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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC3

Gene

Polr2h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Short name:
RNA polymerases I, II, and III subunit ABC3
Alternative name(s):
DNA-directed RNA polymerase II subunit H
RPB17
RPB8 homolog
Gene namesi
Name:Polr2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2384309 Polr2h

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000739982 – 150DNA-directed RNA polymerases I, II, and III subunit RPABC3Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ923G2
MaxQBiQ923G2
PaxDbiQ923G2
PeptideAtlasiQ923G2
PRIDEiQ923G2

PTM databases

iPTMnetiQ923G2
PhosphoSitePlusiQ923G2

Expressioni

Gene expression databases

BgeeiENSMUSG00000021018 Expressed in 300 organ(s), highest expression level in liver
CleanExiMM_POLR2H
GenevisibleiQ923G2 MM

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A (By similarity).By similarity

Protein-protein interaction databases

BioGridi232836, 3 interactors
IntActiQ923G2, 1 interactor
MINTiQ923G2
STRINGi10090.ENSMUSP00000021405

Structurei

3D structure databases

ProteinModelPortaliQ923G2
SMRiQ923G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 40Non-specific ssDNA bindingBy similarityAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3400 Eukaryota
ENOG4111FT0 LUCA
GeneTreeiENSGT00390000018195
HOGENOMiHOG000175572
HOVERGENiHBG036116
InParanoidiQ923G2
KOiK03016
OMAiGLLMCLE
OrthoDBiEOG091G0QJA
PhylomeDBiQ923G2
TreeFamiTF103043

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR005570 RNA_pol_Rpb8
PANTHERiPTHR10917 PTHR10917, 1 hit
PfamiView protein in Pfam
PF03870 RNA_pol_Rpb8, 1 hit
PIRSFiPIRSF000779 RNA_pol_Rpb8, 1 hit
SMARTiView protein in SMART
SM00658 RPOL8c, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q923G2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGILFEDIF DVKDIDPEGK KFDRVSRLHC ESESFKMDLI LDVNIQIYPV
60 70 80 90 100
DLGDKFRLVI ASTLYEDGTL DDGEYNPTDD RPSRADQFEY VMYGKVYRIE
110 120 130 140 150
GDETSTEAAT RLSAYVSYGG LLMRLQGDAN NLHGFEVDSR VYLLMKKLAF
Length:150
Mass (Da):17,143
Last modified:January 23, 2007 - v3
Checksum:i944D0860809F1425
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P6I2A0A338P6I2_MOUSE
DNA-directed RNA polymerases I, II,...
Polr2h
143Annotation score:
A0A338P6B4A0A338P6B4_MOUSE
DNA-directed RNA polymerases I, II,...
Polr2h
108Annotation score:
A0A338P6M3A0A338P6M3_MOUSE
DNA-directed RNA polymerases I, II,...
Polr2h mCG_129794
91Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161617 mRNA Translation: BAE36495.1
AK146429 mRNA Translation: BAE27163.1
BC002306 mRNA Translation: AAH02306.1
BC092087 mRNA Translation: AAH92087.1
BC125612 mRNA Translation: AAI25613.1
BC125638 mRNA Translation: AAI25639.1
CCDSiCCDS28058.1
RefSeqiNP_663607.1, NM_145632.2
UniGeneiMm.288730

Genome annotation databases

EnsembliENSMUST00000021405; ENSMUSP00000021405; ENSMUSG00000021018
GeneIDi245841
KEGGimmu:245841
UCSCiuc007yqz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161617 mRNA Translation: BAE36495.1
AK146429 mRNA Translation: BAE27163.1
BC002306 mRNA Translation: AAH02306.1
BC092087 mRNA Translation: AAH92087.1
BC125612 mRNA Translation: AAI25613.1
BC125638 mRNA Translation: AAI25639.1
CCDSiCCDS28058.1
RefSeqiNP_663607.1, NM_145632.2
UniGeneiMm.288730

3D structure databases

ProteinModelPortaliQ923G2
SMRiQ923G2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232836, 3 interactors
IntActiQ923G2, 1 interactor
MINTiQ923G2
STRINGi10090.ENSMUSP00000021405

PTM databases

iPTMnetiQ923G2
PhosphoSitePlusiQ923G2

Proteomic databases

EPDiQ923G2
MaxQBiQ923G2
PaxDbiQ923G2
PeptideAtlasiQ923G2
PRIDEiQ923G2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021405; ENSMUSP00000021405; ENSMUSG00000021018
GeneIDi245841
KEGGimmu:245841
UCSCiuc007yqz.1 mouse

Organism-specific databases

CTDi5437
MGIiMGI:2384309 Polr2h

Phylogenomic databases

eggNOGiKOG3400 Eukaryota
ENOG4111FT0 LUCA
GeneTreeiENSGT00390000018195
HOGENOMiHOG000175572
HOVERGENiHBG036116
InParanoidiQ923G2
KOiK03016
OMAiGLLMCLE
OrthoDBiEOG091G0QJA
PhylomeDBiQ923G2
TreeFamiTF103043

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-113418 Formation of the Early Elongation Complex
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-MMU-6803529 FGFR2 alternative splicing
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-72086 mRNA Capping
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-75955 RNA Polymerase II Transcription Elongation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

PROiPR:Q923G2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021018 Expressed in 300 organ(s), highest expression level in liver
CleanExiMM_POLR2H
GenevisibleiQ923G2 MM

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR005570 RNA_pol_Rpb8
PANTHERiPTHR10917 PTHR10917, 1 hit
PfamiView protein in Pfam
PF03870 RNA_pol_Rpb8, 1 hit
PIRSFiPIRSF000779 RNA_pol_Rpb8, 1 hit
SMARTiView protein in SMART
SM00658 RPOL8c, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPAB3_MOUSE
AccessioniPrimary (citable) accession number: Q923G2
Secondary accession number(s): Q3TT30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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