UniProtKB - Q923G3 (Q923G3_MOUSE)
Protein
F-actin-capping protein subunit beta
Gene
Capzb
Organism
Mus musculus (Mouse)
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.UniRule annotation
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- barbed-end actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit betaUniRule annotation |
Gene namesi | Name:CapzbImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:104652, Capzb |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Other locations
- sarcomere ARBA annotation
Cytoskeleton
- F-actin capping protein complex Source: UniProtKB-UniRule
Other locations
- sarcomere Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000028745, Expressed in placenta and 309 other tissues |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 210 – 230 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OMAi | GRQAHYK |
OrthoDBi | 1076134at2759 |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q923G3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA
60 70 80 90 100
RDKVVGKDYL LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA
110 120 130 140 150
NNAFDQYRDL YFEGGVSSVY LWDLDHGFAG VILIKKAGDG SKKIKGCWDS
160 170 180 190 200
IHVVEVQEKS SGRTAHYKLT STVMLWLQTN KSGSGTMNLG GSLTRQMEKD
210 220 230 240 250
ETVSDCSPHI ANIGRLVEDM ENKIRSTLNE IYFGKTKDIV NGLRSVQTFA
260 270
DKSKQEALKN DLVEALKRKQ QC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC002053 mRNA Translation: AAH02053.1 AK156778 mRNA Translation: BAE33851.1 AK168738 mRNA Translation: BAE40579.1 |
PIRi | C54819 |
RefSeqi | NP_033928.1, NM_009798.4 |
Genome annotation databases
GeneIDi | 12345 |
UCSCi | uc008vlw.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC002053 mRNA Translation: AAH02053.1 AK156778 mRNA Translation: BAE33851.1 AK168738 mRNA Translation: BAE40579.1 |
PIRi | C54819 |
RefSeqi | NP_033928.1, NM_009798.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 7956, 280 antibodies |
Genome annotation databases
GeneIDi | 12345 |
UCSCi | uc008vlw.2, mouse |
Organism-specific databases
CTDi | 832 |
MGIi | MGI:104652, Capzb |
Phylogenomic databases
OMAi | GRQAHYK |
OrthoDBi | 1076134at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12345, 7 hits in 19 CRISPR screens |
ChiTaRSi | Capzb, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028745, Expressed in placenta and 309 other tissues |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q923G3_MOUSE | |
Accessioni | Q923G3Primary (citable) accession number: Q923G3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |