Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Negative elongation factor D

Gene

Nelfcd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Binds RNA which may help to stabilize the NELF complex on nucleic acid. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Negative elongation factor D
Short name:
NELF-D
Alternative name(s):
TH1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nelfcd
Synonyms:Nelfd, Th1, Th1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926424 Nelfcd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002191321 – 591Negative elongation factor DAdd BLAST591

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q922L6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q922L6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q922L6

PRoteomics IDEntifications database

More...
PRIDEi
Q922L6

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q922L6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000016253 Expressed in 294 organ(s), highest expression level in embryo

CleanEx database of gene expression profiles

More...
CleanExi
MM_TH1L

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q922L6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q922L6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The NELF complex is composed of NELFA, NELFB, NELFCD and NELFE; NELFA and NELFCD form a stable subcomplex that binds primarily through NELFCD to the N-terminus of NELFB. Interacts with ARAF1. Interacts with PCF11.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
208252, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104703

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q922L6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NELF-D family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFGF Eukaryota
ENOG410XSDJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231762

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052597

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q922L6

KEGG Orthology (KO)

More...
KOi
K15181

Identification of Orthologs from Complete Genome Data

More...
OMAi
VMEPSYF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006942 TH1

The PANTHER Classification System

More...
PANTHERi
PTHR12144 PTHR12144, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04858 TH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q922L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPAPGTIM GEDYFGNASE WGEEADGGQH QEDDSGEGED DAEVQQECLH
60 70 80 90 100
KFSTRDYIME PSIFNTLKRY FQAGGSPENV IQLLSENYTA VAQTVNLLAE
110 120 130 140 150
WLIQTGVEPV QVQETVENHL KSLLIKHFDP RKADSIFTEE GETPAWLEQM
160 170 180 190 200
IAHTTWRDLF YKLAEAHPDC LMLNFTVKLI SDAGYQGEIT SVSTACQQLE
210 220 230 240 250
VFSRVLRTSL ATILDGGEEN LEKNLPEFAK MVCHGEHTYL FAQAMMSVLA
260 270 280 290 300
QEEQGGSAVR RVAQEVQRFA QEKGHDASQI TLALGTAASY PRACQALGAM
310 320 330 340 350
LSRGALNPAD ITVLFKMFTS MDPPPVELIR VPAFLDLFMQ SLFKPGAKIN
360 370 380 390 400
QDHKHKYIHI LAYAASVVET WKKNKRVSIG KDELKSTSKA IETVHNLCCN
410 420 430 440 450
ENKGASELVA ELSTLYQCIR FPVVAMGVLK WVDWTVSEPR YFQLQTDHTP
460 470 480 490 500
VHLALLDEIS TCHQLLHPQV LQLLVKLFET EHSQLDVMEQ LELKKTLLDR
510 520 530 540 550
MVHLLSRGYV LPVVSYIRKC LEKLDTDISL IRYFVTEVLD VIAPPYTSDF
560 570 580 590
VQLFLPILEN DSIAGTIKAE GEHDPVTEFI AHCKSNFIVV N
Length:591
Mass (Da):66,276
Last modified:November 14, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33DB33547688715D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TW27Q3TW27_MOUSE
Negative elongation factor D
Nelfcd Th1l
607Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31747 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26880 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33744 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB65252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB65253 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB65254 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38G → V in AAH06959 (PubMed:15489334).Curated1
Sequence conflicti416Y → C in CAB65253 (PubMed:11030415).Curated1
Sequence conflicti479E → G in CAB65254 (PubMed:11030415).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ238741 mRNA Translation: CAB65252.1 Different initiation.
AJ238742 mRNA Translation: CAB65253.1 Different initiation.
AJ238743 mRNA Translation: CAB65254.1 Different initiation.
AK010360 mRNA Translation: BAB26880.1 Different initiation.
AK049418 mRNA Translation: BAC33744.1 Different initiation.
AL844534 Genomic DNA No translation available.
BC006959 mRNA Translation: AAH06959.1
BC031747 mRNA Translation: AAH31747.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38358.1

NCBI Reference Sequences

More...
RefSeqi
NP_065605.2, NM_020580.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.271709

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000109075; ENSMUSP00000104703; ENSMUSG00000016253

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57314

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:57314

UCSC genome browser

More...
UCSCi
uc008ofc.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238741 mRNA Translation: CAB65252.1 Different initiation.
AJ238742 mRNA Translation: CAB65253.1 Different initiation.
AJ238743 mRNA Translation: CAB65254.1 Different initiation.
AK010360 mRNA Translation: BAB26880.1 Different initiation.
AK049418 mRNA Translation: BAC33744.1 Different initiation.
AL844534 Genomic DNA No translation available.
BC006959 mRNA Translation: AAH06959.1
BC031747 mRNA Translation: AAH31747.1 Different initiation.
CCDSiCCDS38358.1
RefSeqiNP_065605.2, NM_020580.3
UniGeneiMm.271709

3D structure databases

SMRiQ922L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208252, 2 interactors
STRINGi10090.ENSMUSP00000104703

PTM databases

PhosphoSitePlusiQ922L6

Proteomic databases

EPDiQ922L6
MaxQBiQ922L6
PaxDbiQ922L6
PRIDEiQ922L6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109075; ENSMUSP00000104703; ENSMUSG00000016253
GeneIDi57314
KEGGimmu:57314
UCSCiuc008ofc.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51497
MGIiMGI:1926424 Nelfcd

Phylogenomic databases

eggNOGiENOG410IFGF Eukaryota
ENOG410XSDJ LUCA
GeneTreeiENSGT00390000001799
HOGENOMiHOG000231762
HOVERGENiHBG052597
InParanoidiQ922L6
KOiK15181
OMAiVMEPSYF

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nelfcd mouse

Protein Ontology

More...
PROi
PR:Q922L6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000016253 Expressed in 294 organ(s), highest expression level in embryo
CleanExiMM_TH1L
ExpressionAtlasiQ922L6 baseline and differential
GenevisibleiQ922L6 MM

Family and domain databases

InterProiView protein in InterPro
IPR006942 TH1
PANTHERiPTHR12144 PTHR12144, 1 hit
PfamiView protein in Pfam
PF04858 TH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNELFD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q922L6
Secondary accession number(s): A2AQ05
, Q9QXC8, Q9QXC9, Q9QXD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again