UniProtKB - Q922M5 (CDA7L_MOUSE)
Protein
Cell division cycle-associated 7-like protein
Gene
Cdca7l
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.By similarity1 Publication
GO - Biological processi
- positive regulation of cell population proliferation Source: MGI
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle-associated 7-like proteinAlternative name(s): Transcription factor RAM2 |
Gene namesi | Name:Cdca7l |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384982, Cdca7l |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- fibrillar center Source: MGI
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249314 | 1 – 438 | Cell division cycle-associated 7-like proteinAdd BLAST | 438 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineBy similarity | 1 | |
Modified residuei | 75 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 77 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 101 | PhosphoserineBy similarity | 1 | |
Modified residuei | 104 | PhosphoserineBy similarity | 1 | |
Modified residuei | 135 | PhosphoserineBy similarity | 1 | |
Modified residuei | 136 | PhosphoserineBy similarity | 1 | |
Modified residuei | 159 | PhosphoserineBy similarity | 1 | |
Modified residuei | 183 | PhosphoserineCombined sources | 1 | |
Modified residuei | 185 | PhosphoserineCombined sources | 1 | |
Cross-linki | 210 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 213 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 249 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation increases its interaction with PSIP1.By similarity
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q922M5 |
MaxQBi | Q922M5 |
PaxDbi | Q922M5 |
PeptideAtlasi | Q922M5 |
PRIDEi | Q922M5 |
PTM databases
iPTMneti | Q922M5 |
PhosphoSitePlusi | Q922M5 |
Expressioni
Tissue specificityi
Expressed in all tissues but not detected in total brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000021175, Expressed in metanephric ureteric bud and 250 other tissues |
ExpressionAtlasi | Q922M5, baseline and differential |
Genevisiblei | Q922M5, MM |
Interactioni
Subunit structurei
Interacts with MYC (By similarity).
Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 229982, 3 interactors |
STRINGi | 10090.ENSMUSP00000021592 |
Miscellaneous databases
RNActi | Q922M5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 56 – 115 | PSIP1-bindingBy similarityAdd BLAST | 60 | |
Regioni | 201 – 223 | MYC-bindingBy similarityAdd BLAST | 23 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 9 – 33 | Integrase domain-binding motif 1 (IBM1)By similarityAdd BLAST | 25 | |
Motifi | 63 – 89 | Integrase domain-binding motif 2 (IBM2)By similarityAdd BLAST | 27 |
Phylogenomic databases
eggNOGi | ENOG502QWH1, Eukaryota |
GeneTreei | ENSGT00940000159108 |
HOGENOMi | CLU_035988_0_0_1 |
InParanoidi | Q922M5 |
OMAi | EGFTQND |
OrthoDBi | 1462540at2759 |
PhylomeDBi | Q922M5 |
TreeFami | TF101076 |
Family and domain databases
InterProi | View protein in InterPro IPR040221, CDCA7/CDA7L IPR033578, CDCA7L IPR018866, Znf-4CXXC_R1 |
PANTHERi | PTHR31169, PTHR31169, 1 hit PTHR31169:SF4, PTHR31169:SF4, 1 hit |
Pfami | View protein in Pfam PF10497, zf-4CXXC_R1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q922M5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELATRSQIP KEVADIFSAP SDDEEFVGFQ DDVPMQNLSE SCGSLDSREL
60 70 80 90 100
EKQQNVCFRS KYFTEELRRI FKEDTDSEME DFEGFTESEL NMSSNPELME
110 120 130 140 150
SELSDSDKAY PVMNDAEEDD EEEAAPRRGR STRRSSFGLR VAFQFPTKKL
160 170 180 190 200
ARTPDKDSSH LLDSKTDLRR KKSSRQPKGK EDSASDAEDE SRAESQENSD
210 220 230 240 250
ALLKRAMNIK ENKAMLAQLL AELNSVPDFF PVRTPPSASR RRTPRRAFSE
260 270 280 290 300
GQITRRMNPT RSARPPEKFA LENFTFSATK LTEELYSFRR RKTISGGKCQ
310 320 330 340 350
TYRRHRISSF RSVKDITEED LENIAITVRD KVYDKVLGNT CHQCRQKTID
360 370 380 390 400
TKTVCRNQSC GGVRGQFCGP CLRNRYGEDV RTALLDPKWT CPPCRGICNC
410 420 430
SYCRRRDGRC ATGILIHLAK FYGYDNVKEY LESLQKQL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BJV7 | H3BJV7_MOUSE | Cell division cycle-associated 7-li... | Cdca7l | 226 | Annotation score: | ||
H3BJN2 | H3BJN2_MOUSE | Cell division cycle-associated 7-li... | Cdca7l | 308 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK149673 mRNA Translation: BAE29017.1 BC006933 mRNA Translation: AAH06933.1 |
CCDSi | CCDS49197.1 |
RefSeqi | NP_666152.1, NM_146040.1 |
Genome annotation databases
Ensembli | ENSMUST00000021592; ENSMUSP00000021592; ENSMUSG00000021175 |
GeneIDi | 217946 |
KEGGi | mmu:217946 |
UCSCi | uc007pid.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK149673 mRNA Translation: BAE29017.1 BC006933 mRNA Translation: AAH06933.1 |
CCDSi | CCDS49197.1 |
RefSeqi | NP_666152.1, NM_146040.1 |
3D structure databases
SMRi | Q922M5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229982, 3 interactors |
STRINGi | 10090.ENSMUSP00000021592 |
PTM databases
iPTMneti | Q922M5 |
PhosphoSitePlusi | Q922M5 |
Proteomic databases
EPDi | Q922M5 |
MaxQBi | Q922M5 |
PaxDbi | Q922M5 |
PeptideAtlasi | Q922M5 |
PRIDEi | Q922M5 |
Protocols and materials databases
Antibodypediai | 11993, 230 antibodies |
DNASUi | 217946 |
Genome annotation databases
Ensembli | ENSMUST00000021592; ENSMUSP00000021592; ENSMUSG00000021175 |
GeneIDi | 217946 |
KEGGi | mmu:217946 |
UCSCi | uc007pid.1, mouse |
Organism-specific databases
CTDi | 55536 |
MGIi | MGI:2384982, Cdca7l |
Phylogenomic databases
eggNOGi | ENOG502QWH1, Eukaryota |
GeneTreei | ENSGT00940000159108 |
HOGENOMi | CLU_035988_0_0_1 |
InParanoidi | Q922M5 |
OMAi | EGFTQND |
OrthoDBi | 1462540at2759 |
PhylomeDBi | Q922M5 |
TreeFami | TF101076 |
Miscellaneous databases
BioGRID-ORCSi | 217946, 1 hit in 17 CRISPR screens |
ChiTaRSi | Cdca7l, mouse |
PROi | PR:Q922M5 |
RNActi | Q922M5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021175, Expressed in metanephric ureteric bud and 250 other tissues |
ExpressionAtlasi | Q922M5, baseline and differential |
Genevisiblei | Q922M5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR040221, CDCA7/CDA7L IPR033578, CDCA7L IPR018866, Znf-4CXXC_R1 |
PANTHERi | PTHR31169, PTHR31169, 1 hit PTHR31169:SF4, PTHR31169:SF4, 1 hit |
Pfami | View protein in Pfam PF10497, zf-4CXXC_R1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDA7L_MOUSE | |
Accessioni | Q922M5Primary (citable) accession number: Q922M5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot