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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Gene

Kctd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
Short name:
mBACURD3
Alternative name(s):
BTB/POZ domain-containing protein KCTD10
Gene namesi
Name:Kctd10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2141207 Kctd10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474221 – 315BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ922M3
MaxQBiQ922M3
PaxDbiQ922M3
PRIDEiQ922M3

PTM databases

iPTMnetiQ922M3
PhosphoSitePlusiQ922M3

Expressioni

Gene expression databases

BgeeiENSMUSG00000001098 Expressed in 289 organ(s), highest expression level in aorta
ExpressionAtlasiQ922M3 baseline and differential
GenevisibleiQ922M3 MM

Interactioni

Subunit structurei

Homotetramer; forms a two-fold symmetric tetramer in solution. Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (By similarity). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA (By similarity). Associated with the tectonic-like complex (also named B9 complex); however as Kctd10 has not been identified in all tectonic-like complexes purifications it is unclear whether it is really part of the complex (PubMed:22179047).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ922M3
IntActiQ922M3, 3 interactors
MINTiQ922M3
STRINGi10090.ENSMUSP00000001125

Structurei

3D structure databases

ProteinModelPortaliQ922M3
SMRiQ922M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 100BTBPROSITE-ProRule annotationAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi239 – 245PCNA-bindingBy similarity7

Sequence similaritiesi

Belongs to the BACURD family.Curated

Phylogenomic databases

eggNOGiKOG2716 Eukaryota
ENOG410XQYZ LUCA
GeneTreeiENSGT00920000149007
HOGENOMiHOG000294088
HOVERGENiHBG052219
InParanoidiQ922M3
KOiK15074
PhylomeDBiQ922M3

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q922M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEMSGDSVV SSAVPAAATR TTSFKGASPS SKYVKLNVGG ALYYTTMQTL
60 70 80 90 100
TKQDTMLKAM FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGGVPLPE
110 120 130 140 150
SRREIEELLA EAKYYLVQGL LEECQAALQN KDTYEPFCKV PVITSSKEEQ
160 170 180 190 200
RLIATSNKPA VKLLYNRSNN KYSYTSNSDD NMLKNIELFD KLSLRFNGRV
210 220 230 240 250
LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT KVEFPEARIY
260 270 280 290 300
EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERERIERVR
310
RIHIKRPDDR AHLHQ
Length:315
Mass (Da):35,701
Last modified:December 1, 2001 - v1
Checksum:i590AEF2D4F22D2D9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WGQ9F8WGQ9_MOUSE
BTB/POZ domain-containing adapter f...
Kctd10
316Annotation score:
S4R2A3S4R2A3_MOUSE
BTB/POZ domain-containing adapter f...
Kctd10
100Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028657 mRNA Translation: BAC26050.1
AK041516 mRNA Translation: BAC30969.1
AK145295 mRNA Translation: BAE26350.1
AK147714 mRNA Translation: BAE28090.1
AK161199 mRNA Translation: BAE36235.1
AK163351 mRNA Translation: BAE37313.1
AK166505 mRNA Translation: BAE38815.1
BC006935 mRNA Translation: AAH06935.1
CCDSiCCDS19563.1
RefSeqiNP_001153413.1, NM_001159941.1
NP_080421.2, NM_026145.4
UniGeneiMm.238285
Mm.428824
Mm.490304

Genome annotation databases

EnsembliENSMUST00000102581; ENSMUSP00000099641; ENSMUSG00000001098
GeneIDi330171
KEGGimmu:330171
UCSCiuc008yzm.2 mouse

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028657 mRNA Translation: BAC26050.1
AK041516 mRNA Translation: BAC30969.1
AK145295 mRNA Translation: BAE26350.1
AK147714 mRNA Translation: BAE28090.1
AK161199 mRNA Translation: BAE36235.1
AK163351 mRNA Translation: BAE37313.1
AK166505 mRNA Translation: BAE38815.1
BC006935 mRNA Translation: AAH06935.1
CCDSiCCDS19563.1
RefSeqiNP_001153413.1, NM_001159941.1
NP_080421.2, NM_026145.4
UniGeneiMm.238285
Mm.428824
Mm.490304

3D structure databases

ProteinModelPortaliQ922M3
SMRiQ922M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ922M3
IntActiQ922M3, 3 interactors
MINTiQ922M3
STRINGi10090.ENSMUSP00000001125

PTM databases

iPTMnetiQ922M3
PhosphoSitePlusiQ922M3

Proteomic databases

EPDiQ922M3
MaxQBiQ922M3
PaxDbiQ922M3
PRIDEiQ922M3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102581; ENSMUSP00000099641; ENSMUSG00000001098
GeneIDi330171
KEGGimmu:330171
UCSCiuc008yzm.2 mouse

Organism-specific databases

CTDi83892
MGIiMGI:2141207 Kctd10

Phylogenomic databases

eggNOGiKOG2716 Eukaryota
ENOG410XQYZ LUCA
GeneTreeiENSGT00920000149007
HOGENOMiHOG000294088
HOVERGENiHBG052219
InParanoidiQ922M3
KOiK15074
PhylomeDBiQ922M3

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

PROiPR:Q922M3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001098 Expressed in 289 organ(s), highest expression level in aorta
ExpressionAtlasiQ922M3 baseline and differential
GenevisibleiQ922M3 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBACD3_MOUSE
AccessioniPrimary (citable) accession number: Q922M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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