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UniProtKB - Q922U2 (K2C5_MOUSE)
Protein
Keratin, type II cytoskeletal 5
Gene
Krt5
Organism
Mus musculus (Mouse)
Status
Functioni
Miscellaneous
There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 413 | StutterSequence analysis | 1 |
GO - Molecular functioni
- scaffold protein binding Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-446107, Type I hemidesmosome assembly R-MMU-6805567, Keratinization R-MMU-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin, type II cytoskeletal 5Alternative name(s): Cytokeratin-5 Short name: CK-5 Keratin-5 Short name: K5 Type-II keratin Kb5 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96702, Krt5 |
VEuPathDBi | HostDB:ENSMUSG00000061527 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: MGI
- keratin filament Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Intermediate filament, KeratinPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000063728 | 1 – 580 | Keratin, type II cytoskeletal 5Add BLAST | 580 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | PhosphoserineBy similarity | 1 | |
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 36 | PhosphoserineBy similarity | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 61 | PhosphoserineCombined sources | 1 | |
Modified residuei | 68 | PhosphoserineBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 75 | PhosphoserineBy similarity | 1 | |
Modified residuei | 79 | PhosphoserineBy similarity | 1 | |
Modified residuei | 526 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3797 |
jPOSTi | Q922U2 |
PaxDbi | Q922U2 |
PRIDEi | Q922U2 |
ProteomicsDBi | 269168 |
PTM databases
iPTMneti | Q922U2 |
PhosphoSitePlusi | Q922U2 |
Expressioni
Tissue specificityi
Expressed in the corneal epithelium (at protein level) (PubMed:26758872). Expressed in the back epidermis of newborns (at protein level) (PubMed:11408584).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000061527, Expressed in cornea and 224 other tissues |
ExpressionAtlasi | Q922U2, baseline and differential |
Genevisiblei | Q922U2, MM |
Interactioni
Subunit structurei
Heterodimer of a type I and a type II keratin. Heterodimer with type I keratin KRT25 leading to the formation of keratin intermediate filament (KIF) network. Heterodimer with KRT14.
Interacts with TCHP (By similarity).
Interacts with EPPK1 (PubMed:18285451).
By similarity1 PublicationGO - Molecular functioni
- scaffold protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 225482, 18 interactors |
ComplexPortali | CPX-5867, Keratin-5 - Keratin-14 dimer complex |
STRINGi | 10090.ENSMUSP00000023709 |
Miscellaneous databases
RNActi | Q922U2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 162 – 475 | IF rodPROSITE-ProRule annotationAdd BLAST | 314 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 161 | HeadSequence analysisAdd BLAST | 161 | |
Regioni | 162 – 197 | Coil 1ASequence analysisAdd BLAST | 36 | |
Regioni | 198 – 216 | Linker 1Sequence analysisAdd BLAST | 19 | |
Regioni | 217 – 309 | Coil 1BSequence analysisAdd BLAST | 93 | |
Regioni | 310 – 332 | Linker 12Sequence analysisAdd BLAST | 23 | |
Regioni | 333 – 471 | Coil 2Sequence analysisAdd BLAST | 139 | |
Regioni | 472 – 580 | TailSequence analysisAdd BLAST | 109 | |
Regioni | 555 – 580 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the intermediate filament family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QURK, Eukaryota |
GeneTreei | ENSGT00940000160458 |
HOGENOMi | CLU_012560_6_1_1 |
InParanoidi | Q922U2 |
OMAi | MHTHISD |
OrthoDBi | 824246at2759 |
PhylomeDBi | Q922U2 |
