Krt5

Functionⁱ

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	413	StutterSequence analysis		1

GO - Molecular functionⁱ

scaffold protein binding Source: MGI
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6805567 Keratinization R-MMU-6809371 Formation of the cornified envelope

Reactomeⁱ

R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Keratin, type II cytoskeletal 5 Alternative name(s): Cytokeratin-5 Short name: CK-5 Keratin-5 Short name: K5 Type-II keratin Kb5
Gene namesⁱ	Name:Krt5By similarity Synonyms:Krt2-5Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:96702 Krt5

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament, Keratin

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063728	1 – 580	Keratin, type II cytoskeletal 5Add BLAST		580

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	5	PhosphoserineBy similarity	1
Modified residueⁱ	8	PhosphoserineBy similarity	1
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	21	PhosphoserineCombined sources	1
Modified residueⁱ	26	PhosphoserineCombined sources	1
Modified residueⁱ	36	PhosphoserineBy similarity	1
Modified residueⁱ	47	PhosphoserineCombined sources	1
Modified residueⁱ	61	PhosphoserineCombined sources	1
Modified residueⁱ	68	PhosphoserineBy similarity	1
Modified residueⁱ	72	PhosphoserineBy similarity	1
Modified residueⁱ	75	PhosphoserineBy similarity	1
Modified residueⁱ	79	PhosphoserineBy similarity	1
Modified residueⁱ	526	Omega-N-methylarginineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q922U2
PRIDEⁱ	Q922U2

PTM databases

iPTMnetⁱ	Q922U2
PhosphoSitePlusⁱ	Q922U2

Expressionⁱ

Tissue specificityⁱ

Expressed in epidermis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000061527 Expressed in 211 organ(s), highest expression level in cornea
CleanExⁱ	MM_KRT5
ExpressionAtlasⁱ	Q922U2 baseline and differential
Genevisibleⁱ	Q922U2 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network. Heterodimer with KRT14. Interacts with TCHP (By similarity). Interacts with EPPK1 (PubMed:18285451).By similarity1 Publication

GO - Molecular functionⁱ

scaffold protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	225482, 12 interactors
IntActⁱ	Q922U2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000023709

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q922U2
SMRⁱ	Q922U2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	162 – 475	IF rodPROSITE-ProRule annotationAdd BLAST		314

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 161	HeadSequence analysisAdd BLAST	161
Regionⁱ	162 – 197	Coil 1ASequence analysisAdd BLAST	36
Regionⁱ	198 – 216	Linker 1Sequence analysisAdd BLAST	19
Regionⁱ	217 – 309	Coil 1BSequence analysisAdd BLAST	93
Regionⁱ	310 – 332	Linker 12Sequence analysisAdd BLAST	23
Regionⁱ	333 – 471	Coil 2Sequence analysisAdd BLAST	139
Regionⁱ	472 – 580	TailSequence analysisAdd BLAST	109

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	2 – 38	Ser-richSequence analysisAdd BLAST	37
Compositional biasⁱ	39 – 133	Gly-richSequence analysisAdd BLAST	95
Compositional biasⁱ	495 – 562	Gly-richSequence analysisAdd BLAST	68

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IG4R Eukaryota ENOG410YY6B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118796
HOGENOMⁱ	HOG000230976
HOVERGENⁱ	HBG013015
InParanoidⁱ	Q922U2
KEGG Orthology (KO) More...KOⁱ	K07605
OMAⁱ	GMRGFSS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09KR
PhylomeDBⁱ	Q922U2
TreeFamⁱ	TF317854

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR032444 Keratin_2_head IPR003054 Keratin_II
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit
PRINTSⁱ	PR01276 TYPE2KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q922U2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG 
        60         70         80         90        100
ACGAGGYGSR SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG 
       110        120        130        140        150
FGGGAGSGFG FGGGAGFGGG YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ 
       160        170        180        190        200
IDPTIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL DTKWALLQEQ 
       210        220        230        240        250
GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN MQDLVEDYKN 
       260        270        280        290        300
KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF 
       310        320        330        340        350
FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE 
       360        370        380        390        400
AESWYQTKYE ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ 
       410        420        430        440        450
CANLQNAIAE AEQRGELALK DARNKLTELE EALQKAKQDM ARLLREYQEL 
       460        470        480        490        500
MNTKLALDVE IATYRKLLEG EECRLSGEGV GPVNISVVTN SVSSGYGGGS 
       510        520        530        540        550
SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG GSGFSAGSSQ 
       560        570        580
GGMSFGSGGG SGSSVKFVST TSSSRRSFKS

