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Protein

Pleiotropic regulator 1

Gene

Plrg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotropic regulator 1
Gene namesi
Name:Plrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1858197 Plrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511341 – 513Pleiotropic regulator 1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei119PhosphoserineBy similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ922V4
MaxQBiQ922V4
PaxDbiQ922V4
PeptideAtlasiQ922V4
PRIDEiQ922V4

PTM databases

iPTMnetiQ922V4
PhosphoSitePlusiQ922V4

Expressioni

Gene expression databases

BgeeiENSMUSG00000027998 Expressed in 294 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ922V4 baseline and differential
GenevisibleiQ922V4 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts directly in the complex with BCAS2 and PRPF19.By similarity

Protein-protein interaction databases

BioGridi207280, 3 interactors
IntActiQ922V4, 3 interactors
MINTiQ922V4
STRINGi10090.ENSMUSP00000114968

Structurei

3D structure databases

ProteinModelPortaliQ922V4
SMRiQ922V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati201 – 240WD 1Add BLAST40
Repeati243 – 282WD 2Add BLAST40
Repeati285 – 324WD 3Add BLAST40
Repeati327 – 366WD 4Add BLAST40
Repeati369 – 409WD 5Add BLAST41
Repeati410 – 448WD 6Add BLAST39
Repeati459 – 498WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat PRL1/PRL2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0285 Eukaryota
ENOG410XQV9 LUCA
GeneTreeiENSGT00930000150962
HOGENOMiHOG000207595
HOVERGENiHBG053621
InParanoidiQ922V4
KOiK12862
OrthoDBiEOG091G08RE
PhylomeDBiQ922V4
TreeFamiTF105684

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q922V4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN
60 70 80 90 100
EYGPVLHMPT SKENLKEKGP QNATDSYPHK QYPANQGQDV EYLVTGTHPY
110 120 130 140 150
PAGPGVALTA DTKIQRMPSE SAAQSLAVAL PSQTRVDANR TGPAGSEYRH
160 170 180 190 200
PGASDRSQPT AMNSIMETGN TKNSALMAKK APTMPKPQWH PPWKLYRVIS
210 220 230 240 250
GHLGWVRCIA VEPGNQWFVT GSADRTIKIW DLASGKLKLS LTGHISTVRG
260 270 280 290 300
VIVSTRSPYL FSCGEDKQVK CWDLEYNKVI RHYHGHLSAV YGLDLHPTLD
310 320 330 340 350
VLVTCSRDST ARIWDVRTKA SVHTLSGHTN AVATVRCQAA EPQIITGSHD
360 370 380 390 400
TTIRLWDLVA GKTRVTLTNH KKSVRAVVLH PLLYTFASGS PDNIKQWKFP
410 420 430 440 450
DGGFIQNLSG HNAIINTLAV NADGVLVSGA DNGTMHLWDW RTGYNFQRVH
460 470 480 490 500
AAVQPGSLDS ESGIFACAFD RSESRLLTAE ADKTIKVYRE DETATEETHP
510
VSWKPEIIKR KRF
Length:513
Mass (Da):56,938
Last modified:December 1, 2001 - v1
Checksum:i8C9A2ED99D84ADEA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4V1D3Z4V1_MOUSE
Pleiotropic regulator 1
Plrg1
504Annotation score:
F8WI31F8WI31_MOUSE
Pleiotropic regulator 1
Plrg1
383Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102A → P in AAC04388 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044334 mRNA Translation: AAC04388.1
AK075993 mRNA Translation: BAC36104.1
AK076007 mRNA Translation: BAC36115.1
AK077197 mRNA Translation: BAC36675.1
BC006750 mRNA Translation: AAH06750.1
BC052895 mRNA No translation available.
CCDSiCCDS17433.1
RefSeqiNP_058064.2, NM_016784.3
UniGeneiMm.286349

Genome annotation databases

EnsembliENSMUST00000150268; ENSMUSP00000114968; ENSMUSG00000027998
GeneIDi53317
KEGGimmu:53317
UCSCiuc008ppi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044334 mRNA Translation: AAC04388.1
AK075993 mRNA Translation: BAC36104.1
AK076007 mRNA Translation: BAC36115.1
AK077197 mRNA Translation: BAC36675.1
BC006750 mRNA Translation: AAH06750.1
BC052895 mRNA No translation available.
CCDSiCCDS17433.1
RefSeqiNP_058064.2, NM_016784.3
UniGeneiMm.286349

3D structure databases

ProteinModelPortaliQ922V4
SMRiQ922V4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207280, 3 interactors
IntActiQ922V4, 3 interactors
MINTiQ922V4
STRINGi10090.ENSMUSP00000114968

PTM databases

iPTMnetiQ922V4
PhosphoSitePlusiQ922V4

Proteomic databases

EPDiQ922V4
MaxQBiQ922V4
PaxDbiQ922V4
PeptideAtlasiQ922V4
PRIDEiQ922V4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000150268; ENSMUSP00000114968; ENSMUSG00000027998
GeneIDi53317
KEGGimmu:53317
UCSCiuc008ppi.1 mouse

Organism-specific databases

CTDi5356
MGIiMGI:1858197 Plrg1

Phylogenomic databases

eggNOGiKOG0285 Eukaryota
ENOG410XQV9 LUCA
GeneTreeiENSGT00930000150962
HOGENOMiHOG000207595
HOVERGENiHBG053621
InParanoidiQ922V4
KOiK12862
OrthoDBiEOG091G08RE
PhylomeDBiQ922V4
TreeFamiTF105684

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q922V4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027998 Expressed in 294 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ922V4 baseline and differential
GenevisibleiQ922V4 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLRG1_MOUSE
AccessioniPrimary (citable) accession number: Q922V4
Secondary accession number(s): O55039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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