TreeFami | TF317854 |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR032444, Keratin_2_head IPR003054, Keratin_II |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF16208, Keratin_2_head, 1 hit |
PRINTSi | PR01276, TYPE2KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q922U2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRQSSVSFR SGGSRSFSAA SAITPSVSRT SFSSVSRSGG GGGGRISLGG
60 70 80 90 100
ACGAGGYGSR SLYNVGGSKR ISYSSGGGSF RNQFGAGGFG FGGGAGSGFG
110 120 130 140 150
FGGGAGSGFG FGGGAGFGGG YGGAGFPVCP PGGIQEVTVN QNLLTPLNLQ
160 170 180 190 200
IDPTIQRVRT EEREQIKTLN NKFASFIDKV RFLEQQNKVL DTKWALLQEQ
210 220 230 240 250
GTKTIKQNLD PLFEQYINNL RRQLDGVLGE RGRLDSELRN MQDLVEDYKN
260 270 280 290 300
KYEDEINKRT TAENEFVMLK KDVDAAYMNK VELEARVDAL MDEINFMKMF
310 320 330 340 350
FDAELSQMQT HVSDTSVVLS MDNNRSLDLD SIIAEVKAQY EDIANRSRTE
360 370 380 390 400
AESWYQTKYE ELQQTAGRHG DDLRNTKHEI SEMNRMIQRL RSEIDNVKKQ
410 420 430 440 450
CANLQNAIAE AEQRGELALK DARNKLTELE EALQKAKQDM ARLLREYQEL
460 470 480 490 500
MNTKLALDVE IATYRKLLEG EECRLSGEGV GPVNISVVTN SVSSGYGGGS
510 520 530 540 550
SIGVGSGFGG GLGSGFAGGL GPRFTRGGGG LGLGSGLSVG GSGFSAGSSQ
560 570 580
GGMSFGSGGG SGSSVKFVST TSSSRRSFKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | V → I in AAL16774 (PubMed:11408584).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF306785 Genomic DNA Translation: AAL16774.1 BC006780 mRNA Translation: AAH06780.1 |
CCDSi | CCDS27861.1 |
RefSeqi | NP_081287.1, NM_027011.2 |
Genome annotation databases
Ensembli | ENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527 |
GeneIDi | 110308 |
KEGGi | mmu:110308 |
UCSCi | uc007xtw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF306785 Genomic DNA Translation: AAL16774.1 BC006780 mRNA Translation: AAH06780.1 |
CCDSi | CCDS27861.1 |
RefSeqi | NP_081287.1, NM_027011.2 |
3D structure databases
SMRi | Q922U2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 225482, 18 interactors |
ComplexPortali | CPX-5867, Keratin-5 - Keratin-14 dimer complex |
STRINGi | 10090.ENSMUSP00000023709 |
PTM databases
iPTMneti | Q922U2 |
PhosphoSitePlusi | Q922U2 |
Proteomic databases
CPTACi | non-CPTAC-3797 |
jPOSTi | Q922U2 |
PaxDbi | Q922U2 |
PRIDEi | Q922U2 |
ProteomicsDBi | 269168 |
Protocols and materials databases
Antibodypediai | 3501, 1502 antibodies from 49 providers |
DNASUi | 110308 |
Genome annotation databases
Ensembli | ENSMUST00000023709; ENSMUSP00000023709; ENSMUSG00000061527 |
GeneIDi | 110308 |
KEGGi | mmu:110308 |
UCSCi | uc007xtw.1, mouse |
Organism-specific databases
CTDi | 3852 |
MGIi | MGI:96702, Krt5 |
VEuPathDBi | HostDB:ENSMUSG00000061527 |
Phylogenomic databases
eggNOGi | ENOG502QURK, Eukaryota |
GeneTreei | ENSGT00940000160458 |
HOGENOMi | CLU_012560_6_1_1 |
InParanoidi | Q922U2 |
OMAi | MHTHISD |
OrthoDBi | 824246at2759 |
PhylomeDBi | Q922U2 |
TreeFami | TF317854 |
Enzyme and pathway databases
Reactomei | R-MMU-446107, Type I hemidesmosome assembly R-MMU-6805567, Keratinization R-MMU-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 110308, 2 hits in 65 CRISPR screens |
ChiTaRSi | Krt5, mouse |
PROi | PR:Q922U2 |
RNActi | Q922U2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000061527, Expressed in cornea and 224 other tissues |
ExpressionAtlasi | Q922U2, baseline and differential |
Genevisiblei | Q922U2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR018039, IF_conserved IPR039008, IF_rod_dom IPR032444, Keratin_2_head IPR003054, Keratin_II |
Pfami | View protein in Pfam PF00038, Filament, 1 hit PF16208, Keratin_2_head, 1 hit |
PRINTSi | PR01276, TYPE2KERATIN |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | K2C5_MOUSE | |
Accessioni | Q922U2Primary (citable) accession number: Q922U2 Secondary accession number(s): Q920F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families