Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 58  Show
  1. 1
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Strain: FVB/N.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy..
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 50454 other entries.

  2. 2
    Category: Sequences.
    Source: MGI:1914719.

    This publication is cited by 16990 and mapped to 30045 other entries.

  3. 3
    "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.
    Hayashizaki Y.
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:1914719.

    This publication is cited by 16993 and mapped to 41200 other entries.

  4. 4
    "CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome."
    Yamaguchi T., Omatsu N., Matsushita S., Osumi T.
    J. Biol. Chem. 279:30490-30497(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: CGI-58 interacts with perilipin and is localized to lipid dropletsImported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is mapped to 18 other entries.

  5. 5
    "Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes."
    Subramanian V., Rothenberg A., Gomez C., Cohen A.W., Garcia A., Bhattacharyya S., Shapiro L., Dolios G., Wang R., Lisanti M.P., Brasaemle D.L.
    J. Biol. Chem. 279:42062-42071(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: CGI-58 binds to perilipin A-coated lipid droplets in a manner that is dependent upon the metabolic status of the adipocyte and the activity of cAMP-dependent protein kinaseImported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is cited by 1 and mapped to 9 other entries.

  6. 6
    "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:1914719.

    This publication is cited by 10619 and mapped to 43873 other entries.

  7. 7
    "BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system."
    Magdaleno S., Jensen P., Brumwell C.L., Seal A., Lehman K., Asbury A., Cheung T., Cornelius T., Batten D.M., Eden C., Norland S.M., Rice D.S., Dosooye N., Shakya S., Mehta P., Curran T.
    PLoS Biol. 4:e86-e86(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:1914719.

    This publication is mapped to 20494 other entries.

  8. 8
    "Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome."
    Lass A., Zimmermann R., Haemmerle G., Riederer M., Schoiswohl G., Schweiger M., Kienesberger P., Strauss J.G., Gorkiewicz G., Zechner R.
    Cell Metab. 3:309-319(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: CGI-58 interacts with adipose triglyceride lipase stimulating its TG hydrolase activity up to 20-foldImported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is cited by 2 and mapped to 28 other entries.

  9. 9
    "Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism."
    Schweiger M., Schreiber R., Haemmerle G., Lass A., Fledelius C., Jacobsen P., Tornqvist H., Zechner R., Zimmermann R.
    J. Biol. Chem. 281:40236-40241(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:1914719.

    This publication is mapped to 15 other entries.

  10. 10
    "CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation."
    Yamaguchi T., Omatsu N., Morimoto E., Nakashima H., Ueno K., Tanaka T., Satouchi K., Hirose F., Osumi T.
    J. Lipid Res. 48:1078-1089(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: CGI-58 facilitates lipolysis in cooperation with perilipin and other factors including lipasesImported.
    Source: GeneRIF:67469.

    This publication is mapped to 12 other entries.

  11. 11
    "The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding."
    Schweiger M., Schoiswohl G., Lass A., Radner F.P., Haemmerle G., Malli R., Graier W., Cornaciu I., Oberer M., Salvayre R., Fischer J., Zechner R., Zimmermann R.
    J. Biol. Chem. 283:17211-17220(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Source: MGI:1914719.

    This publication is mapped to 16 other entries.

  12. 12
    "CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid."
    Ghosh A.K., Ramakrishnan G., Chandramohan C., Rajasekharan R.
    J. Biol. Chem. 283:24525-24533(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: CGI-58 the causative gene for Chanarin-Dorfman syndrome mediates acylation of lysophosphatidic acidImported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is cited by 1 and mapped to 13 other entries.

  13. 13
    "CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes."
    Akiyama M., Sakai K., Takayama C., Yanagi T., Yamanaka Y., McMillan J.R., Shimizu H.
    Am. J. Pathol. 173:1349-1360(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, Expression.
    Annotation: CGI-58 is expressed and packaged into lamellar granules (LG) during keratinization and likely plays crucial role(s) in keratinocyte differentiation and LG lipid metabolism contributing to skin lipid barrier formation.Imported.
    Source: GeneRIF:67469.

    This publication is cited by 1 and mapped to 10 other entries.

