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Protein

Chitinase domain-containing protein 1

Gene

Chid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase domain-containing protein 1
Gene namesi
Name:Chid1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915288 Chid1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028060920 – 393Chitinase domain-containing protein 1Add BLAST374

Proteomic databases

PaxDbiQ922Q9
PeptideAtlasiQ922Q9
PRIDEiQ922Q9

PTM databases

iPTMnetiQ922Q9
PhosphoSitePlusiQ922Q9

Expressioni

Gene expression databases

BgeeiENSMUSG00000025512
CleanExiMM_CHID1
ExpressionAtlasiQ922Q9 baseline and differential
GenevisibleiQ922Q9 MM

Interactioni

Subunit structurei

Interacts with STAB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130360

Structurei

3D structure databases

ProteinModelPortaliQ922Q9
SMRiQ922Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2091 Eukaryota
ENOG410XQB6 LUCA
GeneTreeiENSGT00390000012069
HOGENOMiHOG000006155
HOVERGENiHBG055278
InParanoidiQ922Q9
KOiK17525
PhylomeDBiQ922Q9
TreeFamiTF319271

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q922Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLLHVLWL ALVCGSVHTT LSKSDAKKAA SKMLLEKTQF SDKPVQDRGL
60 70 80 90 100
VVTDIKAEDV VLEHRSYCSS RARERNFAGE VLGYVTPWNS HGYDVAKVFG
110 120 130 140 150
SKFTQISPVW LQLKRRGREM FEITGLHDVD QGWMRAVKKH AKGVRIVPRL
160 170 180 190 200
LFEDWTYDDF RNVLDSEDEI EELSKTVAQV AKNQHFDGFV VEVWSQLLSQ
210 220 230 240 250
KHVGLIHMLT HLAEALHQAR LLVILVIPPA VTPGTDQLGM FTHKEFEQLA
260 270 280 290 300
PILDGFSLMT YDYSTSQQPG PNAPLSWIRA CVQVLDPKSQ WRSKILLGLN
310 320 330 340 350
FYGMDYAASK DAREPVIGAR YVQTLKDHRP RVVWDSQAAE HFFEYKKNRG
360 370 380 390
GRHVVFYPTL KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL
Length:393
Mass (Da):44,906
Last modified:December 1, 2001 - v1
Checksum:i492C5C84288B1DDC
GO
Isoform 2 (identifier: Q922Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     235-320: Missing.

Show »
Length:307
Mass (Da):35,241
Checksum:i73C8E8B8E07C632F
GO

Sequence cautioni

The sequence AAH61063 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29142 differs from that shown. Reason: Erroneous termination at position 306. Translated as Tyr.Curated
The sequence BAC34365 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE35662 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti334W → R in BAE35662 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023827235 – 320Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014071 mRNA Translation: BAB29142.1 Sequence problems.
AK050655 mRNA Translation: BAC34365.1 Different initiation.
AK160156 mRNA Translation: BAE35662.1 Different initiation.
BC006876 mRNA Translation: AAH06876.1
BC061063 mRNA Translation: AAH61063.1 Different initiation.
RefSeqiNP_001136153.1, NM_001142681.1
NP_080798.2, NM_026522.5
UniGeneiMm.245355

Genome annotation databases

EnsembliENSMUST00000118694; ENSMUSP00000112891; ENSMUSG00000025512 [Q922Q9-2]
ENSMUST00000153191; ENSMUSP00000114693; ENSMUSG00000025512 [Q922Q9-1]
GeneIDi68038
KEGGimmu:68038
UCSCiuc009klp.2 mouse [Q922Q9-2]
uc009klq.2 mouse [Q922Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCHID1_MOUSE
AccessioniPrimary (citable) accession number: Q922Q9
Secondary accession number(s): Q3TVF7
, Q6P8U4, Q8C7C5, Q9CXR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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