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Protein

Mitochondrial amidoxime reducing component 2

Gene

Marc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively (By similarity).By similarity

Cofactori

Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMolybdenum

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial amidoxime reducing component 2 (EC:1.-.-.-)
Short name:
mARC2
Alternative name(s):
Molybdenum cofactor sulfurase C-terminal domain-containing protein 2
Short name:
MOSC domain-containing protein 2
Short name:
Moco sulfurase C-terminal domain-containing protein 2
Gene namesi
Name:Marc2
Synonyms:Mg87, Mosc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914497 Marc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000027334236 – 338Mitochondrial amidoxime reducing component 2Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei156N6-acetyllysine; alternateCombined sources1
Cross-linki156Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki187Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ922Q1
MaxQBiQ922Q1
PaxDbiQ922Q1
PeptideAtlasiQ922Q1
PRIDEiQ922Q1

PTM databases

iPTMnetiQ922Q1
PhosphoSitePlusiQ922Q1
SwissPalmiQ922Q1

Expressioni

Gene expression databases

BgeeiENSMUSG00000073481 Expressed in 293 organ(s), highest expression level in jejunum
CleanExiMM_MOSC2
ExpressionAtlasiQ922Q1 baseline and differential
GenevisibleiQ922Q1 MM

Interactioni

Subunit structurei

Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MARC2.By similarity

Protein-protein interaction databases

IntActiQ922Q1, 5 interactors
MINTiQ922Q1
STRINGi10090.ENSMUSP00000066715

Structurei

3D structure databases

ProteinModelPortaliQ922Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 336MOSCPROSITE-ProRule annotationAdd BLAST149

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2362 Eukaryota
COG3217 LUCA
GeneTreeiENSGT00530000063150
HOGENOMiHOG000180196
HOVERGENiHBG081982
InParanoidiQ922Q1
OMAiGYPFLLI
OrthoDBiEOG091G0S9F
PhylomeDBiQ922Q1
TreeFamiTF316807

Family and domain databases

InterProiView protein in InterPro
IPR005302 MoCF_Sase_C
IPR005303 MOSC_N
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q922Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSSSTALA RLGLPGQPRS TWLGVAALGL AAVALGTVAW RRTRPRRRRQ
60 70 80 90 100
LQQVGTVSKV WIYPIKSCKG VSVCETECTD MGLRCGKVRD RFWMVVKEDG
110 120 130 140 150
HMVTARQEPR LVLVSITLEN NYLTLEAPGM EQIVLPIKLP SSNKIHNCRL
160 170 180 190 200
FGLDIKGRDC GDEVAQWFTN YLKTQAYRLV QFDTSMKGRT TKKLYPSESY
210 220 230 240 250
LQNYEVAYPD CSPVHLISEA SLVDLNTRLK KKVKMEYFRP NIVVSGCEAF
260 270 280 290 300
EEDTWDELLI GDVEMKRVLS CPRCVLTTVD PDTGIIDRKE PLETLKSYRL
310 320 330
CDPSVKSIYQ SSPLFGMYFS VEKLGSLRVG DPVYRMVD
Length:338
Mass (Da):38,194
Last modified:December 1, 2001 - v1
Checksum:i436E6C7224B807DA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZH6E0CZH6_MOUSE
Mitochondrial amidoxime reducing co...
Marc2 Mosc2
190Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051230 mRNA Translation: BAC34565.1
BC006888 mRNA Translation: AAH06888.1
CCDSiCCDS15594.1
RefSeqiNP_598445.1, NM_133684.3
UniGeneiMm.177724

Genome annotation databases

EnsembliENSMUST00000068725; ENSMUSP00000066715; ENSMUSG00000073481
GeneIDi67247
KEGGimmu:67247
UCSCiuc007dyq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051230 mRNA Translation: BAC34565.1
BC006888 mRNA Translation: AAH06888.1
CCDSiCCDS15594.1
RefSeqiNP_598445.1, NM_133684.3
UniGeneiMm.177724

3D structure databases

ProteinModelPortaliQ922Q1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ922Q1, 5 interactors
MINTiQ922Q1
STRINGi10090.ENSMUSP00000066715

PTM databases

iPTMnetiQ922Q1
PhosphoSitePlusiQ922Q1
SwissPalmiQ922Q1

Proteomic databases

EPDiQ922Q1
MaxQBiQ922Q1
PaxDbiQ922Q1
PeptideAtlasiQ922Q1
PRIDEiQ922Q1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068725; ENSMUSP00000066715; ENSMUSG00000073481
GeneIDi67247
KEGGimmu:67247
UCSCiuc007dyq.1 mouse

Organism-specific databases

CTDi54996
MGIiMGI:1914497 Marc2

Phylogenomic databases

eggNOGiKOG2362 Eukaryota
COG3217 LUCA
GeneTreeiENSGT00530000063150
HOGENOMiHOG000180196
HOVERGENiHBG081982
InParanoidiQ922Q1
OMAiGYPFLLI
OrthoDBiEOG091G0S9F
PhylomeDBiQ922Q1
TreeFamiTF316807

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Miscellaneous databases

PROiPR:Q922Q1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073481 Expressed in 293 organ(s), highest expression level in jejunum
CleanExiMM_MOSC2
ExpressionAtlasiQ922Q1 baseline and differential
GenevisibleiQ922Q1 MM

Family and domain databases

InterProiView protein in InterPro
IPR005302 MoCF_Sase_C
IPR005303 MOSC_N
IPR011037 Pyrv_Knase-like_insert_dom_sf
PfamiView protein in Pfam
PF03473 MOSC, 1 hit
PF03476 MOSC_N, 1 hit
SUPFAMiSSF50800 SSF50800, 1 hit
PROSITEiView protein in PROSITE
PS51340 MOSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMARC2_MOUSE
AccessioniPrimary (citable) accession number: Q922Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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