  14. 14
    "Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation."
    Granneman J.G., Moore H.P., Mottillo E.P., Zhu Z.
    J. Biol. Chem. 284:3049-3057(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: results indicate that the interaction between Abhd5 and Mldp is dynamic and essential for regulating the activity of Atgl at lipid droplets containing MldpImported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is cited by 1 and mapped to 3 other entries.

  15. 15
    Category: Function.
    Annotation: findings show CGI-58 is a CoA-dependent lysophosphatidic acid acyltransferase that channels fatty acids released from the hydrolysis of stored triacylglycerols into phospholipidsImported.
    Source: GeneRIF:67469.

    This publication is mapped to 1 other entry.

  16. 16
    "Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)."
    Granneman J.G., Moore H.P., Krishnamoorthy R., Rathod M.
    J. Biol. Chem. 284:34538-34544(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: Results demonstrate that Plin binds Abhd5 with high affinity and thereby suppresses the interaction of Abhd5 with Atgl.Imported.
    Source: GeneRIF:67469.

    This publication is mapped to 4 other entries.

  17. 17
    "Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)."
    Radner F.P., Streith I.E., Schoiswohl G., Schweiger M., Kumari M., Eichmann T.O., Rechberger G., Koefeler H.C., Eder S., Schauer S., Theussl H.C., Preiss-Landl K., Lass A., Zimmermann R., Hoefler G., Zechner R., Haemmerle G.
    J. Biol. Chem. 285:7300-7311(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Triglyceride accumulation and liver steatosis in newborn Cgi-58(-/-) mice establish a role for CGI-58 in ATGL-mediated TG hydrolysis and supply of fatty acids as energy substrate and CGI-58 plays an essential role in skin lipid metabolism.Imported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is mapped to 8 other entries.

  18. 18
    "Identification of a novel splicing isoform of murine CGI-58."
    Yang X., Lu X., Liu J.
    FEBS Lett. 584:903-910(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Data report a new alternative splicing isoform of the murine CGI-58 gene termed mCGI-58S that has a predominant cytoplasmic location. The splicing event may be involved in the regulation of lipid homeostasis.Imported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is mapped to 4 other entries.

  19. 19
    "The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase."
    Gruber A., Cornaciu I., Lass A., Schweiger M., Poeschl M., Eder C., Kumari M., Schoiswohl G., Wolinski H., Kohlwein S.D., Zechner R., Zimmermann R., Oberer M.
    J. Biol. Chem. 285:12289-12298(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: the N-terminal Trp-rich region of CGI-58 is essential for correct localization and ATGL-activating function of CGI-58Imported.
    Source: GeneRIF:67469.

    This publication is mapped to 3 other entries.

  20. 20
    "CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance."
    Brown J.M., Betters J.L., Lord C., Ma Y., Han X., Yang K., Alger H.M., Melchior J., Sawyer J., Shah R., Wilson M.D., Liu X., Graham M.J., Lee R., Crooke R., Shulman G.I., Xue B., Shi H., Yu L.
    J. Lipid Res. 51:3306-3315(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: CGI-58 plays a critical role in limiting hepatic steatosis and maintaining hepatic glycerophospholipid homeostasis and in promoting high-fat-diet-induced obesity and insulin resistance.Imported.
    Source: MGI:1914719, GeneRIF:67469.

    This publication is mapped to 4 other entries.

  21. 21
    "Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase."
    Granneman J.G., Moore H.P., Mottillo E.P., Zhu Z., Zhou L.
    J. Biol. Chem. 286:5126-5135(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: MGI:1914719.

    This publication is cited by 2 and mapped to 6 other entries.

  22. 22
    Category: Expression.
    Source: MGI:1914719.

    This publication is mapped to 50263 other entries.

  23. 23
    Category: Function, Pathology & Biotech.
    Source: MGI:1914719.

    This publication is mapped to 34843 other entries.

  24. 24
    "Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)."
    Gandotra S., Lim K., Girousse A., Saudek V., O'Rahilly S., Savage D.B.
    J. Biol. Chem. 286:34998-35006(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: the C terminus sequesters ABHD5 and thus inhibits basal ATGL activityImported.
    Source: GeneRIF:67469.

    This publication is mapped to 21 other entries.

  25. 25
    "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Source: MGI:1914719.

    This publication is mapped to 48660 other entries.

1 to 25 of 58  Show
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again