Species	Score	Length	Source
Q923I7	Sodium/glucose cotransporter 2		HUMAN		672	UniRef90_P31639
Sodium/nucleoside cotransporter		RABIT		672
Sodium/glucose cotransporter 2		RAT		670
sodium/glucose cotransporter 2 isoform X2		PHYCD		714
sodium/glucose cotransporter 2 isoform X2		DIPOR		684
+72

Protein	Similar proteins		Species	Score	Length	Source
Q923I7	Sodium/glucose cotransporter 2		HUMAN		672	UniRef50_P31639
Sodium/nucleoside cotransporter		RABIT		672
Sodium/glucose cotransporter 2		RAT		670
sodium/glucose cotransporter 2 isoform X2		PHYCD		714
sodium/glucose cotransporter 2 isoform X2		DIPOR		684
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY033886 mRNA Translation: AAK61606.1 BC022226 mRNA Translation: AAH22226.1
CCDSⁱ	CCDS21894.1
RefSeqⁱ	NP_573517.1, NM_133254.3
UniGeneⁱ	Mm.38870

3D structure databases

ProteinModelPortalⁱ	Q923I7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000112597

STRINGⁱ

10090.ENSMUSP00000112597

Chemistry databases

BindingDBⁱ	Q923I7
ChEMBLⁱ	CHEMBL1075302
GuidetoPHARMACOLOGYⁱ	916

PTM databases

iPTMnetⁱ	Q923I7
PhosphoSitePlusⁱ	Q923I7

Proteomic databases

MaxQBⁱ	Q923I7
PaxDbⁱ	Q923I7
PRIDEⁱ	Q923I7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000118169; ENSMUSP00000112597; ENSMUSG00000030781
GeneIDⁱ	246787
KEGGⁱ	mmu:246787
UCSCⁱ	uc009jyu.1 mouse

Organism-specific databases

CTDⁱ	6524
MGIⁱ	MGI:2181411 Slc5a2

Phylogenomic databases

eggNOGⁱ	ENOG410IP49 Eukaryota COG4146 LUCA
GeneTreeⁱ	ENSGT00760000118955
HOGENOMⁱ	HOG000025422
HOVERGENⁱ	HBG052859
InParanoidⁱ	Q923I7
KOⁱ	K14382
OMAⁱ	CWIPVVQ
OrthoDBⁱ	EOG091G077U
PhylomeDBⁱ	Q923I7
TreeFamⁱ	TF352855

Enzyme and pathway databases

Reactomeⁱ	R-MMU-189200 Cellular hexose transport

Reactomeⁱ

R-MMU-189200 Cellular hexose transport

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q923I7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030781 Expressed in 264 organ(s), highest expression level in proximal tubule
ExpressionAtlasⁱ	Q923I7 baseline and differential
Genevisibleⁱ	Q923I7 MM

Family and domain databases

Gene3Dⁱ	1.20.1730.10, 1 hit
InterProⁱ	View protein in InterPro IPR038377 Na/Glc_symporter_sf IPR001734 Na/solute_symporter IPR018212 Na/solute_symporter_CS
Pfamⁱ	View protein in Pfam PF00474 SSF, 1 hit
TIGRFAMsⁱ	TIGR00813 sss, 1 hit
PROSITEⁱ	View protein in PROSITE PS00456 NA_SOLUT_SYMP_1, 1 hit PS00457 NA_SOLUT_SYMP_2, 1 hit PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC5A2_MOUSE
Accessionⁱ	Q923I7Primary (citable) accession number: Q923I7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q923I7 (SC5A2_MOUSE)

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Sodium/glucose cotransporter 2

Slc5a2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