Length:580

Mass (Da):61,767

Last modified:December 1, 2001 - v1

Checksum:ⁱ304B341FD4224B41

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	139	V → I in AAL16774 (PubMed:11408584).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF306785 Genomic DNA Translation: AAL16774.1 BC006780 mRNA Translation: AAH06780.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27861.1
NCBI Reference Sequences More...RefSeqⁱ	NP_081287.1, NM_027011.2
UniGeneⁱ	Mm.451847

Genome annotation databases

Ensemblⁱ	ENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527
GeneIDⁱ	110308
KEGGⁱ	mmu:110308
UCSC genome browser More...UCSCⁱ	uc007xtw.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q922U2	Keratin 5		MOUSE		580	UniRef100_Q922U2
Uncharacterized protein		MOUSE		198

Protein	Similar proteins		Species	Score	Length	Source
Q922U2	Keratin, type II cytoskeletal 5		RAT		576	UniRef90_Q922U2
Keratin 5		MOUSE		580
UPI000B4EABE6		MERUN		589
UPI000A304703		MUSPA		580
Uncharacterized protein		MOUSE		198
+3

Protein	Similar proteins		Species	Score	Length	Source
Q922U2	Keratin, type II cytoskeletal 73		HUMAN		540	UniRef50_Q86Y46
Keratin, type II cytoskeletal 5		RAT		576
Keratin 73		AOTNA		541
Keratin 73		FELCA		540
Keratin 73		COLAP		540
+233

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF306785 Genomic DNA Translation: AAL16774.1 BC006780 mRNA Translation: AAH06780.1
CCDSⁱ	CCDS27861.1
RefSeqⁱ	NP_081287.1, NM_027011.2
UniGeneⁱ	Mm.451847

3D structure databases

ProteinModelPortalⁱ	Q922U2
SMRⁱ	Q922U2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	225482, 12 interactors
IntActⁱ	Q922U2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000023709

PTM databases

iPTMnetⁱ	Q922U2
PhosphoSitePlusⁱ	Q922U2

Proteomic databases

PaxDbⁱ	Q922U2
PRIDEⁱ	Q922U2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527
GeneIDⁱ	110308
KEGGⁱ	mmu:110308
UCSCⁱ	uc007xtw.1 mouse

Organism-specific databases

CTDⁱ	3852
MGIⁱ	MGI:96702 Krt5

Phylogenomic databases

eggNOGⁱ	ENOG410IG4R Eukaryota ENOG410YY6B LUCA
GeneTreeⁱ	ENSGT00760000118796
HOGENOMⁱ	HOG000230976
HOVERGENⁱ	HBG013015
InParanoidⁱ	Q922U2
KOⁱ	K07605
OMAⁱ	GMRGFSS
OrthoDBⁱ	EOG091G09KR
PhylomeDBⁱ	Q922U2
TreeFamⁱ	TF317854

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6805567 Keratinization R-MMU-6809371 Formation of the cornified envelope

Reactomeⁱ

R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q922U2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000061527 Expressed in 211 organ(s), highest expression level in cornea
CleanExⁱ	MM_KRT5
ExpressionAtlasⁱ	Q922U2 baseline and differential
Genevisibleⁱ	Q922U2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR032444 Keratin_2_head IPR003054 Keratin_II
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit
Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF16208 Keratin_2_head, 1 hit
PRINTSⁱ	PR01276 TYPE2KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	K2C5_MOUSE
Accessionⁱ	Q922U2Primary (citable) accession number: Q922U2 Secondary accession number(s): Q920F2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q922U2 (K2C5_MOUSE)

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Keratin, type II cytoskeletal 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Mitochondrion

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